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UniProtKB - O76014 (KRT37_HUMAN)
Protein
Keratin, type I cuticular Ha7
Gene
KRT37
Organism
Homo sapiens (Human)
Status
Functioni
Miscellaneous
There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 353 | Stutter | 1 |
GO - Molecular functioni
- structural molecule activity Source: ProtInc
GO - Biological processi
- epithelial cell differentiation Source: GO_Central
- intermediate filament organization Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | O76014 |
Reactomei | R-HSA-6805567, Keratinization R-HSA-6809371, Formation of the cornified envelope |
SignaLinki | O76014 |
Names & Taxonomyi
Protein namesi | Recommended name: Keratin, type I cuticular Ha7Alternative name(s): Hair keratin, type I Ha7 Keratin-37 Short name: K37 |
Gene namesi | Name:KRT37 Synonyms:HHA7, HKA7, KRTHA7 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6455, KRT37 |
MIMi | 604541, gene |
neXtProti | NX_O76014 |
VEuPathDBi | HostDB:ENSG00000108417 |
Subcellular locationi
Cytoskeleton
- cytoskeleton Source: GO_Central
- intermediate filament Source: UniProtKB-KW
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Keywords - Cellular componenti
Intermediate filament, KeratinPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000108417 |
PharmGKBi | PA30244 |
Miscellaneous databases
Pharosi | O76014, Tdark |
Genetic variation databases
BioMutai | KRT37 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000063694 | 1 – 449 | Keratin, type I cuticular Ha7Add BLAST | 449 |
Proteomic databases
jPOSTi | O76014 |
MassIVEi | O76014 |
PaxDbi | O76014 |
PeptideAtlasi | O76014 |
PRIDEi | O76014 |
ProteomicsDBi | 50346 |
PTM databases
iPTMneti | O76014 |
PhosphoSitePlusi | O76014 |
Expressioni
Gene expression databases
Bgeei | ENSG00000108417, Expressed in ectocervix and 23 other tissues |
Genevisiblei | O76014, HS |
Organism-specific databases
HPAi | ENSG00000108417, Tissue enriched (skin) |
Interactioni
Binary interactionsi
O76014
Protein-protein interaction databases
BioGRIDi | 114235, 111 interactors |
IntActi | O76014, 43 interactors |
STRINGi | 9606.ENSP00000225550 |
Miscellaneous databases
RNActi | O76014, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 104 – 415 | IF rodPROSITE-ProRule annotationAdd BLAST | 312 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 104 | HeadAdd BLAST | 104 | |
Regioni | 105 – 139 | Coil 1AAdd BLAST | 35 | |
Regioni | 140 – 150 | Linker 1Add BLAST | 11 | |
Regioni | 151 – 251 | Coil 1BAdd BLAST | 101 | |
Regioni | 252 – 267 | Linker 12Add BLAST | 16 | |
Regioni | 268 – 411 | Coil 2Add BLAST | 144 | |
Regioni | 416 – 449 | TailAdd BLAST | 34 |
Sequence similaritiesi
Belongs to the intermediate filament family.PROSITE-ProRule annotation
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502SIYJ, Eukaryota |
GeneTreei | ENSGT00940000163444 |
HOGENOMi | CLU_012560_8_0_1 |
InParanoidi | O76014 |
OMAi | MNREHCP |
OrthoDBi | 657425at2759 |
PhylomeDBi | O76014 |
TreeFami | TF332742 |
Family and domain databases
InterProi | View protein in InterPro IPR018039, IF_conserved IPR039008, IF_rod_dom IPR002957, Keratin_I |
PANTHERi | PTHR23239, PTHR23239, 1 hit |
Pfami | View protein in Pfam PF00038, Filament, 1 hit |
PRINTSi | PR01248, TYPE1KERATIN |
SMARTi | View protein in SMART SM01391, Filament, 1 hit |
PROSITEi | View protein in PROSITE PS00226, IF_ROD_1, 1 hit PS51842, IF_ROD_2, 1 hit |
i Sequence
Sequence statusi: Complete.
O76014-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTSFYSTSSC PLGCTMAPGA RNVFVSPIDV GCQPVAEANA ASMCLLANVA
60 70 80 90 100
HANRVRVGST PLGRPSLCLP PTSHTACPLP GTCHIPGNIG ICGAYGKNTL
110 120 130 140 150
NGHEKETMKF LNDRLANYLE KVRQLEQENA ELETTLLERS KCHESTVCPD
160 170 180 190 200
YQSYFRTIEE LQQKILCSKA ENARLIVQID NAKLAADDFR IKLESERSLH
210 220 230 240 250
QLVEADKCGT QKLLDDATLA KADLEAQQES LKEEQLSLKS NHEQEVKILR
260 270 280 290 300
SQLGEKFRIE LDIEPTIDLN RVLGEMRAQY EAMVETNHQD VEQWFQAQSE
310 320 330 340 350
GISLQAMSCS EELQCCQSEI LELRCTVNAL EVERQAQHTL KDCLQNSLCE
360 370 380 390 400
AEDRYGTELA QMQSLISNLE EQLSEIRADL ERQNQEYQVL LDVKARLENE
410 420 430 440
IATYRNLLES EDCKLPCNPC STPASCTSCP SCGPVTGGSP SGHGASMGR
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049795 | 13 | G → C. Corresponds to variant dbSNP:rs9910204Ensembl. | 1 | |
Natural variantiVAR_049796 | 39 | N → S. Corresponds to variant dbSNP:rs9916724Ensembl. | 1 | |
Natural variantiVAR_049797 | 72 | T → A. Corresponds to variant dbSNP:rs9916484Ensembl. | 1 | |
Natural variantiVAR_049798 | 73 | S → C. Corresponds to variant dbSNP:rs9916475Ensembl. | 1 | |
Natural variantiVAR_049799 | 217 | A → V. Corresponds to variant dbSNP:rs16966811Ensembl. | 1 | |
Natural variantiVAR_049800 | 306 | A → D. Corresponds to variant dbSNP:rs2071607Ensembl. | 1 | |
Natural variantiVAR_049801 | 421 | S → F. Corresponds to variant dbSNP:rs35371972Ensembl. | 1 | |
Natural variantiVAR_049802 | 422 | T → M. Corresponds to variant dbSNP:rs8071814Ensembl. | 1 | |
Natural variantiVAR_049803 | 434 | P → S. Corresponds to variant dbSNP:rs17737019Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y16793 Genomic DNA Translation: CAA76389.3 |
CCDSi | CCDS32653.1 |
RefSeqi | NP_003761.3, NM_003770.4 |
Genome annotation databases
Ensembli | ENST00000225550.4; ENSP00000225550.3; ENSG00000108417.4 ENST00000574588.1; ENSP00000458693.1; ENSG00000263022.1 |
GeneIDi | 8688 |
KEGGi | hsa:8688 |
MANE-Selecti | ENST00000225550.4; ENSP00000225550.3; NM_003770.5; NP_003761.3 |
UCSCi | uc002hwp.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y16793 Genomic DNA Translation: CAA76389.3 |
CCDSi | CCDS32653.1 |
RefSeqi | NP_003761.3, NM_003770.4 |
3D structure databases
AlphaFoldDBi | O76014 |
SMRi | O76014 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 114235, 111 interactors |
IntActi | O76014, 43 interactors |
STRINGi | 9606.ENSP00000225550 |
PTM databases
iPTMneti | O76014 |
PhosphoSitePlusi | O76014 |
Genetic variation databases
BioMutai | KRT37 |
Proteomic databases
jPOSTi | O76014 |
MassIVEi | O76014 |
PaxDbi | O76014 |
PeptideAtlasi | O76014 |
PRIDEi | O76014 |
ProteomicsDBi | 50346 |
Protocols and materials databases
Antibodypediai | 28843, 38 antibodies from 15 providers |
DNASUi | 8688 |
Genome annotation databases
Ensembli | ENST00000225550.4; ENSP00000225550.3; ENSG00000108417.4 ENST00000574588.1; ENSP00000458693.1; ENSG00000263022.1 |
GeneIDi | 8688 |
KEGGi | hsa:8688 |
MANE-Selecti | ENST00000225550.4; ENSP00000225550.3; NM_003770.5; NP_003761.3 |
UCSCi | uc002hwp.2, human |
Organism-specific databases
CTDi | 8688 |
GeneCardsi | KRT37 |
HGNCi | HGNC:6455, KRT37 |
HPAi | ENSG00000108417, Tissue enriched (skin) |
MIMi | 604541, gene |
neXtProti | NX_O76014 |
OpenTargetsi | ENSG00000108417 |
PharmGKBi | PA30244 |
VEuPathDBi | HostDB:ENSG00000108417 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SIYJ, Eukaryota |
GeneTreei | ENSGT00940000163444 |
HOGENOMi | CLU_012560_8_0_1 |
InParanoidi | O76014 |
OMAi | MNREHCP |
OrthoDBi | 657425at2759 |
PhylomeDBi | O76014 |
TreeFami | TF332742 |
Enzyme and pathway databases
PathwayCommonsi | O76014 |
Reactomei | R-HSA-6805567, Keratinization R-HSA-6809371, Formation of the cornified envelope |
SignaLinki | O76014 |
Miscellaneous databases
BioGRID-ORCSi | 8688, 10 hits in 1065 CRISPR screens |
GenomeRNAii | 8688 |
Pharosi | O76014, Tdark |
PROi | PR:O76014 |
RNActi | O76014, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000108417, Expressed in ectocervix and 23 other tissues |
Genevisiblei | O76014, HS |
Family and domain databases
InterProi | View protein in InterPro IPR018039, IF_conserved IPR039008, IF_rod_dom IPR002957, Keratin_I |
PANTHERi | PTHR23239, PTHR23239, 1 hit |
Pfami | View protein in Pfam PF00038, Filament, 1 hit |
PRINTSi | PR01248, TYPE1KERATIN |
SMARTi | View protein in SMART SM01391, Filament, 1 hit |
PROSITEi | View protein in PROSITE PS00226, IF_ROD_1, 1 hit PS51842, IF_ROD_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | KRT37_HUMAN | |
Accessioni | O76014Primary (citable) accession number: O76014 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | April 13, 2004 | |
Last modified: | May 25, 2022 | |
This is version 157 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families