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Protein

Olfactory receptor 2J2

Gene

OR2J2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  • G protein-coupled receptor activity Source: UniProtKB-KW
  • olfactory receptor activity Source: GO_Central

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2J2
Alternative name(s):
Hs6M1-6
Olfactory receptor 6-8
Short name:
OR6-8
Olfactory receptor OR6-19
Gene namesi
Name:OR2J2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000204700.4
HGNCiHGNC:8260 OR2J2
neXtProtiNX_O76002

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26ExtracellularSequence analysisAdd BLAST26
Transmembranei27 – 50Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini51 – 58CytoplasmicSequence analysis8
Transmembranei59 – 80Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini81 – 101ExtracellularSequence analysisAdd BLAST21
Transmembranei102 – 121Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini122 – 140CytoplasmicSequence analysisAdd BLAST19
Transmembranei141 – 159Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini160 – 196ExtracellularSequence analysisAdd BLAST37
Transmembranei197 – 220Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini221 – 237CytoplasmicSequence analysisAdd BLAST17
Transmembranei238 – 260Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini261 – 273ExtracellularSequence analysisAdd BLAST13
Transmembranei274 – 293Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini294 – 312CytoplasmicSequence analysisAdd BLAST19

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi26707
PharmGKBiPA32177

Polymorphism and mutation databases

BioMutaiOR2J2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504831 – 312Olfactory receptor 2J2Add BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi98 ↔ 190PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO76002
PeptideAtlasiO76002
PRIDEiO76002
ProteomicsDBi50340

Expressioni

Gene expression databases

BgeeiENSG00000204700 Expressed in 7 organ(s), highest expression level in right testis
CleanExiHS_OR2J2
ExpressionAtlasiO76002 baseline and differential
GenevisibleiO76002 HS

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000366372

Structurei

3D structure databases

ProteinModelPortaliO76002
SMRiO76002
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JAWR Eukaryota
ENOG4111DPD LUCA
HOVERGENiHBG017625
InParanoidiO76002
KOiK04257
OrthoDBiEOG091G0CU6
PhylomeDBiO76002
TreeFamiTF336512

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O76002-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMIKKNASSE DFFILLGFSN WPQLEVVLFV VILIFYLMTL TGNLFIIILS
60 70 80 90 100
YVDSHLHTPM YFFLSNLSFL DLCHTTSSIP QLLVNLRGPE KTISYAGCMV
110 120 130 140 150
QLYFVLALGI AECVLLVVMS YDRYVAVCRP LHYTVLMHPR FCHLLAAASW
160 170 180 190 200
VIGFTISALH SSFTFWVPLC GHRLVDHFFC EVPALLRLSC VDTHANELTL
210 220 230 240 250
MVMSSIFVLI PLILILTAYG AIARAVLSMQ STTGLQKVFR TCGAHLMVVS
260 270 280 290 300
LFFIPVMCMY LQPPSENSPD QGKFIALFYT VVTPSLNPLI YTLRNKHVKG
310
AAKRLLGWEW GK
Length:312
Mass (Da):35,204
Last modified:November 1, 1998 - v1
Checksum:iFB7D20BB2379C43E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A126GWS4A0A126GWS4_HUMAN
Olfactory receptor
OR2J2
312Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26V → A in AAI08897 (PubMed:15489334).Curated1

Polymorphismi

Three OR2J2 alleles are known: 6M1-6*01, 6M1-6*02 and 6M1-6*03. The sequence shown is that of allele 6M1-6*01.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01094574H → Y in allele 6M1-6*02 and allele 6M1-6*03. 3 PublicationsCorresponds to variant dbSNP:rs3116855Ensembl.1
Natural variantiVAR_010946111A → T in allele 6M1-6*03. 2 PublicationsCorresponds to variant dbSNP:rs3129157Ensembl.1
Natural variantiVAR_010947146A → V in allele 6M1-6*02 and allele 6M1-6*03. 3 PublicationsCorresponds to variant dbSNP:rs3116856Ensembl.1
Natural variantiVAR_010948218A → T in allele 6M1-6*02 and allele 6M1-6*03. 3 PublicationsCorresponds to variant dbSNP:rs3130743Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ302571 Genomic DNA Translation: CAC20491.1
AJ302572 Genomic DNA Translation: CAC20492.1
AJ302573 Genomic DNA Translation: CAC20493.1
AJ302574 Genomic DNA Translation: CAC20494.1
AJ302575 Genomic DNA Translation: CAC20495.1
AJ302576 Genomic DNA Translation: CAC20496.1
AJ302577 Genomic DNA Translation: CAC20497.1
AJ302578 Genomic DNA Translation: CAC20498.1
AJ302579 Genomic DNA Translation: CAC20499.1
AJ302580 Genomic DNA Translation: CAC20500.1
AJ302581 Genomic DNA Translation: CAC20501.1
AJ302582 Genomic DNA Translation: CAC20502.1
AJ302583 Genomic DNA Translation: CAC20503.1
CR388415 Genomic DNA No translation available.
AL662852 Genomic DNA No translation available.
AL645937 Genomic DNA No translation available.
CR759834 Genomic DNA No translation available.
AL022727 Genomic DNA Translation: CAA18784.1
BX248093 Genomic DNA No translation available.
BC069121 mRNA Translation: AAH69121.1
BC108896 mRNA Translation: AAI08897.1
BC108897 mRNA Translation: AAI08898.1
BC108898 mRNA Translation: AAI08899.1
BC108899 mRNA Translation: AAI08900.1
BK004438 Genomic DNA Translation: DAA04836.1
CCDSiCCDS43434.1
RefSeqiNP_112167.2, NM_030905.2
UniGeneiHs.163518

Genome annotation databases

EnsembliENST00000358688; ENSP00000351519; ENSG00000196231
ENST00000377167; ENSP00000366372; ENSG00000204700
ENST00000411588; ENSP00000396524; ENSG00000231676
ENST00000415857; ENSP00000392497; ENSG00000226000
ENST00000419605; ENSP00000408988; ENSG00000232945
ENST00000427744; ENSP00000403186; ENSG00000234746
ENST00000440124; ENSP00000398238; ENSG00000225550
ENST00000457762; ENSP00000416299; ENSG00000226347
GeneIDi26707
KEGGihsa:26707
UCSCiuc011dlm.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ302571 Genomic DNA Translation: CAC20491.1
AJ302572 Genomic DNA Translation: CAC20492.1
AJ302573 Genomic DNA Translation: CAC20493.1
AJ302574 Genomic DNA Translation: CAC20494.1
AJ302575 Genomic DNA Translation: CAC20495.1
AJ302576 Genomic DNA Translation: CAC20496.1
AJ302577 Genomic DNA Translation: CAC20497.1
AJ302578 Genomic DNA Translation: CAC20498.1
AJ302579 Genomic DNA Translation: CAC20499.1
AJ302580 Genomic DNA Translation: CAC20500.1
AJ302581 Genomic DNA Translation: CAC20501.1
AJ302582 Genomic DNA Translation: CAC20502.1
AJ302583 Genomic DNA Translation: CAC20503.1
CR388415 Genomic DNA No translation available.
AL662852 Genomic DNA No translation available.
AL645937 Genomic DNA No translation available.
CR759834 Genomic DNA No translation available.
AL022727 Genomic DNA Translation: CAA18784.1
BX248093 Genomic DNA No translation available.
BC069121 mRNA Translation: AAH69121.1
BC108896 mRNA Translation: AAI08897.1
BC108897 mRNA Translation: AAI08898.1
BC108898 mRNA Translation: AAI08899.1
BC108899 mRNA Translation: AAI08900.1
BK004438 Genomic DNA Translation: DAA04836.1
CCDSiCCDS43434.1
RefSeqiNP_112167.2, NM_030905.2
UniGeneiHs.163518

3D structure databases

ProteinModelPortaliO76002
SMRiO76002
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000366372

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR2J2

Proteomic databases

PaxDbiO76002
PeptideAtlasiO76002
PRIDEiO76002
ProteomicsDBi50340

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358688; ENSP00000351519; ENSG00000196231
ENST00000377167; ENSP00000366372; ENSG00000204700
ENST00000411588; ENSP00000396524; ENSG00000231676
ENST00000415857; ENSP00000392497; ENSG00000226000
ENST00000419605; ENSP00000408988; ENSG00000232945
ENST00000427744; ENSP00000403186; ENSG00000234746
ENST00000440124; ENSP00000398238; ENSG00000225550
ENST00000457762; ENSP00000416299; ENSG00000226347
GeneIDi26707
KEGGihsa:26707
UCSCiuc011dlm.3 human

Organism-specific databases

CTDi26707
DisGeNETi26707
EuPathDBiHostDB:ENSG00000204700.4
GeneCardsiOR2J2
H-InvDBiHIX0165964
HIX0166461
HIX0167456
HIX0201070
HIX0201087
HGNCiHGNC:8260 OR2J2
neXtProtiNX_O76002
PharmGKBiPA32177
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JAWR Eukaryota
ENOG4111DPD LUCA
HOVERGENiHBG017625
InParanoidiO76002
KOiK04257
OrthoDBiEOG091G0CU6
PhylomeDBiO76002
TreeFamiTF336512

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR2J2
GenomeRNAii26707
PROiPR:O76002

Gene expression databases

BgeeiENSG00000204700 Expressed in 7 organ(s), highest expression level in right testis
CleanExiHS_OR2J2
ExpressionAtlasiO76002 baseline and differential
GenevisibleiO76002 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOR2J2_HUMAN
AccessioniPrimary (citable) accession number: O76002
Secondary accession number(s): A6NCU9
, A6NLD0, B0UY53, Q32N09, Q5ST39, Q5SUJ6, Q6IF24, Q9GZK2, Q9GZL3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  5. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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