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UniProtKB - O75973 (C1QRF_HUMAN)
Protein
C1q-related factor
Gene
C1QL1
Organism
Homo sapiens (Human)
Status
Functioni
May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity).
By similarityGO - Molecular functioni
- signaling receptor binding Source: Ensembl
GO - Biological processi
- locomotory behavior Source: UniProtKB
- maintenance of synapse structure Source: Ensembl
- motor learning Source: Ensembl
- neuron remodeling Source: Ensembl
Enzyme and pathway databases
PathwayCommonsi | O75973 |
SignaLinki | O75973 |
Names & Taxonomyi
Protein namesi | Recommended name: C1q-related factorAlternative name(s): C1q and tumor necrosis factor-related protein 14 Short name: C1q/TNF-related protein 14 Complement component 1 Q subcomponent-like 1 |
Gene namesi | Name:C1QL1 Synonyms:C1QRF, CRF, CTRP14 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:24182, C1QL1 |
MIMi | 611586, gene |
neXtProti | NX_O75973 |
VEuPathDBi | HostDB:ENSG00000131094 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular space Source: GO_Central
- synaptic cleft Source: Ensembl
Other locations
- climbing fiber Source: Ensembl
- collagen trimer Source: UniProtKB-KW
- cytoplasm Source: Ensembl
- presynapse Source: Ensembl
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 10882 |
OpenTargetsi | ENSG00000131094 |
PharmGKBi | PA134951551 |
Miscellaneous databases
Pharosi | O75973, Tdark |
Genetic variation databases
BioMutai | C1QL1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 16 | Sequence analysisAdd BLAST | 16 | |
ChainiPRO_0000003527 | 17 – 258 | C1q-related factorAdd BLAST | 242 |
Proteomic databases
MassIVEi | O75973 |
MaxQBi | O75973 |
PaxDbi | O75973 |
PeptideAtlasi | O75973 |
PRIDEi | O75973 |
ProteomicsDBi | 50335 |
PTM databases
iPTMneti | O75973 |
PhosphoSitePlusi | O75973 |
Expressioni
Tissue specificityi
Expressed in brainstem.
Gene expression databases
Bgeei | ENSG00000131094, Expressed in cerebral cortex and 157 other tissues |
Genevisiblei | O75973, HS |
Organism-specific databases
HPAi | ENSG00000131094, Tissue enriched (brain) |
Interactioni
Subunit structurei
Interacts with ADGRB3. Forms heterooligomers with C1QL4, when proteins are coexpressed; this interaction does not occur after secretion.
By similarityBinary interactionsi
O75973
With | #Exp. | IntAct |
---|---|---|
C1QTNF8 [P60827] | 2 | EBI-10826419,EBI-10826404 |
GO - Molecular functioni
- signaling receptor binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 116090, 39 interactors |
IntActi | O75973, 23 interactors |
STRINGi | 9606.ENSP00000253407 |
Miscellaneous databases
RNActi | O75973, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 67 – 115 | Collagen-likeAdd BLAST | 49 | |
Domaini | 125 – 258 | C1qPROSITE-ProRule annotationAdd BLAST | 134 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 39 – 117 | DisorderedSequence analysisAdd BLAST | 79 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 74 – 109 | Pro residuesSequence analysisAdd BLAST | 36 |
Keywords - Domaini
Collagen, SignalPhylogenomic databases
eggNOGi | ENOG502QSKV, Eukaryota |
GeneTreei | ENSGT00940000162478 |
HOGENOMi | CLU_001074_3_1_1 |
InParanoidi | O75973 |
OMAi | FTCAIPG |
OrthoDBi | 1320954at2759 |
PhylomeDBi | O75973 |
TreeFami | TF329591 |
Family and domain databases
Gene3Di | 2.60.120.40, 1 hit |
InterProi | View protein in InterPro IPR001073, C1q_dom IPR008160, Collagen IPR008983, Tumour_necrosis_fac-like_dom |
Pfami | View protein in Pfam PF00386, C1q, 1 hit PF01391, Collagen, 1 hit |
PRINTSi | PR00007, COMPLEMNTC1Q |
SMARTi | View protein in SMART SM00110, C1Q, 1 hit |
SUPFAMi | SSF49842, SSF49842, 1 hit |
PROSITEi | View protein in PROSITE PS50871, C1Q, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
