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UniProtKB - O75969 (AKAP3_HUMAN)

Entry version 163 (23 Feb 2022)
Sequence version 2 (15 Dec 2009)
Previous versions | rss
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Protein

A-kinase anchor protein 3

Gene

AKAP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • protein kinase A binding Source: GO_Central
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O75969

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		O75969

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
A-kinase anchor protein 3
Short name:
AKAP-3
Alternative name(s):
A-kinase anchor protein 110 kDa
Short name:
AKAP 110
Cancer/testis antigen 82
Short name:
CT82
Fibrous sheath protein of 95 kDa
Short name:
FSP95
Fibrousheathin I
Fibrousheathin-1
Protein kinase A-anchoring protein 3
Short name:
PRKA3
Sperm oocyte-binding protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AKAP3
Synonyms:AKAP110, SOB1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:373, AKAP3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604689, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O75969

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000111254

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasmic vesicle

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi131L → P: Abolishes interaction with ROPN1. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		10566

Open Targets

More...OpenTargetsi		ENSG00000111254

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA24667

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O75969, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		AKAP3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000645261 – 853A-kinase anchor protein 3Add BLAST853

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei205PhosphoserineCombined sources1
Modified residuei208PhosphoserineCombined sources1
Modified residuei403PhosphoserineCombined sources1
Modified residuei404PhosphotyrosineCombined sources1
Modified residuei635PhosphoserineCombined sources1
Modified residuei636PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on tyrosine residues.

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O75969

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O75969

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O75969

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O75969

PeptideAtlas

More...PeptideAtlasi		O75969

PRoteomics IDEntifications database

More...PRIDEi		O75969

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		50329

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O75969

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O75969

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Testis specific; only expressed in spermatids.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000111254, Expressed in testis and 124 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O75969, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O75969, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000111254, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ROPN1 AND ROPN1L.

Interacts with QRICH2 (PubMed:30683861).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115817, 9 interactors

Protein interaction database and analysis system

More...IntActi		O75969, 5 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000228850

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O75969, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O75969

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni124 – 137PKA-RII subunit binding domainAdd BLAST14
Regioni188 – 240DisorderedSequence analysisAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi200 – 214Polar residuesSequence analysisAdd BLAST15
Compositional biasi218 – 240Basic and acidic residuesSequence analysisAdd BLAST23

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

RII-binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AKAP110 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502SM7F, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153313

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_017072_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O75969

Identification of Orthologs from Complete Genome Data

More...OMAi		ENFICDS

Database of Orthologous Groups

More...OrthoDBi		221175at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O75969

TreeFam database of animal gene trees

More...TreeFami		TF105403

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR020799, AKAP_110
IPR018292, AKAP_110_C
IPR018459, RII-bd_1
IPR008382, SPHK1-interactor_AKAP_110

The PANTHER Classification System

More...PANTHERi		PTHR10226, PTHR10226, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05716, AKAP_110, 1 hit
PF10522, RII_binding_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00807, AKAP_110, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O75969-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEKVDWLQS QNGVCKVDVY SPGDNQAQDW KMDTSTDPVR VLSWLRRDLE 
        60         70         80         90        100
KSTAEFQDVR FKPGESFGGE TSNSGDPHKG FSVDYYNTTT KGTPERLHFE 
       110        120        130        140        150
MTHKEIPCQG PRAQLGNGSS VDEVSFYANR LTNLVIAMAR KEINEKIDGS 
       160        170        180        190        200
ENKCVYQSLY MGNEPTPTKS LSKIASELVN ETVSACSRNA APDKAPGSGD 
       210        220        230        240        250
RVSGSSQSPP NLKYKSTLKI KESTKERQGP DDKPPSKKSF FYKEVFESRN 
       260        270        280        290        300
GDYAREGGRF FPRERKRFRG QERPDDFTAS VSEGIMTYAN SVVSDMMVSI 
       310        320        330        340        350
MKTLKIQVKD TTIATILLKK VLLKHAKEVV SDLIDSFLRN LHSVTGTLMT 
       360        370        380        390        400
DTQFVSAVKR TVFSHGSQKA TDIMDAMLRK LYNVMFAKKV PEHVRKAQDK 
       410        420        430        440        450
AESYSLISMK GMGDPKNRNV NFAMKSETKL REKMYSEPKS EEETCAKTLG 
       460        470        480        490        500
EHIIKEGLTL WHKTQQKECK SLGFQHAAFE APNTQRKPAS DISFEYPEDI 
       510        520        530        540        550
GNLSLPPYPP EKPENFMYDS DSWAEDLIVS ALLLIQYHLA QGGRRDARSF 
       560        570        580        590        600
VEAAGTTNFP ANEPPVAPDE SCLKSAPIVG DQEQAEKKDL RSVFFNFIRN 
       610        620        630        640        650
LLSETIFKRD QSPEPKVPEQ PVKEDRKLCE RPLASSPPRL YEDDETPGAL 
       660        670        680        690        700
SGLTKMAVSQ IDGHMSGQMV EHLMNSVMKL CVIIAKSCDA SLAELGDDKS 
       710        720        730        740        750
GDASRLTSAF PDSLYECLPA KGTGSAEAVL QNAYQAIHNE MRGTSGQPPE 
       760        770        780        790        800
GCAAPTVIVS NHNLTDTVQN KQLQAVLQWV AASELNVPIL YFAGDDEGIQ 
       810        820        830        840        850
EKLLQLSAAA VDKGCSVGEV LQSVLRYEKE RQLNEAVGNV TPLQLLDWLM 

VNL
Length:853
Mass (Da):94,751
Last modified:December 15, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCFDEA26922B5A86E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H2S4F5H2S4_HUMAN
A-kinase anchor protein 3
AKAP3
96Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H7P4F5H7P4_HUMAN
A-kinase anchor protein 3
AKAP3
161Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti272E → D in AAD21218 (PubMed:10334916).Curated1
Sequence conflicti282S → G in AAC35854 (PubMed:10529264).Curated1
Sequence conflicti402E → V in AAC35854 (PubMed:10529264).Curated1
Sequence conflicti467K → N in AAC35854 (PubMed:10529264).Curated1
Sequence conflicti597F → S AA sequence (PubMed:10529264).Curated1
Sequence conflicti700S → L in AAC35854 (PubMed:10529264).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_055488118G → E4 PublicationsCorresponds to variant dbSNP:rs2072355Ensembl.1
Natural variantiVAR_060730464T → S3 PublicationsCorresponds to variant dbSNP:rs11063266Ensembl.1
Natural variantiVAR_055489500I → T1 PublicationCorresponds to variant dbSNP:rs12366671Ensembl.1
Natural variantiVAR_061000525E → K3 PublicationsCorresponds to variant dbSNP:rs1990312Ensembl.1
Natural variantiVAR_055490661I → T. Corresponds to variant dbSNP:rs1990313Ensembl.1
Natural variantiVAR_055491700S → F. Corresponds to variant dbSNP:rs2041291Ensembl.1
Natural variantiVAR_059112700S → P. Corresponds to variant dbSNP:rs2041290Ensembl.1
Natural variantiVAR_055492725S → L. Corresponds to variant dbSNP:rs2072357Ensembl.1
Natural variantiVAR_036428831R → C in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs143517596Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U85715 mRNA Translation: AAD21218.1
AF087003 mRNA Translation: AAC35854.1
AF093408 mRNA Translation: AAC63371.1
AK292451 mRNA Translation: BAF85140.1
AC005832 Genomic DNA No translation available.
BC047535 mRNA Translation: AAH47535.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS8531.1

NCBI Reference Sequences

More...RefSeqi		NP_001265238.1, NM_001278309.1
NP_006413.3, NM_006422.3
XP_005253721.1, XM_005253664.2
XP_011519210.1, XM_011520908.1
XP_011519211.1, XM_011520909.1
XP_011519212.1, XM_011520910.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000228850; ENSP00000228850; ENSG00000111254
ENST00000545990; ENSP00000440994; ENSG00000111254

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10566

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10566

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000228850.6; ENSP00000228850.1; NM_001278309.2; NP_001265238.2

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U85715 mRNA Translation: AAD21218.1
AF087003 mRNA Translation: AAC35854.1
AF093408 mRNA Translation: AAC63371.1
AK292451 mRNA Translation: BAF85140.1
AC005832 Genomic DNA No translation available.
BC047535 mRNA Translation: AAH47535.1
CCDSiCCDS8531.1
RefSeqiNP_001265238.1, NM_001278309.1
NP_006413.3, NM_006422.3
XP_005253721.1, XM_005253664.2
XP_011519210.1, XM_011520908.1
XP_011519211.1, XM_011520909.1
XP_011519212.1, XM_011520910.2

3D structure databases

SMRiO75969
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi115817, 9 interactors
IntActiO75969, 5 interactors
STRINGi9606.ENSP00000228850

PTM databases

iPTMnetiO75969
PhosphoSitePlusiO75969

Genetic variation databases

BioMutaiAKAP3

Proteomic databases

EPDiO75969
jPOSTiO75969
MassIVEiO75969
PaxDbiO75969
PeptideAtlasiO75969
PRIDEiO75969
ProteomicsDBi50329

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		22296, 187 antibodies from 33 providers

The DNASU plasmid repository

More...DNASUi		10566

Genome annotation databases

EnsembliENST00000228850; ENSP00000228850; ENSG00000111254
ENST00000545990; ENSP00000440994; ENSG00000111254
GeneIDi10566
KEGGihsa:10566
MANE-SelectiENST00000228850.6; ENSP00000228850.1; NM_001278309.2; NP_001265238.2

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10566
DisGeNETi10566

GeneCards: human genes, protein and diseases

More...GeneCardsi		AKAP3
HGNCiHGNC:373, AKAP3
HPAiENSG00000111254, Tissue enriched (testis)
MIMi604689, gene
neXtProtiNX_O75969
OpenTargetsiENSG00000111254
PharmGKBiPA24667
VEuPathDBiHostDB:ENSG00000111254

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502SM7F, Eukaryota
GeneTreeiENSGT00940000153313
HOGENOMiCLU_017072_0_0_1
InParanoidiO75969
OMAiENFICDS
OrthoDBi221175at2759
PhylomeDBiO75969
TreeFamiTF105403

Enzyme and pathway databases

PathwayCommonsiO75969
SignaLinkiO75969

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		10566, 15 hits in 1034 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		AKAP3, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		AKAP3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10566
PharosiO75969, Tbio

Protein Ontology

More...PROi		PR:O75969
RNActiO75969, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000111254, Expressed in testis and 124 other tissues
ExpressionAtlasiO75969, baseline and differential
GenevisibleiO75969, HS

Family and domain databases

InterProiView protein in InterPro
IPR020799, AKAP_110
IPR018292, AKAP_110_C
IPR018459, RII-bd_1
IPR008382, SPHK1-interactor_AKAP_110
PANTHERiPTHR10226, PTHR10226, 1 hit
PfamiView protein in Pfam
PF05716, AKAP_110, 1 hit
PF10522, RII_binding_1, 1 hit
SMARTiView protein in SMART
SM00807, AKAP_110, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAKAP3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75969
Secondary accession number(s): O75945, Q86X01, Q9UM61
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: December 15, 2009
Last modified: February 23, 2022
This is version 163 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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