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UniProtKB - O75952 (CABYR_HUMAN)

Entry version 174 (23 Feb 2022)
Sequence version 2 (23 Jan 2007)
Previous versions | rss
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Protein

Calcium-binding tyrosine phosphorylation-regulated protein

Gene

CABYR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction. Isoform 1 binds calcium in vitro. Isoform 2 and isoform 6 probably bind calcium. Isoform 3 and isoform 5 do not bind calcium in vitro. Isoform 4 probably does not bind calcium.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O75952

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		O75952

SIGNOR Signaling Network Open Resource

More...SIGNORi		O75952

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calcium-binding tyrosine phosphorylation-regulated protein
Alternative name(s):
Calcium-binding protein 86
Cancer/testis antigen 88
Short name:
CT88
Fibrousheathin II
Fibrousheathin-2
Short name:
FSP-2
Testis-specific calcium-binding protein CBP86
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CABYR
Synonyms:CBP86, FSP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:15569, CABYR

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		612135, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O75952

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000154040

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Flagellum, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi146T → A: Does not affect phosphorylation. 1 Publication1
Mutagenesisi151T → A: Decreases phosphorylation. Abolishes phosphorylation; when associated with A-155. 1 Publication1
Mutagenesisi154S → A: Does not affect phosphorylation. Does not affect phosphorylation; when associated with A-159. 1 Publication1
Mutagenesisi155S → A: Decreases phosphorylation and interaction with GSK3B. Abolishes phosphorylation and decreases interaction with GSK3B; when associated with A-151. 1 Publication1
Mutagenesisi159T → A: Does not affect phosphorylation. Does not affect phosphorylation; when associated with A-154. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		26256

Open Targets

More...OpenTargetsi		ENSG00000154040

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26005

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O75952, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CABYR

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000892681 – 493Calcium-binding tyrosine phosphorylation-regulated proteinAdd BLAST493

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei151Phosphothreonine1 Publication1
Modified residuei155Phosphoserine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Isoform 1 is phosphorylated on tyrosine residues during in vitro capacitation. Isoform 3 and isoform 5 are phosphorylated by GSK3B in vitro. Dephosphorylation affects its ability to bind calcium.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O75952

MaxQB - The MaxQuant DataBase

More...MaxQBi		O75952

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O75952

PeptideAtlas

More...PeptideAtlasi		O75952

PRoteomics IDEntifications database

More...PRIDEi		O75952

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		50313 [O75952-1]
50314 [O75952-2]
50315 [O75952-3]
50316 [O75952-4]
50317 [O75952-5]
50318 [O75952-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O75952

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O75952

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in elongating spermatids and spermatozoa (at protein level). Isoform 1 is expressed in testis. Isoform 3 and isoform 5 are also expressed in brain, pancreas and numerous brain tumors.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000154040, Expressed in sperm and 165 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O75952, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O75952, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000154040, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with FSCB (By similarity). Isoform 3 self-associates. Isoform 3 and isoform 5 interact with GSK3B. Isoform 1 does not interact with GSK3B.

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		117642, 6 interactors

Protein interaction database and analysis system

More...IntActi		O75952, 2 interactors

Molecular INTeraction database

More...MINTi		O75952

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000483621

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O75952, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O75952

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini12 – 49RIIaAdd BLAST38

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni85 – 164DisorderedSequence analysisAdd BLAST80
Regioni244 – 271DisorderedSequence analysisAdd BLAST28
Regioni330 – 354DisorderedSequence analysisAdd BLAST25
Regioni426 – 493DisorderedSequence analysisAdd BLAST68

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi99 – 114Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi149 – 163Pro residuesSequence analysisAdd BLAST15
Compositional biasi244 – 265Polar residuesSequence analysisAdd BLAST22
Compositional biasi339 – 354Polar residuesSequence analysisAdd BLAST16
Compositional biasi426 – 440Polar residuesSequence analysisAdd BLAST15

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502S1NF, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000000444

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_061187_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O75952

Identification of Orthologs from Complete Genome Data

More...OMAi		VHISSIY

Database of Orthologous Groups

More...OrthoDBi		919811at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O75952

TreeFam database of animal gene trees

More...TreeFami		TF332959

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR038848, CABYR
IPR003117, cAMP_dep_PK_reg_su_I/II_a/b

