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UniProtKB - O76013 (KRT36_HUMAN)
Protein
Keratin, type I cuticular Ha6
Gene
KRT36
Organism
Homo sapiens (Human)
Status
Functioni
Miscellaneous
There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 342 | Stutter | 1 |
GO - Molecular functioni
- structural constituent of skin epidermis Source: GO_Central
GO - Biological processi
- epithelial cell differentiation Source: GO_Central
- intermediate filament organization Source: GO_Central
- regulation of keratinocyte differentiation Source: Ensembl
Enzyme and pathway databases
PathwayCommonsi | O76013 |
Reactomei | R-HSA-6805567, Keratinization R-HSA-6809371, Formation of the cornified envelope |
SignaLinki | O76013 |
Names & Taxonomyi
Protein namesi | Recommended name: Keratin, type I cuticular Ha6Alternative name(s): Hair keratin, type I Ha6 Keratin-36 Short name: K36 |
Gene namesi | Name:KRT36 Synonyms:HHA6, HKA6, KRTHA6 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6454, KRT36 |
MIMi | 604540, gene |
neXtProti | NX_O76013 |
VEuPathDBi | HostDB:ENSG00000126337 |
Subcellular locationi
Cytoskeleton
- cytoskeleton Source: GO_Central
- intermediate filament cytoskeleton Source: GO_Central
- keratin filament Source: ComplexPortal
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Keywords - Cellular componenti
Intermediate filament, KeratinPathology & Biotechi
Organism-specific databases
DisGeNETi | 8689 |
OpenTargetsi | ENSG00000126337 |
PharmGKBi | PA30243 |
Miscellaneous databases
Pharosi | O76013, Tdark |
Genetic variation databases
BioMutai | KRT36 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000063693 | 1 – 467 | Keratin, type I cuticular Ha6Add BLAST | 467 |
Proteomic databases
jPOSTi | O76013 |
MassIVEi | O76013 |
PaxDbi | O76013 |
PeptideAtlasi | O76013 |
PRIDEi | O76013 |
ProteomicsDBi | 50344 [O76013-1] 50345 [O76013-2] |
PTM databases
CarbonylDBi | O76013 |
iPTMneti | O76013 |
PhosphoSitePlusi | O76013 |
Expressioni
Tissue specificityi
Expressed in the hair follicles.1 Publication
Gene expression databases
Bgeei | ENSG00000126337, Expressed in tongue and 40 other tissues |
Genevisiblei | O76013, HS |
Organism-specific databases
HPAi | ENSG00000126337, Group enriched (lymphoid tissue, skin) |
Interactioni
Subunit structurei
Heterotetramer of two type I and two type II keratins.
By similarityBinary interactionsi
Isoform 2 [O76013-2]
Protein-protein interaction databases
BioGRIDi | 114236, 61 interactors |
ComplexPortali | CPX-5663, Keratin-36 - Keratin-86 dimer complex |
IntActi | O76013, 63 interactors |
STRINGi | 9606.ENSP00000329165 |
Miscellaneous databases
RNActi | O76013, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 93 – 404 | IF rodPROSITE-ProRule annotationAdd BLAST | 312 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 93 | HeadAdd BLAST | 93 | |
Regioni | 94 – 128 | Coil 1AAdd BLAST | 35 | |
Regioni | 129 – 139 | Linker 1Add BLAST | 11 | |
Regioni | 140 – 240 | Coil 1BAdd BLAST | 101 | |
Regioni | 241 – 256 | Linker 12Add BLAST | 16 | |
Regioni | 257 – 400 | Coil 2Add BLAST | 144 | |
Regioni | 401 – 467 | TailAdd BLAST | 67 |
Sequence similaritiesi
Belongs to the intermediate filament family.PROSITE-ProRule annotation
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502QQY9, Eukaryota |
GeneTreei | ENSGT00940000161311 |
HOGENOMi | CLU_012560_8_0_1 |
InParanoidi | O76013 |
OMAi | AHPCSTE |
OrthoDBi | 798081at2759 |
PhylomeDBi | O76013 |
TreeFami | TF332742 |
Family and domain databases
InterProi | View protein in InterPro IPR018039, IF_conserved IPR039008, IF_rod_dom IPR002957, Keratin_I |
PANTHERi | PTHR23239, PTHR23239, 1 hit |
Pfami | View protein in Pfam PF00038, Filament, 1 hit |
PRINTSi | PR01248, TYPE1KERATIN |
SMARTi | View protein in SMART SM01391, Filament, 1 hit |
PROSITEi | View protein in PROSITE PS00226, IF_ROD_1, 1 hit PS51842, IF_ROD_2, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: O76013-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MATQTCTPTF STGSIKGLCG TAGGISRVSS IRSVGSCRVP SLAGAAGYIS
60 70 80 90 100
SARSGLSGLG SCLPGSYLSS ECHTSGFVGS GGWFCEGSFN GSEKETMQFL
110 120 130 140 150
NDRLANYLEK VRQLERENAE LESRIQEWYE FQIPYICPDY QSYFKTIEDF
160 170 180 190 200
QQKILLTKSE NARLVLQIDN AKLAADDFRT KYETELSLRQ LVEADINGLR
210 220 230 240 250
RILDELTLCK ADLEAQVESL KEELMCLKKN HEEEVSVLRC QLGDRLNVEV
260 270 280 290 300
DAAPPVDLNK ILEDMRCQYE ALVENNRRDV EAWFNTQTEE LNQQVVSSSE
310 320 330 340 350
QLQCCQTEII ELRRTVNALE IELQAQHSMR NSLESTLAET EARYSSQLAQ
360 370 380 390 400
MQCLISNVEA QLSEIRCDLE RQNQEYQVLL DVKARLEGEI ATYRHLLEGE
410 420 430 440 450
DCKLPPQPCA TACKPVIRVP SVPPVPCVPS VPCTPAPQVG TQIRTITEEI
460
RDGKVISSRE HVQSRPL
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_024490 | 119 | A → V. Corresponds to variant dbSNP:rs8082683EnsemblClinVar. | 1 | |
Natural variantiVAR_024491 | 126 | Q → R. Corresponds to variant dbSNP:rs8069943EnsemblClinVar. | 1 | |
Natural variantiVAR_049792 | 179 | R → Q. Corresponds to variant dbSNP:rs9675246Ensembl. | 1 | |
Natural variantiVAR_049793 | 277 | R → C. Corresponds to variant dbSNP:rs9904102Ensembl. | 1 | |
Natural variantiVAR_020306 | 315 | T → M. Corresponds to variant dbSNP:rs2301354Ensembl. | 1 | |
Natural variantiVAR_049794 | 357 | N → T. Corresponds to variant dbSNP:rs11657323Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_036403 | 1 – 52 | MATQT…YISSA → ML in isoform 2. 1 PublicationAdd BLAST | 52 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y16792 Genomic DNA Translation: CAA76388.1 CH471152 Genomic DNA Translation: EAW60738.1 BC043581 mRNA Translation: AAH43581.1 |
CCDSi | CCDS11395.1 [O76013-1] |
RefSeqi | NP_003762.1, NM_003771.4 [O76013-1] |
Genome annotation databases
Ensembli | ENST00000328119.11; ENSP00000329165.6; ENSG00000126337.14 ENST00000393986.2; ENSP00000377555.2; ENSG00000126337.14 [O76013-2] |
GeneIDi | 8689 |
KEGGi | hsa:8689 |
MANE-Selecti | ENST00000328119.11; ENSP00000329165.6; NM_003771.5; NP_003762.1 |
UCSCi | uc002hwt.3, human [O76013-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y16792 Genomic DNA Translation: CAA76388.1 CH471152 Genomic DNA Translation: EAW60738.1 BC043581 mRNA Translation: AAH43581.1 |
CCDSi | CCDS11395.1 [O76013-1] |
RefSeqi | NP_003762.1, NM_003771.4 [O76013-1] |
3D structure databases
AlphaFoldDBi | O76013 |
SMRi | O76013 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 114236, 61 interactors |
ComplexPortali | CPX-5663, Keratin-36 - Keratin-86 dimer complex |
IntActi | O76013, 63 interactors |
STRINGi | 9606.ENSP00000329165 |
PTM databases
CarbonylDBi | O76013 |
iPTMneti | O76013 |
PhosphoSitePlusi | O76013 |
Genetic variation databases
BioMutai | KRT36 |
Proteomic databases
jPOSTi | O76013 |
MassIVEi | O76013 |
PaxDbi | O76013 |
PeptideAtlasi | O76013 |
PRIDEi | O76013 |
ProteomicsDBi | 50344 [O76013-1] 50345 [O76013-2] |
Protocols and materials databases
Antibodypediai | 16678, 138 antibodies from 26 providers |
DNASUi | 8689 |
Genome annotation databases
Ensembli | ENST00000328119.11; ENSP00000329165.6; ENSG00000126337.14 ENST00000393986.2; ENSP00000377555.2; ENSG00000126337.14 [O76013-2] |
GeneIDi | 8689 |
KEGGi | hsa:8689 |
MANE-Selecti | ENST00000328119.11; ENSP00000329165.6; NM_003771.5; NP_003762.1 |
UCSCi | uc002hwt.3, human [O76013-1] |
Organism-specific databases
CTDi | 8689 |
DisGeNETi | 8689 |
GeneCardsi | KRT36 |
HGNCi | HGNC:6454, KRT36 |
HPAi | ENSG00000126337, Group enriched (lymphoid tissue, skin) |
MIMi | 604540, gene |
neXtProti | NX_O76013 |
OpenTargetsi | ENSG00000126337 |
PharmGKBi | PA30243 |
VEuPathDBi | HostDB:ENSG00000126337 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QQY9, Eukaryota |
GeneTreei | ENSGT00940000161311 |
HOGENOMi | CLU_012560_8_0_1 |
InParanoidi | O76013 |
OMAi | AHPCSTE |
OrthoDBi | 798081at2759 |
PhylomeDBi | O76013 |
TreeFami | TF332742 |
Enzyme and pathway databases
PathwayCommonsi | O76013 |
Reactomei | R-HSA-6805567, Keratinization R-HSA-6809371, Formation of the cornified envelope |
SignaLinki | O76013 |
Miscellaneous databases
BioGRID-ORCSi | 8689, 9 hits in 1064 CRISPR screens |
GeneWikii | KRT36 |
GenomeRNAii | 8689 |
Pharosi | O76013, Tdark |
PROi | PR:O76013 |
RNActi | O76013, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000126337, Expressed in tongue and 40 other tissues |
Genevisiblei | O76013, HS |
Family and domain databases
InterProi | View protein in InterPro IPR018039, IF_conserved IPR039008, IF_rod_dom IPR002957, Keratin_I |
PANTHERi | PTHR23239, PTHR23239, 1 hit |
Pfami | View protein in Pfam PF00038, Filament, 1 hit |
PRINTSi | PR01248, TYPE1KERATIN |
SMARTi | View protein in SMART SM01391, Filament, 1 hit |
PROSITEi | View protein in PROSITE PS00226, IF_ROD_1, 1 hit PS51842, IF_ROD_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | KRT36_HUMAN | |
Accessioni | O76013Primary (citable) accession number: O76013 Secondary accession number(s): Q86XG4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | November 1, 1998 | |
Last modified: | May 25, 2022 | |
This is version 170 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families