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Protein

Multiple PDZ domain protein

Gene

MPDZ

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Interacts with HTR2C and provokes its clustering at the cell surface (By similarity). Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses.By similarity2 Publications

GO - Molecular functioni

  • protein C-terminus binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processHost-virus interaction

Names & Taxonomyi

Protein namesi
Recommended name:
Multiple PDZ domain protein
Alternative name(s):
Multi-PDZ domain protein 1
Gene namesi
Name:MPDZ
Synonyms:MUPP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000107186.16
HGNCiHGNC:7208 MPDZ
MIMi603785 gene
neXtProtiNX_O75970

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane, Postsynaptic cell membrane, Synapse, Synaptosome, Tight junction

Pathology & Biotechi

Involvement in diseasei

Hydrocephalus, non-syndromic, autosomal recessive 2 (HYC2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease characterized by a disturbance of cerebrospinal fluid circulation causing accumulation of ventricular cerebrospinal fluid, which results in progressive ventricular dilatation with onset in utero. Affected individuals may have neurologic impairment.
See also OMIM:615219

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi147 – 150GLGF → PSES: Loss of interaction with CAMK2A. 1 Publication4

Organism-specific databases

DisGeNETi8777
MalaCardsiMPDZ
MIMi615219 phenotype
OpenTargetsiENSG00000107186
Orphaneti269505 Congenital communicating hydrocephalus
PharmGKBiPA30914

Polymorphism and mutation databases

BioMutaiMPDZ

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000945941 – 2070Multiple PDZ domain proteinAdd BLAST2070

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei230PhosphoserineCombined sources1
Modified residuei483PhosphoserineCombined sources1
Modified residuei790PhosphoserineCombined sources1
Modified residuei1078PhosphoserineCombined sources1
Modified residuei1170Omega-N-methylarginineBy similarity1
Modified residuei1818PhosphoserineCombined sources1
Modified residuei1824PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiO75970
MaxQBiO75970
PaxDbiO75970
PeptideAtlasiO75970
PRIDEiO75970
ProteomicsDBi50330
50331 [O75970-2]
50332 [O75970-3]

PTM databases

iPTMnetiO75970
PhosphoSitePlusiO75970

Expressioni

Tissue specificityi

Expressed in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000107186 Expressed in 224 organ(s), highest expression level in corpus callosum
ExpressionAtlasiO75970 baseline and differential
GenevisibleiO75970 HS

Organism-specific databases

HPAiCAB013512
HPA020255
HPA026686

Interactioni

Subunit structurei

Interacts with CLDN5, DLG4, GRIN1, F11R/JAM, CLDN1, NG2, CRB1, MPP4 and MPP5 (By similarity). Interacts with HTR2A, HTR2B, HTR2C, PLEKHA1/TAPP1, PLEKHA2/TAPP2, CXADR, SYNGAP1, CAMK2A and CAMK2B. Interacts with FAT4 (via cytoplasmic domain) (By similarity). Interacts with DLL1 (By similarity).By similarity6 Publications
(Microbial infection) Interacts with human adenovirus type 9 E4-ORF1 protein.1 Publication
(Microbial infection) Interacts with human papillomavirus 18/HPV18 protein E6.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114307, 36 interactors
CORUMiO75970
ELMiO75970
IntActiO75970, 37 interactors
MINTiO75970
STRINGi9606.ENSP00000370410

Structurei

Secondary structure

12070
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO75970
SMRiO75970
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO75970

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 63L27PROSITE-ProRule annotationAdd BLAST63
Domaini137 – 224PDZ 1PROSITE-ProRule annotationAdd BLAST88
Domaini257 – 337PDZ 2PROSITE-ProRule annotationAdd BLAST81
Domaini377 – 463PDZ 3PROSITE-ProRule annotationAdd BLAST87
Domaini553 – 634PDZ 4PROSITE-ProRule annotationAdd BLAST82
Domaini700 – 786PDZ 5PROSITE-ProRule annotationAdd BLAST87
Domaini1008 – 1089PDZ 6PROSITE-ProRule annotationAdd BLAST82
Domaini1151 – 1243PDZ 7PROSITE-ProRule annotationAdd BLAST93
Domaini1350 – 1433PDZ 8PROSITE-ProRule annotationAdd BLAST84
Domaini1483 – 1564PDZ 9PROSITE-ProRule annotationAdd BLAST82
Domaini1629 – 1712PDZ 10PROSITE-ProRule annotationAdd BLAST84
Domaini1725 – 1807PDZ 11PROSITE-ProRule annotationAdd BLAST83
Domaini1862 – 1948PDZ 12PROSITE-ProRule annotationAdd BLAST87
Domaini1987 – 2070PDZ 13PROSITE-ProRule annotationAdd BLAST84

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1818 – 1848Ser-richAdd BLAST31

Domaini

The PDZ domain 1 binds NG2. The PDZ domains 7 and 10 bind the Ad9 E4-ORF1 oncoprotein. The PDZ domain 9 binds F11R. The PDZ domain 10 binds the C-terminus of CLDN1 and KIT and the C-terminal PDZ-binding motif of HTR2C. The PDZ domain 13 binds CXADR (By similarity). The PDZ domain 2 binds CAMK2A and CAMK2B. The PDZ domains 10 and 13 bind PLEKHA1 and PLEKHA2. The PDZ domain 13 binds SYNGAP1.By similarity3 Publications

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3528 Eukaryota
ENOG4110362 LUCA
GeneTreeiENSGT00760000119017
HOVERGENiHBG080134
InParanoidiO75970
KOiK06095
PhylomeDBiO75970
TreeFamiTF330709

Family and domain databases

InterProiView protein in InterPro
IPR015132 L27_2
IPR004172 L27_dom
IPR036892 L27_dom_sf
IPR032078 MPDZ
IPR001478 PDZ
IPR036034 PDZ_sf
PfamiView protein in Pfam
PF09045 L27_2, 1 hit
PF16667 MPDZ_u10, 1 hit
PF00595 PDZ, 12 hits
SMARTiView protein in SMART
SM00228 PDZ, 13 hits
SUPFAMiSSF101288 SSF101288, 1 hit
SSF50156 SSF50156, 13 hits
PROSITEiView protein in PROSITE
PS51022 L27, 1 hit
PS50106 PDZ, 13 hits

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 10 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: O75970-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLEAIDKNRA LHAAERLQTK LRERGDVANE DKLSLLKSVL QSPLFSQILS
60 70 80 90 100
LQTSVQQLKD QVNIATSATS NIEYAHVPHL SPAVIPTLQN ESFLLSPNNG
110 120 130 140 150
NLEALTGPGI PHINGKPACD EFDQLIKNMA QGRHVEVFEL LKPPSGGLGF
160 170 180 190 200
SVVGLRSENR GELGIFVQEI QEGSVAHRDG RLKETDQILA INGQALDQTI
210 220 230 240 250
THQQAISILQ KAKDTVQLVI ARGSLPQLVS PIVSRSPSAA STISAHSNPV
260 270 280 290 300
HWQHMETIEL VNDGSGLGFG IIGGKATGVI VKTILPGGVA DQHGRLCSGD
310 320 330 340 350
HILKIGDTDL AGMSSEQVAQ VLRQCGNRVK LMIARGAIEE RTAPTALGIT
360 370 380 390 400
LSSSPTSTPE LRVDASTQKG EESETFDVEL TKNVQGLGIT IAGYIGDKKL
410 420 430 440 450
EPSGIFVKSI TKSSAVEHDG RIQIGDQIIA VDGTNLQGFT NQQAVEVLRH
460 470 480 490 500
TGQTVLLTLM RRGMKQEAEL MSREDVTKDA DLSPVNASII KENYEKDEDF
510 520 530 540 550
LSSTRNTNIL PTEEEGYPLL SAEIEEIEDA QKQEAALLTK WQRIMGINYE
560 570 580 590 600
IVVAHVSKFS ENSGLGISLE ATVGHHFIRS VLPEGPVGHS GKLFSGDELL
610 620 630 640 650
EVNGITLLGE NHQDVVNILK ELPIEVTMVC CRRTVPPTTQ SELDSLDLCD
660 670 680 690 700
IELTEKPHVD LGEFIGSSET EDPVLAMTDA GQSTEEVQAP LAMWEAGIQH
710 720 730 740 750
IELEKGSKGL GFSILDYQDP IDPASTVIII RSLVPGGIAE KDGRLLPGDR
760 770 780 790 800
LMFVNDVNLE NSSLEEAVEA LKGAPSGTVR IGVAKPLPLS PEEGYVSAKE
810 820 830 840 850
DSFLYPPHSC EEAGLADKPL FRADLALVGT NDADLVDEST FESPYSPEND
860 870 880 890 900
SIYSTQASIL SLHGSSCGDG LNYGSSLPSS PPKDVIENSC DPVLDLHMSL
910 920 930 940 950
EELYTQNLLQ RQDENTPSVD ISMGPASGFT INDYTPANAI EQQYECENTI
960 970 980 990 1000
VWTESHLPSE VISSAELPSV LPDSAGKGSE YLLEQSSLAC NAECVMLQNV
1010 1020 1030 1040 1050
SKESFERTIN IAKGNSSLGM TVSANKDGLG MIVRSIIHGG AISRDGRIAI
1060 1070 1080 1090 1100
GDCILSINEE STISVTNAQA RAMLRRHSLI GPDIKITYVP AEHLEEFKIS
1110 1120 1130 1140 1150
LGQQSGRVMA LDIFSSYTGR DIPELPEREE GEGEESELQN TAYSNWNQPR
1160 1170 1180 1190 1200
RVELWREPSK SLGISIVGGR GMGSRLSNGE VMRGIFIKHV LEDSPAGKNG
1210 1220 1230 1240 1250
TLKPGDRIVE VDGMDLRDAS HEQAVEAIRK AGNPVVFMVQ SIINRPRKSP
1260 1270 1280 1290 1300
LPSLLHNLYP KYNFSSTNPF ADSLQINADK APSQSESEPE KAPLCSVPPP
1310 1320 1330 1340 1350
PPSAFAEMGS DHTQSSASKI SQDVDKEDEF GYSWKNIRER YGTLTGELHM
1360 1370 1380 1390 1400
IELEKGHSGL GLSLAGNKDR SRMSVFIVGI DPNGAAGKDG RLQIADELLE
1410 1420 1430 1440 1450
INGQILYGRS HQNASSIIKC APSKVKIIFI RNKDAVNQMA VCPGNAVEPL
1460 1470 1480 1490 1500
PSNSENLQNK ETEPTVTTSD AAVDLSSFKN VQHLELPKDQ GGLGIAISEE
1510 1520 1530 1540 1550
DTLSGVIIKS LTEHGVAATD GRLKVGDQIL AVDDEIVVGY PIEKFISLLK
1560 1570 1580 1590 1600
TAKMTVKLTI HAENPDSQAV PSAAGAASGE KKNSSQSLMV PQSGSPEPES
1610 1620 1630 1640 1650
IRNTSRSSTP AIFASDPATC PIIPGCETTI EISKGRTGLG LSIVGGSDTL
1660 1670 1680 1690 1700
LGAIIIHEVY EEGAACKDGR LWAGDQILEV NGIDLRKATH DEAINVLRQT
1710 1720 1730 1740 1750
PQRVRLTLYR DEAPYKEEEV CDTLTIELQK KPGKGLGLSI VGKRNDTGVF
1760 1770 1780 1790 1800
VSDIVKGGIA DADGRLMQGD QILMVNGEDV RNATQEAVAA LLKCSLGTVT
1810 1820 1830 1840 1850
LEVGRIKAGP FHSERRPSQS SQVSEGSLSS FTFPLSGSST SESLESSSKK
1860 1870 1880 1890 1900
NALASEIQGL RTVEMKKGPT DSLGISIAGG VGSPLGDVPI FIAMMHPTGV
1910 1920 1930 1940 1950
AAQTQKLRVG DRIVTICGTS TEGMTHTQAV NLLKNASGSI EMQVVAGGDV
1960 1970 1980 1990 2000
SVVTGHQQEP ASSSLSFTGL TSSSIFQDDL GPPQCKSITL ERGPDGLGFS
2010 2020 2030 2040 2050
IVGGYGSPHG DLPIYVKTVF AKGAASEDGR LKRGDQIIAV NGQSLEGVTH
2060 2070
EEAVAILKRT KGTVTLMVLS
Length:2,070
Mass (Da):221,618
Last modified:January 11, 2011 - v2
Checksum:iA4D304C20401FD45
GO
Isoform 2 (identifier: O75970-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1794-1822: Missing.

Show »
Length:2,041
Mass (Da):218,507
Checksum:i03736D2490F3E2C7
GO
Isoform 3 (identifier: O75970-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1248-1280: Missing.

Show »
Length:2,037
Mass (Da):217,915
Checksum:i99D1557E87DECAE9
GO
Isoform 4 (identifier: O75970-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1248-1280: Missing.
     1794-1822: Missing.

Show »
Length:2,008
Mass (Da):214,804
Checksum:iC0EBEA38A7020807
GO

Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H1U9F5H1U9_HUMAN
Multiple PDZ domain protein
MPDZ
2,084Annotation score:
H0YGQ3H0YGQ3_HUMAN
Multiple PDZ domain protein
MPDZ
1,006Annotation score:
H0YH70H0YH70_HUMAN
Multiple PDZ domain protein
MPDZ
95Annotation score:
B7ZB24B7ZB24_HUMAN
cDNA, FLJ79388, highly similar to M...
MPDZ
929Annotation score:
F8WDQ8F8WDQ8_HUMAN
Multiple PDZ domain protein
MPDZ
191Annotation score:
H3BM19H3BM19_HUMAN
Multiple PDZ domain protein
MPDZ
79Annotation score:
A0A075B6R8A0A075B6R8_HUMAN
Multiple PDZ domain protein
MPDZ
611Annotation score:
F5H8D6F5H8D6_HUMAN
Multiple PDZ domain protein
MPDZ
128Annotation score:
H0YF96H0YF96_HUMAN
Multiple PDZ domain protein
MPDZ
34Annotation score:
H0YFZ6H0YFZ6_HUMAN
Multiple PDZ domain protein
MPDZ
30Annotation score:

Sequence cautioni

The sequence AAC61870 differs from that shown. Aberrant splicing.Curated
The sequence BAC05409 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAE06123 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAI56786 differs from that shown. Aberrant splicing.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1950V → M in CAI56786 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05611592S → L. Corresponds to variant dbSNP:rs17273542Ensembl.1
Natural variantiVAR_056116351L → F. Corresponds to variant dbSNP:rs3739757Ensembl.1
Natural variantiVAR_056117702E → K. Corresponds to variant dbSNP:rs4741289EnsemblClinVar.1
Natural variantiVAR_056118702E → V. Corresponds to variant dbSNP:rs4740548EnsemblClinVar.1
Natural variantiVAR_0561191604T → A. Corresponds to variant dbSNP:rs16930134EnsemblClinVar.1
Natural variantiVAR_0561201663G → R. Corresponds to variant dbSNP:rs2274648Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0404501248 – 1280Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_0404511794 – 1822Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST29

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF093419 mRNA Translation: AAC61870.1 Sequence problems.
AB210041 mRNA Translation: BAE06123.1 Different initiation.
AL161449 Genomic DNA No translation available.
AL162386 Genomic DNA No translation available.
AL353639 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58704.1
BC140793 mRNA Translation: AAI40794.1
BC144564 mRNA Translation: AAI44565.1
CR936648 mRNA Translation: CAI56786.1 Sequence problems.
AK098775 mRNA Translation: BAC05409.1 Different initiation.
AJ001319 mRNA Translation: CAA04680.1
CCDSiCCDS47951.1 [O75970-2]
CCDS59119.1 [O75970-5]
CCDS59120.1 [O75970-3]
CCDS83342.1 [O75970-1]
RefSeqiNP_001248335.1, NM_001261406.1 [O75970-3]
NP_001248336.1, NM_001261407.1 [O75970-5]
NP_001317566.1, NM_001330637.1 [O75970-1]
NP_003820.2, NM_003829.4 [O75970-2]
XP_006716948.1, XM_006716885.3 [O75970-1]
XP_006716949.1, XM_006716886.3 [O75970-1]
XP_006716950.1, XM_006716887.3 [O75970-1]
XP_006716951.1, XM_006716888.3 [O75970-2]
XP_006716952.1, XM_006716889.3 [O75970-3]
XP_006716954.1, XM_006716891.3 [O75970-5]
XP_016870742.1, XM_017015253.1 [O75970-5]
UniGeneiHs.169378

Genome annotation databases

EnsembliENST00000319217; ENSP00000320006; ENSG00000107186 [O75970-1]
ENST00000381022; ENSP00000370410; ENSG00000107186 [O75970-3]
ENST00000447879; ENSP00000415208; ENSG00000107186 [O75970-3]
ENST00000536827; ENSP00000444151; ENSG00000107186 [O75970-5]
ENST00000541718; ENSP00000439807; ENSG00000107186 [O75970-2]
GeneIDi8777
KEGGihsa:8777
UCSCiuc003zlb.5 human [O75970-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMPDZ_HUMAN
AccessioniPrimary (citable) accession number: O75970
Secondary accession number(s): A6NLC2
, B2RTS3, B7ZMI4, O43798, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: January 11, 2011
Last modified: September 12, 2018
This is version 161 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health

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