UniProtKB - O75954 (TSN9_HUMAN)
Protein
Tetraspanin-9
Gene
TSPAN9
Organism
Homo sapiens (Human)
Status
Functioni
Enzyme and pathway databases
PathwayCommonsi | O75954 |
Protein family/group databases
TCDBi | 8.A.40.1.22, the tetraspanin (tetraspanin) family |
Names & Taxonomyi
Protein namesi | Recommended name: Tetraspanin-9Short name: Tspan-9 Alternative name(s): Tetraspan NET-5 |
Gene namesi | Name:TSPAN9 Synonyms:NET5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:21640, TSPAN9 |
MIMi | 613137, gene |
neXtProti | NX_O75954 |
VEuPathDBi | HostDB:ENSG00000011105.11 |
Subcellular locationi
Other locations
- Membrane By similarity; Multi-pass membrane protein By similarity
Note: Colocalizes with GP6 in tetraspanin microdomains on the platelet surface.By similarity
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: UniProtKB
- tetraspanin-enriched microdomain Source: UniProtKB
Other locations
- focal adhesion Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 13 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 14 – 34 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 35 – 55 | ExtracellularSequence analysisAdd BLAST | 21 | |
Transmembranei | 56 – 76 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 77 – 85 | CytoplasmicSequence analysis | 9 | |
Transmembranei | 86 – 106 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 107 – 203 | ExtracellularSequence analysisAdd BLAST | 97 | |
Transmembranei | 204 – 224 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 225 – 239 | CytoplasmicSequence analysisAdd BLAST | 15 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 10867 |
OpenTargetsi | ENSG00000011105 |
PharmGKBi | PA142670694 |
Miscellaneous databases
Pharosi | O75954, Tbio |
Genetic variation databases
BioMutai | TSPAN9 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000219253 | 1 – 239 | Tetraspanin-9Add BLAST | 239 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 180 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Glycosylated.By similarity
Keywords - PTMi
GlycoproteinProteomic databases
EPDi | O75954 |
jPOSTi | O75954 |
MassIVEi | O75954 |
MaxQBi | O75954 |
PaxDbi | O75954 |
PeptideAtlasi | O75954 |
PRIDEi | O75954 |
ProteomicsDBi | 50320 |
PTM databases
GlyGeni | O75954, 1 site |
SwissPalmi | O75954 |
Expressioni
Tissue specificityi
Expressed in megakaryocytes and platelets (at protein level).1 Publication
Gene expression databases
Bgeei | ENSG00000011105, Expressed in cerebellar hemisphere and 233 other tissues |
ExpressionAtlasi | O75954, baseline and differential |
Genevisiblei | O75954, HS |
Organism-specific databases
HPAi | ENSG00000011105, Tissue enhanced (brain, heart muscle) |
Interactioni
Subunit structurei
Found in a complex with GP6.
By similarityProtein-protein interaction databases
BioGRIDi | 116076, 5 interactors |
IntActi | O75954, 4 interactors |
MINTi | O75954 |
STRINGi | 9606.ENSP00000011898 |
Miscellaneous databases
RNActi | O75954, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the tetraspanin (TM4SF) family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3882, Eukaryota |
GeneTreei | ENSGT00940000158225 |
HOGENOMi | CLU_055524_4_3_1 |
InParanoidi | O75954 |
OMAi | KMWFDEN |
OrthoDBi | 1224210at2759 |
PhylomeDBi | O75954 |
TreeFami | TF352892 |
Family and domain databases
Gene3Di | 1.10.1450.10, 1 hit |
InterProi | View protein in InterPro IPR000301, Tetraspanin IPR018499, Tetraspanin/Peripherin IPR018503, Tetraspanin_CS IPR008952, Tetraspanin_EC2_sf |
Pfami | View protein in Pfam PF00335, Tetraspanin, 1 hit |
PIRSFi | PIRSF002419, Tetraspanin, 1 hit |
PRINTSi | PR00259, TMFOUR |
SUPFAMi | SSF48652, SSF48652, 1 hit |
PROSITEi | View protein in PROSITE PS00421, TM4_1, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
O75954-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MARGCLCCLK YMMFLFNLIF WLCGCGLLGV GIWLSVSQGN FATFSPSFPS
60 70 80 90 100
LSAANLVIAI GTIVMVTGFL GCLGAIKENK CLLLSFFIVL LVILLAELIL
110 120 130 140 150
LILFFVYMDK VNENAKKDLK EGLLLYHTEN NVGLKNAWNI IQAEMRCCGV
160 170 180 190 200
TDYTDWYPVL GENTVPDRCC MENSQGCGRN ATTPLWRTGC YEKVKMWFDD
210 220 230
NKHVLGTVGM CILIMQILGM AFSMTLFQHI HRTGKKYDA
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB5MD23 | B5MD23_HUMAN | Tetraspanin | TSPAN9 | 271 | Annotation score: | ||
A0A1W2PQ04 | A0A1W2PQ04_HUMAN | Tetraspanin-9 | TSPAN9 | 176 | Annotation score: | ||
A0A3B3IST1 | A0A3B3IST1_HUMAN | Tetraspanin-9 | TSPAN9 | 131 | Annotation score: | ||
E9PHL0 | E9PHL0_HUMAN | Tetraspanin-9 | TSPAN9 | 59 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 216 | Q → R in BAD96899 (Ref. 4) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF089749 mRNA Translation: AAC35859.1 AK027366 mRNA Translation: BAG51307.1 CR542109 mRNA Translation: CAG46906.1 AK223179 mRNA Translation: BAD96899.1 AC005912 Genomic DNA No translation available. CH471116 Genomic DNA Translation: EAW88868.1 CH471116 Genomic DNA Translation: EAW88869.1 BC071881 mRNA Translation: AAH71881.1 |
CCDSi | CCDS8520.1 |
RefSeqi | NP_001161792.1, NM_001168320.1 NP_006666.1, NM_006675.4 |
Genome annotation databases
Ensembli | ENST00000011898; ENSP00000011898; ENSG00000011105 ENST00000537971; ENSP00000444799; ENSG00000011105 |
GeneIDi | 10867 |
KEGGi | hsa:10867 |
UCSCi | uc001qlp.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF089749 mRNA Translation: AAC35859.1 AK027366 mRNA Translation: BAG51307.1 CR542109 mRNA Translation: CAG46906.1 AK223179 mRNA Translation: BAD96899.1 AC005912 Genomic DNA No translation available. CH471116 Genomic DNA Translation: EAW88868.1 CH471116 Genomic DNA Translation: EAW88869.1 BC071881 mRNA Translation: AAH71881.1 |
CCDSi | CCDS8520.1 |
RefSeqi | NP_001161792.1, NM_001168320.1 NP_006666.1, NM_006675.4 |
3D structure databases
SMRi | O75954 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 116076, 5 interactors |
IntActi | O75954, 4 interactors |
MINTi | O75954 |
STRINGi | 9606.ENSP00000011898 |
Protein family/group databases
TCDBi | 8.A.40.1.22, the tetraspanin (tetraspanin) family |
PTM databases
GlyGeni | O75954, 1 site |
SwissPalmi | O75954 |
Genetic variation databases
BioMutai | TSPAN9 |
Proteomic databases
EPDi | O75954 |
jPOSTi | O75954 |
MassIVEi | O75954 |
MaxQBi | O75954 |
PaxDbi | O75954 |
PeptideAtlasi | O75954 |
PRIDEi | O75954 |
ProteomicsDBi | 50320 |
Protocols and materials databases
Antibodypediai | 2820, 156 antibodies |
DNASUi | 10867 |
Genome annotation databases
Ensembli | ENST00000011898; ENSP00000011898; ENSG00000011105 ENST00000537971; ENSP00000444799; ENSG00000011105 |
GeneIDi | 10867 |
KEGGi | hsa:10867 |
UCSCi | uc001qlp.4, human |
Organism-specific databases
CTDi | 10867 |
DisGeNETi | 10867 |
GeneCardsi | TSPAN9 |
HGNCi | HGNC:21640, TSPAN9 |
HPAi | ENSG00000011105, Tissue enhanced (brain, heart muscle) |
MIMi | 613137, gene |
neXtProti | NX_O75954 |
OpenTargetsi | ENSG00000011105 |
PharmGKBi | PA142670694 |
VEuPathDBi | HostDB:ENSG00000011105.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3882, Eukaryota |
GeneTreei | ENSGT00940000158225 |
HOGENOMi | CLU_055524_4_3_1 |
InParanoidi | O75954 |
OMAi | KMWFDEN |
OrthoDBi | 1224210at2759 |
PhylomeDBi | O75954 |
TreeFami | TF352892 |
Enzyme and pathway databases
PathwayCommonsi | O75954 |
Miscellaneous databases
BioGRID-ORCSi | 10867, 3 hits in 990 CRISPR screens |
ChiTaRSi | TSPAN9, human |
GenomeRNAii | 10867 |
Pharosi | O75954, Tbio |
PROi | PR:O75954 |
RNActi | O75954, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000011105, Expressed in cerebellar hemisphere and 233 other tissues |
ExpressionAtlasi | O75954, baseline and differential |
Genevisiblei | O75954, HS |
Family and domain databases
Gene3Di | 1.10.1450.10, 1 hit |
InterProi | View protein in InterPro IPR000301, Tetraspanin IPR018499, Tetraspanin/Peripherin IPR018503, Tetraspanin_CS IPR008952, Tetraspanin_EC2_sf |
Pfami | View protein in Pfam PF00335, Tetraspanin, 1 hit |
PIRSFi | PIRSF002419, Tetraspanin, 1 hit |
PRINTSi | PR00259, TMFOUR |
SUPFAMi | SSF48652, SSF48652, 1 hit |
PROSITEi | View protein in PROSITE PS00421, TM4_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TSN9_HUMAN | |
Accessioni | O75954Primary (citable) accession number: O75954 Secondary accession number(s): D3DUQ7, Q53FV2, Q6FGJ8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | November 1, 1998 | |
Last modified: | April 7, 2021 | |
This is version 147 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families