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Protein

SAM and SH3 domain-containing protein 3

Gene

SASH3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as a signaling adapter protein in lymphocytes.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
SAM and SH3 domain-containing protein 3
Alternative name(s):
SH3 protein expressed in lymphocytes homolog
Gene namesi
Name:SASH3
Synonyms:CXorf9, SLY
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000122122.9
HGNCiHGNC:15975 SASH3
MIMi300441 gene
neXtProtiNX_O75995

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi54440
OpenTargetsiENSG00000122122
PharmGKBiPA162402388

Polymorphism and mutation databases

BioMutaiSASH3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000719621 – 380SAM and SH3 domain-containing protein 3Add BLAST380

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei27Phosphoserine1 Publication1
Modified residuei34PhosphoserineCombined sources1
Modified residuei42PhosphoserineCombined sources1
Modified residuei61PhosphothreonineCombined sources1
Modified residuei97PhosphoserineCombined sources1
Modified residuei103PhosphothreonineCombined sources1
Modified residuei110PhosphoserineCombined sources1
Modified residuei112PhosphothreonineCombined sources1
Modified residuei113PhosphoserineCombined sources1
Modified residuei116PhosphotyrosineCombined sources1
Modified residuei120PhosphoserineCombined sources1
Modified residuei318PhosphothreonineCombined sources1
Modified residuei320PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO75995
MaxQBiO75995
PaxDbiO75995
PeptideAtlasiO75995
PRIDEiO75995
ProteomicsDBi50337

PTM databases

iPTMnetiO75995
PhosphoSitePlusiO75995

Expressioni

Gene expression databases

BgeeiENSG00000122122
CleanExiHS_SASH3
GenevisibleiO75995 HS

Organism-specific databases

HPAiHPA001085

Interactioni

Protein-protein interaction databases

BioGridi119956, 1 interactor
IntActiO75995, 1 interactor
STRINGi9606.ENSP00000349359

Structurei

3D structure databases

ProteinModelPortaliO75995
SMRiO75995
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini173 – 234SH3PROSITE-ProRule annotationAdd BLAST62
Domaini252 – 316SAMPROSITE-ProRule annotationAdd BLAST65

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiENOG410INAS Eukaryota
ENOG410YC4U LUCA
GeneTreeiENSGT00390000014672
HOGENOMiHOG000049202
HOVERGENiHBG000461
InParanoidiO75995
OMAiEMGDTLE
OrthoDBiEOG091G0BS1
PhylomeDBiO75995
TreeFamiTF350709

Family and domain databases

CDDicd11968 SH3_SASH3, 1 hit
InterProiView protein in InterPro
IPR021090 rSAM/SH3_domain-containing
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR035722 SASH3
IPR035721 SASH3_SH3
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR12301:SF5 PTHR12301:SF5, 1 hit
PfamiView protein in Pfam
PF07647 SAM_2, 1 hit
PF07653 SH3_2, 1 hit
PF12485 SLY, 1 hit
SMARTiView protein in SMART
SM00454 SAM, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50105 SAM_DOMAIN, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

O75995-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRRKPSNAS EKEPTQKKKL SLQRSSSFKD FAKSKPSSPV VSEKEFNLDD
60 70 80 90 100
NIPEDDSGVP TPEDAGKSGK KLGKKWRAVI SRTMNRKMGK MMVKALSEEM
110 120 130 140 150
ADTLEEGSAS PTSPDYSLDS PGPEKMALAF SEQEEHELPV LSRQASTGSE
160 170 180 190 200
LCSPSPGSGS FGEEPPAPQY TGPFCGRARV HTDFTPSPYD HDSLKLQKGD
210 220 230 240 250
VIQIIEKPPV GTWLGLLNGK VGSFKFIYVD VLPEEAVGHA RPSRRQSKGK
260 270 280 290 300
RPKPKTLHEL LERIGLEEHT STLLLNGYQT LEDFKELRET HLNELNIMDP
310 320 330 340 350
QHRAKLLTAA ELLLDYDTGS EEAEEGAESS QEPVAHTVSE PKVDIPRDSG
360 370 380
CFEGSESGRD DAELAGTEEQ LQGLSLAGAP
Length:380
Mass (Da):41,595
Last modified:May 1, 1999 - v2
Checksum:i6DF3FB7D44797DB3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti79V → A in BAF84712 (PubMed:14702039).Curated1
Sequence conflicti365A → V in BAF84712 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049683 mRNA Translation: CAB41255.1
AK292023 mRNA Translation: BAF84712.1
AL023653 Genomic DNA No translation available.
CH471107 Genomic DNA Translation: EAX11826.1
BC051881 mRNA Translation: AAH51881.1
CCDSiCCDS14614.1
RefSeqiNP_061863.1, NM_018990.3
UniGeneiHs.61469

Genome annotation databases

EnsembliENST00000356892; ENSP00000349359; ENSG00000122122
GeneIDi54440
KEGGihsa:54440
UCSCiuc004euu.4 human

Similar proteinsi

Entry informationi

Entry nameiSASH3_HUMAN
AccessioniPrimary (citable) accession number: O75995
Secondary accession number(s): A6NCH1, A8K7K8, Q5JZ38
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: May 1, 1999
Last modified: June 20, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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