UniProtKB - O76001 (OR2J3_HUMAN)
Protein
Olfactory receptor 2J3
Gene
OR2J3
Organism
Homo sapiens (Human)
Status
Functioni
Odorant receptor involved in the detection of the flavor compound cis-3-hexen-1-ol (C3HEX), a compound typically described as 'green grassy' or the smell of 'cut grass'.1 Publication
GO - Molecular functioni
- G protein-coupled receptor activity Source: UniProtKB-KW
- olfactory receptor activity Source: InterPro
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Olfaction, Sensory transduction |
Enzyme and pathway databases
PathwayCommonsi | O76001 |
Reactomei | R-HSA-381753, Olfactory Signaling Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Olfactory receptor 2J3Alternative name(s): Hs6M1-3 Olfactory receptor OR6-16 Short name: OR6-6 Short name: Olfactory receptor 6-6 |
Gene namesi | Name:OR2J3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000204701.1 |
HGNCi | HGNC:8261, OR2J3 |
MIMi | 615016, gene |
neXtProti | NX_O76001 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 28 | ExtracellularSequence analysisAdd BLAST | 28 | |
Transmembranei | 29 – 52 | Helical; Name=1Sequence analysisAdd BLAST | 24 | |
Topological domaini | 53 – 60 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 61 – 82 | Helical; Name=2Sequence analysisAdd BLAST | 22 | |
Topological domaini | 83 – 103 | ExtracellularSequence analysisAdd BLAST | 21 | |
Transmembranei | 104 – 123 | Helical; Name=3Sequence analysisAdd BLAST | 20 | |
Topological domaini | 124 – 142 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 143 – 161 | Helical; Name=4Sequence analysisAdd BLAST | 19 | |
Topological domaini | 162 – 198 | ExtracellularSequence analysisAdd BLAST | 37 | |
Transmembranei | 199 – 222 | Helical; Name=5Sequence analysisAdd BLAST | 24 | |
Topological domaini | 223 – 239 | CytoplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 240 – 262 | Helical; Name=6Sequence analysisAdd BLAST | 23 | |
Topological domaini | 263 – 275 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 276 – 295 | Helical; Name=7Sequence analysisAdd BLAST | 20 | |
Topological domaini | 296 – 311 | CytoplasmicSequence analysisAdd BLAST | 16 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 442186 |
MalaCardsi | OR2J3 |
MIMi | 615082, phenotype |
PharmGKBi | PA32178 |
Miscellaneous databases
Pharosi | O76001, Tdark |
Polymorphism and mutation databases
BioMutai | OR2J3 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000150484 | 1 – 311 | Olfactory receptor 2J3Add BLAST | 311 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 8 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 100 ↔ 192 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | O76001 |
PeptideAtlasi | O76001 |
PRIDEi | O76001 |
ProteomicsDBi | 50339 |
PTM databases
GlyGeni | O76001, 1 site |
Expressioni
Gene expression databases
Bgeei | ENSG00000204701, Expressed in sural nerve and 7 other tissues |
ExpressionAtlasi | O76001, baseline and differential |
Genevisiblei | O76001, HS |
Organism-specific databases
HPAi | ENSG00000204701, Tissue enhanced (testis) |
Interactioni
Protein-protein interaction databases
STRINGi | 9606.ENSP00000366374 |
Miscellaneous databases
RNActi | O76001, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502RU1S, Eukaryota |
HOGENOMi | CLU_012526_1_2_1 |
InParanoidi | O76001 |
OrthoDBi | 954090at2759 |
PhylomeDBi | O76001 |
TreeFami | TF336512 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR000725, Olfact_rcpt |
Pfami | View protein in Pfam PF13853, 7tm_4, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00245, OLFACTORYR |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
O76001-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNDDGKVNAS SEGYFILVGF SNWPHLEVVI FVVVLIFYLM TLIGNLFIII
60 70 80 90 100
LSYLDSHLHT PMYFFLSNLS FLDLCYTTSS IPQLLVNLWG PEKTISYAGC
110 120 130 140 150
MIQLYFVLAL GTTECVLLVV MSYDRYAAVC RPLHYTVLMH PRFCHLLAVA
160 170 180 190 200
SWVSGFTNSA LHSSFTFWVP LCGHRQVDHF FCEVPALLRL SCVDTHVNEL
210 220 230 240 250
TLMITSSIFV LIPLILILTS YGAIVRAVLR MQSTTGLQKV FGTCGAHLMA
260 270 280 290 300
VSLFFIPAMC IYLQPPSGNS QDQGKFIALF YTVVTPSLNP LIYTLRNKVV
310
RGAVKRLMGW E
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A126GWT2 | A0A126GWT2_HUMAN | Olfactory receptor | OR2J3 | 311 | Annotation score: | ||
A0A140T964 | A0A140T964_HUMAN | Olfactory receptor | OR2J3 | 258 | Annotation score: |
Polymorphismi
Variants Ala-113 and Gln-226 exhibit a reduced ability to smell C3HEX [MIMi:615082]. When both variants are present in the same haplotype (allele 6M1-3*02), the response to C3HEX is abolished. African populations have a higher proportion of the C3HEX-nonresponsive haplotype than other populations. All haplotypes containing Gln-226 show low levels of surface expression.1 Publication
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_010949 | 113 | T → A in allele 6M1-3*02; decreased response to C3HEX. 2 PublicationsCorresponds to variant dbSNP:rs28757581EnsemblClinVar. | 1 | |
Natural variantiVAR_010950 | 226 | R → Q in allele 6M1-3*02; decreased response to C3HEX. 2 PublicationsCorresponds to variant dbSNP:rs3749977EnsemblClinVar. | 1 | |
Natural variantiVAR_010951 | 228 | V → I in allele 6M1-3*03. 1 PublicationCorresponds to variant dbSNP:rs3130764Ensembl. | 1 | |
Natural variantiVAR_010952 | 261 | I → M in allele 6M1-3*03 and allele 6M1-3*04. 3 PublicationsCorresponds to variant dbSNP:rs3130765Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ302547 Genomic DNA Translation: CAC20472.1 AJ302548 Genomic DNA Translation: CAC20473.1 AJ302549 Genomic DNA Translation: CAC20474.1 AJ302550 Genomic DNA Translation: CAC20475.1 AJ302551 Genomic DNA Translation: CAC20476.1 AJ302552 Genomic DNA Translation: CAC21440.1 AJ302553 Genomic DNA Translation: CAC21441.1 AJ302554 Genomic DNA Translation: CAC21442.1 AJ302555 Genomic DNA Translation: CAC21443.1 AJ302556 Genomic DNA Translation: CAC21444.1 AJ302557 Genomic DNA Translation: CAC20477.1 AJ302558 Genomic DNA Translation: CAC20478.1 AL645937 Genomic DNA No translation available. AL022727 Genomic DNA Translation: CAA18783.1 AL662852 Genomic DNA No translation available. AL929561 Genomic DNA No translation available. BX248093 Genomic DNA No translation available. CR547123 Genomic DNA No translation available. CR388415 Genomic DNA No translation available. CR942175 Genomic DNA No translation available. BC136973 mRNA Translation: AAI36974.1 BC136975 mRNA Translation: AAI36976.1 AF399630 Genomic DNA Translation: AAK95115.1 BK004437 Genomic DNA Translation: DAA04835.1 |
CCDSi | CCDS43433.1 |
RefSeqi | NP_001005216.2, NM_001005216.3 |
Genome annotation databases
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Human Olfactory Receptor Data Exploratorium (HORDE) |
Protein Spotlight The intricacy of a smell - Issue 150 of July 2013 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ302547 Genomic DNA Translation: CAC20472.1 AJ302548 Genomic DNA Translation: CAC20473.1 AJ302549 Genomic DNA Translation: CAC20474.1 AJ302550 Genomic DNA Translation: CAC20475.1 AJ302551 Genomic DNA Translation: CAC20476.1 AJ302552 Genomic DNA Translation: CAC21440.1 AJ302553 Genomic DNA Translation: CAC21441.1 AJ302554 Genomic DNA Translation: CAC21442.1 AJ302555 Genomic DNA Translation: CAC21443.1 AJ302556 Genomic DNA Translation: CAC21444.1 AJ302557 Genomic DNA Translation: CAC20477.1 AJ302558 Genomic DNA Translation: CAC20478.1 AL645937 Genomic DNA No translation available. AL022727 Genomic DNA Translation: CAA18783.1 AL662852 Genomic DNA No translation available. AL929561 Genomic DNA No translation available. BX248093 Genomic DNA No translation available. CR547123 Genomic DNA No translation available. CR388415 Genomic DNA No translation available. CR942175 Genomic DNA No translation available. BC136973 mRNA Translation: AAI36974.1 BC136975 mRNA Translation: AAI36976.1 AF399630 Genomic DNA Translation: AAK95115.1 BK004437 Genomic DNA Translation: DAA04835.1 |
CCDSi | CCDS43433.1 |
RefSeqi | NP_001005216.2, NM_001005216.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000366374 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | O76001, 1 site |
Polymorphism and mutation databases
BioMutai | OR2J3 |
Proteomic databases
PaxDbi | O76001 |
PeptideAtlasi | O76001 |
PRIDEi | O76001 |
ProteomicsDBi | 50339 |
Protocols and materials databases
Antibodypediai | 62681, 84 antibodies |
Genome annotation databases
Organism-specific databases
CTDi | 442186 |
DisGeNETi | 442186 |
EuPathDBi | HostDB:ENSG00000204701.1 |
GeneCardsi | OR2J3 |
HGNCi | HGNC:8261, OR2J3 |
HPAi | ENSG00000204701, Tissue enhanced (testis) |
MalaCardsi | OR2J3 |
MIMi | 615016, gene 615082, phenotype |
neXtProti | NX_O76001 |
PharmGKBi | PA32178 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RU1S, Eukaryota |
HOGENOMi | CLU_012526_1_2_1 |
InParanoidi | O76001 |
OrthoDBi | 954090at2759 |
PhylomeDBi | O76001 |
TreeFami | TF336512 |
Enzyme and pathway databases
PathwayCommonsi | O76001 |
Reactomei | R-HSA-381753, Olfactory Signaling Pathway |
Miscellaneous databases
BioGRID-ORCSi | 442186, 6 hits in 459 CRISPR screens |
GeneWikii | OR2J3 |
GenomeRNAii | 442186 |
Pharosi | O76001, Tdark |
PROi | PR:O76001 |
RNActi | O76001, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000204701, Expressed in sural nerve and 7 other tissues |
ExpressionAtlasi | O76001, baseline and differential |
Genevisiblei | O76001, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR000725, Olfact_rcpt |
Pfami | View protein in Pfam PF13853, 7tm_4, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00245, OLFACTORYR |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | OR2J3_HUMAN | |
Accessioni | O76001Primary (citable) accession number: O76001 Secondary accession number(s): B0UY52 Q9GZL5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 20, 2001 |
Last sequence update: | November 1, 1998 | |
Last modified: | December 2, 2020 | |
This is version 174 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Protein Spotlight
Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries