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Protein

Calcium-binding tyrosine phosphorylation-regulated protein

Gene

CABYR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction. Isoform 1 binds calcium in vitro. Isoform 2 and isoform 6 probably bind calcium. Isoform 3 and isoform 5 do not bind calcium in vitro. Isoform 4 probably does not bind calcium.

GO - Molecular functioni

  • calcium ion binding Source: BHF-UCL
  • enzyme binding Source: BHF-UCL
  • protein heterodimerization activity Source: BHF-UCL
  • SH3 domain binding Source: BHF-UCL

GO - Biological processi

Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

SIGNORiO75952

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-binding tyrosine phosphorylation-regulated protein
Alternative name(s):
Calcium-binding protein 86
Cancer/testis antigen 88
Short name:
CT88
Fibrousheathin II
Fibrousheathin-2
Short name:
FSP-2
Testis-specific calcium-binding protein CBP86
Gene namesi
Name:CABYR
Synonyms:CBP86, FSP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000154040.20
HGNCiHGNC:15569 CABYR
MIMi612135 gene
neXtProtiNX_O75952

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Flagellum, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi146T → A: Does not affect phosphorylation. 1 Publication1
Mutagenesisi151T → A: Decreases phosphorylation. Abolishes phosphorylation; when associated with A-155. 1 Publication1
Mutagenesisi154S → A: Does not affect phosphorylation. Does not affect phosphorylation; when associated with A-159. 1 Publication1
Mutagenesisi155S → A: Decreases phosphorylation and interaction with GSK3B. Abolishes phosphorylation and decreases interaction with GSK3B; when associated with A-151. 1 Publication1
Mutagenesisi159T → A: Does not affect phosphorylation. Does not affect phosphorylation; when associated with A-154. 1 Publication1

Organism-specific databases

DisGeNETi26256
OpenTargetsiENSG00000154040
PharmGKBiPA26005

Polymorphism and mutation databases

BioMutaiCABYR

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000892681 – 493Calcium-binding tyrosine phosphorylation-regulated proteinAdd BLAST493

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei151Phosphothreonine1 Publication1
Modified residuei155Phosphoserine1 Publication1

Post-translational modificationi

Isoform 1 is phosphorylated on tyrosine residues during in vitro capacitation. Isoform 3 and isoform 5 are phosphorylated by GSK3B in vitro. Dephosphorylation affects its ability to bind calcium.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO75952
MaxQBiO75952
PaxDbiO75952
PeptideAtlasiO75952
PRIDEiO75952
ProteomicsDBi50313
50314 [O75952-2]
50315 [O75952-3]
50316 [O75952-4]
50317 [O75952-5]
50318 [O75952-6]

PTM databases

iPTMnetiO75952
PhosphoSitePlusiO75952

Expressioni

Tissue specificityi

Expressed in elongating spermatids and spermatozoa (at protein level). Isoform 1 is expressed in testis. Isoform 3 and isoform 5 are also expressed in brain, pancreas and numerous brain tumors.3 Publications

Gene expression databases

BgeeiENSG00000154040 Expressed in 146 organ(s), highest expression level in sperm
CleanExiHS_CABYR
ExpressionAtlasiO75952 baseline and differential
GenevisibleiO75952 HS

Organism-specific databases

HPAiHPA040703
HPA047801

Interactioni

Subunit structurei

Interacts with FSCB (By similarity). Isoform 3 self-associates. Isoform 3 and isoform 5 interact with GSK3B. Isoform 1 does not interact with GSK3B.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
GSK3BP498413EBI-10900795,EBI-373586

GO - Molecular functioni

Protein-protein interaction databases

BioGridi117642, 2 interactors
IntActiO75952, 1 interactor
STRINGi9606.ENSP00000432870

Structurei

3D structure databases

ProteinModelPortaliO75952
SMRiO75952
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 49RIIaAdd BLAST38

Phylogenomic databases

eggNOGiENOG410IFPT Eukaryota
ENOG410ZQAQ LUCA
GeneTreeiENSGT00390000000444
HOVERGENiHBG080982
InParanoidiO75952
OMAiGVTYVEQ
OrthoDBiEOG091G18VB
PhylomeDBiO75952
TreeFamiTF332959

