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UniProtKB - O76009 (KT33A_HUMAN)
Protein
Keratin, type I cuticular Ha3-I
Gene
KRT33A
Organism
Homo sapiens (Human)
Status
Functioni
Miscellaneous
There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 305 | Stutter | 1 |
GO - Molecular functioni
- structural molecule activity Source: InterPro
GO - Biological processi
- epithelial cell differentiation Source: GO_Central
- intermediate filament organization Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | O76009 |
Reactomei | R-HSA-6805567, Keratinization R-HSA-6809371, Formation of the cornified envelope |
SignaLinki | O76009 |
Names & Taxonomyi
Protein namesi | Recommended name: Keratin, type I cuticular Ha3-IAlternative name(s): Hair keratin, type I Ha3-I Keratin-33A Short name: K33A |
Gene namesi | Name:KRT33A Synonyms:HHA3-I, HKA3A, KRTHA3A |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6450, KRT33A |
MIMi | 602761, gene |
neXtProti | NX_O76009 |
VEuPathDBi | HostDB:ENSG00000006059 |
Subcellular locationi
Cytoskeleton
- cytoskeleton Source: GO_Central
- intermediate filament Source: UniProtKB-KW
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- extracellular space Source: UniProtKB
Keywords - Cellular componenti
Intermediate filament, KeratinPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000006059 |
PharmGKBi | PA30239 |
Miscellaneous databases
Pharosi | O76009, Tdark |
Genetic variation databases
BioMutai | KRT33A |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000063688 | 1 – 404 | Keratin, type I cuticular Ha3-IAdd BLAST | 404 |
Proteomic databases
jPOSTi | O76009 |
MassIVEi | O76009 |
PaxDbi | O76009 |
PeptideAtlasi | O76009 |
PRIDEi | O76009 |
ProteomicsDBi | 50342 |
PTM databases
iPTMneti | O76009 |
PhosphoSitePlusi | O76009 |
SwissPalmi | O76009 |
Expressioni
Tissue specificityi
Expressed in the hair follicles.1 Publication
Gene expression databases
Bgeei | ENSG00000006059, Expressed in hair follicle and 64 other tissues |
Genevisiblei | O76009, HS |
Organism-specific databases
HPAi | ENSG00000006059, Tissue enriched (skin) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 110081, 6 interactors |
IntActi | O76009, 2 interactors |
STRINGi | 9606.ENSP00000007735 |
Miscellaneous databases
RNActi | O76009, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 56 – 367 | IF rodPROSITE-ProRule annotationAdd BLAST | 312 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 56 | HeadAdd BLAST | 56 | |
Regioni | 57 – 91 | Coil 1AAdd BLAST | 35 | |
Regioni | 92 – 102 | Linker 1Add BLAST | 11 | |
Regioni | 103 – 203 | Coil 1BAdd BLAST | 101 | |
Regioni | 204 – 219 | Linker 12Add BLAST | 16 | |
Regioni | 220 – 363 | Coil 2Add BLAST | 144 | |
Regioni | 364 – 404 | TailAdd BLAST | 41 |
Sequence similaritiesi
Belongs to the intermediate filament family.PROSITE-ProRule annotation
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502SNBF, Eukaryota |
GeneTreei | ENSGT00940000153980 |
HOGENOMi | CLU_012560_8_0_1 |
InParanoidi | O76009 |
OMAi | NACDTSI |
OrthoDBi | 772040at2759 |
PhylomeDBi | O76009 |
TreeFami | TF332742 |
Family and domain databases
InterProi | View protein in InterPro IPR018039, IF_conserved IPR039008, IF_rod_dom IPR002957, Keratin_I |
PANTHERi | PTHR23239, PTHR23239, 1 hit |
Pfami | View protein in Pfam PF00038, Filament, 1 hit |
PRINTSi | PR01248, TYPE1KERATIN |
SMARTi | View protein in SMART SM01391, Filament, 1 hit |
PROSITEi | View protein in PROSITE PS00226, IF_ROD_1, 1 hit PS51842, IF_ROD_2, 1 hit |
i Sequence
Sequence statusi: Complete.
O76009-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSYSCGLPSL SCRTSCSSRP CVPPSCHGCT LPGACNIPAN VSNCNWFCEG
60 70 80 90 100
SFNGSEKETM QFLNDRLASY LEKVRQLERD NAELENLIRE RSQQQEPLVC
110 120 130 140 150
ASYQSYFKTI EELQQKILCS KSENARLVVQ IDNAKLASDD FRTKYETELS
160 170 180 190 200
LRQLVESDIN GLRRILDELT LCRSDLEAQV ESLKEELLCL KQNHEQEVNT
210 220 230 240 250
LRCQLGDRLN VEVDAAPTVD LNQVLNETRS QYEALVETNR REVEQWFATQ
260 270 280 290 300
TEELNKQVVS SSEQLQSYQA EIIELRRTVN ALEIELQAQH NLRDSLENTL
310 320 330 340 350
TESEARYSSQ LSQVQRLITN VESQLAEIRS DLERQNQEYQ VLLDVRARLE
360 370 380 390 400
CEINTYRSLL ESEDCKLPSN PCATTNACDK STGPCISNPC GLRARCGPCN
TFGY
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 82 | A → T in BAG36784 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 94 | Q → R in CAG17613 (PubMed:15617563).Curated | 1 | |
Sequence conflicti | 153 – 154 | QL → HV in CAA76384 (PubMed:9756910).Curated | 2 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_054432 | 270 | A → V3 PublicationsCorresponds to variant dbSNP:rs12937519Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y16788 Genomic DNA Translation: CAA76384.1 AJ633621 mRNA Translation: CAG17613.2 AK314088 mRNA Translation: BAG36784.1 AC003958 Genomic DNA No translation available. CH471152 Genomic DNA Translation: EAW60727.1 BC069135 mRNA Translation: AAH69135.1 |
CCDSi | CCDS11388.1 |
RefSeqi | NP_004129.2, NM_004138.3 |
Genome annotation databases
Ensembli | ENST00000007735.4; ENSP00000007735.3; ENSG00000006059.4 ENST00000576236.1; ENSP00000461221.1; ENSG00000261986.1 |
GeneIDi | 3883 |
KEGGi | hsa:3883 |
MANE-Selecti | ENST00000007735.4; ENSP00000007735.3; NM_004138.4; NP_004129.2 |
UCSCi | uc002hwk.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y16788 Genomic DNA Translation: CAA76384.1 AJ633621 mRNA Translation: CAG17613.2 AK314088 mRNA Translation: BAG36784.1 AC003958 Genomic DNA No translation available. CH471152 Genomic DNA Translation: EAW60727.1 BC069135 mRNA Translation: AAH69135.1 |
CCDSi | CCDS11388.1 |
RefSeqi | NP_004129.2, NM_004138.3 |
3D structure databases
AlphaFoldDBi | O76009 |
SMRi | O76009 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 110081, 6 interactors |
IntActi | O76009, 2 interactors |
STRINGi | 9606.ENSP00000007735 |
PTM databases
iPTMneti | O76009 |
PhosphoSitePlusi | O76009 |
SwissPalmi | O76009 |
Genetic variation databases
BioMutai | KRT33A |
Proteomic databases
jPOSTi | O76009 |
MassIVEi | O76009 |
PaxDbi | O76009 |
PeptideAtlasi | O76009 |
PRIDEi | O76009 |
ProteomicsDBi | 50342 |
Protocols and materials databases
Antibodypediai | 66112, 93 antibodies from 19 providers |
DNASUi | 3883 |
Genome annotation databases
Ensembli | ENST00000007735.4; ENSP00000007735.3; ENSG00000006059.4 ENST00000576236.1; ENSP00000461221.1; ENSG00000261986.1 |
GeneIDi | 3883 |
KEGGi | hsa:3883 |
MANE-Selecti | ENST00000007735.4; ENSP00000007735.3; NM_004138.4; NP_004129.2 |
UCSCi | uc002hwk.3, human |
Organism-specific databases
CTDi | 3883 |
GeneCardsi | KRT33A |
HGNCi | HGNC:6450, KRT33A |
HPAi | ENSG00000006059, Tissue enriched (skin) |
MIMi | 602761, gene |
neXtProti | NX_O76009 |
OpenTargetsi | ENSG00000006059 |
PharmGKBi | PA30239 |
VEuPathDBi | HostDB:ENSG00000006059 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SNBF, Eukaryota |
GeneTreei | ENSGT00940000153980 |
HOGENOMi | CLU_012560_8_0_1 |
InParanoidi | O76009 |
OMAi | NACDTSI |
OrthoDBi | 772040at2759 |
PhylomeDBi | O76009 |
TreeFami | TF332742 |
Enzyme and pathway databases
PathwayCommonsi | O76009 |
Reactomei | R-HSA-6805567, Keratinization R-HSA-6809371, Formation of the cornified envelope |
SignaLinki | O76009 |
Miscellaneous databases
BioGRID-ORCSi | 3883, 17 hits in 1059 CRISPR screens |
GeneWikii | KRT33A |
GenomeRNAii | 3883 |
Pharosi | O76009, Tdark |
PROi | PR:O76009 |
RNActi | O76009, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000006059, Expressed in hair follicle and 64 other tissues |
Genevisiblei | O76009, HS |
Family and domain databases
InterProi | View protein in InterPro IPR018039, IF_conserved IPR039008, IF_rod_dom IPR002957, Keratin_I |
PANTHERi | PTHR23239, PTHR23239, 1 hit |
Pfami | View protein in Pfam PF00038, Filament, 1 hit |
PRINTSi | PR01248, TYPE1KERATIN |
SMARTi | View protein in SMART SM01391, Filament, 1 hit |
PROSITEi | View protein in PROSITE PS00226, IF_ROD_1, 1 hit PS51842, IF_ROD_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | KT33A_HUMAN | |
Accessioni | O76009Primary (citable) accession number: O76009 Secondary accession number(s): B2RA87, Q6NTB9, Q6ZZB9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | February 10, 2009 | |
Last modified: | May 25, 2022 | |
This is version 160 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families