KRT33A

Functionⁱ

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	305	Stutter		1

GO - Molecular functionⁱ

structural molecule activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cornification Source: Reactome
keratinization Source: Reactome

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6805567 Keratinization R-HSA-6809371 Formation of the cornified envelope

Reactomeⁱ

R-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Keratin, type I cuticular Ha3-I Alternative name(s): Hair keratin, type I Ha3-I Keratin-33A Short name: K33A
Gene namesⁱ	Name:KRT33A Synonyms:HHA3-I, HKA3A, KRTHA3A
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000006059.3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6450 KRT33A
MIMⁱ	602761 gene
neXtProtⁱ	NX_O76009

Subcellular locationⁱ

GO - Cellular component

Keywords - Cellular componentⁱ

Intermediate filament, Keratin

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000006059
PharmGKBⁱ	PA30239

Polymorphism and mutation databases

BioMutaⁱ	KRT33A

BioMutaⁱ

KRT33A

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000063688	1 – 404	Keratin, type I cuticular Ha3-IAdd BLAST		404

Proteomic databases

PaxDbⁱ	O76009
PeptideAtlas More...PeptideAtlasⁱ	O76009
PRIDEⁱ	O76009
ProteomicsDBⁱ	12653 50342

PTM databases

iPTMnetⁱ	O76009
PhosphoSitePlusⁱ	O76009
SwissPalmⁱ	O76009

Expressionⁱ

Tissue specificityⁱ

Expressed in the hair follicles.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000006059 Expressed in 55 organ(s), highest expression level in hair follicle
CleanExⁱ	HS_KRT33A
Genevisibleⁱ	O76009 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA055194

HPAⁱ

HPA055194

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	110081, 4 interactors
IntActⁱ	O76009, 2 interactors
STRINGⁱ	9606.ENSP00000007735

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O76009
SMRⁱ	O76009
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	56 – 367	IF rodPROSITE-ProRule annotationAdd BLAST		312

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	1 – 56	HeadAdd BLAST	56
Regionⁱ	57 – 91	Coil 1AAdd BLAST	35
Regionⁱ	92 – 102	Linker 1Add BLAST	11
Regionⁱ	103 – 203	Coil 1BAdd BLAST	101
Regionⁱ	204 – 219	Linker 12Add BLAST	16
Regionⁱ	220 – 363	Coil 2Add BLAST	144
Regionⁱ	364 – 404	TailAdd BLAST	41

Sequence similaritiesⁱ

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	ENOG410IF9P Eukaryota ENOG410YK2A LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140814
HOGENOMⁱ	HOG000230975
HOVERGENⁱ	HBG013015
InParanoidⁱ	O76009
KEGG Orthology (KO) More...KOⁱ	K07604
OMAⁱ	NACDKSI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G087I
PhylomeDBⁱ	O76009
TreeFamⁱ	TF332742

Family and domain databases

InterProⁱ	View protein in InterPro IPR001664 IF IPR018039 IF_conserved IPR039008 IF_rod_dom IPR002957 Keratin_I
PANTHERⁱ	PTHR23239 PTHR23239, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00038 Filament, 1 hit
PRINTSⁱ	PR01248 TYPE1KERATIN
SMARTⁱ	View protein in SMART SM01391 Filament, 1 hit
PROSITEⁱ	View protein in PROSITE PS00226 IF_ROD_1, 1 hit PS51842 IF_ROD_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

O76009-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSYSCGLPSL SCRTSCSSRP CVPPSCHGCT LPGACNIPAN VSNCNWFCEG 
        60         70         80         90        100
SFNGSEKETM QFLNDRLASY LEKVRQLERD NAELENLIRE RSQQQEPLVC 
       110        120        130        140        150
ASYQSYFKTI EELQQKILCS KSENARLVVQ IDNAKLASDD FRTKYETELS 
       160        170        180        190        200
LRQLVESDIN GLRRILDELT LCRSDLEAQV ESLKEELLCL KQNHEQEVNT 
       210        220        230        240        250
LRCQLGDRLN VEVDAAPTVD LNQVLNETRS QYEALVETNR REVEQWFATQ 
       260        270        280        290        300
TEELNKQVVS SSEQLQSYQA EIIELRRTVN ALEIELQAQH NLRDSLENTL 
       310        320        330        340        350
TESEARYSSQ LSQVQRLITN VESQLAEIRS DLERQNQEYQ VLLDVRARLE 
       360        370        380        390        400
CEINTYRSLL ESEDCKLPSN PCATTNACDK STGPCISNPC GLRARCGPCN 

TFGY

Length:404

Mass (Da):45,940

Last modified:February 10, 2009 - v2

Checksum:ⁱ14B0C556E64485B0

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	82	A → T in BAG36784 (PubMed:14702039).Curated	1
Sequence conflictⁱ	94	Q → R in CAG17613 (PubMed:15617563).Curated	1
Sequence conflictⁱ	153 – 154	QL → HV in CAA76384 (PubMed:9756910).Curated	2

