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Entry version 162 (07 Oct 2020)
Sequence version 2 (20 Jan 2009)
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Protein

Keratin, type I cuticular Ha4

Gene

KRT34

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Caution

It is uncertain whether Met-1 or Met-43 is the initiator.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei347Stutter1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
O76011

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-6805567, Keratinization
R-HSA-6809371, Formation of the cornified envelope

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Keratin, type I cuticular Ha4
Alternative name(s):
Hair keratin, type I Ha4
Keratin-34
Short name:
K34
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KRT34
Synonyms:HHA4, HKA4, KRTHA4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000131737.5

Human Gene Nomenclature Database

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HGNCi
HGNC:6452, KRT34

Online Mendelian Inheritance in Man (OMIM)

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MIMi
602763, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O76011

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Intermediate filament, Keratin

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

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DisGeNETi
3885

Open Targets

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OpenTargetsi
ENSG00000131737

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30241

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O76011, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KRT34

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000636911 – 436Keratin, type I cuticular Ha4Add BLAST436

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O76011

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
O76011

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O76011

PeptideAtlas

More...
PeptideAtlasi
O76011

PRoteomics IDEntifications database

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PRIDEi
O76011

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
12648
50343

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O76011

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O76011

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O76011

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the hair follicles.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000131737, Expressed in hair follicle and 64 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O76011, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000131737, Tissue enhanced (cervix, uterine, skin, tongue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

