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Protein

Tetraspanin-9

Gene

TSPAN9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • cell surface receptor signaling pathway Source: GO_Central

Protein family/group databases

TCDBi8.A.40.1.22 the tetraspanin (tetraspanin) family

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-9
Short name:
Tspan-9
Alternative name(s):
Tetraspan NET-5
Gene namesi
Name:TSPAN9
Synonyms:NET5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000011105.11
HGNCiHGNC:21640 TSPAN9
MIMi613137 gene
neXtProtiNX_O75954

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 13CytoplasmicSequence analysisAdd BLAST13
Transmembranei14 – 34HelicalSequence analysisAdd BLAST21
Topological domaini35 – 55ExtracellularSequence analysisAdd BLAST21
Transmembranei56 – 76HelicalSequence analysisAdd BLAST21
Topological domaini77 – 85CytoplasmicSequence analysis9
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Topological domaini107 – 203ExtracellularSequence analysisAdd BLAST97
Transmembranei204 – 224HelicalSequence analysisAdd BLAST21
Topological domaini225 – 239CytoplasmicSequence analysisAdd BLAST15

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10867
OpenTargetsiENSG00000011105
PharmGKBiPA142670694

Polymorphism and mutation databases

BioMutaiTSPAN9

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192531 – 239Tetraspanin-9Add BLAST239

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi180N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiO75954
MaxQBiO75954
PaxDbiO75954
PeptideAtlasiO75954
PRIDEiO75954
ProteomicsDBi50320

PTM databases

SwissPalmiO75954

Expressioni

Tissue specificityi

Expressed in megakaryocytes and platelets (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000011105 Expressed in 220 organ(s), highest expression level in cerebellar hemisphere
CleanExiHS_TSPAN9
ExpressionAtlasiO75954 baseline and differential
GenevisibleiO75954 HS

Organism-specific databases

HPAiHPA014002

Interactioni

Subunit structurei

Found in a complex with GP6.By similarity

Protein-protein interaction databases

BioGridi116076, 2 interactors
IntActiO75954, 1 interactor
MINTiO75954
STRINGi9606.ENSP00000011898

Structurei

3D structure databases

ProteinModelPortaliO75954
SMRiO75954
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00880000137858
HOGENOMiHOG000230651
HOVERGENiHBG002324
InParanoidiO75954
KOiK17350
OMAiYEGYATL
PhylomeDBiO75954
TreeFamiTF352892

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR018503 Tetraspanin_CS
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit
PROSITEiView protein in PROSITE
PS00421 TM4_1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

O75954-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARGCLCCLK YMMFLFNLIF WLCGCGLLGV GIWLSVSQGN FATFSPSFPS
60 70 80 90 100
LSAANLVIAI GTIVMVTGFL GCLGAIKENK CLLLSFFIVL LVILLAELIL
110 120 130 140 150
LILFFVYMDK VNENAKKDLK EGLLLYHTEN NVGLKNAWNI IQAEMRCCGV
160 170 180 190 200
TDYTDWYPVL GENTVPDRCC MENSQGCGRN ATTPLWRTGC YEKVKMWFDD
210 220 230
NKHVLGTVGM CILIMQILGM AFSMTLFQHI HRTGKKYDA
Length:239
Mass (Da):26,779
Last modified:November 1, 1998 - v1
Checksum:iDD7BA332BF6584EB
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B5MD23B5MD23_HUMAN
Tetraspanin
TSPAN9
271Annotation score:
A0A1W2PQ04A0A1W2PQ04_HUMAN
Tetraspanin-9
TSPAN9
176Annotation score:
E9PHL0E9PHL0_HUMAN
Tetraspanin-9
TSPAN9
59Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti216Q → R in BAD96899 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF089749 mRNA Translation: AAC35859.1
AK027366 mRNA Translation: BAG51307.1
CR542109 mRNA Translation: CAG46906.1
AK223179 mRNA Translation: BAD96899.1
AC005912 Genomic DNA No translation available.
CH471116 Genomic DNA Translation: EAW88868.1
CH471116 Genomic DNA Translation: EAW88869.1
BC071881 mRNA Translation: AAH71881.1
CCDSiCCDS8520.1
RefSeqiNP_001161792.1, NM_001168320.1
NP_006666.1, NM_006675.4
UniGeneiHs.504517

Genome annotation databases

EnsembliENST00000011898; ENSP00000011898; ENSG00000011105
ENST00000537971; ENSP00000444799; ENSG00000011105
GeneIDi10867
KEGGihsa:10867
UCSCiuc001qlp.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF089749 mRNA Translation: AAC35859.1
AK027366 mRNA Translation: BAG51307.1
CR542109 mRNA Translation: CAG46906.1
AK223179 mRNA Translation: BAD96899.1
AC005912 Genomic DNA No translation available.
CH471116 Genomic DNA Translation: EAW88868.1
CH471116 Genomic DNA Translation: EAW88869.1
BC071881 mRNA Translation: AAH71881.1
CCDSiCCDS8520.1
RefSeqiNP_001161792.1, NM_001168320.1
NP_006666.1, NM_006675.4
UniGeneiHs.504517

3D structure databases

ProteinModelPortaliO75954
SMRiO75954
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116076, 2 interactors
IntActiO75954, 1 interactor
MINTiO75954
STRINGi9606.ENSP00000011898

Protein family/group databases

TCDBi8.A.40.1.22 the tetraspanin (tetraspanin) family

PTM databases

SwissPalmiO75954

Polymorphism and mutation databases

BioMutaiTSPAN9

Proteomic databases

EPDiO75954
MaxQBiO75954
PaxDbiO75954
PeptideAtlasiO75954
PRIDEiO75954
ProteomicsDBi50320

Protocols and materials databases

DNASUi10867
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000011898; ENSP00000011898; ENSG00000011105
ENST00000537971; ENSP00000444799; ENSG00000011105
GeneIDi10867
KEGGihsa:10867
UCSCiuc001qlp.4 human

Organism-specific databases

CTDi10867
DisGeNETi10867
EuPathDBiHostDB:ENSG00000011105.11
GeneCardsiTSPAN9
HGNCiHGNC:21640 TSPAN9
HPAiHPA014002
MIMi613137 gene
neXtProtiNX_O75954
OpenTargetsiENSG00000011105
PharmGKBiPA142670694
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00880000137858
HOGENOMiHOG000230651
HOVERGENiHBG002324
InParanoidiO75954
KOiK17350
OMAiYEGYATL
PhylomeDBiO75954
TreeFamiTF352892

Miscellaneous databases

ChiTaRSiTSPAN9 human
GenomeRNAii10867
PROiPR:O75954
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000011105 Expressed in 220 organ(s), highest expression level in cerebellar hemisphere
CleanExiHS_TSPAN9
ExpressionAtlasiO75954 baseline and differential
GenevisibleiO75954 HS

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR018503 Tetraspanin_CS
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit
PROSITEiView protein in PROSITE
PS00421 TM4_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTSN9_HUMAN
AccessioniPrimary (citable) accession number: O75954
Secondary accession number(s): D3DUQ7, Q53FV2, Q6FGJ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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