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_054432	270	A → V3 PublicationsCorresponds to variant dbSNP:rs12937519Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y16788 Genomic DNA Translation: CAA76384.1 AJ633621 mRNA Translation: CAG17613.2 AK314088 mRNA Translation: BAG36784.1 AC003958 Genomic DNA No translation available. CH471152 Genomic DNA Translation: EAW60727.1 BC069135 mRNA Translation: AAH69135.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11388.1
NCBI Reference Sequences More...RefSeqⁱ	NP_004129.2, NM_004138.3
UniGeneⁱ	Hs.512579

Genome annotation databases

Ensemblⁱ	ENST00000007735; ENSP00000007735; ENSG00000006059 ENST00000576236; ENSP00000461221; ENSG00000261986
GeneIDⁱ	3883
KEGGⁱ	hsa:3883
UCSC genome browser More...UCSCⁱ	uc002hwk.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
O76009	Keratin, type I cuticular Ha1		HUMAN		416	UniRef90_Q15323
Keratin, type I cuticular Ha3-I		PANTR		404
Uncharacterized protein		PONAB		418
Uncharacterized protein		NOMLE		416
Uncharacterized protein		MACMU		416
+81

Protein	Similar proteins		Species	Score	Length	Source
O76009	Keratin, type I cuticular Ha1		HUMAN		416	UniRef50_Q15323
Keratin, type I cuticular Ha3-I		PANTR		404
Keratin, type I cuticular Ha2		MOUSE		407
Keratin, type I cuticular Ha5		SHEEP		455
Keratin, type I cuticular Ha5		BOVIN		454
+373

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y16788 Genomic DNA Translation: CAA76384.1 AJ633621 mRNA Translation: CAG17613.2 AK314088 mRNA Translation: BAG36784.1 AC003958 Genomic DNA No translation available. CH471152 Genomic DNA Translation: EAW60727.1 BC069135 mRNA Translation: AAH69135.1
CCDSⁱ	CCDS11388.1
RefSeqⁱ	NP_004129.2, NM_004138.3
UniGeneⁱ	Hs.512579

3D structure databases

ProteinModelPortalⁱ	O76009
SMRⁱ	O76009
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110081, 4 interactors
IntActⁱ	O76009, 2 interactors
STRINGⁱ	9606.ENSP00000007735

PTM databases

iPTMnetⁱ	O76009
PhosphoSitePlusⁱ	O76009
SwissPalmⁱ	O76009

Polymorphism and mutation databases

BioMutaⁱ	KRT33A

BioMutaⁱ

KRT33A

Proteomic databases

PaxDbⁱ	O76009
PeptideAtlasⁱ	O76009
PRIDEⁱ	O76009
ProteomicsDBⁱ	12653 50342

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000007735; ENSP00000007735; ENSG00000006059 ENST00000576236; ENSP00000461221; ENSG00000261986
GeneIDⁱ	3883
KEGGⁱ	hsa:3883
UCSCⁱ	uc002hwk.3 human

Organism-specific databases

CTDⁱ	3883
EuPathDBⁱ	HostDB:ENSG00000006059.3
GeneCardsⁱ	KRT33A
H-InvDBⁱ	HIX0039114
HGNCⁱ	HGNC:6450 KRT33A
HPAⁱ	HPA055194
MIMⁱ	602761 gene
neXtProtⁱ	NX_O76009
OpenTargetsⁱ	ENSG00000006059
PharmGKBⁱ	PA30239
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IF9P Eukaryota ENOG410YK2A LUCA
GeneTreeⁱ	ENSGT00900000140814
HOGENOMⁱ	HOG000230975
HOVERGENⁱ	HBG013015
InParanoidⁱ	O76009
KOⁱ	K07604
OMAⁱ	NACDKSI
OrthoDBⁱ	EOG091G087I
PhylomeDBⁱ	O76009
TreeFamⁱ	TF332742

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6805567 Keratinization R-HSA-6809371 Formation of the cornified envelope

Reactomeⁱ

R-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope

Miscellaneous databases

GeneWikiⁱ	KRT33A
GenomeRNAiⁱ	3883
Protein Ontology More...PROⁱ	PR:O76009
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000006059 Expressed in 55 organ(s), highest expression level in hair follicle
CleanExⁱ	HS_KRT33A
Genevisibleⁱ	O76009 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR001664 IF IPR018039 IF_conserved IPR039008 IF_rod_dom IPR002957 Keratin_I
PANTHERⁱ	PTHR23239 PTHR23239, 1 hit
Pfamⁱ	View protein in Pfam PF00038 Filament, 1 hit
PRINTSⁱ	PR01248 TYPE1KERATIN
SMARTⁱ	View protein in SMART SM01391 Filament, 1 hit
PROSITEⁱ	View protein in PROSITE PS00226 IF_ROD_1, 1 hit PS51842 IF_ROD_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KT33A_HUMAN
Accessionⁱ	O76009Primary (citable) accession number: O76009 Secondary accession number(s): B2RA87, Q6NTB9, Q6ZZB9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	February 10, 2009
	Last modified:	November 7, 2018
	This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM

UniProtKB

UniParc

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UniRef

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Supporting data

UniProtKB - O76009 (KT33A_HUMAN)

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Keratin, type I cuticular Ha3-I

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Cytosol

Extracellular region or secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