UniProtKB - O75954 (TSN9_HUMAN)

BLAST

>sp|O75954|TSN9_HUMAN Tetraspanin-9 OS=Homo sapiens OX=9606 GN=TSPAN9 PE=1 SV=1
MARGCLCCLKYMMFLFNLIFWLCGCGLLGVGIWLSVSQGNFATFSPSFPSLSAANLVIAI
GTIVMVTGFLGCLGAIKENKCLLLSFFIVLLVILLAELILLILFFVYMDKVNENAKKDLK
EGLLLYHTENNVGLKNAWNIIQAEMRCCGVTDYTDWYPVLGENTVPDRCCMENSQGCGRN
ATTPLWRTGCYEKVKMWFDDNKHVLGTVGMCILIMQILGMAFSMTLFQHIHRTGKKYDA

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History
Entry version 131 (07 Nov 2018)
Sequence version 1 (01 Nov 1998)
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Protein

Tetraspanin-9

Gene

TSPAN9

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

GO - Biological processⁱ

cell surface receptor signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein family/group databases

TCDBⁱ	8.A.40.1.22 the tetraspanin (tetraspanin) family

TCDBⁱ

8.A.40.1.22 the tetraspanin (tetraspanin) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Tetraspanin-9 Short name: Tspan-9 Alternative name(s): Tetraspan NET-5
Gene namesⁱ	Name:TSPAN9 Synonyms:NET5
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000011105.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:21640 TSPAN9
MIMⁱ	613137 gene
neXtProtⁱ	NX_O75954

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 13	CytoplasmicSequence analysisAdd BLAST	13
Transmembraneⁱ	14 – 34	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	35 – 55	ExtracellularSequence analysisAdd BLAST	21
Transmembraneⁱ	56 – 76	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	77 – 85	CytoplasmicSequence analysis	9
Transmembraneⁱ	86 – 106	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	107 – 203	ExtracellularSequence analysisAdd BLAST	97
Transmembraneⁱ	204 – 224	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	225 – 239	CytoplasmicSequence analysisAdd BLAST	15

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10867
Open Targets More...OpenTargetsⁱ	ENSG00000011105
PharmGKBⁱ	PA142670694

Polymorphism and mutation databases

BioMutaⁱ	TSPAN9

BioMutaⁱ

TSPAN9

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000219253	1 – 239	Tetraspanin-9Add BLAST		239

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	180	N-linked (GlcNAc...) asparagineSequence analysis		1

Post-translational modificationⁱ

Glycosylated.By similarity

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

EPDⁱ	O75954
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O75954
PaxDbⁱ	O75954
PeptideAtlas More...PeptideAtlasⁱ	O75954
PRIDEⁱ	O75954
ProteomicsDBⁱ	50320

PTM databases

SwissPalmⁱ	O75954

SwissPalmⁱ

O75954

Expressionⁱ

Tissue specificityⁱ

Expressed in megakaryocytes and platelets (at protein level).1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000011105 Expressed in 220 organ(s), highest expression level in cerebellar hemisphere
CleanExⁱ	HS_TSPAN9
ExpressionAtlasⁱ	O75954 baseline and differential
Genevisibleⁱ	O75954 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA014002

HPAⁱ

HPA014002

Interactionⁱ

Subunit structureⁱ

Found in a complex with GP6.By similarity

Protein-protein interaction databases

BioGridⁱ	116076, 2 interactors
IntActⁱ	O75954, 1 interactor
Molecular INTeraction database More...MINTⁱ	O75954
STRINGⁱ	9606.ENSP00000011898

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O75954
SMRⁱ	O75954
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3882 Eukaryota ENOG4111IRY LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00880000137858
HOGENOMⁱ	HOG000230651
HOVERGENⁱ	HBG002324
InParanoidⁱ	O75954
KEGG Orthology (KO) More...KOⁱ	K17350
OMAⁱ	YEGYATL
PhylomeDBⁱ	O75954
TreeFamⁱ	TF352892