Family and domain databases

InterProiView protein in InterPro
IPR038848 CABYR
IPR003117 cAMP_dep_PK_reg_su_I/II_a/b
PANTHERiPTHR15494 PTHR15494, 1 hit
PfamiView protein in Pfam
PF02197 RIIa, 1 hit
SMARTiView protein in SMART
SM00394 RIIa, 1 hit

Sequences (6+)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O75952-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MISSKPRLVV PYGLKTLLEG ISRAVLKTNP SNINQFAAAY FQELTMYRGN
60 70 80 90 100
TTMDIKDLVK QFHQIKVEKW SEGTTPQKKL ECLKEPGKTS VESKVPTQME
110 120 130 140 150
KSTDTDEDNV TRTEYSDKTT QFPSVYAVPG TEQTEAVGGL SSKPATPKTT
160 170 180 190 200
TPPSSPPPTA VSPEFAYVPA DPAQLAAQML GKVSSIHSDQ SDVLMVDVAT
210 220 230 240 250
SMPVVIKEVP SSEAAEDVMV AAPLVCSGKV LEVQVVNQTS VHVDLGSQPK
260 270 280 290 300
ENEAEPSTAS SVPLQDEQEP PAYDQAPEVT LQADIEVMST VHISSVYNDV
310 320 330 340 350
PVTEGVVYIE QLPEQIVIPF TDQVACLKEN EQSKENEQSP RVSPKSVVEK
360 370 380 390 400
TTSGMSKKSV ESVKLAQLEE NAKYSSVYME AEATALLSDT SLKGQPEVPA
410 420 430 440 450
QLLDAEGAIK IGSEKSLHLE VEITSIVSDN TGQEESGENS VPQEMEGKPV
460 470 480 490
LSGEAAEAVH SGTSVKSSSG PFPPAPEGLT APEIEPEGES TAE
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Length:493
Mass (Da):52,774
Last modified:January 23, 2007 - v2
Checksum:i42F97605262C8199
GO
Isoform 2 (identifier: O75952-2) [UniParc]FASTAAdd to basket
Also known as: CBP86-VII

The sequence of this isoform differs from the canonical sequence as follows:
     49-66: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:475
Mass (Da):50,676
Checksum:i01D34365BEDF945B
GO
Isoform 3 (identifier: O75952-3) [UniParc]FASTAAdd to basket
Also known as: CBP86-II

The sequence of this isoform differs from the canonical sequence as follows:
     181-379: GKVSSIHSDQ...ENAKYSSVYM → AMATSERGQP...HKRRKAETEN
     380-493: Missing.

Show »
Length:379
Mass (Da):41,120
Checksum:i9E6748129EEE16E4
GO
Isoform 4 (identifier: O75952-4) [UniParc]FASTAAdd to basket
Also known as: CBP86-IV

The sequence of this isoform differs from the canonical sequence as follows:
     181-221: GKVSSIHSDQ...SEAAEDVMVA → EDVAKKSSGS...HKRRKAETEN
     222-493: Missing.

Show »
Length:221
Mass (Da):23,964
Checksum:i0C6FA78696F9BF11
GO
Isoform 5 (identifier: O75952-5) [UniParc]FASTAAdd to basket
Also known as: CBP86-III

The sequence of this isoform differs from the canonical sequence as follows:
     1-98: Missing.
     181-379: GKVSSIHSDQ...ENAKYSSVYM → AMATSERGQP...HKRRKAETEN
     380-493: Missing.

Show »
Length:281
Mass (Da):30,053
Checksum:i93966975E7AAFF08
GO
Isoform 6 (identifier: O75952-6) [UniParc]FASTAAdd to basket
Also known as: CBP86-VI

The sequence of this isoform differs from the canonical sequence as follows:
     1-201: Missing.

Show »
Length:292
Mass (Da):30,936
Checksum:iE371F64036F2AA37
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0D9SFQ2A0A0D9SFQ2_HUMAN
Calcium binding tyrosine-(Y)-phosph...
CABYR hCG_37186
395Annotation score:
J3KTE8J3KTE8_HUMAN
Calcium-binding tyrosine phosphoryl...
CABYR
293Annotation score:
G9BQT7G9BQT7_HUMAN
Calcium-binding tyrosine phosphoryl...
CABYR
196Annotation score:
J3KT09J3KT09_HUMAN
Calcium-binding tyrosine phosphoryl...
CABYR
84Annotation score:
J3KRI0J3KRI0_HUMAN
Calcium-binding tyrosine phosphoryl...
CABYR
73Annotation score:
J3QLW5J3QLW5_HUMAN
Calcium-binding tyrosine phosphoryl...
CABYR
46Annotation score:
J3QQK7J3QQK7_HUMAN
Calcium-binding tyrosine phosphoryl...
CABYR
36Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti423I → V in AAC35373 (PubMed:11820818).Curated1
Sequence conflicti423I → V in AAL56051 (PubMed:11820818).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03004074T → M. Corresponds to variant dbSNP:rs3786417Ensembl.1
Natural variantiVAR_050709186I → V. Corresponds to variant dbSNP:rs35118855Ensembl.1
Natural variantiVAR_030041448K → R1 PublicationCorresponds to variant dbSNP:rs1049682Ensembl.1
Natural variantiVAR_023818490S → A1 PublicationCorresponds to variant dbSNP:rs1049683Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0162451 – 201Missing in isoform 6. 1 PublicationAdd BLAST201
Alternative sequenceiVSP_0162461 – 98Missing in isoform 5. 1 PublicationAdd BLAST98
Alternative sequenceiVSP_01624749 – 66Missing in isoform 2. 2 PublicationsAdd BLAST18
Alternative sequenceiVSP_016248181 – 379GKVSS…SSVYM → AMATSERGQPPPCSNMWTLY CLTDKNQQGHPSPPPAPGPF PQATLYLPNPKDPQFQQHPP KVTFPTYVMGDTKKTSAPPF ILVGSNVQEAQGWKPLPGHA VVSQSDVLRYVAMQVPIAVP ADEKYQKHTLSPQNANPPSG QDVPRPKSPVFLSVAFPVED VAKKSSGSGDKCAPFGSYGI AGEVTVTTAHKRRKAETEN in isoform 3 and isoform 5. 2 PublicationsAdd BLAST199
Alternative sequenceiVSP_016249181 – 221GKVSS…DVMVA → EDVAKKSSGSGDKCAPFGSY GIAGEVTVTTAHKRRKAETE N in isoform 4. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_016250222 – 493Missing in isoform 4. 1 PublicationAdd BLAST272
Alternative sequenceiVSP_016251380 – 493Missing in isoform 3 and isoform 5. 2 PublicationsAdd BLAST114

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF088868 mRNA Translation: AAC35373.1
AF295037 mRNA Translation: AAG17889.1
AF295038 mRNA Translation: AAG17890.1
AF295039 mRNA Translation: AAG17891.1
AF329634 mRNA Translation: AAL56051.1
AY007205 mRNA Translation: AAG01891.1
AK313243 mRNA Translation: BAG36054.1
AC090772 Genomic DNA No translation available.
CH471088 Genomic DNA Translation: EAX01177.1
BC011996 mRNA Translation: AAH11996.1
CCDSiCCDS11881.1 [O75952-1]
CCDS11882.1 [O75952-2]
CCDS11883.1 [O75952-5]
CCDS42420.1 [O75952-3]
CCDS45840.1 [O75952-4]
RefSeqiNP_036321.2, NM_012189.3 [O75952-1]
NP_619584.1, NM_138643.2 [O75952-5]
NP_619585.1, NM_138644.2 [O75952-3]
NP_722452.1, NM_153768.2 [O75952-2]
NP_722453.1, NM_153769.2 [O75952-3]
NP_722454.1, NM_153770.2 [O75952-4]
XP_016881195.1, XM_017025706.1
UniGeneiHs.511983

