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Protein

Keratin, type I cuticular Ha4

Gene

KRT34

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Caution

It is uncertain whether Met-1 or Met-43 is the initiator.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei347Stutter1

GO - Molecular functioni

  • structural molecule activity Source: ProtInc

GO - Biological processi

  • cornification Source: Reactome
  • epidermis development Source: ProtInc
  • keratinization Source: Reactome

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cuticular Ha4
Alternative name(s):
Hair keratin, type I Ha4
Keratin-34
Short name:
K34
Gene namesi
Name:KRT34
Synonyms:HHA4, HKA4, KRTHA4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000131737.5
HGNCiHGNC:6452 KRT34
MIMi602763 gene
neXtProtiNX_O76011

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000131737
PharmGKBiPA30241

Polymorphism and mutation databases

BioMutaiKRT34

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000636911 – 436Keratin, type I cuticular Ha4Add BLAST436

Proteomic databases

EPDiO76011
PaxDbiO76011
PeptideAtlasiO76011
PRIDEiO76011
ProteomicsDBi12648
50343

PTM databases

iPTMnetiO76011
PhosphoSitePlusiO76011
SwissPalmiO76011

Expressioni

Tissue specificityi

Expressed in the hair follicles.1 Publication

Gene expression databases

BgeeiENSG00000131737 Expressed in 47 organ(s), highest expression level in hair follicle
CleanExiHS_KRT34
GenevisibleiO76011 HS

Organism-specific databases

HPAiHPA055194
HPA072208

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi110083, 7 interactors
IntActiO76011, 259 interactors
STRINGi9606.ENSP00000377570

Structurei

3D structure databases

ProteinModelPortaliO76011
SMRiO76011
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini98 – 409IF rodPROSITE-ProRule annotationAdd BLAST312

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 98HeadAdd BLAST98
Regioni99 – 133Coil 1AAdd BLAST35
Regioni134 – 144Linker 1Add BLAST11
Regioni145 – 245Coil 1BAdd BLAST101
Regioni246 – 261Linker 12Add BLAST16
Regioni262 – 405Coil 2Add BLAST144
Regioni406 – 436TailAdd BLAST31

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IF9P Eukaryota
ENOG410YK2A LUCA
GeneTreeiENSGT00900000140814
HOGENOMiHOG000230975
HOVERGENiHBG013015
InParanoidiO76011
KOiK07604
OMAiTITPCIS
OrthoDBiEOG091G087I
PhylomeDBiO76011

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR002957 Keratin_I
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PRINTSiPR01248 TYPE1KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O76011-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLYAKPPPTI NGIKGLQRKE RLKPAHIHLQ QLTCFSITCS STMSYSCCLP
60 70 80 90 100
SLGCRTSCSS RPCVPPSCHG YTLPGACNIP ANVSNCNWFC EGSFNGSEKE
110 120 130 140 150
TMQFLNDRLA SYLEKVRQLE RDNAELEKLI QERSQQQEPL LCPSYQSYFK
160 170 180 190 200
TIEELQQKIL CAKAENARLV VNIDNAKLAS DDFRSKYQTE QSLRLLVESD
210 220 230 240 250
INSIRRILDE LTLCKSDLES QVESLREELI CLKKNHEEEV NTLRSQLGDR
260 270 280 290 300
LNVEVDTAPT VDLNQVLNET RSQYEALVEI NRREVEQWFA TQTEELNKQV
310 320 330 340 350
VSSSEQLQSC QAEIIELRRT VNALEIELQA QHNLRDSLEN TLTESEAHYS
360 370 380 390 400
SQLSQVQSLI TNVESQLAEI RCDLERQNQE YQVLLDVRAR LECEINTYRS
410 420 430
LLESEDCKLP CNPCATTNAS GNSCGPCGTS QKGCCN
Length:436
Mass (Da):49,424
Last modified:January 20, 2009 - v2
Checksum:iEE39CB9622A94CA8
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A140TA69A0A140TA69_HUMAN
Keratin, type I cuticular Ha4
KRT34
436Annotation score:

Sequence cautioni

The sequence CAA76386 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti246Q → P in CAA76386 (PubMed:9756910).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_056017280I → T1 PublicationCorresponds to variant dbSNP:rs2239710Ensembl.1
Natural variantiVAR_056018348H → R. Corresponds to variant dbSNP:rs2071599Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16790 Genomic DNA Translation: CAA76386.1 Different initiation.
BC033252 mRNA Translation: AAH33252.1
BC041070 mRNA Translation: AAH41070.1
CCDSiCCDS11390.1
RefSeqiNP_066293.2, NM_021013.3
XP_003403930.1, XM_003403882.4
UniGeneiHs.296942

Genome annotation databases

EnsembliENST00000394001; ENSP00000377570; ENSG00000131737
GeneIDi100653049
3885
KEGGihsa:100653049
hsa:3885
UCSCiuc002hwm.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16790 Genomic DNA Translation: CAA76386.1 Different initiation.
BC033252 mRNA Translation: AAH33252.1
BC041070 mRNA Translation: AAH41070.1
CCDSiCCDS11390.1
RefSeqiNP_066293.2, NM_021013.3
XP_003403930.1, XM_003403882.4
UniGeneiHs.296942

3D structure databases

ProteinModelPortaliO76011
SMRiO76011
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110083, 7 interactors
IntActiO76011, 259 interactors
STRINGi9606.ENSP00000377570

PTM databases

iPTMnetiO76011
PhosphoSitePlusiO76011
SwissPalmiO76011

Polymorphism and mutation databases

BioMutaiKRT34

Proteomic databases

EPDiO76011
PaxDbiO76011
PeptideAtlasiO76011
PRIDEiO76011
ProteomicsDBi12648
50343

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000394001; ENSP00000377570; ENSG00000131737
GeneIDi100653049
3885
KEGGihsa:100653049
hsa:3885
UCSCiuc002hwm.4 human

Organism-specific databases

CTDi3885
EuPathDBiHostDB:ENSG00000131737.5
GeneCardsiKRT34
H-InvDBiHIX0027181
HIX0135626
HGNCiHGNC:6452 KRT34
HPAiHPA055194
HPA072208
MIMi602763 gene
neXtProtiNX_O76011
OpenTargetsiENSG00000131737
PharmGKBiPA30241
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF9P Eukaryota
ENOG410YK2A LUCA
GeneTreeiENSGT00900000140814
HOGENOMiHOG000230975
HOVERGENiHBG013015
InParanoidiO76011
KOiK07604
OMAiTITPCIS
OrthoDBiEOG091G087I
PhylomeDBiO76011

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope

Miscellaneous databases

GeneWikiiKeratin_34
PROiPR:O76011
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000131737 Expressed in 47 organ(s), highest expression level in hair follicle
CleanExiHS_KRT34
GenevisibleiO76011 HS

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR002957 Keratin_I
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PRINTSiPR01248 TYPE1KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKRT34_HUMAN
AccessioniPrimary (citable) accession number: O76011
Secondary accession number(s): Q8IUT8, Q8N4W2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 20, 2009
Last modified: September 12, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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