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UniProtKB - O76009 (KT33A_HUMAN)

Entry version 160 (25 May 2022)
Sequence version 2 (10 Feb 2009)
Previous versions | rss
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Protein

Keratin, type I cuticular Ha3-I

Gene

KRT33A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei305Stutter1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O76009

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6805567, Keratinization
R-HSA-6809371, Formation of the cornified envelope

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		O76009

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Keratin, type I cuticular Ha3-I
Alternative name(s):
Hair keratin, type I Ha3-I
Keratin-33A
Short name:
K33A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KRT33A
Synonyms:HHA3-I, HKA3A, KRTHA3A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:6450, KRT33A

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602761, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O76009

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000006059

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Intermediate filament, Keratin

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000006059

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30239

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O76009, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		KRT33A

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000636881 – 404Keratin, type I cuticular Ha3-IAdd BLAST404

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O76009

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O76009

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O76009

PeptideAtlas

More...PeptideAtlasi		O76009

PRoteomics IDEntifications database

More...PRIDEi		O76009

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		50342

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O76009

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O76009

SwissPalm database of S-palmitoylation events

More...SwissPalmi		O76009

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the hair follicles.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000006059, Expressed in hair follicle and 64 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O76009, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000006059, Tissue enriched (skin)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110081, 6 interactors

Protein interaction database and analysis system

More...IntActi		O76009, 2 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000007735

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O76009, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		O76009

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O76009

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini56 – 367IF rodPROSITE-ProRule annotationAdd BLAST312

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 56HeadAdd BLAST56
Regioni57 – 91Coil 1AAdd BLAST35
Regioni92 – 102Linker 1Add BLAST11
Regioni103 – 203Coil 1BAdd BLAST101
Regioni204 – 219Linker 12Add BLAST16
Regioni220 – 363Coil 2Add BLAST144
Regioni364 – 404TailAdd BLAST41

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502SNBF, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153980

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_012560_8_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O76009

Identification of Orthologs from Complete Genome Data

More...OMAi		NACDTSI

Database of Orthologous Groups

More...OrthoDBi		772040at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O76009

TreeFam database of animal gene trees

More...TreeFami		TF332742

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR018039, IF_conserved
IPR039008, IF_rod_dom
IPR002957, Keratin_I

The PANTHER Classification System

More...PANTHERi		PTHR23239, PTHR23239, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00038, Filament, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01248, TYPE1KERATIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01391, Filament, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00226, IF_ROD_1, 1 hit
PS51842, IF_ROD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O76009-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSYSCGLPSL SCRTSCSSRP CVPPSCHGCT LPGACNIPAN VSNCNWFCEG 
        60         70         80         90        100
SFNGSEKETM QFLNDRLASY LEKVRQLERD NAELENLIRE RSQQQEPLVC 
       110        120        130        140        150
ASYQSYFKTI EELQQKILCS KSENARLVVQ IDNAKLASDD FRTKYETELS 
       160        170        180        190        200
LRQLVESDIN GLRRILDELT LCRSDLEAQV ESLKEELLCL KQNHEQEVNT 
       210        220        230        240        250
LRCQLGDRLN VEVDAAPTVD LNQVLNETRS QYEALVETNR REVEQWFATQ 
       260        270        280        290        300
TEELNKQVVS SSEQLQSYQA EIIELRRTVN ALEIELQAQH NLRDSLENTL 
       310        320        330        340        350
TESEARYSSQ LSQVQRLITN VESQLAEIRS DLERQNQEYQ VLLDVRARLE 
       360        370        380        390        400
CEINTYRSLL ESEDCKLPSN PCATTNACDK STGPCISNPC GLRARCGPCN 

TFGY
Length:404
Mass (Da):45,940
Last modified:February 10, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i14B0C556E64485B0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti82A → T in BAG36784 (PubMed:14702039).Curated1
Sequence conflicti94Q → R in CAG17613 (PubMed:15617563).Curated1
Sequence conflicti153 – 154QL → HV in CAA76384 (PubMed:9756910).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_054432270A → V3 PublicationsCorresponds to variant dbSNP:rs12937519Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Y16788 Genomic DNA Translation: CAA76384.1
AJ633621 mRNA Translation: CAG17613.2
AK314088 mRNA Translation: BAG36784.1
AC003958 Genomic DNA No translation available.
CH471152 Genomic DNA Translation: EAW60727.1
BC069135 mRNA Translation: AAH69135.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11388.1

NCBI Reference Sequences

More...RefSeqi		NP_004129.2, NM_004138.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000007735.4; ENSP00000007735.3; ENSG00000006059.4
ENST00000576236.1; ENSP00000461221.1; ENSG00000261986.1

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3883

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3883

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000007735.4; ENSP00000007735.3; NM_004138.4; NP_004129.2

UCSC genome browser

More...UCSCi		uc002hwk.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16788 Genomic DNA Translation: CAA76384.1
AJ633621 mRNA Translation: CAG17613.2
AK314088 mRNA Translation: BAG36784.1
AC003958 Genomic DNA No translation available.
CH471152 Genomic DNA Translation: EAW60727.1
BC069135 mRNA Translation: AAH69135.1
CCDSiCCDS11388.1
RefSeqiNP_004129.2, NM_004138.3

3D structure databases

AlphaFoldDBiO76009
SMRiO76009
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi110081, 6 interactors
IntActiO76009, 2 interactors
STRINGi9606.ENSP00000007735

PTM databases

iPTMnetiO76009
PhosphoSitePlusiO76009
SwissPalmiO76009

Genetic variation databases

BioMutaiKRT33A

Proteomic databases

jPOSTiO76009
MassIVEiO76009
PaxDbiO76009
PeptideAtlasiO76009
PRIDEiO76009
ProteomicsDBi50342

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		66112, 93 antibodies from 19 providers

The DNASU plasmid repository

More...DNASUi		3883

Genome annotation databases

EnsembliENST00000007735.4; ENSP00000007735.3; ENSG00000006059.4
ENST00000576236.1; ENSP00000461221.1; ENSG00000261986.1
GeneIDi3883
KEGGihsa:3883
MANE-SelectiENST00000007735.4; ENSP00000007735.3; NM_004138.4; NP_004129.2
UCSCiuc002hwk.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3883

GeneCards: human genes, protein and diseases

More...GeneCardsi		KRT33A
HGNCiHGNC:6450, KRT33A
HPAiENSG00000006059, Tissue enriched (skin)
MIMi602761, gene
neXtProtiNX_O76009
OpenTargetsiENSG00000006059
PharmGKBiPA30239
VEuPathDBiHostDB:ENSG00000006059

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502SNBF, Eukaryota
GeneTreeiENSGT00940000153980
HOGENOMiCLU_012560_8_0_1
InParanoidiO76009
OMAiNACDTSI
OrthoDBi772040at2759
PhylomeDBiO76009
TreeFamiTF332742

Enzyme and pathway databases

PathwayCommonsiO76009
ReactomeiR-HSA-6805567, Keratinization
R-HSA-6809371, Formation of the cornified envelope
SignaLinkiO76009

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3883, 17 hits in 1059 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		KRT33A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3883
PharosiO76009, Tdark

Protein Ontology

More...PROi		PR:O76009
RNActiO76009, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000006059, Expressed in hair follicle and 64 other tissues
GenevisibleiO76009, HS

Family and domain databases

InterProiView protein in InterPro
IPR018039, IF_conserved
IPR039008, IF_rod_dom
IPR002957, Keratin_I
PANTHERiPTHR23239, PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038, Filament, 1 hit
PRINTSiPR01248, TYPE1KERATIN
SMARTiView protein in SMART
SM01391, Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226, IF_ROD_1, 1 hit
PS51842, IF_ROD_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKT33A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O76009
Secondary accession number(s): B2RA87, Q6NTB9, Q6ZZB9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 10, 2009
Last modified: May 25, 2022
This is version 160 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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