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Entry version 200 (12 Aug 2020)
Sequence version 2 (26 Sep 2003)
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Protein

Glutaredoxin-3

Gene

GLRX3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (PubMed:26613676, PubMed:27519415). Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). Required for hemoglobin maturation (PubMed:23615448). Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity.By similarity3 Publications

Miscellaneous

Silencing of Grx3 in HeLa cells decreases the activities of several cytosolic Fe/S proteins, such as ACO1, a major component of post-transcriptional iron regulation. As a consequence, Grx3-depleted cells show decreased levels of ferritin and increased levels of transferrin receptor, features characteristic of cellular iron starvation (PubMed:23615448).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi159Iron-sulfur (2Fe-2S); shared with dimeric partner2 Publications1
Metal bindingi261Iron-sulfur (2Fe-2S); shared with dimeric partner2 Publications1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandIron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
O76003

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-917937, Iron uptake and transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glutaredoxin-3
Alternative name(s):
PKC-interacting cousin of thioredoxin1 Publication
Short name:
PICOT1 Publication
PKC-theta-interacting protein
Short name:
PKCq-interacting protein
Thioredoxin-like protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GLRX3
Synonyms:PICOT1 Publication, TXNL2
ORF Names:HUSSY-22
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000108010.11

Human Gene Nomenclature Database

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HGNCi
HGNC:15987, GLRX3

Online Mendelian Inheritance in Man (OMIM)

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MIMi
612754, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_O76003

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi159C → S: Loss of 2Fe-2S-binding; when associated with S-261. Loss of 2Fe-2S-binding and interaction with BOLA2; when associated with 197-D-A-198. 2 Publications1
Mutagenesisi197 – 198WP → DA: Loss of 2Fe-2S-binding and interaction with BOLA2; when associated with S-159. 1 Publication2
Mutagenesisi261C → S: Loss of 2Fe-2S-binding; when associated with S-159. Loss of 2Fe-2S-binding and interaction with BOLA2; when associated with 299-D-A-300. 2 Publications1
Mutagenesisi299 – 300WP → DA: Loss of 2Fe-2S-binding and interaction with BOLA2; when associated with S-261. 1 Publication2

Organism-specific databases

DisGeNET

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DisGeNETi
10539

Open Targets

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OpenTargetsi
ENSG00000108010

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA162389829

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
O76003, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GLRX3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001200192 – 335Glutaredoxin-3Add BLAST334

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei117PhosphoserineCombined sources1
Modified residuei120PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
CPTAC-206
CPTAC-207

Encyclopedia of Proteome Dynamics

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EPDi
O76003

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O76003

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
O76003

MaxQB - The MaxQuant DataBase

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MaxQBi
O76003

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O76003

PeptideAtlas

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PeptideAtlasi
O76003

PRoteomics IDEntifications database

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PRIDEi
O76003

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
50341

2D gel databases

REPRODUCTION-2DPAGE

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REPRODUCTION-2DPAGEi
IPI00008552

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O76003

MetOSite database of methionine sulfoxide sites

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MetOSitei
O76003

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O76003

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O76003

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in heart, spleen, testis and, to a lower extent, in thymus and peripheral blood leukocytes. Weakly expressed in lung, placenta, colon and small intestine.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000108010, Expressed in testis and 236 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O76003, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O76003, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000108010, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; the homodimer is independent of 2Fe-2S clusters (PubMed:27519415). Heterotrimer; forms a heterotrimeric complex composed by two BOLA2 molecules and one GLRX3 molecule; linked by [2Fe-2S] clusters (PubMed:22309771, PubMed:26613676, PubMed:27519415).

Interacts (via N-terminus) with PRKCQ/PKC-theta (PubMed:10636891).

Interacts (via C-terminus) with CSRP3 (By similarity).

Interacts with CSRP2 (By similarity).

