KRT36

Functionⁱ

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	342	Stutter		1

GO - Molecular functionⁱ

structural constituent of epidermis
Source: UniProtKB
Non-traceable author statementⁱ
- 9756910

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cornification Source: Reactome
keratinization Source: Reactome
regulation of keratinocyte differentiation Source: Ensembl

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6805567 Keratinization R-HSA-6809371 Formation of the cornified envelope

Reactomeⁱ

R-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Keratin, type I cuticular Ha6 Alternative name(s): Hair keratin, type I Ha6 Keratin-36 Short name: K36
Gene namesⁱ	Name:KRT36 Synonyms:HHA6, HKA6, KRTHA6
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000126337.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6454 KRT36
MIMⁱ	604540 gene
neXtProtⁱ	NX_O76013

Subcellular locationⁱ

GO - Cellular component

Keywords - Cellular componentⁱ

Intermediate filament, Keratin

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000126337
PharmGKBⁱ	PA30243

Polymorphism and mutation databases

BioMutaⁱ	KRT36

BioMutaⁱ

KRT36

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000063693	1 – 467	Keratin, type I cuticular Ha6Add BLAST		467

Proteomic databases

PaxDbⁱ	O76013
PeptideAtlas More...PeptideAtlasⁱ	O76013
PRIDEⁱ	O76013
ProteomicsDBⁱ	12650 50344 50345 [O76013-2]

PTM databases

CarbonylDBⁱ	O76013
iPTMnetⁱ	O76013
PhosphoSitePlusⁱ	O76013

Expressionⁱ

Tissue specificityⁱ

Expressed in the hair follicles.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000126337 Expressed in 26 organ(s), highest expression level in tongue
CleanExⁱ	HS_KRT36
Genevisibleⁱ	O76013 HS

Interactionⁱ

Subunit structureⁱ

Heterotetramer of two type I and two type II keratins.By similarity

Protein-protein interaction databases

BioGridⁱ	114236, 10 interactors
IntActⁱ	O76013, 63 interactors
STRINGⁱ	9606.ENSP00000329165

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O76013
SMRⁱ	O76013
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	93 – 404	IF rodPROSITE-ProRule annotationAdd BLAST		312

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	1 – 93	HeadAdd BLAST	93
Regionⁱ	94 – 128	Coil 1AAdd BLAST	35
Regionⁱ	129 – 139	Linker 1Add BLAST	11
Regionⁱ	140 – 240	Coil 1BAdd BLAST	101
Regionⁱ	241 – 256	Linker 12Add BLAST	16
Regionⁱ	257 – 400	Coil 2Add BLAST	144
Regionⁱ	401 – 467	TailAdd BLAST	67

Sequence similaritiesⁱ

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	ENOG410IFTF Eukaryota ENOG410Y9IV LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140814
HOGENOMⁱ	HOG000230975
HOVERGENⁱ	HBG013015
InParanoidⁱ	O76013
KEGG Orthology (KO) More...KOⁱ	K07604
OMAⁱ	ECKPAVR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G087I
PhylomeDBⁱ	O76013
TreeFamⁱ	TF332742

Family and domain databases

InterProⁱ	View protein in InterPro IPR001664 IF IPR018039 IF_conserved IPR039008 IF_rod_dom IPR002957 Keratin_I
PANTHERⁱ	PTHR23239 PTHR23239, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00038 Filament, 1 hit
PRINTSⁱ	PR01248 TYPE1KERATIN
SMARTⁱ	View protein in SMART SM01391 Filament, 1 hit
PROSITEⁱ	View protein in PROSITE PS00226 IF_ROD_1, 1 hit PS51842 IF_ROD_2, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: O76013-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATQTCTPTF STGSIKGLCG TAGGISRVSS IRSVGSCRVP SLAGAAGYIS 
        60         70         80         90        100
SARSGLSGLG SCLPGSYLSS ECHTSGFVGS GGWFCEGSFN GSEKETMQFL 
       110        120        130        140        150
NDRLANYLEK VRQLERENAE LESRIQEWYE FQIPYICPDY QSYFKTIEDF 
       160        170        180        190        200
QQKILLTKSE NARLVLQIDN AKLAADDFRT KYETELSLRQ LVEADINGLR 
       210        220        230        240        250
RILDELTLCK ADLEAQVESL KEELMCLKKN HEEEVSVLRC QLGDRLNVEV 
       260        270        280        290        300
DAAPPVDLNK ILEDMRCQYE ALVENNRRDV EAWFNTQTEE LNQQVVSSSE 
       310        320        330        340        350
QLQCCQTEII ELRRTVNALE IELQAQHSMR NSLESTLAET EARYSSQLAQ 
       360        370        380        390        400
MQCLISNVEA QLSEIRCDLE RQNQEYQVLL DVKARLEGEI ATYRHLLEGE 
       410        420        430        440        450
DCKLPPQPCA TACKPVIRVP SVPPVPCVPS VPCTPAPQVG TQIRTITEEI 
       460 
RDGKVISSRE HVQSRPL