Family and domain databases

Gene3Dⁱ	1.10.1450.10, 1 hit
InterProⁱ	View protein in InterPro IPR000301 Tetraspanin IPR018499 Tetraspanin/Peripherin IPR018503 Tetraspanin_CS IPR008952 Tetraspanin_EC2_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00335 Tetraspannin, 1 hit
PIRSFⁱ	PIRSF002419 Tetraspanin, 1 hit
PRINTSⁱ	PR00259 TMFOUR
SUPFAMⁱ	SSF48652 SSF48652, 1 hit
PROSITEⁱ	View protein in PROSITE PS00421 TM4_1, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

O75954-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MARGCLCCLK YMMFLFNLIF WLCGCGLLGV GIWLSVSQGN FATFSPSFPS 
        60         70         80         90        100
LSAANLVIAI GTIVMVTGFL GCLGAIKENK CLLLSFFIVL LVILLAELIL 
       110        120        130        140        150
LILFFVYMDK VNENAKKDLK EGLLLYHTEN NVGLKNAWNI IQAEMRCCGV 
       160        170        180        190        200
TDYTDWYPVL GENTVPDRCC MENSQGCGRN ATTPLWRTGC YEKVKMWFDD 
       210        220        230 
NKHVLGTVGM CILIMQILGM AFSMTLFQHI HRTGKKYDA

Length:239

Mass (Da):26,779

Last modified:November 1, 1998 - v1

Checksum:ⁱDD7BA332BF6584EB

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

B5MD23	B5MD23_HUMAN	Tetraspanin Tetraspanin	TSPAN9	271	Annotation score:
A0A1W2PQ04	A0A1W2PQ04_HUMAN	Tetraspanin-9 Tetraspanin-9	TSPAN9	176	Annotation score:
E9PHL0	E9PHL0_HUMAN	Tetraspanin-9 Tetraspanin-9	TSPAN9	59	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	216	Q → R in BAD96899 (Ref. 4) Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF089749 mRNA Translation: AAC35859.1 AK027366 mRNA Translation: BAG51307.1 CR542109 mRNA Translation: CAG46906.1 AK223179 mRNA Translation: BAD96899.1 AC005912 Genomic DNA No translation available. CH471116 Genomic DNA Translation: EAW88868.1 CH471116 Genomic DNA Translation: EAW88869.1 BC071881 mRNA Translation: AAH71881.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8520.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001161792.1, NM_001168320.1 NP_006666.1, NM_006675.4
UniGeneⁱ	Hs.504517

Genome annotation databases

Ensemblⁱ	ENST00000011898; ENSP00000011898; ENSG00000011105 ENST00000537971; ENSP00000444799; ENSG00000011105
GeneIDⁱ	10867
KEGGⁱ	hsa:10867
UCSC genome browser More...UCSCⁱ	uc001qlp.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O75954	Tetraspanin		MACMU		330	UniRef100_O75954
Tetraspanin		CERAT		330
Tetraspanin		RHIRO		330
Tetraspanin		PAPAN		330
Tetraspanin		GORGO		330
+7

Protein	Similar proteins		Species	Score	Length	Source
O75954	Tetraspanin-9		MOUSE		239	UniRef90_Q8BJU2
Tetraspanin-9		PIG		239
Tetraspanin-9		XENTR		239
Tetraspanin		MESAU		332
Tetraspanin		PROCO		330
+90

Protein	Similar proteins		Species	Score	Length	Source
O75954	Tetraspanin-9		MOUSE		239	UniRef50_Q8BJU2
Tetraspanin-9		XENTR		239
Tetraspanin-9		PIG		239
Tetraspanin		MESAU		332
Tetraspanin		NOMLE		330
+195

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF089749 mRNA Translation: AAC35859.1 AK027366 mRNA Translation: BAG51307.1 CR542109 mRNA Translation: CAG46906.1 AK223179 mRNA Translation: BAD96899.1 AC005912 Genomic DNA No translation available. CH471116 Genomic DNA Translation: EAW88868.1 CH471116 Genomic DNA Translation: EAW88869.1 BC071881 mRNA Translation: AAH71881.1
CCDSⁱ	CCDS8520.1
RefSeqⁱ	NP_001161792.1, NM_001168320.1 NP_006666.1, NM_006675.4
UniGeneⁱ	Hs.504517

3D structure databases

ProteinModelPortalⁱ	O75954
SMRⁱ	O75954
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116076, 2 interactors
IntActⁱ	O75954, 1 interactor
MINTⁱ	O75954
STRINGⁱ	9606.ENSP00000011898

Protein family/group databases

TCDBⁱ	8.A.40.1.22 the tetraspanin (tetraspanin) family

TCDBⁱ

8.A.40.1.22 the tetraspanin (tetraspanin) family

PTM databases

SwissPalmⁱ	O75954

SwissPalmⁱ

O75954

Polymorphism and mutation databases

BioMutaⁱ	TSPAN9

BioMutaⁱ

TSPAN9

Proteomic databases

EPDⁱ	O75954
MaxQBⁱ	O75954
PaxDbⁱ	O75954
PeptideAtlasⁱ	O75954
PRIDEⁱ	O75954
ProteomicsDBⁱ	50320

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	10867
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000011898; ENSP00000011898; ENSG00000011105 ENST00000537971; ENSP00000444799; ENSG00000011105
GeneIDⁱ	10867
KEGGⁱ	hsa:10867
UCSCⁱ	uc001qlp.4 human

Organism-specific databases

CTDⁱ	10867
DisGeNETⁱ	10867
EuPathDBⁱ	HostDB:ENSG00000011105.11
GeneCardsⁱ	TSPAN9
HGNCⁱ	HGNC:21640 TSPAN9
HPAⁱ	HPA014002
MIMⁱ	613137 gene
neXtProtⁱ	NX_O75954
OpenTargetsⁱ	ENSG00000011105
PharmGKBⁱ	PA142670694
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3882 Eukaryota ENOG4111IRY LUCA
GeneTreeⁱ	ENSGT00880000137858
HOGENOMⁱ	HOG000230651
HOVERGENⁱ	HBG002324
InParanoidⁱ	O75954
KOⁱ	K17350
OMAⁱ	YEGYATL
PhylomeDBⁱ	O75954
TreeFamⁱ	TF352892

Miscellaneous databases

ChiTaRSⁱ	TSPAN9 human
GenomeRNAiⁱ	10867
Protein Ontology More...PROⁱ	PR:O75954
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000011105 Expressed in 220 organ(s), highest expression level in cerebellar hemisphere
CleanExⁱ	HS_TSPAN9
ExpressionAtlasⁱ	O75954 baseline and differential
Genevisibleⁱ	O75954 HS

Family and domain databases

Gene3Dⁱ	1.10.1450.10, 1 hit
InterProⁱ	View protein in InterPro IPR000301 Tetraspanin IPR018499 Tetraspanin/Peripherin IPR018503 Tetraspanin_CS IPR008952 Tetraspanin_EC2_sf
Pfamⁱ	View protein in Pfam PF00335 Tetraspannin, 1 hit
PIRSFⁱ	PIRSF002419 Tetraspanin, 1 hit
PRINTSⁱ	PR00259 TMFOUR
SUPFAMⁱ	SSF48652 SSF48652, 1 hit
PROSITEⁱ	View protein in PROSITE PS00421 TM4_1, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TSN9_HUMAN
Accessionⁱ	O75954Primary (citable) accession number: O75954 Secondary accession number(s): D3DUQ7, Q53FV2, Q6FGJ8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
	Last sequence update:	November 1, 1998
	Last modified:	November 7, 2018
	This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O75954 (TSN9_HUMAN)

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Tetraspanin-9

TSPAN9

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Plasma Membrane

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