By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

O76003
With#Exp.IntAct
ADAMTSL3 [P82987]3EBI-374781,EBI-10221726
ALKBH3 [Q96Q83]3EBI-374781,EBI-6658697
BOLA1 [Q9Y3E2]14EBI-374781,EBI-1049556
BOLA2B [A0A087WZT3]3EBI-374781,EBI-12006120
BOLA3 [Q53S33]5EBI-374781,EBI-12086950
CA9 [Q16790]9EBI-374781,EBI-12259996
CBLB [Q13191]3EBI-374781,EBI-744027
CDC20B - isoform 5 [Q86Y33-5]3EBI-374781,EBI-11983537
CERCAM [Q5T4B2]3EBI-374781,EBI-12261896
CGGBP1 [Q9UFW8]3EBI-374781,EBI-723153
CIAPIN1 [Q6FI81]18EBI-374781,EBI-750511
CIAPIN1 - isoform 1 [Q6FI81-1]2EBI-374781,EBI-16172762
COL8A1 [P27658]3EBI-374781,EBI-747133
FAM118A [Q9NWS6]3EBI-374781,EBI-8638992
FLJ13057 [Q53SE7]3EBI-374781,EBI-10172181
itself2EBI-374781,EBI-374781
GNG13 [Q9P2W3]3EBI-374781,EBI-11427343
GRN [P28799]9EBI-374781,EBI-747754
HEPH - isoform 3 [Q9BQS7-3]3EBI-374781,EBI-22734368
HSD3B7 [Q9H2F3]3EBI-374781,EBI-3918847
IKZF1 [Q13422]3EBI-374781,EBI-745305
IL10 [P22301]3EBI-374781,EBI-1031632
IRX6 [P78412]5EBI-374781,EBI-12100506
KLHDC9 [Q8NEP7]5EBI-374781,EBI-12214879
KPRP [Q5T749]3EBI-374781,EBI-10981970
KRT31 [Q15323]3EBI-374781,EBI-948001
KRT38 [O76015]3EBI-374781,EBI-1047263
KRTAP10-11 [P60412]4EBI-374781,EBI-10217483
KRTAP10-5 [P60370]6EBI-374781,EBI-10172150
KRTAP10-8 [P60410]8EBI-374781,EBI-10171774
KRTAP10-9 [P60411]8EBI-374781,EBI-10172052
KRTAP12-3 [P60328]3EBI-374781,EBI-11953334
KRTAP4-11 [Q9BYQ6]8EBI-374781,EBI-10302392
KRTAP4-12 [Q9BQ66]7EBI-374781,EBI-739863
KRTAP4-2 [Q9BYR5]3EBI-374781,EBI-10172511
KRTAP4-4 [Q9BYR3]3EBI-374781,EBI-11958132
KRTAP4-5 [Q9BYR2]5EBI-374781,EBI-11993254
KRTAP4-7 [Q9BYR0]3EBI-374781,EBI-10302547
KRTAP5-11 [Q6L8G4]3EBI-374781,EBI-11993296
KRTAP5-3 [Q6L8H2]7EBI-374781,EBI-11974251
KRTAP5-4 [Q6L8H1]3EBI-374781,EBI-11963072
KRTAP5-6 [Q6L8G9]7EBI-374781,EBI-10250562
KRTAP5-9 [P26371]8EBI-374781,EBI-3958099
KRTAP9-2 [Q9BYQ4]8EBI-374781,EBI-1044640
KRTAP9-3 [Q9BYQ3]3EBI-374781,EBI-1043191
KRTAP9-8 [Q9BYQ0]3EBI-374781,EBI-11958364
LCE2D [Q5TA82]6EBI-374781,EBI-10246750
LNX1 [Q8TBB1]3EBI-374781,EBI-739832
MAPKBP1 [O60336]6EBI-374781,EBI-947402
METAP1 [P53582]3EBI-374781,EBI-1051435
MOXD1 [Q6UVY6]7EBI-374781,EBI-7134667
NOTCH2NLA [Q7Z3S9]3EBI-374781,EBI-945833
NTF4 [P34130]3EBI-374781,EBI-3907456
OLFM3 [Q96PB7]3EBI-374781,EBI-10292253
PCSK5 [Q92824]3EBI-374781,EBI-751290
PFDN5 [Q99471]3EBI-374781,EBI-357275
PLSCR1 [O15162]4EBI-374781,EBI-740019
PRKCQ [Q04759]5EBI-374781,EBI-374762
RCOR3 - isoform 2 [Q9P2K3-2]3EBI-374781,EBI-1504830
RECK [Q6P9E2]3EBI-374781,EBI-10253121
RGS20 [O76081]4EBI-374781,EBI-1052678
RGS20 - isoform 5 [O76081-6]3EBI-374781,EBI-10178530
SMARCC1 [Q92922]3EBI-374781,EBI-355653
SOX7 [Q9BT81]3EBI-374781,EBI-7239117
STAU1 [O95793]3EBI-374781,EBI-358174
STRA6 - isoform 6 [Q9BX79-6]3EBI-374781,EBI-12140683
TCF4 [P15884]3EBI-374781,EBI-533224
TCL1B [O95988]5EBI-374781,EBI-727338
TMEM25 [Q86YD3]4EBI-374781,EBI-10260688
TRAF1 [Q13077]5EBI-374781,EBI-359224
TRIM36 [Q9NQ86]6EBI-374781,EBI-2341518
TRIM42 [Q8IWZ5]6EBI-374781,EBI-5235829
UGP2 [Q16851]3EBI-374781,EBI-743729
ZBTB44 [Q8NCP5]3EBI-374781,EBI-5658292
ZNF124 [Q15973]3EBI-374781,EBI-2555767
ZNF148 [Q9UQR1]3EBI-374781,EBI-2688184
ZNF410 - isoform 3 [Q86VK4-3]3EBI-374781,EBI-11741890
ZNF426 [Q9BUY5]3EBI-374781,EBI-743265
ZNF490 [Q9ULM2]3EBI-374781,EBI-1105370
ZNF544 [Q6NX49]3EBI-374781,EBI-2841978
ZNF774 [Q6NX45]3EBI-374781,EBI-10251462

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
115793, 117 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
O76003

Database of interacting proteins

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DIPi
DIP-31306N

Protein interaction database and analysis system

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IntActi
O76003, 116 interactors

Molecular INTeraction database

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MINTi
O76003

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000357633

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
O76003, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1335
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O76003

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O76003

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2 – 117ThioredoxinPROSITE-ProRule annotationAdd BLAST116
Domaini144 – 236Glutaredoxin 1PROSITE-ProRule annotationAdd BLAST93
Domaini237 – 335Glutaredoxin 2PROSITE-ProRule annotationAdd BLAST99

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The thioredoxin domain lacks the two redox-active cysteines. This strongly suggests that it lacks thioredoxin activity.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0911, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00550000075030

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_026126_12_2_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O76003

Identification of Orthologs from Complete Genome Data

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OMAi
CGQMNEV

Database of Orthologous Groups

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OrthoDBi
1449534at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O76003

TreeFam database of animal gene trees

More...
TreeFami
TF314151

Family and domain databases

Conserved Domains Database

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CDDi
cd03028, GRX_PICOT_like, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.30.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002109, Glutaredoxin
IPR033658, GRX_PICOT-like
IPR004480, Monothiol_GRX-rel
IPR036249, Thioredoxin-like_sf
IPR013766, Thioredoxin_domain

The PANTHER Classification System

More...
PANTHERi
PTHR10293, PTHR10293, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00462, Glutaredoxin, 2 hits
PF00085, Thioredoxin, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF52833, SSF52833, 3 hits

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR00365, TIGR00365, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51354, GLUTAREDOXIN_2, 2 hits
PS51352, THIOREDOXIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

O76003-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAGAAEAAV AAVEEVGSAG QFEELLRLKA KSLLVVHFWA PWAPQCAQMN
60 70 80 90 100
EVMAELAKEL PQVSFVKLEA EGVPEVSEKY EISSVPTFLF FKNSQKIDRL
110 120 130 140 150
DGAHAPELTK KVQRHASSGS FLPSANEHLK EDLNLRLKKL THAAPCMLFM
160 170 180 190 200
KGTPQEPRCG FSKQMVEILH KHNIQFSSFD IFSDEEVRQG LKAYSSWPTY
210 220 230 240 250
PQLYVSGELI GGLDIIKELE ASEELDTICP KAPKLEERLK VLTNKASVML
260 270 280 290 300
FMKGNKQEAK CGFSKQILEI LNSTGVEYET FDILEDEEVR QGLKAYSNWP
310 320 330
TYPQLYVKGE LVGGLDIVKE LKENGELLPI LRGEN
Length:335
Mass (Da):37,432
Last modified:September 26, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i46D644413D9EDFDA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2A → E in CAA09375 (PubMed:11124703).Curated1
Sequence conflicti67K → R in BAG51067 (PubMed:14702039).Curated1
Sequence conflicti210I → T in BAG51059 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01687521Q → H3 PublicationsCorresponds to variant dbSNP:rs13991Ensembl.1
Natural variantiVAR_016876123P → S3 PublicationsCorresponds to variant dbSNP:rs2274217Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF118649 mRNA Translation: AAF28841.1
AF118652 mRNA Translation: AAF28844.1
AJ010841 mRNA Translation: CAA09375.1
AK022131 mRNA Translation: BAG51067.1
AK021926 mRNA Translation: BAG51059.1
AL139123 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49152.1
CH471066 Genomic DNA Translation: EAW49154.1
CH471066 Genomic DNA Translation: EAW49155.1
BC005289 mRNA Translation: AAH05289.1
BC014372 mRNA Translation: AAH14372.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7661.1

NCBI Reference Sequences

More...
RefSeqi
NP_001186797.1, NM_001199868.1
NP_006532.2, NM_006541.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000331244; ENSP00000330836; ENSG00000108010
ENST00000368644; ENSP00000357633; ENSG00000108010
ENST00000481034; ENSP00000435445; ENSG00000108010

Database of genes from NCBI RefSeq genomes

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GeneIDi
10539

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:10539

UCSC genome browser

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UCSCi
uc001lkm.3, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF118649 mRNA Translation: AAF28841.1
AF118652 mRNA Translation: AAF28844.1
AJ010841 mRNA Translation: CAA09375.1
AK022131 mRNA Translation: BAG51067.1
AK021926 mRNA Translation: BAG51059.1
AL139123 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49152.1
CH471066 Genomic DNA Translation: EAW49154.1
CH471066 Genomic DNA Translation: EAW49155.1
BC005289 mRNA Translation: AAH05289.1
BC014372 mRNA Translation: AAH14372.2
CCDSiCCDS7661.1
RefSeqiNP_001186797.1, NM_001199868.1
NP_006532.2, NM_006541.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DIYNMR-A1-117[»]
2WZ9X-ray1.55A1-125[»]
2YANX-ray1.90A/B232-334[»]
3ZYWX-ray1.84A/B130-232[»]
SMRiO76003
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi115793, 117 interactors
CORUMiO76003
DIPiDIP-31306N
IntActiO76003, 116 interactors
MINTiO76003
STRINGi9606.ENSP00000357633

PTM databases

iPTMnetiO76003
MetOSiteiO76003
PhosphoSitePlusiO76003
SwissPalmiO76003

Polymorphism and mutation databases

BioMutaiGLRX3

2D gel databases

REPRODUCTION-2DPAGEiIPI00008552

Proteomic databases

CPTACiCPTAC-206
CPTAC-207
EPDiO76003
jPOSTiO76003
MassIVEiO76003
MaxQBiO76003
PaxDbiO76003
PeptideAtlasiO76003
PRIDEiO76003
ProteomicsDBi50341

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
32521, 352 antibodies

Genome annotation databases

EnsembliENST00000331244; ENSP00000330836; ENSG00000108010
ENST00000368644; ENSP00000357633; ENSG00000108010
ENST00000481034; ENSP00000435445; ENSG00000108010
GeneIDi10539
KEGGihsa:10539
UCSCiuc001lkm.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10539
DisGeNETi10539
EuPathDBiHostDB:ENSG00000108010.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GLRX3
HGNCiHGNC:15987, GLRX3
HPAiENSG00000108010, Low tissue specificity
MIMi612754, gene
neXtProtiNX_O76003
OpenTargetsiENSG00000108010
PharmGKBiPA162389829

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0911, Eukaryota
GeneTreeiENSGT00550000075030
HOGENOMiCLU_026126_12_2_1
InParanoidiO76003
OMAiCGQMNEV
OrthoDBi1449534at2759
PhylomeDBiO76003
TreeFamiTF314151

Enzyme and pathway databases

PathwayCommonsiO76003
ReactomeiR-HSA-917937, Iron uptake and transport

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
10539, 208 hits in 878 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
GLRX3, human
EvolutionaryTraceiO76003

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
GLRX3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10539
PharosiO76003, Tbio

Protein Ontology

More...
PROi
PR:O76003
RNActiO76003, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000108010, Expressed in testis and 236 other tissues
ExpressionAtlasiO76003, baseline and differential
GenevisibleiO76003, HS

Family and domain databases

CDDicd03028, GRX_PICOT_like, 2 hits
Gene3Di3.40.30.10, 3 hits
InterProiView protein in InterPro
IPR002109, Glutaredoxin
IPR033658, GRX_PICOT-like
IPR004480, Monothiol_GRX-rel
IPR036249, Thioredoxin-like_sf
IPR013766, Thioredoxin_domain
PANTHERiPTHR10293, PTHR10293, 1 hit
PfamiView protein in Pfam
PF00462, Glutaredoxin, 2 hits
PF00085, Thioredoxin, 1 hit
SUPFAMiSSF52833, SSF52833, 3 hits
TIGRFAMsiTIGR00365, TIGR00365, 1 hit
PROSITEiView protein in PROSITE
PS51354, GLUTAREDOXIN_2, 2 hits
PS51352, THIOREDOXIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGLRX3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O76003
Secondary accession number(s): B3KMP7
, B3KMQ5, D3DRG2, Q5JV01, Q96CE0, Q9P1B0, Q9P1B1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: September 26, 2003
Last modified: August 12, 2020
This is version 200 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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