SASH3

Functionⁱ

May function as a signaling adapter protein in lymphocytes.By similarity

GO - Biological processⁱ

homeostasis of number of cells within a tissue Source: Ensembl
positive regulation of B cell proliferation Source: Ensembl
positive regulation of CD4-positive, alpha-beta T cell differentiation Source: Ensembl
positive regulation of immunoglobulin production Source: Ensembl
positive regulation of interferon-gamma production Source: Ensembl
positive regulation of interleukin-10 production Source: Ensembl
positive regulation of interleukin-2 production Source: Ensembl
positive regulation of interleukin-4 production Source: Ensembl
positive regulation of organ growth Source: Ensembl
positive regulation of T cell cytokine production Source: Ensembl
positive regulation of T cell proliferation Source: Ensembl
positive regulation of tumor necrosis factor production Source: Ensembl

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: SAM and SH3 domain-containing protein 3 Alternative name(s): SH3 protein expressed in lymphocytes homolog
Gene namesⁱ	Name:SASH3 Synonyms:CXorf9, SLY
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome X

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000122122.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:15975 SASH3
MIMⁱ	300441 gene
neXtProtⁱ	NX_O75995

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	54440
Open Targets More...OpenTargetsⁱ	ENSG00000122122
PharmGKBⁱ	PA162402388

Polymorphism and mutation databases

BioMutaⁱ	SASH3

BioMutaⁱ

SASH3

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000071962	1 – 380	SAM and SH3 domain-containing protein 3Add BLAST		380

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	27	Phosphoserine1 Publication	1
Modified residueⁱ	34	PhosphoserineCombined sources	1
Modified residueⁱ	42	PhosphoserineCombined sources	1
Modified residueⁱ	61	PhosphothreonineCombined sources	1
Modified residueⁱ	97	PhosphoserineCombined sources	1
Modified residueⁱ	103	PhosphothreonineCombined sources	1
Modified residueⁱ	110	PhosphoserineCombined sources	1
Modified residueⁱ	112	PhosphothreonineCombined sources	1
Modified residueⁱ	113	PhosphoserineCombined sources	1
Modified residueⁱ	116	PhosphotyrosineCombined sources	1
Modified residueⁱ	120	PhosphoserineCombined sources	1
Modified residueⁱ	318	PhosphothreonineCombined sources	1
Modified residueⁱ	320	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	O75995
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O75995
PaxDbⁱ	O75995
PeptideAtlas More...PeptideAtlasⁱ	O75995
PRIDEⁱ	O75995
ProteomicsDBⁱ	50337

PTM databases

iPTMnetⁱ	O75995
PhosphoSitePlusⁱ	O75995

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000122122
CleanExⁱ	HS_SASH3
Genevisibleⁱ	O75995 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA001085

HPAⁱ

HPA001085

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	119956, 1 interactor
IntActⁱ	O75995, 1 interactor
STRINGⁱ	9606.ENSP00000349359

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O75995
SMRⁱ	O75995
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	173 – 234	SH3PROSITE-ProRule annotationAdd BLAST		62
Domainⁱ	252 – 316	SAMPROSITE-ProRule annotationAdd BLAST		65

Keywords - Domainⁱ

SH3 domain

Phylogenomic databases

eggNOGⁱ	ENOG410INAS Eukaryota ENOG410YC4U LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000014672
HOGENOMⁱ	HOG000049202
HOVERGENⁱ	HBG000461
InParanoidⁱ	O75995
OMAⁱ	EMGDTLE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BS1
PhylomeDBⁱ	O75995
TreeFamⁱ	TF350709

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd11968 SH3_SASH3, 1 hit
InterProⁱ	View protein in InterPro IPR021090 rSAM/SH3_domain-containing IPR001660 SAM IPR013761 SAM/pointed_sf IPR035722 SASH3 IPR035721 SASH3_SH3 IPR036028 SH3-like_dom_sf IPR001452 SH3_domain
PANTHERⁱ	PTHR12301:SF5 PTHR12301:SF5, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07647 SAM_2, 1 hit PF07653 SH3_2, 1 hit PF12485 SLY, 1 hit
SMARTⁱ	View protein in SMART SM00454 SAM, 1 hit SM00326 SH3, 1 hit
SUPFAMⁱ	SSF47769 SSF47769, 1 hit SSF50044 SSF50044, 1 hit
PROSITEⁱ	View protein in PROSITE PS50105 SAM_DOMAIN, 1 hit PS50002 SH3, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

O75995-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLRRKPSNAS EKEPTQKKKL SLQRSSSFKD FAKSKPSSPV VSEKEFNLDD 
        60         70         80         90        100
NIPEDDSGVP TPEDAGKSGK KLGKKWRAVI SRTMNRKMGK MMVKALSEEM 
       110        120        130        140        150
ADTLEEGSAS PTSPDYSLDS PGPEKMALAF SEQEEHELPV LSRQASTGSE 
       160        170        180        190        200
LCSPSPGSGS FGEEPPAPQY TGPFCGRARV HTDFTPSPYD HDSLKLQKGD 
       210        220        230        240        250
VIQIIEKPPV GTWLGLLNGK VGSFKFIYVD VLPEEAVGHA RPSRRQSKGK 
       260        270        280        290        300
RPKPKTLHEL LERIGLEEHT STLLLNGYQT LEDFKELRET HLNELNIMDP 
       310        320        330        340        350
QHRAKLLTAA ELLLDYDTGS EEAEEGAESS QEPVAHTVSE PKVDIPRDSG 
       360        370        380
CFEGSESGRD DAELAGTEEQ LQGLSLAGAP

Length:380

Mass (Da):41,595

Last modified:May 1, 1999 - v2

Checksum:ⁱ6DF3FB7D44797DB3

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	79	V → A in BAF84712 (PubMed:14702039).Curated		1
Sequence conflictⁱ	365	A → V in BAF84712 (PubMed:14702039).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL049683 mRNA Translation: CAB41255.1 AK292023 mRNA Translation: BAF84712.1 AL023653 Genomic DNA No translation available. CH471107 Genomic DNA Translation: EAX11826.1 BC051881 mRNA Translation: AAH51881.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS14614.1
NCBI Reference Sequences More...RefSeqⁱ	NP_061863.1, NM_018990.3
UniGeneⁱ	Hs.61469

Genome annotation databases

Ensemblⁱ	ENST00000356892; ENSP00000349359; ENSG00000122122
GeneIDⁱ	54440
KEGGⁱ	hsa:54440
UCSC genome browser More...UCSCⁱ	uc004euu.4 human

Protein	Similar proteins		Species	Score	Length
O75995	SAM and SH3 domain-containing protein 3		MOUSE		380
UPI000A329BD3		MESAU		442
SAM and SH3 domain containing 3		MACMU		387
UPI0003314C0E		SORAR		386
UPI0007A72820		MINNA		383
+112

Protein	Similar proteins		Species	Score	Length
O75995	SAM and SH3 domain-containing protein 3		MOUSE		380
UPI000A329BD3		MESAU		442
SAM and SH3 domain containing 3		MACMU		387
UPI0003314C0E		SORAR		386
UPI0007A72820		MINNA		383
+186

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL049683 mRNA Translation: CAB41255.1 AK292023 mRNA Translation: BAF84712.1 AL023653 Genomic DNA No translation available. CH471107 Genomic DNA Translation: EAX11826.1 BC051881 mRNA Translation: AAH51881.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS14614.1
NCBI Reference Sequences More...RefSeqⁱ	NP_061863.1, NM_018990.3
UniGeneⁱ	Hs.61469

3D structure databases

ProteinModelPortalⁱ	O75995
SMRⁱ	O75995
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119956, 1 interactor
IntActⁱ	O75995, 1 interactor
STRINGⁱ	9606.ENSP00000349359

PTM databases

iPTMnetⁱ	O75995
PhosphoSitePlusⁱ	O75995

Polymorphism and mutation databases

BioMutaⁱ	SASH3

BioMutaⁱ

SASH3

Proteomic databases

EPDⁱ	O75995
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O75995
PaxDbⁱ	O75995
PeptideAtlas More...PeptideAtlasⁱ	O75995
PRIDEⁱ	O75995
ProteomicsDBⁱ	50337

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000356892; ENSP00000349359; ENSG00000122122
GeneIDⁱ	54440
KEGGⁱ	hsa:54440
UCSC genome browser More...UCSCⁱ	uc004euu.4 human

Organism-specific databases

CTDⁱ	54440
DisGeNET More...DisGeNETⁱ	54440
EuPathDBⁱ	HostDB:ENSG00000122122.9
GeneCardsⁱ	SASH3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:15975 SASH3
Human Protein Atlas More...HPAⁱ	HPA001085
MIMⁱ	300441 gene
neXtProtⁱ	NX_O75995
Open Targets More...OpenTargetsⁱ	ENSG00000122122
PharmGKBⁱ	PA162402388
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410INAS Eukaryota ENOG410YC4U LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000014672
HOGENOMⁱ	HOG000049202
HOVERGENⁱ	HBG000461
InParanoidⁱ	O75995
OMAⁱ	EMGDTLE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BS1
PhylomeDBⁱ	O75995
TreeFamⁱ	TF350709

Miscellaneous databases

ChiTaRSⁱ	SASH3 human
GenomeRNAiⁱ	54440
Protein Ontology More...PROⁱ	PR:O75995
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000122122
CleanExⁱ	HS_SASH3
Genevisibleⁱ	O75995 HS

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd11968 SH3_SASH3, 1 hit
InterProⁱ	View protein in InterPro IPR021090 rSAM/SH3_domain-containing IPR001660 SAM IPR013761 SAM/pointed_sf IPR035722 SASH3 IPR035721 SASH3_SH3 IPR036028 SH3-like_dom_sf IPR001452 SH3_domain
PANTHERⁱ	PTHR12301:SF5 PTHR12301:SF5, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07647 SAM_2, 1 hit PF07653 SH3_2, 1 hit PF12485 SLY, 1 hit
SMARTⁱ	View protein in SMART SM00454 SAM, 1 hit SM00326 SH3, 1 hit
SUPFAMⁱ	SSF47769 SSF47769, 1 hit SSF50044 SSF50044, 1 hit
PROSITEⁱ	View protein in PROSITE PS50105 SAM_DOMAIN, 1 hit PS50002 SH3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SASH3_HUMAN
Accessionⁱ	O75995Primary (citable) accession number: O75995 Secondary accession number(s): A6NCH1, A8K7K8, Q5JZ38
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 24, 2003
	Last sequence update:	May 1, 1999
	Last modified:	June 20, 2018
	This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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Annotation systems

Supporting data

UniProtKB - O75995 (SASH3_HUMAN)

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SAM and SH3 domain-containing protein 3

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