O76011
With#Exp.IntAct
A1CF [Q9NQ94]3EBI-1047093,EBI-2809489
ABHD15 [Q6UXT9]3EBI-1047093,EBI-2824666
ABI2 - isoform 2 [Q9NYB9-2]3EBI-1047093,EBI-11096309
ADRA2C [P18825]3EBI-1047093,EBI-12015266
AGXT [P21549]3EBI-1047093,EBI-727098
AIMP2 [Q13155]3EBI-1047093,EBI-745226
ALDH3B1 [P43353]3EBI-1047093,EBI-2558314
AMOT [A2BDD9]3EBI-1047093,EBI-17286414
ANKRD11 [X5D778]3EBI-1047093,EBI-17183751
ANKS1A [Q49AR9]3EBI-1047093,EBI-11954519
ARMC7 [Q9H6L4]3EBI-1047093,EBI-742909
ASMTL [O95671]3EBI-1047093,EBI-743231
ATG9A - isoform 3 [Q7Z3C6-3]3EBI-1047093,EBI-12006308
ATPAF2 [Q8N5M1]3EBI-1047093,EBI-1166928
BATF2 [Q8N1L9]3EBI-1047093,EBI-742695
BCAS2 [O75934]5EBI-1047093,EBI-1050106
BEX1 [Q9HBH7]3EBI-1047093,EBI-7162175
BEX2 [Q9BXY8]3EBI-1047093,EBI-745073
BEX3 [Q00994]3EBI-1047093,EBI-741753
BHLHE23 [Q8NDY6]3EBI-1047093,EBI-12144263
BOLA3 [Q53S33]3EBI-1047093,EBI-12086950
C11orf87 [Q6NUJ2]3EBI-1047093,EBI-6660291
C17orf50 [Q8WW18]3EBI-1047093,EBI-12877892
C19orf57 - isoform 2 [Q0VDD7-2]3EBI-1047093,EBI-12040255
C1orf216 [Q8TAB5]3EBI-1047093,EBI-747505
C5orf49 [A4QMS7]3EBI-1047093,EBI-12039847
CBX8 [Q9HC52]3EBI-1047093,EBI-712912
CCDC120 [Q96HB5]3EBI-1047093,EBI-744556
CCDC13 [Q8IYE1]3EBI-1047093,EBI-10961312
CCDC146 [Q8IYE0]3EBI-1047093,EBI-10749669
CCDC196 [A0A1B0GWI1]3EBI-1047093,EBI-10181422
CCDC198 [E9PSE9]3EBI-1047093,EBI-11748295
CCDC24 [Q8N4L8]5EBI-1047093,EBI-1104933
CCHCR1 - isoform 3 [Q8TD31-3]3EBI-1047093,EBI-10175300
CCNC [P24863]3EBI-1047093,EBI-395261
CDC20B - isoform 5 [Q86Y33-5]3EBI-1047093,EBI-11983537
CDK18 [Q07002]3EBI-1047093,EBI-746238
CERK [Q8TCT0]3EBI-1047093,EBI-10274247
CFAP206 [Q8IYR0]3EBI-1047093,EBI-749051
CFAP53 [Q96M91]3EBI-1047093,EBI-742422
CHRD [Q9H2X0]3EBI-1047093,EBI-947551
CHRNG - isoform 2 [P07510-2]3EBI-1047093,EBI-11979451
CLCNKA - isoform 3 [P51800-3]3EBI-1047093,EBI-11980535
CLDN19 - isoform 2 [Q8N6F1-2]3EBI-1047093,EBI-12256978
CLEC18A [A5D8T8]3EBI-1047093,EBI-10173491
CTRC [Q99895]3EBI-1047093,EBI-10295404
CWC25 [Q9NXE8]3EBI-1047093,EBI-746052
CYSRT1 [A8MQ03]5EBI-1047093,EBI-3867333
CYTH4 [Q9UIA0]3EBI-1047093,EBI-11521003
DCTN3 - isoform 2 [O75935-2]3EBI-1047093,EBI-12091947
DDIT4L [Q96D03]3EBI-1047093,EBI-742054
DDX6 [P26196]5EBI-1047093,EBI-351257
DHRS1 [Q96LJ7]3EBI-1047093,EBI-746300
DMRT3 [Q9NQL9]3EBI-1047093,EBI-9679045
DOCK2 [Q92608]3EBI-1047093,EBI-448771
EFCAB3 - isoform 2 [Q8N7B9-2]3EBI-1047093,EBI-11958551
EIF4G1 - isoform 9 [Q04637-9]3EBI-1047093,EBI-12012124
EPDR1 [Q9UM22]3EBI-1047093,EBI-946972
EXOC8 [Q8IYI6]3EBI-1047093,EBI-742102
EXOSC5 [Q9NQT4]3EBI-1047093,EBI-371876
FAM110A [Q9BQ89]3EBI-1047093,EBI-1752811
FAM214B [Q7L5A3]3EBI-1047093,EBI-745689
FAM50B [Q9Y247]3EBI-1047093,EBI-742802
FAM71C [Q8NEG0]3EBI-1047093,EBI-752049
FAM83A [Q86UY5]3EBI-1047093,EBI-1384254
FAM90A1 [Q86YD7]3EBI-1047093,EBI-6658203
FARS2 [O95363]3EBI-1047093,EBI-2513774
FBXW5 [Q969U6]5EBI-1047093,EBI-741068
FNDC11 [Q9BVV2]3EBI-1047093,EBI-744935
FOXD4L1 [Q9NU39]3EBI-1047093,EBI-11320806
FRS3 [O43559]5EBI-1047093,EBI-725515
GADD45GIP1 [Q8TAE8]3EBI-1047093,EBI-372506
GAST [P01350]3EBI-1047093,EBI-3436637
GATAD2A [Q86YP4]3EBI-1047093,EBI-726224
GEM [P55040]3EBI-1047093,EBI-744104
GLYCTK [Q8IVS8]3EBI-1047093,EBI-748515
GNE - isoform 2 [Q9Y223-2]3EBI-1047093,EBI-11975289
GNG10 [P50151]3EBI-1047093,EBI-10211741
GNG13 [Q9P2W3]3EBI-1047093,EBI-11427343
GPS2 [Q13227]3EBI-1047093,EBI-713355
GRN [P28799]3EBI-1047093,EBI-747754
GSC2 [O15499]3EBI-1047093,EBI-19954058
GSTP1 [P09211]3EBI-1047093,EBI-353467
HAPLN2 [Q9GZV7]5EBI-1047093,EBI-11956675
HBA2 [P69905]3EBI-1047093,EBI-714680
hCG_1987119 [A0A024R8L2]3EBI-1047093,EBI-14103818
HCK - isoform 2 [P08631-2]3EBI-1047093,EBI-9834454
HDAC4 - isoform 2 [P56524-2]3EBI-1047093,EBI-11953488
HGS [O14964]3EBI-1047093,EBI-740220
HOXA1 [P49639]3EBI-1047093,EBI-740785
HOXB5 [P09067]3EBI-1047093,EBI-3893317
HOXB9 [P17482]3EBI-1047093,EBI-745290
HOXC8 [P31273]5EBI-1047093,EBI-1752118
HSPA12B [Q96MM6]3EBI-1047093,EBI-10291310
HSPD1 [P10809]3EBI-1047093,EBI-352528
HYAL2 [Q12891]3EBI-1047093,EBI-2806068
ICAM4 - isoform 3 [Q14773-3]3EBI-1047093,EBI-10233928
INIP [Q9NRY2]3EBI-1047093,EBI-2881520
INO80B [Q9C086]3EBI-1047093,EBI-715611
ISCU [Q9H1K1]3EBI-1047093,EBI-1047335
ITGB5 [P18084]3EBI-1047093,EBI-1223434
ITPKB [P27987]3EBI-1047093,EBI-751388
JOSD1 [Q15040]3EBI-1047093,EBI-2510602
KANK2 [Q63ZY3]3EBI-1047093,EBI-2556193
KCTD9 [Q7L273]3EBI-1047093,EBI-4397613
KDELR1 [P24390]3EBI-1047093,EBI-1043076
KIDINS220 - isoform 2 [Q9ULH0-2]3EBI-1047093,EBI-11046235
KLC4 [Q9NSK0]3EBI-1047093,EBI-949319
KLHL38 [Q2WGJ6]5EBI-1047093,EBI-6426443
KLK8 [O60259]3EBI-1047093,EBI-3915857
KRT1 [P04264]3EBI-1047093,EBI-298429
KRT20 [P35900]3EBI-1047093,EBI-742094
KRT3 [P12035]5EBI-1047093,EBI-2430095
KRT6A [P02538]3EBI-1047093,EBI-702198
KRT6C [P48668]3EBI-1047093,EBI-2564105
KRT71 [Q3SY84]3EBI-1047093,EBI-2952676
KRT74 [Q7RTS7]3EBI-1047093,EBI-968660
KRT75 [O95678]4EBI-1047093,EBI-2949715
KRT78 [Q8N1N4]3EBI-1047093,EBI-1056564
KRT79 [Q5XKE5]3EBI-1047093,EBI-2514135
KRT8 [P05787]3EBI-1047093,EBI-297852
KRT80 - isoform 2 [Q6KB66-2]5EBI-1047093,EBI-11999246
KRT81 [Q14533]3EBI-1047093,EBI-739648
KRT82 [Q9NSB4]3EBI-1047093,EBI-1045341
KRT83 [P78385]3EBI-1047093,EBI-10221390
KRT85 [P78386]6EBI-1047093,EBI-1049371
KRT86 [O43790]3EBI-1047093,EBI-9996498
KRTAP12-2 [P59991]3EBI-1047093,EBI-10176379
KRTAP19-5 [Q3LI72]3EBI-1047093,EBI-1048945
KRTAP19-7 [Q3SYF9]3EBI-1047093,EBI-10241353
KRTAP26-1 [Q6PEX3]3EBI-1047093,EBI-3957672
LMO2 - isoform 3 [P25791-3]3EBI-1047093,EBI-11959475
LMO4 [P61968]5EBI-1047093,EBI-2798728
LRRC29 [Q8WV35]3EBI-1047093,EBI-10276755
LRRC41 [Q15345]3EBI-1047093,EBI-721408
LYSMD1 [Q96S90]3EBI-1047093,EBI-10293291
LYVE1 [Q9Y5Y7]3EBI-1047093,EBI-10329546
MAB21L2 [Q9Y586]3EBI-1047093,EBI-6659161
MAD2L2 [Q9UI95]3EBI-1047093,EBI-77889
MAP3K7CL - isoform 1 [P57077-4]3EBI-1047093,EBI-10215880
MAPKBP1 [O60336]3EBI-1047093,EBI-947402
MATR3 [P43243]3EBI-1047093,EBI-352602
MBD3L2 [Q8NHZ7]3EBI-1047093,EBI-11989378
METTL17 - isoform 2 [Q9H7H0-2]3EBI-1047093,EBI-11098807
MIDN [Q504T8]3EBI-1047093,EBI-7153979
MIIP [Q5JXC2]3EBI-1047093,EBI-2801965
MKRN3 [Q13064]3EBI-1047093,EBI-2340269
MNS1 [Q8NEH6]3EBI-1047093,EBI-743811
MOS [P00540]3EBI-1047093,EBI-1757866
MSRB3 - isoform 2 [Q8IXL7-2]3EBI-1047093,EBI-10699187
MYOZ1 [Q9NP98]3EBI-1047093,EBI-744402
MYOZ3 [Q8TDC0]3EBI-1047093,EBI-5662487
NAB2 [Q15742]3EBI-1047093,EBI-8641936
NAXD [Q8IW45]3EBI-1047093,EBI-8650724
NEK6 - isoform 4 [Q9HC98-4]3EBI-1047093,EBI-11750983
NFKBID [Q8NI38]3EBI-1047093,EBI-10271199
NMU [P48645]3EBI-1047093,EBI-10210351
NOTO [A8MTQ0]3EBI-1047093,EBI-17490746
NPBWR2 [P48146]3EBI-1047093,EBI-10210114
NUP42 - isoform 2 [O15504-2]3EBI-1047093,EBI-14488689
P2RX7 [Q99572]3EBI-1047093,EBI-1753251
PDE9A - isoform PDE9A2 [O76083-2]5EBI-1047093,EBI-11524542
PDGFRB [P09619]3EBI-1047093,EBI-641237
PGLYRP3 [Q96LB9]3EBI-1047093,EBI-12339509
PIN1 [Q13526]3EBI-1047093,EBI-714158
PITX1 [P78337]3EBI-1047093,EBI-748265
PITX2 - isoform PTX2C [Q99697-2]3EBI-1047093,EBI-12138495
PKN1 [Q16512]5EBI-1047093,EBI-602382
PLLP [Q9Y342]3EBI-1047093,EBI-3919291
POP5 [Q969H6]3EBI-1047093,EBI-366525
PPP1R18 [Q6NYC8]3EBI-1047093,EBI-2557469
PPP1R27 [Q86WC6]3EBI-1047093,EBI-5235602
PPP3R2 [A0A494C014]3EBI-1047093,EBI-12859744
PRPF18 [Q99633]3EBI-1047093,EBI-2798416
PRPF31 [Q8WWY3]3EBI-1047093,EBI-1567797
PRR19 - isoform 2 [A6NJB7-2]6EBI-1047093,EBI-11998870
PRR35 [P0CG20]5EBI-1047093,EBI-11986293
PSMA1 [P25786]3EBI-1047093,EBI-359352
PSMB1 [P20618]3EBI-1047093,EBI-372273
PTPMT1 [Q8WUK0]3EBI-1047093,EBI-7199479
R3HDM2 [Q9Y2K5]3EBI-1047093,EBI-948428
RAB33A [Q14088]3EBI-1047093,EBI-744685
RAB3IL1 [Q8TBN0]3EBI-1047093,EBI-743796
RASD1 [Q9Y272]3EBI-1047093,EBI-740818
RFC5 [P40937]3EBI-1047093,EBI-712376
RIN1 [Q13671]3EBI-1047093,EBI-366017
RIPPLY1 [Q0D2K3]3EBI-1047093,EBI-10226430
RTP5 [Q14D33]3EBI-1047093,EBI-10217913
SAMD11 [Q96NU1]3EBI-1047093,EBI-14067109
SCNM1 [Q9BWG6]5EBI-1047093,EBI-748391
SEC14L4 [Q9UDX3]3EBI-1047093,EBI-10320311
SEMA4C [Q9C0C4]3EBI-1047093,EBI-10303490
SHC3 [Q92529]3EBI-1047093,EBI-79084
SLC15A2 [Q16348]3EBI-1047093,EBI-12806032
SLC22A5 [O76082]3EBI-1047093,EBI-9846338
SLC23A1 - isoform 3 [Q9UHI7-3]3EBI-1047093,EBI-11998660
SLC25A42 [Q86VD7]3EBI-1047093,EBI-6598313
SMARCD1 [Q96GM5]3EBI-1047093,EBI-358489
SMARCE1 [Q969G3]3EBI-1047093,EBI-455078
SMCP [P49901]3EBI-1047093,EBI-750494
SMG9 [Q9H0W8]5EBI-1047093,EBI-2872322
SNRPB - isoform SM-B [P14678-2]3EBI-1047093,EBI-372475
SPAG8 - isoform 2 [Q99932-2]3EBI-1047093,EBI-11959123
SPATA46 [Q5T0L3]3EBI-1047093,EBI-750105
SPRY3 [O43610]3EBI-1047093,EBI-12290641
STMN3 [Q9NZ72]3EBI-1047093,EBI-725557
SUOX [P51687]3EBI-1047093,EBI-3921347
TACO1 [Q9BSH4]3EBI-1047093,EBI-747797
TAPBPL [Q9BX59]3EBI-1047093,EBI-12017416
TBC1D22B [Q9NU19]3EBI-1047093,EBI-8787464
TCHP [Q9BT92]3EBI-1047093,EBI-740781
TEKT3 [Q9BXF9]3EBI-1047093,EBI-8644516
TEKT4 [Q8WW24]5EBI-1047093,EBI-750487
TENT5B [Q96A09]3EBI-1047093,EBI-752030
TEPSIN [Q96N21]3EBI-1047093,EBI-11139477
TFAP2D [Q7Z6R9]3EBI-1047093,EBI-11952651
THAP7 [Q9BT49]3EBI-1047093,EBI-741350
TLE5 - isoform 2 [Q08117-2]3EBI-1047093,EBI-11741437
TLX3 [O43711]3EBI-1047093,EBI-3939165
TMEM174 [Q8WUU8]3EBI-1047093,EBI-10276729
TMSB4X [P62328]3EBI-1047093,EBI-712598
TRIM42 [Q8IWZ5]3EBI-1047093,EBI-5235829
TRIM74 - isoform 2 [Q86UV6-2]3EBI-1047093,EBI-10259086
TRIML2 [Q8N7C3]3EBI-1047093,EBI-11059915
TSG101 [Q99816]5EBI-1047093,EBI-346882
TTC23 - isoform 3 [Q5W5X9-3]3EBI-1047093,EBI-9090990
TTC9C [Q8N5M4]3EBI-1047093,EBI-2851213
TUSC5 [A5PKU2]3EBI-1047093,EBI-11988865
TXLNA [P40222]3EBI-1047093,EBI-359793
TXLNB [Q8N3L3]3EBI-1047093,EBI-6116822
USP2 [O75604]3EBI-1047093,EBI-743272
UTP14C [Q5TAP6]3EBI-1047093,EBI-11737646
UTP23 [Q9BRU9]3EBI-1047093,EBI-5457544
VENTX [O95231]4EBI-1047093,EBI-10191303
WDR25 - isoform 2 [Q64LD2-2]3EBI-1047093,EBI-12032042
WWOX - isoform 5 [Q9NZC7-5]3EBI-1047093,EBI-12040603
ZDHHC1 [Q8WTX9]3EBI-1047093,EBI-2818796
ZFHX3 - isoform B [Q15911-2]5EBI-1047093,EBI-10237226
ZFYVE26 - isoform 5 [Q68DK2-5]3EBI-1047093,EBI-8656416
ZIC1 [Q15915]3EBI-1047093,EBI-11963196
ZNF124 [Q15973]3EBI-1047093,EBI-2555767
ZNF148 - isoform 2 [Q9UQR1-2]3EBI-1047093,EBI-11742222
ZNF319 [Q9P2F9]3EBI-1047093,EBI-11993110
ZNF414 [Q96IQ9]3EBI-1047093,EBI-744257
ZNF446 - isoform 2 [Q9NWS9-2]3EBI-1047093,EBI-740232
ZNF580 [Q9UK33]3EBI-1047093,EBI-746277
ZNF581 [Q9P0T4]3EBI-1047093,EBI-745520
ZNF79 [Q15937]3EBI-1047093,EBI-10237274

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
110083, 262 interactors

Protein interaction database and analysis system

More...
IntActi
O76011, 251 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000377570

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
O76011, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O76011

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini98 – 409IF rodPROSITE-ProRule annotationAdd BLAST312

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 98HeadAdd BLAST98
Regioni99 – 133Coil 1AAdd BLAST35
Regioni134 – 144Linker 1Add BLAST11
Regioni145 – 245Coil 1BAdd BLAST101
Regioni246 – 261Linker 12Add BLAST16
Regioni262 – 405Coil 2Add BLAST144
Regioni406 – 436TailAdd BLAST31

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502RTXS, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163426

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_012560_8_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O76011

KEGG Orthology (KO)

More...
KOi
K07604

Identification of Orthologs from Complete Genome Data

More...
OMAi
PTINGIK

Database of Orthologous Groups

More...
OrthoDBi
772040at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O76011

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.5.1160, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018039, IF_conserved
IPR039008, IF_rod_dom
IPR042180, IF_rod_dom_coil1B
IPR002957, Keratin_I

The PANTHER Classification System

More...
PANTHERi
PTHR23239, PTHR23239, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00038, Filament, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01248, TYPE1KERATIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01391, Filament, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00226, IF_ROD_1, 1 hit
PS51842, IF_ROD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O76011-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLYAKPPPTI NGIKGLQRKE RLKPAHIHLQ QLTCFSITCS STMSYSCCLP
60 70 80 90 100
SLGCRTSCSS RPCVPPSCHG YTLPGACNIP ANVSNCNWFC EGSFNGSEKE
110 120 130 140 150
TMQFLNDRLA SYLEKVRQLE RDNAELEKLI QERSQQQEPL LCPSYQSYFK
160 170 180 190 200
TIEELQQKIL CAKAENARLV VNIDNAKLAS DDFRSKYQTE QSLRLLVESD
210 220 230 240 250
INSIRRILDE LTLCKSDLES QVESLREELI CLKKNHEEEV NTLRSQLGDR
260 270 280 290 300
LNVEVDTAPT VDLNQVLNET RSQYEALVEI NRREVEQWFA TQTEELNKQV
310 320 330 340 350
VSSSEQLQSC QAEIIELRRT VNALEIELQA QHNLRDSLEN TLTESEAHYS
360 370 380 390 400
SQLSQVQSLI TNVESQLAEI RCDLERQNQE YQVLLDVRAR LECEINTYRS
410 420 430
LLESEDCKLP CNPCATTNAS GNSCGPCGTS QKGCCN
Length:436
Mass (Da):49,424
Last modified:January 20, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEE39CB9622A94CA8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A140TA69A0A140TA69_HUMAN
Keratin, type I cuticular Ha4
KRT34
436Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA76386 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti246Q → P in CAA76386 (PubMed:9756910).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_056017280I → T1 PublicationCorresponds to variant dbSNP:rs2239710Ensembl.1
Natural variantiVAR_056018348H → R. Corresponds to variant dbSNP:rs2071599Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Y16790 Genomic DNA Translation: CAA76386.1 Different initiation.
BC033252 mRNA Translation: AAH33252.1
BC041070 mRNA Translation: AAH41070.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11390.1

NCBI Reference Sequences

More...
RefSeqi
NP_066293.2, NM_021013.3
XP_003403930.1, XM_003403882.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000394001; ENSP00000377570; ENSG00000131737

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100653049
3885

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:100653049
hsa:3885

UCSC genome browser

More...
UCSCi
uc002hwm.4, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16790 Genomic DNA Translation: CAA76386.1 Different initiation.
BC033252 mRNA Translation: AAH33252.1
BC041070 mRNA Translation: AAH41070.1
CCDSiCCDS11390.1
RefSeqiNP_066293.2, NM_021013.3
XP_003403930.1, XM_003403882.4

3D structure databases

SMRiO76011
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi110083, 262 interactors
IntActiO76011, 251 interactors
STRINGi9606.ENSP00000377570

PTM databases

iPTMnetiO76011
PhosphoSitePlusiO76011
SwissPalmiO76011

Polymorphism and mutation databases

BioMutaiKRT34

Proteomic databases

jPOSTiO76011
MassIVEiO76011
PaxDbiO76011
PeptideAtlasiO76011
PRIDEiO76011
ProteomicsDBi12648
50343

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
28834, 106 antibodies

Genome annotation databases

EnsembliENST00000394001; ENSP00000377570; ENSG00000131737
GeneIDi100653049
3885
KEGGihsa:100653049
hsa:3885
UCSCiuc002hwm.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3885
DisGeNETi3885
EuPathDBiHostDB:ENSG00000131737.5

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KRT34
HGNCiHGNC:6452, KRT34
HPAiENSG00000131737, Tissue enhanced (cervix, uterine, skin, tongue)
MIMi602763, gene
neXtProtiNX_O76011
OpenTargetsiENSG00000131737
PharmGKBiPA30241

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502RTXS, Eukaryota
GeneTreeiENSGT00940000163426
HOGENOMiCLU_012560_8_0_1
InParanoidiO76011
KOiK07604
OMAiPTINGIK
OrthoDBi772040at2759
PhylomeDBiO76011

Enzyme and pathway databases

PathwayCommonsiO76011
ReactomeiR-HSA-6805567, Keratinization
R-HSA-6809371, Formation of the cornified envelope

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
3885, 2 hits in 871 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Keratin_34
PharosiO76011, Tbio

Protein Ontology

More...
PROi
PR:O76011
RNActiO76011, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000131737, Expressed in hair follicle and 64 other tissues
GenevisibleiO76011, HS

Family and domain databases

Gene3Di1.20.5.1160, 1 hit
InterProiView protein in InterPro
IPR018039, IF_conserved
IPR039008, IF_rod_dom
IPR042180, IF_rod_dom_coil1B
IPR002957, Keratin_I
PANTHERiPTHR23239, PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038, Filament, 1 hit
PRINTSiPR01248, TYPE1KERATIN
SMARTiView protein in SMART
SM01391, Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226, IF_ROD_1, 1 hit
PS51842, IF_ROD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKRT34_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O76011
Secondary accession number(s): Q8IUT8, Q8N4W2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 20, 2009
Last modified: October 7, 2020
This is version 162 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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