UniProtKB - O75954 (TSN9_HUMAN)
Protein
Tetraspanin-9
Gene
TSPAN9
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- cell surface receptor signaling pathway Source: GO_Central
Protein family/group databases
TCDBi | 8.A.40.1.22 the tetraspanin (tetraspanin) family |
Names & Taxonomyi
Protein namesi | Recommended name: Tetraspanin-9Short name: Tspan-9 Alternative name(s): Tetraspan NET-5 |
Gene namesi | Name:TSPAN9 Synonyms:NET5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000011105.11 |
HGNCi | HGNC:21640 TSPAN9 |
MIMi | 613137 gene |
neXtProti | NX_O75954 |
Subcellular locationi
Other locations
- Membrane By similarity; Multi-pass membrane protein By similarity
Note: Colocalizes with GP6 in tetraspanin microdomains on the platelet surface.By similarity
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: UniProtKB
- tetraspanin-enriched microdomain Source: UniProtKB
Other locations
- focal adhesion Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 13 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 14 – 34 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 35 – 55 | ExtracellularSequence analysisAdd BLAST | 21 | |
Transmembranei | 56 – 76 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 77 – 85 | CytoplasmicSequence analysis | 9 | |
Transmembranei | 86 – 106 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 107 – 203 | ExtracellularSequence analysisAdd BLAST | 97 | |
Transmembranei | 204 – 224 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 225 – 239 | CytoplasmicSequence analysisAdd BLAST | 15 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 10867 |
OpenTargetsi | ENSG00000011105 |
PharmGKBi | PA142670694 |
Polymorphism and mutation databases
BioMutai | TSPAN9 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000219253 | 1 – 239 | Tetraspanin-9Add BLAST | 239 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 180 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Glycosylated.By similarity
Keywords - PTMi
GlycoproteinProteomic databases
EPDi | O75954 |
jPOSTi | O75954 |
MaxQBi | O75954 |
PaxDbi | O75954 |
PeptideAtlasi | O75954 |
PRIDEi | O75954 |
ProteomicsDBi | 50320 |
PTM databases
SwissPalmi | O75954 |
Expressioni
Tissue specificityi
Expressed in megakaryocytes and platelets (at protein level).1 Publication
Gene expression databases
Bgeei | ENSG00000011105 Expressed in 220 organ(s), highest expression level in cerebellar hemisphere |
ExpressionAtlasi | O75954 baseline and differential |
Genevisiblei | O75954 HS |
Organism-specific databases
HPAi | HPA014002 |
Interactioni
Subunit structurei
Found in a complex with GP6.By similarity
Protein-protein interaction databases
BioGridi | 116076, 3 interactors |
IntActi | O75954, 1 interactor |
MINTi | O75954 |
STRINGi | 9606.ENSP00000011898 |
Structurei
3D structure databases
ProteinModelPortali | O75954 |
SMRi | O75954 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the tetraspanin (TM4SF) family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3882 Eukaryota ENOG4111IRY LUCA |
GeneTreei | ENSGT00940000158225 |
HOGENOMi | HOG000230651 |
HOVERGENi | HBG002324 |
InParanoidi | O75954 |
KOi | K17350 |
OMAi | YEGYATL |
OrthoDBi | 1224210at2759 |
PhylomeDBi | O75954 |
TreeFami | TF352892 |
Family and domain databases
Gene3Di | 1.10.1450.10, 1 hit |
InterProi | View protein in InterPro IPR000301 Tetraspanin IPR018499 Tetraspanin/Peripherin IPR018503 Tetraspanin_CS IPR008952 Tetraspanin_EC2_sf |
Pfami | View protein in Pfam PF00335 Tetraspanin, 1 hit |
PIRSFi | PIRSF002419 Tetraspanin, 1 hit |
PRINTSi | PR00259 TMFOUR |
SUPFAMi | SSF48652 SSF48652, 1 hit |
PROSITEi | View protein in PROSITE PS00421 TM4_1, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
O75954-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MARGCLCCLK YMMFLFNLIF WLCGCGLLGV GIWLSVSQGN FATFSPSFPS
60 70 80 90 100
LSAANLVIAI GTIVMVTGFL GCLGAIKENK CLLLSFFIVL LVILLAELIL
110 120 130 140 150
LILFFVYMDK VNENAKKDLK EGLLLYHTEN NVGLKNAWNI IQAEMRCCGV
160 170 180 190 200
TDYTDWYPVL GENTVPDRCC MENSQGCGRN ATTPLWRTGC YEKVKMWFDD
210 220 230
NKHVLGTVGM CILIMQILGM AFSMTLFQHI HRTGKKYDA
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB5MD23 | B5MD23_HUMAN | Tetraspanin | TSPAN9 | 271 | Annotation score: | ||
A0A1W2PQ04 | A0A1W2PQ04_HUMAN | Tetraspanin-9 | TSPAN9 | 176 | Annotation score: | ||
A0A3B3IST1 | A0A3B3IST1_HUMAN | Tetraspanin-9 | TSPAN9 | 131 | Annotation score: | ||
E9PHL0 | E9PHL0_HUMAN | Tetraspanin-9 | TSPAN9 | 59 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 216 | Q → R in BAD96899 (Ref. 4) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF089749 mRNA Translation: AAC35859.1 AK027366 mRNA Translation: BAG51307.1 CR542109 mRNA Translation: CAG46906.1 AK223179 mRNA Translation: BAD96899.1 AC005912 Genomic DNA No translation available. CH471116 Genomic DNA Translation: EAW88868.1 CH471116 Genomic DNA Translation: EAW88869.1 BC071881 mRNA Translation: AAH71881.1 |
CCDSi | CCDS8520.1 |
RefSeqi | NP_001161792.1, NM_001168320.1 NP_006666.1, NM_006675.4 |
UniGenei | Hs.504517 |
Genome annotation databases
Ensembli | ENST00000011898; ENSP00000011898; ENSG00000011105 ENST00000537971; ENSP00000444799; ENSG00000011105 |
GeneIDi | 10867 |
KEGGi | hsa:10867 |
UCSCi | uc001qlp.4 human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF089749 mRNA Translation: AAC35859.1 AK027366 mRNA Translation: BAG51307.1 CR542109 mRNA Translation: CAG46906.1 AK223179 mRNA Translation: BAD96899.1 AC005912 Genomic DNA No translation available. CH471116 Genomic DNA Translation: EAW88868.1 CH471116 Genomic DNA Translation: EAW88869.1 BC071881 mRNA Translation: AAH71881.1 |
CCDSi | CCDS8520.1 |
RefSeqi | NP_001161792.1, NM_001168320.1 NP_006666.1, NM_006675.4 |
UniGenei | Hs.504517 |
3D structure databases
ProteinModelPortali | O75954 |
SMRi | O75954 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
BioGridi | 116076, 3 interactors |
IntActi | O75954, 1 interactor |
MINTi | O75954 |
STRINGi | 9606.ENSP00000011898 |
Protein family/group databases
TCDBi | 8.A.40.1.22 the tetraspanin (tetraspanin) family |
PTM databases
SwissPalmi | O75954 |
Polymorphism and mutation databases
BioMutai | TSPAN9 |
Proteomic databases
EPDi | O75954 |
jPOSTi | O75954 |
MaxQBi | O75954 |
PaxDbi | O75954 |
PeptideAtlasi | O75954 |
PRIDEi | O75954 |
ProteomicsDBi | 50320 |
Protocols and materials databases
DNASUi | 10867 |
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000011898; ENSP00000011898; ENSG00000011105 ENST00000537971; ENSP00000444799; ENSG00000011105 |
GeneIDi | 10867 |
KEGGi | hsa:10867 |
UCSCi | uc001qlp.4 human |
Organism-specific databases
CTDi | 10867 |
DisGeNETi | 10867 |
EuPathDBi | HostDB:ENSG00000011105.11 |
GeneCardsi | TSPAN9 |
HGNCi | HGNC:21640 TSPAN9 |
HPAi | HPA014002 |
MIMi | 613137 gene |
neXtProti | NX_O75954 |
OpenTargetsi | ENSG00000011105 |
PharmGKBi | PA142670694 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3882 Eukaryota ENOG4111IRY LUCA |
GeneTreei | ENSGT00940000158225 |
HOGENOMi | HOG000230651 |
HOVERGENi | HBG002324 |
InParanoidi | O75954 |
KOi | K17350 |
OMAi | YEGYATL |
OrthoDBi | 1224210at2759 |
PhylomeDBi | O75954 |
TreeFami | TF352892 |
Miscellaneous databases
ChiTaRSi | TSPAN9 human |
GenomeRNAii | 10867 |
PROi | PR:O75954 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000011105 Expressed in 220 organ(s), highest expression level in cerebellar hemisphere |
ExpressionAtlasi | O75954 baseline and differential |
Genevisiblei | O75954 HS |
Family and domain databases
Gene3Di | 1.10.1450.10, 1 hit |
InterProi | View protein in InterPro IPR000301 Tetraspanin IPR018499 Tetraspanin/Peripherin IPR018503 Tetraspanin_CS IPR008952 Tetraspanin_EC2_sf |
Pfami | View protein in Pfam PF00335 Tetraspanin, 1 hit |
PIRSFi | PIRSF002419 Tetraspanin, 1 hit |
PRINTSi | PR00259 TMFOUR |
SUPFAMi | SSF48652 SSF48652, 1 hit |
PROSITEi | View protein in PROSITE PS00421 TM4_1, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | TSN9_HUMAN | |
Accessioni | O75954Primary (citable) accession number: O75954 Secondary accession number(s): D3DUQ7, Q53FV2, Q6FGJ8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | November 1, 1998 | |
Last modified: | February 13, 2019 | |
This is version 134 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot