UniProtKB - O75995 (SASH3_HUMAN)
Protein
SAM and SH3 domain-containing protein 3
Gene
SASH3
Organism
Homo sapiens (Human)
Status
Functioni
May function as a signaling adapter protein in lymphocytes.By similarity
GO - Biological processi
- homeostasis of number of cells within a tissue Source: Ensembl
- positive regulation of adaptive immune response Source: GO_Central
- positive regulation of B cell proliferation Source: GO_Central
- positive regulation of CD4-positive, alpha-beta T cell differentiation Source: Ensembl
- positive regulation of immunoglobulin production Source: GO_Central
- positive regulation of interferon-gamma production Source: Ensembl
- positive regulation of interleukin-10 production Source: Ensembl
- positive regulation of interleukin-2 production Source: Ensembl
- positive regulation of interleukin-4 production Source: Ensembl
- positive regulation of organ growth Source: Ensembl
- positive regulation of T cell cytokine production Source: Ensembl
- positive regulation of T cell proliferation Source: Ensembl
- positive regulation of tumor necrosis factor production Source: Ensembl
Enzyme and pathway databases
PathwayCommonsi | O75995 |
Names & Taxonomyi
Protein namesi | Recommended name: SAM and SH3 domain-containing protein 3Alternative name(s): SH3 protein expressed in lymphocytes homolog |
Gene namesi | Name:SASH3 Synonyms:CXorf9, SLY |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000122122.9 |
HGNCi | HGNC:15975, SASH3 |
MIMi | 300441, gene |
neXtProti | NX_O75995 |
Subcellular locationi
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 54440 |
OpenTargetsi | ENSG00000122122 |
PharmGKBi | PA162402388 |
Miscellaneous databases
Pharosi | O75995, Tdark |
Polymorphism and mutation databases
BioMutai | SASH3 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000071962 | 1 – 380 | SAM and SH3 domain-containing protein 3Add BLAST | 380 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 27 | Phosphoserine1 Publication | 1 | |
Modified residuei | 34 | PhosphoserineCombined sources | 1 | |
Modified residuei | 42 | PhosphoserineCombined sources | 1 | |
Modified residuei | 61 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 97 | PhosphoserineCombined sources | 1 | |
Modified residuei | 103 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 110 | PhosphoserineCombined sources | 1 | |
Modified residuei | 112 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 113 | PhosphoserineCombined sources | 1 | |
Modified residuei | 116 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 120 | PhosphoserineCombined sources | 1 | |
Modified residuei | 318 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 320 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | O75995 |
jPOSTi | O75995 |
MassIVEi | O75995 |
MaxQBi | O75995 |
PaxDbi | O75995 |
PeptideAtlasi | O75995 |
PRIDEi | O75995 |
ProteomicsDBi | 50337 |
PTM databases
iPTMneti | O75995 |
PhosphoSitePlusi | O75995 |
Expressioni
Gene expression databases
Bgeei | ENSG00000122122, Expressed in granulocyte and 117 other tissues |
Genevisiblei | O75995, HS |
Organism-specific databases
HPAi | ENSG00000122122, Tissue enhanced (blood, bone marrow, lymphoid tissue) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 119956, 1 interactor |
IntActi | O75995, 3 interactors |
STRINGi | 9606.ENSP00000349359 |
Miscellaneous databases
RNActi | O75995, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 173 – 234 | SH3PROSITE-ProRule annotationAdd BLAST | 62 | |
Domaini | 252 – 316 | SAMPROSITE-ProRule annotationAdd BLAST | 65 |
Keywords - Domaini
SH3 domainPhylogenomic databases
eggNOGi | KOG4384, Eukaryota |
GeneTreei | ENSGT00940000160111 |
HOGENOMi | CLU_027875_0_0_1 |
InParanoidi | O75995 |
OMAi | DKEPTQK |
OrthoDBi | 278880at2759 |
PhylomeDBi | O75995 |
TreeFami | TF350709 |
Family and domain databases
CDDi | cd11968, SH3_SASH3, 1 hit |
Gene3Di | 1.10.150.50, 1 hit |
InterProi | View protein in InterPro IPR021090, rSAM/SH3_domain-containing IPR001660, SAM IPR013761, SAM/pointed_sf IPR035722, SASH3 IPR035721, SASH3_SH3 IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
PANTHERi | PTHR12301:SF5, PTHR12301:SF5, 1 hit |
Pfami | View protein in Pfam PF07647, SAM_2, 1 hit PF07653, SH3_2, 1 hit PF12485, SLY, 1 hit |
SMARTi | View protein in SMART SM00454, SAM, 1 hit SM00326, SH3, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS50105, SAM_DOMAIN, 1 hit PS50002, SH3, 1 hit |
i Sequence
Sequence statusi: Complete.
O75995-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLRRKPSNAS EKEPTQKKKL SLQRSSSFKD FAKSKPSSPV VSEKEFNLDD
60 70 80 90 100
NIPEDDSGVP TPEDAGKSGK KLGKKWRAVI SRTMNRKMGK MMVKALSEEM
110 120 130 140 150
ADTLEEGSAS PTSPDYSLDS PGPEKMALAF SEQEEHELPV LSRQASTGSE
160 170 180 190 200
LCSPSPGSGS FGEEPPAPQY TGPFCGRARV HTDFTPSPYD HDSLKLQKGD
210 220 230 240 250
VIQIIEKPPV GTWLGLLNGK VGSFKFIYVD VLPEEAVGHA RPSRRQSKGK
260 270 280 290 300
RPKPKTLHEL LERIGLEEHT STLLLNGYQT LEDFKELRET HLNELNIMDP
310 320 330 340 350
QHRAKLLTAA ELLLDYDTGS EEAEEGAESS QEPVAHTVSE PKVDIPRDSG
360 370 380
CFEGSESGRD DAELAGTEEQ LQGLSLAGAP
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 79 | V → A in BAF84712 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 365 | A → V in BAF84712 (PubMed:14702039).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL049683 mRNA Translation: CAB41255.1 AK292023 mRNA Translation: BAF84712.1 AL023653 Genomic DNA No translation available. CH471107 Genomic DNA Translation: EAX11826.1 BC051881 mRNA Translation: AAH51881.1 |
CCDSi | CCDS14614.1 |
RefSeqi | NP_061863.1, NM_018990.3 |
Genome annotation databases
Ensembli | ENST00000356892; ENSP00000349359; ENSG00000122122 |
GeneIDi | 54440 |
KEGGi | hsa:54440 |
UCSCi | uc004euu.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL049683 mRNA Translation: CAB41255.1 AK292023 mRNA Translation: BAF84712.1 AL023653 Genomic DNA No translation available. CH471107 Genomic DNA Translation: EAX11826.1 BC051881 mRNA Translation: AAH51881.1 |
CCDSi | CCDS14614.1 |
RefSeqi | NP_061863.1, NM_018990.3 |
3D structure databases
SMRi | O75995 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 119956, 1 interactor |
IntActi | O75995, 3 interactors |
STRINGi | 9606.ENSP00000349359 |
PTM databases
iPTMneti | O75995 |
PhosphoSitePlusi | O75995 |
Polymorphism and mutation databases
BioMutai | SASH3 |
Proteomic databases
EPDi | O75995 |
jPOSTi | O75995 |
MassIVEi | O75995 |
MaxQBi | O75995 |
PaxDbi | O75995 |
PeptideAtlasi | O75995 |
PRIDEi | O75995 |
ProteomicsDBi | 50337 |
Protocols and materials databases
Antibodypediai | 381, 50 antibodies |
Genome annotation databases
Ensembli | ENST00000356892; ENSP00000349359; ENSG00000122122 |
GeneIDi | 54440 |
KEGGi | hsa:54440 |
UCSCi | uc004euu.4, human |
Organism-specific databases
CTDi | 54440 |
DisGeNETi | 54440 |
EuPathDBi | HostDB:ENSG00000122122.9 |
GeneCardsi | SASH3 |
HGNCi | HGNC:15975, SASH3 |
HPAi | ENSG00000122122, Tissue enhanced (blood, bone marrow, lymphoid tissue) |
MIMi | 300441, gene |
neXtProti | NX_O75995 |
OpenTargetsi | ENSG00000122122 |
PharmGKBi | PA162402388 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4384, Eukaryota |
GeneTreei | ENSGT00940000160111 |
HOGENOMi | CLU_027875_0_0_1 |
InParanoidi | O75995 |
OMAi | DKEPTQK |
OrthoDBi | 278880at2759 |
PhylomeDBi | O75995 |
TreeFami | TF350709 |
Enzyme and pathway databases
PathwayCommonsi | O75995 |
Miscellaneous databases
BioGRID-ORCSi | 54440, 8 hits in 467 CRISPR screens |
ChiTaRSi | SASH3, human |
GenomeRNAii | 54440 |
Pharosi | O75995, Tdark |
PROi | PR:O75995 |
RNActi | O75995, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000122122, Expressed in granulocyte and 117 other tissues |
Genevisiblei | O75995, HS |
Family and domain databases
CDDi | cd11968, SH3_SASH3, 1 hit |
Gene3Di | 1.10.150.50, 1 hit |
InterProi | View protein in InterPro IPR021090, rSAM/SH3_domain-containing IPR001660, SAM IPR013761, SAM/pointed_sf IPR035722, SASH3 IPR035721, SASH3_SH3 IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
PANTHERi | PTHR12301:SF5, PTHR12301:SF5, 1 hit |
Pfami | View protein in Pfam PF07647, SAM_2, 1 hit PF07653, SH3_2, 1 hit PF12485, SLY, 1 hit |
SMARTi | View protein in SMART SM00454, SAM, 1 hit SM00326, SH3, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS50105, SAM_DOMAIN, 1 hit PS50002, SH3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SASH3_HUMAN | |
Accessioni | O75995Primary (citable) accession number: O75995 Secondary accession number(s): A6NCH1, A8K7K8, Q5JZ38 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 24, 2003 |
Last sequence update: | May 1, 1999 | |
Last modified: | December 2, 2020 | |
This is version 147 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM