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Protein

A-kinase anchor protein 3

Gene

AKAP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction.

GO - Molecular functioni

  • protein kinase A binding Source: GO_Central

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
A-kinase anchor protein 3
Short name:
AKAP-3
Alternative name(s):
A-kinase anchor protein 110 kDa
Short name:
AKAP 110
Cancer/testis antigen 82
Short name:
CT82
Fibrous sheath protein of 95 kDa
Short name:
FSP95
Fibrousheathin I
Fibrousheathin-1
Protein kinase A-anchoring protein 3
Short name:
PRKA3
Sperm oocyte-binding protein
Gene namesi
Name:AKAP3
Synonyms:AKAP110, SOB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000111254.7
HGNCiHGNC:373 AKAP3
MIMi604689 gene
neXtProtiNX_O75969

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi131L → P: Abolishes interaction with ROPN1. 1 Publication1

Organism-specific databases

DisGeNETi10566
OpenTargetsiENSG00000111254
PharmGKBiPA24667

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000645261 – 853A-kinase anchor protein 3Add BLAST853

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei205PhosphoserineCombined sources1
Modified residuei208PhosphoserineCombined sources1
Modified residuei403PhosphoserineCombined sources1
Modified residuei404PhosphotyrosineCombined sources1
Modified residuei635PhosphoserineCombined sources1
Modified residuei636PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated on tyrosine residues.

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO75969
PaxDbiO75969
PeptideAtlasiO75969
PRIDEiO75969
ProteomicsDBi50329

PTM databases

iPTMnetiO75969
PhosphoSitePlusiO75969

Expressioni

Tissue specificityi

Testis specific; only expressed in spermatids.

Gene expression databases

BgeeiENSG00000111254 Expressed in 101 organ(s), highest expression level in testis
CleanExiHS_AKAP3
ExpressionAtlasiO75969 baseline and differential
GenevisibleiO75969 HS

Organism-specific databases

HPAiHPA039765

Interactioni

Subunit structurei

Interacts with ROPN1 AND ROPN1L.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115817, 8 interactors
IntActiO75969, 4 interactors
STRINGi9606.ENSP00000228850

Structurei

3D structure databases

ProteinModelPortaliO75969
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni124 – 137PKA-RII subunit binding domainAdd BLAST14

Domaini

RII-binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.

Sequence similaritiesi

Belongs to the AKAP110 family.Curated

Phylogenomic databases

eggNOGiENOG410IEV9 Eukaryota
ENOG411183Z LUCA
GeneTreeiENSGT00420000029845
HOGENOMiHOG000220883
HOVERGENiHBG050478
InParanoidiO75969
KOiK16520
OMAiMTYANSV
OrthoDBiEOG091G0209
PhylomeDBiO75969
TreeFamiTF105403

Family and domain databases

InterProiView protein in InterPro
IPR020799 AKAP_110
IPR018292 AKAP_110_C
IPR018459 RII_binding_1
IPR008382 SPHK1-interactor_AKAP_110
PANTHERiPTHR10226 PTHR10226, 1 hit
PfamiView protein in Pfam
PF05716 AKAP_110, 1 hit
PF10522 RII_binding_1, 1 hit
SMARTiView protein in SMART
SM00807 AKAP_110, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O75969-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEKVDWLQS QNGVCKVDVY SPGDNQAQDW KMDTSTDPVR VLSWLRRDLE
60 70 80 90 100
KSTAEFQDVR FKPGESFGGE TSNSGDPHKG FSVDYYNTTT KGTPERLHFE
110 120 130 140 150
MTHKEIPCQG PRAQLGNGSS VDEVSFYANR LTNLVIAMAR KEINEKIDGS
160 170 180 190 200
ENKCVYQSLY MGNEPTPTKS LSKIASELVN ETVSACSRNA APDKAPGSGD
210 220 230 240 250
RVSGSSQSPP NLKYKSTLKI KESTKERQGP DDKPPSKKSF FYKEVFESRN
260 270 280 290 300
GDYAREGGRF FPRERKRFRG QERPDDFTAS VSEGIMTYAN SVVSDMMVSI
310 320 330 340 350
MKTLKIQVKD TTIATILLKK VLLKHAKEVV SDLIDSFLRN LHSVTGTLMT
360 370 380 390 400
DTQFVSAVKR TVFSHGSQKA TDIMDAMLRK LYNVMFAKKV PEHVRKAQDK
410 420 430 440 450
AESYSLISMK GMGDPKNRNV NFAMKSETKL REKMYSEPKS EEETCAKTLG
460 470 480 490 500
EHIIKEGLTL WHKTQQKECK SLGFQHAAFE APNTQRKPAS DISFEYPEDI
510 520 530 540 550
GNLSLPPYPP EKPENFMYDS DSWAEDLIVS ALLLIQYHLA QGGRRDARSF
560 570 580 590 600
VEAAGTTNFP ANEPPVAPDE SCLKSAPIVG DQEQAEKKDL RSVFFNFIRN
610 620 630 640 650
LLSETIFKRD QSPEPKVPEQ PVKEDRKLCE RPLASSPPRL YEDDETPGAL
660 670 680 690 700
SGLTKMAVSQ IDGHMSGQMV EHLMNSVMKL CVIIAKSCDA SLAELGDDKS
710 720 730 740 750
GDASRLTSAF PDSLYECLPA KGTGSAEAVL QNAYQAIHNE MRGTSGQPPE
760 770 780 790 800
GCAAPTVIVS NHNLTDTVQN KQLQAVLQWV AASELNVPIL YFAGDDEGIQ
810 820 830 840 850
EKLLQLSAAA VDKGCSVGEV LQSVLRYEKE RQLNEAVGNV TPLQLLDWLM

VNL
Length:853
Mass (Da):94,751
Last modified:December 15, 2009 - v2
Checksum:iCFDEA26922B5A86E
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H2S4F5H2S4_HUMAN
A-kinase anchor protein 3
AKAP3
96Annotation score:
F5H7P4F5H7P4_HUMAN
A-kinase anchor protein 3
AKAP3
161Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti272E → D in AAD21218 (PubMed:10334916).Curated1
Sequence conflicti282S → G in AAC35854 (PubMed:10529264).Curated1
Sequence conflicti402E → V in AAC35854 (PubMed:10529264).Curated1
Sequence conflicti467K → N in AAC35854 (PubMed:10529264).Curated1
Sequence conflicti597F → S AA sequence (PubMed:10529264).Curated1
Sequence conflicti700S → L in AAC35854 (PubMed:10529264).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055488118G → E4 PublicationsCorresponds to variant dbSNP:rs2072355Ensembl.1
Natural variantiVAR_060730464T → S3 PublicationsCorresponds to variant dbSNP:rs11063266Ensembl.1
Natural variantiVAR_055489500I → T1 PublicationCorresponds to variant dbSNP:rs12366671Ensembl.1
Natural variantiVAR_061000525E → K3 PublicationsCorresponds to variant dbSNP:rs1990312Ensembl.1
Natural variantiVAR_055490661I → T. Corresponds to variant dbSNP:rs1990313Ensembl.1
Natural variantiVAR_055491700S → F. Corresponds to variant dbSNP:rs2041291Ensembl.1
Natural variantiVAR_059112700S → P. Corresponds to variant dbSNP:rs2041290Ensembl.1
Natural variantiVAR_055492725S → L. Corresponds to variant dbSNP:rs2072357Ensembl.1
Natural variantiVAR_036428831R → C in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs143517596Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U85715 mRNA Translation: AAD21218.1
AF087003 mRNA Translation: AAC35854.1
AF093408 mRNA Translation: AAC63371.1
AK292451 mRNA Translation: BAF85140.1
AC005832 Genomic DNA No translation available.
BC047535 mRNA Translation: AAH47535.1
CCDSiCCDS8531.1
RefSeqiNP_001265238.1, NM_001278309.1
NP_006413.3, NM_006422.3
XP_005253721.1, XM_005253664.2
XP_011519210.1, XM_011520908.1
XP_011519211.1, XM_011520909.1
XP_011519212.1, XM_011520910.2
UniGeneiHs.98397

Genome annotation databases

EnsembliENST00000228850; ENSP00000228850; ENSG00000111254
ENST00000545990; ENSP00000440994; ENSG00000111254
GeneIDi10566
KEGGihsa:10566

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U85715 mRNA Translation: AAD21218.1
AF087003 mRNA Translation: AAC35854.1
AF093408 mRNA Translation: AAC63371.1
AK292451 mRNA Translation: BAF85140.1
AC005832 Genomic DNA No translation available.
BC047535 mRNA Translation: AAH47535.1
CCDSiCCDS8531.1
RefSeqiNP_001265238.1, NM_001278309.1
NP_006413.3, NM_006422.3
XP_005253721.1, XM_005253664.2
XP_011519210.1, XM_011520908.1
XP_011519211.1, XM_011520909.1
XP_011519212.1, XM_011520910.2
UniGeneiHs.98397

3D structure databases

ProteinModelPortaliO75969
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115817, 8 interactors
IntActiO75969, 4 interactors
STRINGi9606.ENSP00000228850

PTM databases

iPTMnetiO75969
PhosphoSitePlusiO75969

Proteomic databases

EPDiO75969
PaxDbiO75969
PeptideAtlasiO75969
PRIDEiO75969
ProteomicsDBi50329

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000228850; ENSP00000228850; ENSG00000111254
ENST00000545990; ENSP00000440994; ENSG00000111254
GeneIDi10566
KEGGihsa:10566

Organism-specific databases

CTDi10566
DisGeNETi10566
EuPathDBiHostDB:ENSG00000111254.7
GeneCardsiAKAP3
H-InvDBiHIX0026339
HGNCiHGNC:373 AKAP3
HPAiHPA039765
MIMi604689 gene
neXtProtiNX_O75969
OpenTargetsiENSG00000111254
PharmGKBiPA24667
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEV9 Eukaryota
ENOG411183Z LUCA
GeneTreeiENSGT00420000029845
HOGENOMiHOG000220883
HOVERGENiHBG050478
InParanoidiO75969
KOiK16520
OMAiMTYANSV
OrthoDBiEOG091G0209
PhylomeDBiO75969
TreeFamiTF105403

Miscellaneous databases

ChiTaRSiAKAP3 human
GeneWikiiAKAP3
GenomeRNAii10566
PROiPR:O75969
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000111254 Expressed in 101 organ(s), highest expression level in testis
CleanExiHS_AKAP3
ExpressionAtlasiO75969 baseline and differential
GenevisibleiO75969 HS

Family and domain databases

InterProiView protein in InterPro
IPR020799 AKAP_110
IPR018292 AKAP_110_C
IPR018459 RII_binding_1
IPR008382 SPHK1-interactor_AKAP_110
PANTHERiPTHR10226 PTHR10226, 1 hit
PfamiView protein in Pfam
PF05716 AKAP_110, 1 hit
PF10522 RII_binding_1, 1 hit
SMARTiView protein in SMART
SM00807 AKAP_110, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAKAP3_HUMAN
AccessioniPrimary (citable) accession number: O75969
Secondary accession number(s): O75945, Q86X01, Q9UM61
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: December 15, 2009
Last modified: November 7, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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