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Entry version 153 (12 Aug 2020)
Sequence version 3 (05 May 2009)
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Protein

Keratin, type I cuticular Ha8

Gene

KRT38

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei353Stutter1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • structural molecule activity Source: ProtInc

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
O76015

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6805567, Keratinization
R-HSA-6809371, Formation of the cornified envelope

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Keratin, type I cuticular Ha8
Alternative name(s):
Hair keratin, type I Ha8
Keratin-38
Short name:
K38
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KRT38
Synonyms:HHA8, HKA8, KRTHA8
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000171360.3

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6456, KRT38

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604542, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O76015

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Intermediate filament, Keratin

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000171360

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30245

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O76015, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KRT38

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000636951 – 456Keratin, type I cuticular Ha8Add BLAST456

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O76015

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
O76015

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O76015

PeptideAtlas

More...
PeptideAtlasi
O76015

PRoteomics IDEntifications database

More...
PRIDEi
O76015

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
12652
50347

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O76015

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O76015

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000171360, Expressed in hair follicle and 20 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O76015, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000171360, Tissue enriched (skin)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

O76015
With#Exp.IntAct
ABI3 [Q9P2A4]3EBI-1047263,EBI-742038
AMOTL2 - isoform 4 [Q9Y2J4-4]3EBI-1047263,EBI-10187270
ANKRD36BP1 [Q96IX9]3EBI-1047263,EBI-744859
BEX2 [Q9BXY8]3EBI-1047263,EBI-745073
C19orf57 [Q0VDD7]3EBI-1047263,EBI-741210
C1orf216 [Q8TAB5]6EBI-1047263,EBI-747505
CCDC120 [Q96HB5]3EBI-1047263,EBI-744556
CCDC146 [Q8IYE0]5EBI-1047263,EBI-10749669
CCDC146 - isoform 2 [Q8IYE0-2]4EBI-1047263,EBI-10247802
CD300A [Q9UGN4]3EBI-1047263,EBI-10320732
CEP57L1 - isoform 2 [Q8IYX8-2]3EBI-1047263,EBI-10181988
DMRT3 [Q9NQL9]3EBI-1047263,EBI-9679045
DTNB - isoform 5 [O60941-5]3EBI-1047263,EBI-11984733
FAM110A [Q9BQ89]3EBI-1047263,EBI-1752811
FAM90A1 [Q86YD7]3EBI-1047263,EBI-6658203
GLRX3 [O76003]3EBI-1047263,EBI-374781
GNG10 [P50151]6EBI-1047263,EBI-10211741
GNG13 [Q9P2W3]3EBI-1047263,EBI-11427343
HAUS1 [Q96CS2]5EBI-1047263,EBI-2514791
HDAC4 [P56524]3EBI-1047263,EBI-308629
HGS [A0A0S2Z4Q4]3EBI-1047263,EBI-16429135
HGS [O14964]6EBI-1047263,EBI-740220
HMG20B [Q9P0W2]6EBI-1047263,EBI-713401
HOXA1 [P49639]6EBI-1047263,EBI-740785
HSF4 - isoform HSF4A [Q9ULV5-2]3EBI-1047263,EBI-12056251
KIFC3 - isoform 4 [Q9BVG8-5]3EBI-1047263,EBI-14069005
KLHL38 [Q2WGJ6]6EBI-1047263,EBI-6426443
KRT1 [P04264]3EBI-1047263,EBI-298429
KRT2 [P35908]11EBI-1047263,EBI-1247312
KRT3 [P12035]3EBI-1047263,EBI-2430095
KRT4 [P19013]9EBI-1047263,EBI-2371606
KRT5 [P13647]6EBI-1047263,EBI-702187
KRT6A [P02538]14EBI-1047263,EBI-702198
KRT6B [P04259]8EBI-1047263,EBI-740907
KRT6C [P48668]6EBI-1047263,EBI-2564105
KRT71 [Q3SY84]6EBI-1047263,EBI-2952676
KRT72 [Q14CN4]3EBI-1047263,EBI-1221280
KRT74 [Q7RTS7]3EBI-1047263,EBI-968660
KRT75 [O95678]3EBI-1047263,EBI-2949715
KRT76 [Q01546]3EBI-1047263,EBI-2952745
KRT79 [Q5XKE5]6EBI-1047263,EBI-2514135
KRT8 [P05787]7EBI-1047263,EBI-297852
KRT80 - isoform 2 [Q6KB66-2]5EBI-1047263,EBI-11999246
KRT81 [Q14533]10EBI-1047263,EBI-739648
KRT83 [P78385]8EBI-1047263,EBI-10221390
KRT85 [P78386]3EBI-1047263,EBI-1049371
KRT86 [O43790]3EBI-1047263,EBI-9996498
LHX4 [A0A0S2Z5S9]3EBI-1047263,EBI-16429099
LMO3 - isoform 4 [Q8TAP4-4]3EBI-1047263,EBI-11742507
LMO4 [P61968]3EBI-1047263,EBI-2798728
MAGEB4 [O15481]5EBI-1047263,EBI-751857
MAPKBP1 [O60336]3EBI-1047263,EBI-947402
PIK3R2 [O00459]5EBI-1047263,EBI-346930
PIN1 [Q13526]6EBI-1047263,EBI-714158
POU4F2 [Q12837]3EBI-1047263,EBI-17236143
PSMA1 [P25786]6EBI-1047263,EBI-359352
PSMC5 [P62195]6EBI-1047263,EBI-357745
PTGER3 - isoform 12 [P43115-12]3EBI-1047263,EBI-10234038
RHPN1-AS1 [Q9BWJ2]3EBI-1047263,EBI-10300934
SCNM1 [Q9BWG6]9EBI-1047263,EBI-748391
SMARCD1 [Q96GM5]3EBI-1047263,EBI-358489
TBC1D21 [Q8IYX1]5EBI-1047263,EBI-12018146
TRIML2 [Q8N7C3]3EBI-1047263,EBI-11059915
TXLNA [P40222]6EBI-1047263,EBI-359793
TXLNB [Q8N3L3]9EBI-1047263,EBI-6116822
TXNDC5 [Q86UY0]3EBI-1047263,EBI-2825190
USHBP1 [Q8N6Y0]6EBI-1047263,EBI-739895
UTP23 [Q9BRU9]3EBI-1047263,EBI-5457544
ZFYVE21 [Q9BQ24]3EBI-1047263,EBI-2849569
ZNF20 [P17024]3EBI-1047263,EBI-717634
ZNF417 [Q8TAU3]6EBI-1047263,EBI-740727
ZNF587 [Q96SQ5]3EBI-1047263,EBI-6427977
A8K2R33EBI-1047263,EBI-9977437

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
114234, 48 interactors

Protein interaction database and analysis system

More...
IntActi
O76015, 74 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000246646

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
O76015, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O76015

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini104 – 415IF rodPROSITE-ProRule annotationAdd BLAST312

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 104HeadAdd BLAST104
Regioni105 – 139Coil 1AAdd BLAST35
Regioni140 – 150Linker 1Add BLAST11
Regioni151 – 251Coil 1BAdd BLAST101
Regioni252 – 267Linker 12Add BLAST16
Regioni268 – 411Coil 2Add BLAST144
Regioni412 – 456TailAdd BLAST45

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502SIYJ, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163444

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_012560_8_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O76015

KEGG Orthology (KO)

More...
KOi
K07604

Identification of Orthologs from Complete Genome Data

More...
OMAi
GSCGTYG

Database of Orthologous Groups

More...
OrthoDBi
657425at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O76015

TreeFam database of animal gene trees

More...
TreeFami
TF332742

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.5.1160, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018039, IF_conserved
IPR039008, IF_rod_dom
IPR042180, IF_rod_dom_coil1B
IPR002957, Keratin_I

The PANTHER Classification System

More...
PANTHERi
PTHR23239, PTHR23239, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00038, Filament, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01248, TYPE1KERATIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01391, Filament, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00226, IF_ROD_1, 1 hit
PS51842, IF_ROD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O76015-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSSYSSSSC PLGCTMAPGA RNVSVSPIDI GCQPGAEANI APMCLLANVA
60 70 80 90 100
HANRVRVGST PLGRPSLCLP PTCHTACPLP GTCHIPGNIG ICGAYGENTL
110 120 130 140 150
NGHEKETMQF LNDRLANYLE KVRQLEQENA ELEATLLERS KCHESTVCPD
160 170 180 190 200
YQSYFHTIEE LQQKILCSKA ENARLIVQID NAKLAADDFR IKLESERSLR
210 220 230 240 250
QLVEADKCGT QKLLDDATLA KADLEAQQES LKEEQLSLKS NHEQEVKILR
260 270 280 290 300
SQLGEKLRIE LDIEPTIDLN RVLGEMRAQY EAMLETNRQD VEQWFQAQSE
310 320 330 340 350
GISLQDMSCS EELQCCQSEI LELRCTVNAL EVERQAQHTL KDCLQNSLCE
360 370 380 390 400
AEDRFGTELA QMQSLISNVE EQLSEIRADL ERQNQEYQVL LDVKTRLENE
410 420 430 440 450
IATYRNLLES EDCKLPCNPC STSPSCVTAP CAPRPSCGPC TTCGPTCGAS

TTGSRF
Length:456
Mass (Da):50,480
Last modified:May 5, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8AE2E9BE95FC8E72
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti113D → G in CAH10351 (PubMed:15617563).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_055137423S → P4 PublicationsCorresponds to variant dbSNP:rs897416Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Y16794 Genomic DNA Translation: CAA76390.2
AC019349 Genomic DNA No translation available.
CH471152 Genomic DNA Translation: EAW60734.1
BC131715 mRNA Translation: AAI31716.1
AJ786656 mRNA Translation: CAH10351.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11392.1

NCBI Reference Sequences

More...
RefSeqi
NP_006762.3, NM_006771.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000246646; ENSP00000246646; ENSG00000171360

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8687

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8687

UCSC genome browser

More...
UCSCi
uc002hwq.2, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16794 Genomic DNA Translation: CAA76390.2
AC019349 Genomic DNA No translation available.
CH471152 Genomic DNA Translation: EAW60734.1
BC131715 mRNA Translation: AAI31716.1
AJ786656 mRNA Translation: CAH10351.1
CCDSiCCDS11392.1
RefSeqiNP_006762.3, NM_006771.3

3D structure databases

SMRiO76015
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi114234, 48 interactors
IntActiO76015, 74 interactors
STRINGi9606.ENSP00000246646

PTM databases

iPTMnetiO76015
PhosphoSitePlusiO76015

Polymorphism and mutation databases

BioMutaiKRT38

Proteomic databases

jPOSTiO76015
MassIVEiO76015
PaxDbiO76015
PeptideAtlasiO76015
PRIDEiO76015
ProteomicsDBi12652
50347

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
44473, 58 antibodies

Genome annotation databases

EnsembliENST00000246646; ENSP00000246646; ENSG00000171360
GeneIDi8687
KEGGihsa:8687
UCSCiuc002hwq.2, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
8687
EuPathDBiHostDB:ENSG00000171360.3

GeneCards: human genes, protein and diseases

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GeneCardsi
KRT38
HGNCiHGNC:6456, KRT38
HPAiENSG00000171360, Tissue enriched (skin)
MIMi604542, gene
neXtProtiNX_O76015
OpenTargetsiENSG00000171360
PharmGKBiPA30245

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG502SIYJ, Eukaryota
GeneTreeiENSGT00940000163444
HOGENOMiCLU_012560_8_0_1
InParanoidiO76015
KOiK07604
OMAiGSCGTYG
OrthoDBi657425at2759
PhylomeDBiO76015
TreeFamiTF332742

Enzyme and pathway databases

PathwayCommonsiO76015
ReactomeiR-HSA-6805567, Keratinization
R-HSA-6809371, Formation of the cornified envelope

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
8687, 4 hits in 863 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
8687
PharosiO76015, Tdark

Protein Ontology

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PROi
PR:O76015
RNActiO76015, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000171360, Expressed in hair follicle and 20 other tissues
GenevisibleiO76015, HS

Family and domain databases

Gene3Di1.20.5.1160, 1 hit
InterProiView protein in InterPro
IPR018039, IF_conserved
IPR039008, IF_rod_dom
IPR042180, IF_rod_dom_coil1B
IPR002957, Keratin_I
PANTHERiPTHR23239, PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038, Filament, 1 hit
PRINTSiPR01248, TYPE1KERATIN
SMARTiView protein in SMART
SM01391, Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226, IF_ROD_1, 1 hit
PS51842, IF_ROD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKRT38_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O76015
Secondary accession number(s): A2RRM5, Q6A164
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 5, 2009
Last modified: August 12, 2020
This is version 153 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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