Length:467

Mass (Da):52,247

Last modified:November 1, 1998 - v1

Checksum:ⁱ492B3B2DE3BCAECD

GO

Isoform 2 (identifier: O76013-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-52: MATQTCTPTFSTGSIKGLCGTAGGISRVSSIRSVGSCRVPSLAGAAGYISSA → ML

« Hide

        10         20         30         40         50
MLRSGLSGLG SCLPGSYLSS ECHTSGFVGS GGWFCEGSFN GSEKETMQFL 
        60         70         80         90        100
NDRLANYLEK VRQLERENAE LESRIQEWYE FQIPYICPDY QSYFKTIEDF 
       110        120        130        140        150
QQKILLTKSE NARLVLQIDN AKLAADDFRT KYETELSLRQ LVEADINGLR 
       160        170        180        190        200
RILDELTLCK ADLEAQVESL KEELMCLKKN HEEEVSVLRC QLGDRLNVEV 
       210        220        230        240        250
DAAPPVDLNK ILEDMRCQYE ALVENNRRDV EAWFNTQTEE LNQQVVSSSE 
       260        270        280        290        300
QLQCCQTEII ELRRTVNALE IELQAQHSMR NSLESTLAET EARYSSQLAQ 
       310        320        330        340        350
MQCLISNVEA QLSEIRCDLE RQNQEYQVLL DVKARLEGEI ATYRHLLEGE 
       360        370        380        390        400
DCKLPPQPCA TACKPVIRVP SVPPVPCVPS VPCTPAPQVG TQIRTITEEI 
       410 
RDGKVISSRE HVQSRPL

Note: No experimental confirmation available.

Show »

Length:417

Mass (Da):47,485

Checksum:ⁱD27B5052EDC12A3B

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_024490	119	A → V. Corresponds to variant dbSNP:rs8082683Ensembl.	1
Natural variantⁱVAR_024491	126	Q → R. Corresponds to variant dbSNP:rs8069943Ensembl.	1
Natural variantⁱVAR_049792	179	R → Q. Corresponds to variant dbSNP:rs9675246Ensembl.	1
Natural variantⁱVAR_049793	277	R → C. Corresponds to variant dbSNP:rs9904102Ensembl.	1
Natural variantⁱVAR_020306	315	T → M. Corresponds to variant dbSNP:rs2301354Ensembl.	1
Natural variantⁱVAR_049794	357	N → T. Corresponds to variant dbSNP:rs11657323Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_036403	1 – 52	MATQT…YISSA → ML in isoform 2. 1 PublicationAdd BLAST		52

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y16792 Genomic DNA Translation: CAA76388.1 CH471152 Genomic DNA Translation: EAW60738.1 BC043581 mRNA Translation: AAH43581.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11395.1 [O76013-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_003762.1, NM_003771.4 [O76013-1]
UniGeneⁱ	Hs.248189

Genome annotation databases

Ensemblⁱ	ENST00000328119; ENSP00000329165; ENSG00000126337 [O76013-1] ENST00000393986; ENSP00000377555; ENSG00000126337 [O76013-2]
GeneIDⁱ	8689
KEGGⁱ	hsa:8689
UCSC genome browser More...UCSCⁱ	uc002hwt.3 human [O76013-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
O76013	Uncharacterized protein		PAPAN		491	UniRef90_O76013
Keratin 36		CALJA		468
Keratin 36		SAIBB		467
Uncharacterized protein		Cebus capucinus imitator		467
KRT36 isoform 2		PONAB		467
+46

Protein	Similar proteins		Species	Score	Length	Source
O76013	Keratin, type I cytoskeletal 40		HUMAN		431	UniRef50_Q6A162
Keratin, type I cytoskeletal 39		MOUSE		482
Keratin, type I cytoskeletal 39		RAT		481
Uncharacterized protein		MACMU		435
Uncharacterized protein		MACFA		435
+283

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y16792 Genomic DNA Translation: CAA76388.1 CH471152 Genomic DNA Translation: EAW60738.1 BC043581 mRNA Translation: AAH43581.1
CCDSⁱ	CCDS11395.1 [O76013-1]
RefSeqⁱ	NP_003762.1, NM_003771.4 [O76013-1]
UniGeneⁱ	Hs.248189

3D structure databases

ProteinModelPortalⁱ	O76013
SMRⁱ	O76013
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114236, 10 interactors
IntActⁱ	O76013, 63 interactors
STRINGⁱ	9606.ENSP00000329165

PTM databases

CarbonylDBⁱ	O76013
iPTMnetⁱ	O76013
PhosphoSitePlusⁱ	O76013

Polymorphism and mutation databases

BioMutaⁱ	KRT36

BioMutaⁱ

KRT36

Proteomic databases

PaxDbⁱ	O76013
PeptideAtlasⁱ	O76013
PRIDEⁱ	O76013
ProteomicsDBⁱ	12650 50344 50345 [O76013-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000328119; ENSP00000329165; ENSG00000126337 [O76013-1] ENST00000393986; ENSP00000377555; ENSG00000126337 [O76013-2]
GeneIDⁱ	8689
KEGGⁱ	hsa:8689
UCSCⁱ	uc002hwt.3 human [O76013-1]

Organism-specific databases

CTDⁱ	8689
EuPathDBⁱ	HostDB:ENSG00000126337.13
GeneCardsⁱ	KRT36
H-InvDBⁱ	HIX0027332
HGNCⁱ	HGNC:6454 KRT36
MIMⁱ	604540 gene
neXtProtⁱ	NX_O76013
OpenTargetsⁱ	ENSG00000126337
PharmGKBⁱ	PA30243
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IFTF Eukaryota ENOG410Y9IV LUCA
GeneTreeⁱ	ENSGT00900000140814
HOGENOMⁱ	HOG000230975
HOVERGENⁱ	HBG013015
InParanoidⁱ	O76013
KOⁱ	K07604
OMAⁱ	ECKPAVR
OrthoDBⁱ	EOG091G087I
PhylomeDBⁱ	O76013
TreeFamⁱ	TF332742

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6805567 Keratinization R-HSA-6809371 Formation of the cornified envelope

Reactomeⁱ

R-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope

Miscellaneous databases

GeneWikiⁱ	KRT36
GenomeRNAiⁱ	8689
Protein Ontology More...PROⁱ	PR:O76013
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000126337 Expressed in 26 organ(s), highest expression level in tongue
CleanExⁱ	HS_KRT36
Genevisibleⁱ	O76013 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR001664 IF IPR018039 IF_conserved IPR039008 IF_rod_dom IPR002957 Keratin_I
PANTHERⁱ	PTHR23239 PTHR23239, 1 hit
Pfamⁱ	View protein in Pfam PF00038 Filament, 1 hit
PRINTSⁱ	PR01248 TYPE1KERATIN
SMARTⁱ	View protein in SMART SM01391 Filament, 1 hit
PROSITEⁱ	View protein in PROSITE PS00226 IF_ROD_1, 1 hit PS51842 IF_ROD_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KRT36_HUMAN
Accessionⁱ	O76013Primary (citable) accession number: O76013 Secondary accession number(s): Q86XG4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	November 1, 1998
	Last modified:	November 7, 2018
	This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM

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UniProtKB - O76013 (KRT36_HUMAN)

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Keratin, type I cuticular Ha6

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Cytosol

Extracellular region or secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