O75973-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLLVLVVLIP VLVSSGGPEG HYEMLGTCRM VCDPYPARGP GAGARTDGGD
60 70 80 90 100
ALSEQSGAPP PSTLVQGPQG KPGRTGKPGP PGPPGDPGPP GPVGPPGEKG
110 120 130 140 150
EPGKPGPPGL PGAGGSGAIS TATYTTVPRV AFYAGLKNPH EGYEVLKFDD
160 170 180 190 200
VVTNLGNNYD AASGKFTCNI PGTYFFTYHV LMRGGDGTSM WADLCKNGQV
210 220 230 240 250
RASAIAQDAD QNYDYASNSV ILHLDAGDEV FIKLDGGKAH GGNSNKYSTF
SGFIIYSD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF095154 mRNA Translation: AAC64186.1 AF410771 Genomic DNA Translation: AAK95248.1 BC008798 mRNA Translation: AAH08798.1 |
CCDSi | CCDS11492.1 |
RefSeqi | NP_006679.1, NM_006688.4 |
Genome annotation databases
Ensembli | ENST00000253407.4; ENSP00000253407.2; ENSG00000131094.4 |
GeneIDi | 10882 |
KEGGi | hsa:10882 |
MANE-Selecti | ENST00000253407.4; ENSP00000253407.2; NM_006688.5; NP_006679.1 |
UCSCi | uc002ihv.4, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
SeattleSNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF095154 mRNA Translation: AAC64186.1 AF410771 Genomic DNA Translation: AAK95248.1 BC008798 mRNA Translation: AAH08798.1 |
CCDSi | CCDS11492.1 |
RefSeqi | NP_006679.1, NM_006688.4 |
3D structure databases
AlphaFoldDBi | O75973 |
SMRi | O75973 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 116090, 39 interactors |
IntActi | O75973, 23 interactors |
STRINGi | 9606.ENSP00000253407 |
PTM databases
iPTMneti | O75973 |
PhosphoSitePlusi | O75973 |
Genetic variation databases
BioMutai | C1QL1 |
Proteomic databases
MassIVEi | O75973 |
MaxQBi | O75973 |
PaxDbi | O75973 |
PeptideAtlasi | O75973 |
PRIDEi | O75973 |
ProteomicsDBi | 50335 |
Protocols and materials databases
Antibodypediai | 29941, 65 antibodies from 15 providers |
DNASUi | 10882 |
Genome annotation databases
Ensembli | ENST00000253407.4; ENSP00000253407.2; ENSG00000131094.4 |
GeneIDi | 10882 |
KEGGi | hsa:10882 |
MANE-Selecti | ENST00000253407.4; ENSP00000253407.2; NM_006688.5; NP_006679.1 |
UCSCi | uc002ihv.4, human |
Organism-specific databases
CTDi | 10882 |
DisGeNETi | 10882 |
GeneCardsi | C1QL1 |
HGNCi | HGNC:24182, C1QL1 |
HPAi | ENSG00000131094, Tissue enriched (brain) |
MIMi | 611586, gene |
neXtProti | NX_O75973 |
OpenTargetsi | ENSG00000131094 |
PharmGKBi | PA134951551 |
VEuPathDBi | HostDB:ENSG00000131094 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QSKV, Eukaryota |
GeneTreei | ENSGT00940000162478 |
HOGENOMi | CLU_001074_3_1_1 |
InParanoidi | O75973 |
OMAi | FTCAIPG |
OrthoDBi | 1320954at2759 |
PhylomeDBi | O75973 |
TreeFami | TF329591 |
Enzyme and pathway databases
PathwayCommonsi | O75973 |
SignaLinki | O75973 |
Miscellaneous databases
BioGRID-ORCSi | 10882, 7 hits in 1066 CRISPR screens |
GeneWikii | C1QL1 |
GenomeRNAii | 10882 |
Pharosi | O75973, Tdark |
PROi | PR:O75973 |
RNActi | O75973, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000131094, Expressed in cerebral cortex and 157 other tissues |
Genevisiblei | O75973, HS |
Family and domain databases
Gene3Di | 2.60.120.40, 1 hit |
InterProi | View protein in InterPro IPR001073, C1q_dom IPR008160, Collagen IPR008983, Tumour_necrosis_fac-like_dom |
Pfami | View protein in Pfam PF00386, C1q, 1 hit PF01391, Collagen, 1 hit |
PRINTSi | PR00007, COMPLEMNTC1Q |
SMARTi | View protein in SMART SM00110, C1Q, 1 hit |
SUPFAMi | SSF49842, SSF49842, 1 hit |
PROSITEi | View protein in PROSITE PS50871, C1Q, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | C1QRF_HUMAN | |
Accessioni | O75973Primary (citable) accession number: O75973 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 27, 2001 |
Last sequence update: | November 1, 1998 | |
Last modified: | May 25, 2022 | |
This is version 163 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot