UniProtKB - O75952 (CABYR_HUMAN)
Calcium-binding tyrosine phosphorylation-regulated protein
CABYR
Functioni
May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction. Isoform 1 binds calcium in vitro. Isoform 2 and isoform 6 probably bind calcium. Isoform 3 and isoform 5 do not bind calcium in vitro. Isoform 4 probably does not bind calcium.
GO - Molecular functioni
- calcium ion binding Source: BHF-UCL
- enzyme binding Source: BHF-UCL
- SH3 domain binding Source: BHF-UCL
GO - Biological processi
- epithelial cilium movement involved in extracellular fluid movement Source: BHF-UCL
- sperm capacitation Source: BHF-UCL
Keywordsi
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | O75952 |
SignaLinki | O75952 |
SIGNORi | O75952 |
Names & Taxonomyi
Protein namesi | Recommended name: Calcium-binding tyrosine phosphorylation-regulated proteinAlternative name(s): Calcium-binding protein 86 Cancer/testis antigen 88 Short name: CT88 Fibrousheathin II Fibrousheathin-2 Short name: FSP-2 Testis-specific calcium-binding protein CBP86 |
Gene namesi | Name:CABYR Synonyms:CBP86, FSP2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15569, CABYR |
MIMi | 612135, gene |
neXtProti | NX_O75952 |
VEuPathDBi | HostDB:ENSG00000154040 |
Subcellular locationi
Cytoskeleton
Other locations
Note: Localized to fibrous sheath including the surface of the longitudinal columns and ribs of the principal piece of sperm flagella.
Cytoskeleton
- cytoskeleton Source: UniProtKB-SubCell
Cytosol
- cytosol Source: HPA
Extracellular region or secreted
- extracellular region Source: GOC
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: BHF-UCL
- motile cilium Source: BHF-UCL
- sperm fibrous sheath Source: BHF-UCL
Keywords - Cellular componenti
Cell projection, Cilium, Cytoplasm, Cytoskeleton, Flagellum, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 146 | T → A: Does not affect phosphorylation. 1 Publication | 1 | |
Mutagenesisi | 151 | T → A: Decreases phosphorylation. Abolishes phosphorylation; when associated with A-155. 1 Publication | 1 | |
Mutagenesisi | 154 | S → A: Does not affect phosphorylation. Does not affect phosphorylation; when associated with A-159. 1 Publication | 1 | |
Mutagenesisi | 155 | S → A: Decreases phosphorylation and interaction with GSK3B. Abolishes phosphorylation and decreases interaction with GSK3B; when associated with A-151. 1 Publication | 1 | |
Mutagenesisi | 159 | T → A: Does not affect phosphorylation. Does not affect phosphorylation; when associated with A-154. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 26256 |
OpenTargetsi | ENSG00000154040 |
PharmGKBi | PA26005 |
Miscellaneous databases
Pharosi | O75952, Tbio |
Genetic variation databases
BioMutai | CABYR |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000089268 | 1 – 493 | Calcium-binding tyrosine phosphorylation-regulated proteinAdd BLAST | 493 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 151 | Phosphothreonine1 Publication | 1 | |
Modified residuei | 155 | Phosphoserine1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
MassIVEi | O75952 |
MaxQBi | O75952 |
PaxDbi | O75952 |
PeptideAtlasi | O75952 |
PRIDEi | O75952 |
ProteomicsDBi | 50313 [O75952-1] 50314 [O75952-2] 50315 [O75952-3] 50316 [O75952-4] 50317 [O75952-5] 50318 [O75952-6] |
PTM databases
iPTMneti | O75952 |
PhosphoSitePlusi | O75952 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000154040, Expressed in sperm and 165 other tissues |
ExpressionAtlasi | O75952, baseline and differential |
Genevisiblei | O75952, HS |
Organism-specific databases
HPAi | ENSG00000154040, Tissue enriched (testis) |
Interactioni
Subunit structurei
Interacts with FSCB (By similarity). Isoform 3 self-associates. Isoform 3 and isoform 5 interact with GSK3B. Isoform 1 does not interact with GSK3B.
By similarity1 PublicationBinary interactionsi
Isoform 3 [O75952-3]
With | #Exp. | IntAct |
---|---|---|
GSK3B [P49841] | 3 | EBI-10900795,EBI-373586 |
Isoform 5 [O75952-5]
With | #Exp. | IntAct |
---|---|---|
GSK3B [P49841] | 3 | EBI-10898671,EBI-373586 |
GO - Molecular functioni
- enzyme binding Source: BHF-UCL
- SH3 domain binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 117642, 6 interactors |
IntActi | O75952, 2 interactors |
MINTi | O75952 |
STRINGi | 9606.ENSP00000483621 |
Miscellaneous databases
RNActi | O75952, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 12 – 49 | RIIaAdd BLAST | 38 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 85 – 164 | DisorderedSequence analysisAdd BLAST | 80 | |
Regioni | 244 – 271 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 330 – 354 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 426 – 493 | DisorderedSequence analysisAdd BLAST | 68 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 99 – 114 | Basic and acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 149 – 163 | Pro residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 244 – 265 | Polar residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 339 – 354 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 426 – 440 | Polar residuesSequence analysisAdd BLAST | 15 |
Phylogenomic databases
eggNOGi | ENOG502S1NF, Eukaryota |
GeneTreei | ENSGT00390000000444 |
HOGENOMi | CLU_061187_0_0_1 |
InParanoidi | O75952 |
OMAi | VHISSIY |
OrthoDBi | 919811at2759 |
PhylomeDBi | O75952 |
TreeFami | TF332959 |
Family and domain databases
InterProi | View protein in InterPro IPR038848, CABYR IPR003117, cAMP_dep_PK_reg_su_I/II_a/b |
PANTHERi | PTHR15494, PTHR15494, 2 hits |
Pfami | View protein in Pfam PF02197, RIIa, 1 hit |
SMARTi | View protein in SMART SM00394, RIIa, 1 hit |
s (6+)i Sequence
Sequence statusi: Complete.
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 6 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MISSKPRLVV PYGLKTLLEG ISRAVLKTNP SNINQFAAAY FQELTMYRGN
60 70 80 90 100
TTMDIKDLVK QFHQIKVEKW SEGTTPQKKL ECLKEPGKTS VESKVPTQME
110 120 130 140 150
KSTDTDEDNV TRTEYSDKTT QFPSVYAVPG TEQTEAVGGL SSKPATPKTT
160 170 180 190 200
TPPSSPPPTA VSPEFAYVPA DPAQLAAQML GKVSSIHSDQ SDVLMVDVAT
210 220 230 240 250
SMPVVIKEVP SSEAAEDVMV AAPLVCSGKV LEVQVVNQTS VHVDLGSQPK
260 270 280 290 300
ENEAEPSTAS SVPLQDEQEP PAYDQAPEVT LQADIEVMST VHISSVYNDV
310 320 330 340 350
PVTEGVVYIE QLPEQIVIPF TDQVACLKEN EQSKENEQSP RVSPKSVVEK
360 370 380 390 400
TTSGMSKKSV ESVKLAQLEE NAKYSSVYME AEATALLSDT SLKGQPEVPA
410 420 430 440 450
QLLDAEGAIK IGSEKSLHLE VEITSIVSDN TGQEESGENS VPQEMEGKPV
460 470 480 490
LSGEAAEAVH SGTSVKSSSG PFPPAPEGLT APEIEPEGES TAE
The sequence of this isoform differs from the canonical sequence as follows:
49-66: Missing.
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0D9SFQ2 | A0A0D9SFQ2_HUMAN | Calcium binding tyrosine-(Y)-phosph... | CABYR hCG_37186 | 395 | Annotation score: | ||
J3KTE8 | J3KTE8_HUMAN | Calcium-binding tyrosine phosphoryl... | CABYR | 293 | Annotation score: | ||
G9BQT7 | G9BQT7_HUMAN | Calcium-binding tyrosine phosphoryl... | CABYR | 196 | Annotation score: | ||
J3QLW5 | J3QLW5_HUMAN | Calcium-binding tyrosine phosphoryl... | CABYR | 46 | Annotation score: | ||
J3QQK7 | J3QQK7_HUMAN | Calcium-binding tyrosine phosphoryl... | CABYR | 36 | Annotation score: | ||
J3KT09 | J3KT09_HUMAN | Calcium-binding tyrosine phosphoryl... | CABYR | 84 | Annotation score: | ||
J3KRI0 | J3KRI0_HUMAN | Calcium-binding tyrosine phosphoryl... | CABYR | 73 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 423 | I → V in AAC35373 (PubMed:11820818).Curated | 1 | |
Sequence conflicti | 423 | I → V in AAL56051 (PubMed:11820818).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_030040 | 74 | T → M. Corresponds to variant dbSNP:rs3786417Ensembl. | 1 | |
Natural variantiVAR_050709 | 186 | I → V. Corresponds to variant dbSNP:rs35118855Ensembl. | 1 | |
Natural variantiVAR_030041 | 448 | K → R1 PublicationCorresponds to variant dbSNP:rs1049682Ensembl. | 1 | |
Natural variantiVAR_023818 | 490 | S → A1 PublicationCorresponds to variant dbSNP:rs1049683Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_016245 | 1 – 201 | Missing in isoform 6. 1 PublicationAdd BLAST | 201 | |
Alternative sequenceiVSP_016246 | 1 – 98 | Missing in isoform 5. 1 PublicationAdd BLAST | 98 | |
Alternative sequenceiVSP_016247 | 49 – 66 | Missing in isoform 2. 2 PublicationsAdd BLAST | 18 | |
Alternative sequenceiVSP_016248 | 181 – 379 | GKVSS…SSVYM → AMATSERGQPPPCSNMWTLY CLTDKNQQGHPSPPPAPGPF PQATLYLPNPKDPQFQQHPP KVTFPTYVMGDTKKTSAPPF ILVGSNVQEAQGWKPLPGHA VVSQSDVLRYVAMQVPIAVP ADEKYQKHTLSPQNANPPSG QDVPRPKSPVFLSVAFPVED VAKKSSGSGDKCAPFGSYGI AGEVTVTTAHKRRKAETEN in isoform 3 and isoform 5. 2 PublicationsAdd BLAST | 199 | |
Alternative sequenceiVSP_016249 | 181 – 221 | GKVSS…DVMVA → EDVAKKSSGSGDKCAPFGSY GIAGEVTVTTAHKRRKAETE N in isoform 4. 1 PublicationAdd BLAST | 41 | |
Alternative sequenceiVSP_016250 | 222 – 493 | Missing in isoform 4. 1 PublicationAdd BLAST | 272 | |
Alternative sequenceiVSP_016251 | 380 – 493 | Missing in isoform 3 and isoform 5. 2 PublicationsAdd BLAST | 114 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF088868 mRNA Translation: AAC35373.1 AF295037 mRNA Translation: AAG17889.1 AF295038 mRNA Translation: AAG17890.1 AF295039 mRNA Translation: AAG17891.1 AF329634 mRNA Translation: AAL56051.1 AY007205 mRNA Translation: AAG01891.1 AK313243 mRNA Translation: BAG36054.1 AC090772 Genomic DNA No translation available. CH471088 Genomic DNA Translation: EAX01177.1 BC011996 mRNA Translation: AAH11996.1 |
CCDSi | CCDS11881.1 [O75952-1] CCDS11882.1 [O75952-2] CCDS11883.1 [O75952-5] CCDS42420.1 [O75952-3] CCDS45840.1 [O75952-4] |
RefSeqi | NP_036321.2, NM_012189.3 [O75952-1] NP_619584.1, NM_138643.2 [O75952-5] NP_619585.1, NM_138644.2 [O75952-3] NP_722452.1, NM_153768.2 [O75952-2] NP_722453.1, NM_153769.2 [O75952-3] NP_722454.1, NM_153770.2 [O75952-4] XP_016881195.1, XM_017025706.1 |
Genome annotation databases
Ensembli | ENST00000327201; ENSP00000317095; ENSG00000154040 [O75952-5] ENST00000399481; ENSP00000382404; ENSG00000154040 [O75952-2] ENST00000399496; ENSP00000382419; ENSG00000154040 [O75952-3] ENST00000399499; ENSP00000382421; ENSG00000154040 [O75952-3] ENST00000415309; ENSP00000399973; ENSG00000154040 [O75952-4] ENST00000463087; ENSP00000432870; ENSG00000154040 ENST00000486759; ENSP00000431142; ENSG00000154040 ENST00000621648; ENSP00000483621; ENSG00000154040 |
GeneIDi | 26256 |
KEGGi | hsa:26256 |
MANE-Selecti | ENST00000399496.8; ENSP00000382419.3; NM_153769.3; NP_722453.1 [O75952-3] |
UCSCi | uc002kux.5, human [O75952-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF088868 mRNA Translation: AAC35373.1 AF295037 mRNA Translation: AAG17889.1 AF295038 mRNA Translation: AAG17890.1 AF295039 mRNA Translation: AAG17891.1 AF329634 mRNA Translation: AAL56051.1 AY007205 mRNA Translation: AAG01891.1 AK313243 mRNA Translation: BAG36054.1 AC090772 Genomic DNA No translation available. CH471088 Genomic DNA Translation: EAX01177.1 BC011996 mRNA Translation: AAH11996.1 |
CCDSi | CCDS11881.1 [O75952-1] CCDS11882.1 [O75952-2] CCDS11883.1 [O75952-5] CCDS42420.1 [O75952-3] CCDS45840.1 [O75952-4] |
RefSeqi | NP_036321.2, NM_012189.3 [O75952-1] NP_619584.1, NM_138643.2 [O75952-5] NP_619585.1, NM_138644.2 [O75952-3] NP_722452.1, NM_153768.2 [O75952-2] NP_722453.1, NM_153769.2 [O75952-3] NP_722454.1, NM_153770.2 [O75952-4] XP_016881195.1, XM_017025706.1 |
3D structure databases
SMRi | O75952 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 117642, 6 interactors |
IntActi | O75952, 2 interactors |
MINTi | O75952 |
STRINGi | 9606.ENSP00000483621 |
PTM databases
iPTMneti | O75952 |
PhosphoSitePlusi | O75952 |
Genetic variation databases
BioMutai | CABYR |
Proteomic databases
MassIVEi | O75952 |
MaxQBi | O75952 |
PaxDbi | O75952 |
PeptideAtlasi | O75952 |
PRIDEi | O75952 |
ProteomicsDBi | 50313 [O75952-1] 50314 [O75952-2] 50315 [O75952-3] 50316 [O75952-4] 50317 [O75952-5] 50318 [O75952-6] |
Protocols and materials databases
Antibodypediai | 22085, 92 antibodies from 24 providers |
DNASUi | 26256 |
Genome annotation databases
Organism-specific databases
CTDi | 26256 |
DisGeNETi | 26256 |
GeneCardsi | CABYR |
HGNCi | HGNC:15569, CABYR |
HPAi | ENSG00000154040, Tissue enriched (testis) |
MIMi | 612135, gene |
neXtProti | NX_O75952 |
OpenTargetsi | ENSG00000154040 |
PharmGKBi | PA26005 |
VEuPathDBi | HostDB:ENSG00000154040 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S1NF, Eukaryota |
GeneTreei | ENSGT00390000000444 |
HOGENOMi | CLU_061187_0_0_1 |
InParanoidi | O75952 |
OMAi | VHISSIY |
OrthoDBi | 919811at2759 |
PhylomeDBi | O75952 |
TreeFami | TF332959 |
Enzyme and pathway databases
PathwayCommonsi | O75952 |
SignaLinki | O75952 |
SIGNORi | O75952 |
Miscellaneous databases
BioGRID-ORCSi | 26256, 3 hits in 1042 CRISPR screens |
ChiTaRSi | CABYR, human |
GeneWikii | CABYR |
GenomeRNAii | 26256 |
Pharosi | O75952, Tbio |
PROi | PR:O75952 |
RNActi | O75952, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000154040, Expressed in sperm and 165 other tissues |
ExpressionAtlasi | O75952, baseline and differential |
Genevisiblei | O75952, HS |
Family and domain databases
InterProi | View protein in InterPro IPR038848, CABYR IPR003117, cAMP_dep_PK_reg_su_I/II_a/b |
PANTHERi | PTHR15494, PTHR15494, 2 hits |
Pfami | View protein in Pfam PF02197, RIIa, 1 hit |
SMARTi | View protein in SMART SM00394, RIIa, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CABYR_HUMAN | |
Accessioni | O75952Primary (citable) accession number: O75952 Secondary accession number(s): B2R857 Q9HCY9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 22, 2005 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 23, 2022 | |
This is version 174 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot