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Protein

C1q-related factor

Gene

C1QL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • locomotory behavior Source: UniProtKB
  • maintenance of synapse structure Source: Ensembl
  • motor learning Source: Ensembl
  • neuron remodeling Source: Ensembl

Names & Taxonomyi

Protein namesi
Recommended name:
C1q-related factor
Alternative name(s):
C1q and tumor necrosis factor-related protein 14
Short name:
C1q/TNF-related protein 14
Complement component 1 Q subcomponent-like 1
Gene namesi
Name:C1QL1
Synonyms:C1QRF, CRF, CTRP14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000131094.3
HGNCiHGNC:24182 C1QL1
MIMi611586 gene
neXtProtiNX_O75973

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi10882
OpenTargetsiENSG00000131094
PharmGKBiPA134951551

Polymorphism and mutation databases

BioMutaiC1QL1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000000352717 – 258C1q-related factorAdd BLAST242

Proteomic databases

MaxQBiO75973
PaxDbiO75973
PeptideAtlasiO75973
PRIDEiO75973
ProteomicsDBi50335

PTM databases

iPTMnetiO75973
PhosphoSitePlusiO75973

Expressioni

Tissue specificityi

Expressed in brainstem.

Gene expression databases

BgeeiENSG00000131094 Expressed in 139 organ(s), highest expression level in cerebral cortex
CleanExiHS_C1QL1
GenevisibleiO75973 HS

Interactioni

Subunit structurei

Interacts with ADGRB3. Forms heterooligomers with C1QL4, when proteins are coexpressed; this interaction does not occur after secretion.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
C1QTNF8P608272EBI-10826419,EBI-10826404

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116090, 25 interactors
IntActiO75973, 4 interactors

Structurei

3D structure databases

ProteinModelPortaliO75973
SMRiO75973
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini67 – 115Collagen-likeAdd BLAST49
Domaini125 – 258C1qPROSITE-ProRule annotationAdd BLAST134

Keywords - Domaini

Collagen, Signal

Phylogenomic databases

eggNOGiENOG410IFA6 Eukaryota
ENOG4111FAZ LUCA
GeneTreeiENSGT00760000119052
HOGENOMiHOG000085653
HOVERGENiHBG108220
InParanoidiO75973
OMAiGTDASHY
OrthoDBiEOG091G0UOF
PhylomeDBiO75973
TreeFamiTF329591

Family and domain databases

Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR001073 C1q_dom
IPR008160 Collagen
IPR008983 Tumour_necrosis_fac-like_dom
PfamiView protein in Pfam
PF00386 C1q, 1 hit
PF01391 Collagen, 1 hit
PRINTSiPR00007 COMPLEMNTC1Q
SMARTiView protein in SMART
SM00110 C1Q, 1 hit
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS50871 C1Q, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O75973-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLVLVVLIP VLVSSGGPEG HYEMLGTCRM VCDPYPARGP GAGARTDGGD
60 70 80 90 100
ALSEQSGAPP PSTLVQGPQG KPGRTGKPGP PGPPGDPGPP GPVGPPGEKG
110 120 130 140 150
EPGKPGPPGL PGAGGSGAIS TATYTTVPRV AFYAGLKNPH EGYEVLKFDD
160 170 180 190 200
VVTNLGNNYD AASGKFTCNI PGTYFFTYHV LMRGGDGTSM WADLCKNGQV
210 220 230 240 250
RASAIAQDAD QNYDYASNSV ILHLDAGDEV FIKLDGGKAH GGNSNKYSTF

SGFIIYSD
Length:258
Mass (Da):26,453
Last modified:November 1, 1998 - v1
Checksum:i52C51CDF59CAE2BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF095154 mRNA Translation: AAC64186.1
AF410771 Genomic DNA Translation: AAK95248.1
BC008798 mRNA Translation: AAH08798.1
CCDSiCCDS11492.1
RefSeqiNP_006679.1, NM_006688.4
UniGeneiHs.134012

Genome annotation databases

EnsembliENST00000253407; ENSP00000253407; ENSG00000131094
GeneIDi10882
KEGGihsa:10882
UCSCiuc002ihv.4 human

Similar proteinsi

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF095154 mRNA Translation: AAC64186.1
AF410771 Genomic DNA Translation: AAK95248.1
BC008798 mRNA Translation: AAH08798.1
CCDSiCCDS11492.1
RefSeqiNP_006679.1, NM_006688.4
UniGeneiHs.134012

3D structure databases

ProteinModelPortaliO75973
SMRiO75973
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116090, 25 interactors
IntActiO75973, 4 interactors

PTM databases

iPTMnetiO75973
PhosphoSitePlusiO75973

Polymorphism and mutation databases

BioMutaiC1QL1

Proteomic databases

MaxQBiO75973
PaxDbiO75973
PeptideAtlasiO75973
PRIDEiO75973
ProteomicsDBi50335

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000253407; ENSP00000253407; ENSG00000131094
GeneIDi10882
KEGGihsa:10882
UCSCiuc002ihv.4 human

Organism-specific databases

CTDi10882
DisGeNETi10882
EuPathDBiHostDB:ENSG00000131094.3
GeneCardsiC1QL1
HGNCiHGNC:24182 C1QL1
MIMi611586 gene
neXtProtiNX_O75973
OpenTargetsiENSG00000131094
PharmGKBiPA134951551
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFA6 Eukaryota
ENOG4111FAZ LUCA
GeneTreeiENSGT00760000119052
HOGENOMiHOG000085653
HOVERGENiHBG108220
InParanoidiO75973
OMAiGTDASHY
OrthoDBiEOG091G0UOF
PhylomeDBiO75973
TreeFamiTF329591

Miscellaneous databases

GeneWikiiC1QL1
GenomeRNAii10882
PROiPR:O75973
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000131094 Expressed in 139 organ(s), highest expression level in cerebral cortex
CleanExiHS_C1QL1
GenevisibleiO75973 HS

Family and domain databases

Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR001073 C1q_dom
IPR008160 Collagen
IPR008983 Tumour_necrosis_fac-like_dom
PfamiView protein in Pfam
PF00386 C1q, 1 hit
PF01391 Collagen, 1 hit
PRINTSiPR00007 COMPLEMNTC1Q
SMARTiView protein in SMART
SM00110 C1Q, 1 hit
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS50871 C1Q, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiC1QRF_HUMAN
AccessioniPrimary (citable) accession number: O75973
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1998
Last modified: September 12, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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