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Protein

Keratin, type I cuticular Ha8

Gene

KRT38

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei353Stutter1

GO - Molecular functioni

  • structural molecule activity Source: ProtInc

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cuticular Ha8
Alternative name(s):
Hair keratin, type I Ha8
Keratin-38
Short name:
K38
Gene namesi
Name:KRT38
Synonyms:HHA8, HKA8, KRTHA8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000171360.3
HGNCiHGNC:6456 KRT38
MIMi604542 gene
neXtProtiNX_O76015

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000171360
PharmGKBiPA30245

Polymorphism and mutation databases

BioMutaiKRT38

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000636951 – 456Keratin, type I cuticular Ha8Add BLAST456

Proteomic databases

PaxDbiO76015
PeptideAtlasiO76015
PRIDEiO76015
ProteomicsDBi12652
50347

PTM databases

iPTMnetiO76015
PhosphoSitePlusiO76015

Expressioni

Gene expression databases

BgeeiENSG00000171360 Expressed in 16 organ(s), highest expression level in hair follicle
CleanExiHS_KRT38
GenevisibleiO76015 HS

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi114234, 46 interactors
IntActiO76015, 74 interactors

Structurei

3D structure databases

ProteinModelPortaliO76015
SMRiO76015
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini104 – 415IF rodPROSITE-ProRule annotationAdd BLAST312

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 104HeadAdd BLAST104
Regioni105 – 139Coil 1AAdd BLAST35
Regioni140 – 150Linker 1Add BLAST11
Regioni151 – 251Coil 1BAdd BLAST101
Regioni252 – 267Linker 12Add BLAST16
Regioni268 – 411Coil 2Add BLAST144
Regioni412 – 456TailAdd BLAST45

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410J94T Eukaryota
ENOG4111D61 LUCA
GeneTreeiENSGT00900000140814
HOGENOMiHOG000230975
HOVERGENiHBG013015
InParanoidiO76015
KOiK07604
OMAiMVEADMC
OrthoDBiEOG091G05GB
PhylomeDBiO76015
TreeFamiTF332742

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR002957 Keratin_I
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PRINTSiPR01248 TYPE1KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

O76015-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSSYSSSSC PLGCTMAPGA RNVSVSPIDI GCQPGAEANI APMCLLANVA
60 70 80 90 100
HANRVRVGST PLGRPSLCLP PTCHTACPLP GTCHIPGNIG ICGAYGENTL
110 120 130 140 150
NGHEKETMQF LNDRLANYLE KVRQLEQENA ELEATLLERS KCHESTVCPD
160 170 180 190 200
YQSYFHTIEE LQQKILCSKA ENARLIVQID NAKLAADDFR IKLESERSLR
210 220 230 240 250
QLVEADKCGT QKLLDDATLA KADLEAQQES LKEEQLSLKS NHEQEVKILR
260 270 280 290 300
SQLGEKLRIE LDIEPTIDLN RVLGEMRAQY EAMLETNRQD VEQWFQAQSE
310 320 330 340 350
GISLQDMSCS EELQCCQSEI LELRCTVNAL EVERQAQHTL KDCLQNSLCE
360 370 380 390 400
AEDRFGTELA QMQSLISNVE EQLSEIRADL ERQNQEYQVL LDVKTRLENE
410 420 430 440 450
IATYRNLLES EDCKLPCNPC STSPSCVTAP CAPRPSCGPC TTCGPTCGAS

TTGSRF
Length:456
Mass (Da):50,480
Last modified:May 5, 2009 - v3
Checksum:i8AE2E9BE95FC8E72
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti113D → G in CAH10351 (PubMed:15617563).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055137423S → P4 PublicationsCorresponds to variant dbSNP:rs897416Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16794 Genomic DNA Translation: CAA76390.2
AC019349 Genomic DNA No translation available.
CH471152 Genomic DNA Translation: EAW60734.1
BC131715 mRNA Translation: AAI31716.1
AJ786656 mRNA Translation: CAH10351.1
CCDSiCCDS11392.1
RefSeqiNP_006762.3, NM_006771.3
UniGeneiHs.248188

Genome annotation databases

EnsembliENST00000246646; ENSP00000246646; ENSG00000171360
GeneIDi8687
KEGGihsa:8687
UCSCiuc002hwq.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16794 Genomic DNA Translation: CAA76390.2
AC019349 Genomic DNA No translation available.
CH471152 Genomic DNA Translation: EAW60734.1
BC131715 mRNA Translation: AAI31716.1
AJ786656 mRNA Translation: CAH10351.1
CCDSiCCDS11392.1
RefSeqiNP_006762.3, NM_006771.3
UniGeneiHs.248188

3D structure databases

ProteinModelPortaliO76015
SMRiO76015
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114234, 46 interactors
IntActiO76015, 74 interactors

PTM databases

iPTMnetiO76015
PhosphoSitePlusiO76015

Polymorphism and mutation databases

BioMutaiKRT38

Proteomic databases

PaxDbiO76015
PeptideAtlasiO76015
PRIDEiO76015
ProteomicsDBi12652
50347

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000246646; ENSP00000246646; ENSG00000171360
GeneIDi8687
KEGGihsa:8687
UCSCiuc002hwq.2 human

Organism-specific databases

CTDi8687
EuPathDBiHostDB:ENSG00000171360.3
GeneCardsiKRT38
H-InvDBiHIX0039116
HGNCiHGNC:6456 KRT38
MIMi604542 gene
neXtProtiNX_O76015
OpenTargetsiENSG00000171360
PharmGKBiPA30245
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J94T Eukaryota
ENOG4111D61 LUCA
GeneTreeiENSGT00900000140814
HOGENOMiHOG000230975
HOVERGENiHBG013015
InParanoidiO76015
KOiK07604
OMAiMVEADMC
OrthoDBiEOG091G05GB
PhylomeDBiO76015
TreeFamiTF332742

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope

Miscellaneous databases

GenomeRNAii8687
PROiPR:O76015
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171360 Expressed in 16 organ(s), highest expression level in hair follicle
CleanExiHS_KRT38
GenevisibleiO76015 HS

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR002957 Keratin_I
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PRINTSiPR01248 TYPE1KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKRT38_HUMAN
AccessioniPrimary (citable) accession number: O76015
Secondary accession number(s): A2RRM5, Q6A164
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 5, 2009
Last modified: November 7, 2018
This is version 139 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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