Genome annotation databases

EnsembliENST00000327201; ENSP00000317095; ENSG00000154040 [O75952-5]
ENST00000399481; ENSP00000382404; ENSG00000154040 [O75952-2]
ENST00000399496; ENSP00000382419; ENSG00000154040 [O75952-3]
ENST00000399499; ENSP00000382421; ENSG00000154040 [O75952-3]
ENST00000415309; ENSP00000399973; ENSG00000154040 [O75952-4]
ENST00000463087; ENSP00000432870; ENSG00000154040 [O75952-1]
ENST00000486759; ENSP00000431142; ENSG00000154040 [O75952-1]
ENST00000621648; ENSP00000483621; ENSG00000154040 [O75952-1]
GeneIDi26256
KEGGihsa:26256
UCSCiuc002kux.5 human [O75952-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF088868 mRNA Translation: AAC35373.1
AF295037 mRNA Translation: AAG17889.1
AF295038 mRNA Translation: AAG17890.1
AF295039 mRNA Translation: AAG17891.1
AF329634 mRNA Translation: AAL56051.1
AY007205 mRNA Translation: AAG01891.1
AK313243 mRNA Translation: BAG36054.1
AC090772 Genomic DNA No translation available.
CH471088 Genomic DNA Translation: EAX01177.1
BC011996 mRNA Translation: AAH11996.1
CCDSiCCDS11881.1 [O75952-1]
CCDS11882.1 [O75952-2]
CCDS11883.1 [O75952-5]
CCDS42420.1 [O75952-3]
CCDS45840.1 [O75952-4]
RefSeqiNP_036321.2, NM_012189.3 [O75952-1]
NP_619584.1, NM_138643.2 [O75952-5]
NP_619585.1, NM_138644.2 [O75952-3]
NP_722452.1, NM_153768.2 [O75952-2]
NP_722453.1, NM_153769.2 [O75952-3]
NP_722454.1, NM_153770.2 [O75952-4]
XP_016881195.1, XM_017025706.1
UniGeneiHs.511983

3D structure databases

ProteinModelPortaliO75952
SMRiO75952
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117642, 2 interactors
IntActiO75952, 1 interactor
STRINGi9606.ENSP00000432870

PTM databases

iPTMnetiO75952
PhosphoSitePlusiO75952

Polymorphism and mutation databases

BioMutaiCABYR

Proteomic databases

EPDiO75952
MaxQBiO75952
PaxDbiO75952
PeptideAtlasiO75952
PRIDEiO75952
ProteomicsDBi50313
50314 [O75952-2]
50315 [O75952-3]
50316 [O75952-4]
50317 [O75952-5]
50318 [O75952-6]

Protocols and materials databases

DNASUi26256
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000327201; ENSP00000317095; ENSG00000154040 [O75952-5]
ENST00000399481; ENSP00000382404; ENSG00000154040 [O75952-2]
ENST00000399496; ENSP00000382419; ENSG00000154040 [O75952-3]
ENST00000399499; ENSP00000382421; ENSG00000154040 [O75952-3]
ENST00000415309; ENSP00000399973; ENSG00000154040 [O75952-4]
ENST00000463087; ENSP00000432870; ENSG00000154040 [O75952-1]
ENST00000486759; ENSP00000431142; ENSG00000154040 [O75952-1]
ENST00000621648; ENSP00000483621; ENSG00000154040 [O75952-1]
GeneIDi26256
KEGGihsa:26256
UCSCiuc002kux.5 human [O75952-1]

Organism-specific databases

CTDi26256
DisGeNETi26256
EuPathDBiHostDB:ENSG00000154040.20
GeneCardsiCABYR
HGNCiHGNC:15569 CABYR
HPAiHPA040703
HPA047801
MIMi612135 gene
neXtProtiNX_O75952
OpenTargetsiENSG00000154040
PharmGKBiPA26005
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFPT Eukaryota
ENOG410ZQAQ LUCA
GeneTreeiENSGT00390000000444
HOVERGENiHBG080982
InParanoidiO75952
OMAiGVTYVEQ
OrthoDBiEOG091G18VB
PhylomeDBiO75952
TreeFamiTF332959

Enzyme and pathway databases

SIGNORiO75952

Miscellaneous databases

ChiTaRSiCABYR human
GeneWikiiCABYR
GenomeRNAii26256
PROiPR:O75952
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000154040 Expressed in 146 organ(s), highest expression level in sperm
CleanExiHS_CABYR
ExpressionAtlasiO75952 baseline and differential
GenevisibleiO75952 HS

Family and domain databases

InterProiView protein in InterPro
IPR038848 CABYR
IPR003117 cAMP_dep_PK_reg_su_I/II_a/b
PANTHERiPTHR15494 PTHR15494, 1 hit
PfamiView protein in Pfam
PF02197 RIIa, 1 hit
SMARTiView protein in SMART
SM00394 RIIa, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCABYR_HUMAN
AccessioniPrimary (citable) accession number: O75952
Secondary accession number(s): B2R857
, Q8WXW5, Q9HAY3, Q9HAY4, Q9HAY5, Q9HCY9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
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