The PANTHER Classification System

More...PANTHERi		PTHR15494, PTHR15494, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02197, RIIa, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00394, RIIa, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O75952-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MISSKPRLVV PYGLKTLLEG ISRAVLKTNP SNINQFAAAY FQELTMYRGN 
        60         70         80         90        100
TTMDIKDLVK QFHQIKVEKW SEGTTPQKKL ECLKEPGKTS VESKVPTQME 
       110        120        130        140        150
KSTDTDEDNV TRTEYSDKTT QFPSVYAVPG TEQTEAVGGL SSKPATPKTT 
       160        170        180        190        200
TPPSSPPPTA VSPEFAYVPA DPAQLAAQML GKVSSIHSDQ SDVLMVDVAT 
       210        220        230        240        250
SMPVVIKEVP SSEAAEDVMV AAPLVCSGKV LEVQVVNQTS VHVDLGSQPK 
       260        270        280        290        300
ENEAEPSTAS SVPLQDEQEP PAYDQAPEVT LQADIEVMST VHISSVYNDV 
       310        320        330        340        350
PVTEGVVYIE QLPEQIVIPF TDQVACLKEN EQSKENEQSP RVSPKSVVEK 
       360        370        380        390        400
TTSGMSKKSV ESVKLAQLEE NAKYSSVYME AEATALLSDT SLKGQPEVPA 
       410        420        430        440        450
QLLDAEGAIK IGSEKSLHLE VEITSIVSDN TGQEESGENS VPQEMEGKPV 
       460        470        480        490 
LSGEAAEAVH SGTSVKSSSG PFPPAPEGLT APEIEPEGES TAE
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Length:493
Mass (Da):52,774
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i42F97605262C8199
GO
Isoform 2 (identifier: O75952-2) [UniParc]FASTAAdd to basket
Also known as: CBP86-VII

The sequence of this isoform differs from the canonical sequence as follows:
     49-66: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:475
Mass (Da):50,676
Checksum:i01D34365BEDF945B
GO
Isoform 3 (identifier: O75952-3) [UniParc]FASTAAdd to basket
Also known as: CBP86-II

The sequence of this isoform differs from the canonical sequence as follows:
     181-379: GKVSSIHSDQ...ENAKYSSVYM → AMATSERGQP...HKRRKAETEN
     380-493: Missing.

Show »
Length:379
Mass (Da):41,120
Checksum:i9E6748129EEE16E4
GO
Isoform 4 (identifier: O75952-4) [UniParc]FASTAAdd to basket
Also known as: CBP86-IV

The sequence of this isoform differs from the canonical sequence as follows:
     181-221: GKVSSIHSDQ...SEAAEDVMVA → EDVAKKSSGS...HKRRKAETEN
     222-493: Missing.

Show »
Length:221
Mass (Da):23,964
Checksum:i0C6FA78696F9BF11
GO
Isoform 5 (identifier: O75952-5) [UniParc]FASTAAdd to basket
Also known as: CBP86-III

The sequence of this isoform differs from the canonical sequence as follows:
     1-98: Missing.
     181-379: GKVSSIHSDQ...ENAKYSSVYM → AMATSERGQP...HKRRKAETEN
     380-493: Missing.

Show »
Length:281
Mass (Da):30,053
Checksum:i93966975E7AAFF08
GO
Isoform 6 (identifier: O75952-6) [UniParc]FASTAAdd to basket
Also known as: CBP86-VI

The sequence of this isoform differs from the canonical sequence as follows:
     1-201: Missing.

Show »
Length:292
Mass (Da):30,936
Checksum:iE371F64036F2AA37
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0D9SFQ2A0A0D9SFQ2_HUMAN
Calcium binding tyrosine-(Y)-phosph...
CABYR hCG_37186
395Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KTE8J3KTE8_HUMAN
Calcium-binding tyrosine phosphoryl...
CABYR
293Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G9BQT7G9BQT7_HUMAN
Calcium-binding tyrosine phosphoryl...
CABYR
196Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QLW5J3QLW5_HUMAN
Calcium-binding tyrosine phosphoryl...
CABYR
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QQK7J3QQK7_HUMAN
Calcium-binding tyrosine phosphoryl...
CABYR
36Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KT09J3KT09_HUMAN
Calcium-binding tyrosine phosphoryl...
CABYR
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KRI0J3KRI0_HUMAN
Calcium-binding tyrosine phosphoryl...
CABYR
73Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti423I → V in AAC35373 (PubMed:11820818).Curated1
Sequence conflicti423I → V in AAL56051 (PubMed:11820818).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03004074T → M. Corresponds to variant dbSNP:rs3786417Ensembl.1
Natural variantiVAR_050709186I → V. Corresponds to variant dbSNP:rs35118855Ensembl.1
Natural variantiVAR_030041448K → R1 PublicationCorresponds to variant dbSNP:rs1049682Ensembl.1
Natural variantiVAR_023818490S → A1 PublicationCorresponds to variant dbSNP:rs1049683Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0162451 – 201Missing in isoform 6. 1 PublicationAdd BLAST201
Alternative sequenceiVSP_0162461 – 98Missing in isoform 5. 1 PublicationAdd BLAST98
Alternative sequenceiVSP_01624749 – 66Missing in isoform 2. 2 PublicationsAdd BLAST18
Alternative sequenceiVSP_016248181 – 379GKVSS…SSVYM → AMATSERGQPPPCSNMWTLY CLTDKNQQGHPSPPPAPGPF PQATLYLPNPKDPQFQQHPP KVTFPTYVMGDTKKTSAPPF ILVGSNVQEAQGWKPLPGHA VVSQSDVLRYVAMQVPIAVP ADEKYQKHTLSPQNANPPSG QDVPRPKSPVFLSVAFPVED VAKKSSGSGDKCAPFGSYGI AGEVTVTTAHKRRKAETEN in isoform 3 and isoform 5. 2 PublicationsAdd BLAST199
Alternative sequenceiVSP_016249181 – 221GKVSS…DVMVA → EDVAKKSSGSGDKCAPFGSY GIAGEVTVTTAHKRRKAETE N in isoform 4. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_016250222 – 493Missing in isoform 4. 1 PublicationAdd BLAST272
Alternative sequenceiVSP_016251380 – 493Missing in isoform 3 and isoform 5. 2 PublicationsAdd BLAST114

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF088868 mRNA Translation: AAC35373.1
AF295037 mRNA Translation: AAG17889.1
AF295038 mRNA Translation: AAG17890.1
AF295039 mRNA Translation: AAG17891.1
AF329634 mRNA Translation: AAL56051.1
AY007205 mRNA Translation: AAG01891.1
AK313243 mRNA Translation: BAG36054.1
AC090772 Genomic DNA No translation available.
CH471088 Genomic DNA Translation: EAX01177.1
BC011996 mRNA Translation: AAH11996.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11881.1 [O75952-1]
CCDS11882.1 [O75952-2]
CCDS11883.1 [O75952-5]
CCDS42420.1 [O75952-3]
CCDS45840.1 [O75952-4]

NCBI Reference Sequences

More...RefSeqi		NP_036321.2, NM_012189.3 [O75952-1]
NP_619584.1, NM_138643.2 [O75952-5]
NP_619585.1, NM_138644.2 [O75952-3]
NP_722452.1, NM_153768.2 [O75952-2]
NP_722453.1, NM_153769.2 [O75952-3]
NP_722454.1, NM_153770.2 [O75952-4]
XP_016881195.1, XM_017025706.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000327201; ENSP00000317095; ENSG00000154040 [O75952-5]
ENST00000399481; ENSP00000382404; ENSG00000154040 [O75952-2]
ENST00000399496; ENSP00000382419; ENSG00000154040 [O75952-3]
ENST00000399499; ENSP00000382421; ENSG00000154040 [O75952-3]
ENST00000415309; ENSP00000399973; ENSG00000154040 [O75952-4]
ENST00000463087; ENSP00000432870; ENSG00000154040
ENST00000486759; ENSP00000431142; ENSG00000154040
ENST00000621648; ENSP00000483621; ENSG00000154040

Database of genes from NCBI RefSeq genomes

More...GeneIDi		26256

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:26256

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000399496.8; ENSP00000382419.3; NM_153769.3; NP_722453.1 [O75952-3]

UCSC genome browser

More...UCSCi		uc002kux.5, human [O75952-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF088868 mRNA Translation: AAC35373.1
AF295037 mRNA Translation: AAG17889.1
AF295038 mRNA Translation: AAG17890.1
AF295039 mRNA Translation: AAG17891.1
AF329634 mRNA Translation: AAL56051.1
AY007205 mRNA Translation: AAG01891.1
AK313243 mRNA Translation: BAG36054.1
AC090772 Genomic DNA No translation available.
CH471088 Genomic DNA Translation: EAX01177.1
BC011996 mRNA Translation: AAH11996.1
CCDSiCCDS11881.1 [O75952-1]
CCDS11882.1 [O75952-2]
CCDS11883.1 [O75952-5]
CCDS42420.1 [O75952-3]
CCDS45840.1 [O75952-4]
RefSeqiNP_036321.2, NM_012189.3 [O75952-1]
NP_619584.1, NM_138643.2 [O75952-5]
NP_619585.1, NM_138644.2 [O75952-3]
NP_722452.1, NM_153768.2 [O75952-2]
NP_722453.1, NM_153769.2 [O75952-3]
NP_722454.1, NM_153770.2 [O75952-4]
XP_016881195.1, XM_017025706.1

3D structure databases

SMRiO75952
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi117642, 6 interactors
IntActiO75952, 2 interactors
MINTiO75952
STRINGi9606.ENSP00000483621

PTM databases

iPTMnetiO75952
PhosphoSitePlusiO75952

Genetic variation databases

BioMutaiCABYR

Proteomic databases

MassIVEiO75952
MaxQBiO75952
PaxDbiO75952
PeptideAtlasiO75952
PRIDEiO75952
ProteomicsDBi50313 [O75952-1]
50314 [O75952-2]
50315 [O75952-3]
50316 [O75952-4]
50317 [O75952-5]
50318 [O75952-6]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		22085, 92 antibodies from 24 providers

The DNASU plasmid repository

More...DNASUi		26256

Genome annotation databases

EnsembliENST00000327201; ENSP00000317095; ENSG00000154040 [O75952-5]
ENST00000399481; ENSP00000382404; ENSG00000154040 [O75952-2]
ENST00000399496; ENSP00000382419; ENSG00000154040 [O75952-3]
ENST00000399499; ENSP00000382421; ENSG00000154040 [O75952-3]
ENST00000415309; ENSP00000399973; ENSG00000154040 [O75952-4]
ENST00000463087; ENSP00000432870; ENSG00000154040
ENST00000486759; ENSP00000431142; ENSG00000154040
ENST00000621648; ENSP00000483621; ENSG00000154040
GeneIDi26256
KEGGihsa:26256
MANE-SelectiENST00000399496.8; ENSP00000382419.3; NM_153769.3; NP_722453.1 [O75952-3]
UCSCiuc002kux.5, human [O75952-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		26256
DisGeNETi26256

GeneCards: human genes, protein and diseases

More...GeneCardsi		CABYR
HGNCiHGNC:15569, CABYR
HPAiENSG00000154040, Tissue enriched (testis)
MIMi612135, gene
neXtProtiNX_O75952
OpenTargetsiENSG00000154040
PharmGKBiPA26005
VEuPathDBiHostDB:ENSG00000154040

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502S1NF, Eukaryota
GeneTreeiENSGT00390000000444
HOGENOMiCLU_061187_0_0_1
InParanoidiO75952
OMAiVHISSIY
OrthoDBi919811at2759
PhylomeDBiO75952
TreeFamiTF332959

Enzyme and pathway databases

PathwayCommonsiO75952
SignaLinkiO75952
SIGNORiO75952

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		26256, 3 hits in 1042 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CABYR, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CABYR

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		26256
PharosiO75952, Tbio

Protein Ontology

More...PROi		PR:O75952
RNActiO75952, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000154040, Expressed in sperm and 165 other tissues
ExpressionAtlasiO75952, baseline and differential
GenevisibleiO75952, HS

Family and domain databases

InterProiView protein in InterPro
IPR038848, CABYR
IPR003117, cAMP_dep_PK_reg_su_I/II_a/b
PANTHERiPTHR15494, PTHR15494, 2 hits
PfamiView protein in Pfam
PF02197, RIIa, 1 hit
SMARTiView protein in SMART
SM00394, RIIa, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCABYR_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75952
Secondary accession number(s): B2R857
, Q8WXW5, Q9HAY3, Q9HAY4, Q9HAY5, Q9HCY9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: January 23, 2007
Last modified: February 23, 2022
This is version 174 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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