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Entry version 168 (13 Feb 2019)
Sequence version 2 (29 Mar 2005)
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Protein

Cell cycle checkpoint protein RAD17

Gene

RAD17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the RAD1-RAD9-HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination.11 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi137 – 144ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • chromatin binding Source: GO_Central
  • DNA clamp loader activity Source: InterPro

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, DNA damage
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-176187 Activation of ATR in response to replication stress
R-HSA-5685938 HDR through Single Strand Annealing (SSA)
R-HSA-5693607 Processing of DNA double-strand break ends
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-69473 G2/M DNA damage checkpoint

SIGNOR Signaling Network Open Resource

More...
SIGNORi
O75943

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cell cycle checkpoint protein RAD17
Short name:
hRad17
Alternative name(s):
RF-C/activator 1 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RAD17
Synonyms:R24L
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000152942.18

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9807 RAD17

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603139 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O75943

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi143K → E: Impairs phosphorylation on S-656. Abolishes interaction with the RAD1-RAD9-HUS1 complex; does not affect interaction with RFC3. 3 Publications1
Mutagenesisi143K → G: Impairs phosphorylation. Impairs interaction with DNA and the RAD1-RAD9-HUS1 complex; does not affect interaction with RFC3. 3 Publications1
Mutagenesisi191S → A: No effect on phosphorylation by ATR. 1 Publication1
Mutagenesisi646S → A: Reduces by 50% phosphorylation by ATR, and abolishes interaction with RAD1. Abolishes phosphorylation by ATR and checkpoint activation without affecting interaction with RFC3, RFC4, ATM or ATR; when associated with A-656. 4 Publications1
Mutagenesisi646S → D: Abolishes interaction with RAD1; when associated with D-656. 4 Publications1
Mutagenesisi656S → A: Reduces by 50% phosphorylation by ATR, and abolishes interaction with RAD1. Abolishes phosphorylation by ATR and checkpoint activation without affecting interaction with RFC3, RFC4, ATM or ATR; when associated with A-646. 4 Publications1
Mutagenesisi656S → D: Abolishes interaction with RAD1; when associated with D-646. 4 Publications1

Organism-specific databases

DisGeNET

More...
DisGeNETi
5884

Open Targets

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OpenTargetsi
ENSG00000152942

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA34167

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RAD17

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002099481 – 681Cell cycle checkpoint protein RAD17Add BLAST681

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei55PhosphothreonineBy similarity1
Modified residuei71PhosphoserineCombined sources1
Modified residuei86PhosphoserineCombined sources1
Modified residuei359PhosphoserineCombined sources1
Modified residuei646Phosphoserine; by ATR and ATM4 Publications1
Modified residuei656Phosphoserine; by ATR and ATM3 Publications1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated. Phosphorylation on Ser-646 and Ser-656 is cell cycle-regulated, enhanced by genotoxic stress, and required for activation of checkpoint signaling. Phosphorylation is mediated by ATR upon UV or replication arrest, whereas it may be mediated both by ATR and ATM upon ionizing radiation. Phosphorylation on both sites is required for interaction with RAD1 but dispensable for interaction with RFC3 or RFC4.5 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O75943

MaxQB - The MaxQuant DataBase

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MaxQBi
O75943

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O75943

PeptideAtlas

More...
PeptideAtlasi
O75943

PRoteomics IDEntifications database

More...
PRIDEi
O75943

ProteomicsDB human proteome resource

More...
ProteomicsDBi
50304
50305 [O75943-2]
50306 [O75943-3]
50307 [O75943-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O75943

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O75943

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Overexpressed in various cancer cell lines and in colon carcinoma (at protein level). Isoform 2 and isoform 3 are the most abundant isoforms in non irradiated cells (at protein level). Ubiquitous at low levels. Highly expressed in testis, where it is expressed within the germinal epithelium of the seminiferous tubuli. Weakly expressed in seminomas (testicular tumors).5 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Isoform 1, isoform 3 and isoform 4 are induced by X-ray irradiation.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000152942 Expressed in 234 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O75943 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O75943 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB004551
HPA005448

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of a DNA-binding complex containing RFC2, RFC3, RFC4 and RFC5. Interacts with RAD1 and RAD9 within the RAD1-RAD9-HUS1 complex. Interacts with RAD9B, POLE, SNU13 and MCM7. DNA damage promotes interaction with ATR or ATM and disrupts interaction with the RAD1-RAD9-HUS1 complex.13 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111821, 33 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
O75943

Database of interacting proteins

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DIPi
DIP-24254N
DIP-34896N

Protein interaction database and analysis system

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IntActi
O75943, 16 interactors

Molecular INTeraction database

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MINTi
O75943

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000370151

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O75943

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni432 – 681Interaction with MCM71 PublicationAdd BLAST250

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the rad17/RAD24 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1970 Eukaryota
COG0470 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00440000039046

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG059834

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O75943

KEGG Orthology (KO)

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KOi
K06662

Identification of Orthologs from Complete Genome Data

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OMAi
AQIAFIQ

Database of Orthologous Groups

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OrthoDBi
674169at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O75943

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004582 Checkpoint_prot_Rad17_Rad24
IPR027417 P-loop_NTPase
IPR018324 Rad17/Rad24_fun/met

The PANTHER Classification System

More...
PANTHERi
PTHR12172 PTHR12172, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00602 rad24, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O75943-1) [UniParc]FASTAAdd to basket
Also known as: Rad17Sp, FM2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSKTFLRPKV SSTKVTDWVD PSFDDFLECS GVSTITATSL GVNNSSHRRK
60 70 80 90 100
NGPSTLESSR FPARKRGNLS SLEQIYGLEN SKEYLSENEP WVDKYKPETQ
110 120 130 140 150
HELAVHKKKI EEVETWLKAQ VLERQPKQGG SILLITGPPG CGKTTTLKIL
160 170 180 190 200
SKEHGIQVQE WINPVLPDFQ KDDFKGMFNT ESSFHMFPYQ SQIAVFKEFL
210 220 230 240 250
LRATKYNKLQ MLGDDLRTDK KIILVEDLPN QFYRDSHTLH EVLRKYVRIG
260 270 280 290 300
RCPLIFIISD SLSGDNNQRL LFPKEIQEEC SISNISFNPV APTIMMKFLN
310 320 330 340 350
RIVTIEANKN GGKITVPDKT SLELLCQGCS GDIRSAINSL QFSSSKGENN
360 370 380 390 400
LRPRKKGMSL KSDAVLSKSK RRKKPDRVFE NQEVQAIGGK DVSLFLFRAL
410 420 430 440 450
GKILYCKRAS LTELDSPRLP SHLSEYERDT LLVEPEEVVE MSHMPGDLFN
460 470 480 490 500
LYLHQNYIDF FMEIDDIVRA SEFLSFADIL SGDWNTRSLL REYSTSIATR
510 520 530 540 550
GVMHSNKARG YAHCQGGGSS FRPLHKPQWF LINKKYRENC LAAKALFPDF
560 570 580 590 600
CLPALCLQTQ LLPYLALLTI PMRNQAQISF IQDIGRLPLK RHFGRLKMEA
610 620 630 640 650
LTDREHGMID PDSGDEAQLN GGHSAEESLG EPTQATVPET WSLPLSQNSA
660 670 680
SELPASQPQP FSAQGDMEEN IIIEDYESDG T
Length:681
Mass (Da):77,055
Last modified:March 29, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i796C2BD48F7995A3
GO
Isoform 2 (identifier: O75943-2) [UniParc]FASTAAdd to basket
Also known as: Rad17Sp2, FM1

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MSKTFLRPKVSSTK → MNQ

Show »
Length:670
Mass (Da):75,836
Checksum:i2C8053B065996228
GO
Isoform 3 (identifier: O75943-3) [UniParc]FASTAAdd to basket
Also known as: FM3

The sequence of this isoform differs from the canonical sequence as follows:
     1-176: Missing.

Show »
Length:505
Mass (Da):57,244
Checksum:i3F873BE5F9EF5F85
GO
Isoform 4 (identifier: O75943-4) [UniParc]FASTAAdd to basket
Also known as: FM4

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: Missing.
     98-99: ET → MN

Show »
Length:584
Mass (Da):66,156
Checksum:i54FE8CE0D06C1971
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JP78A0A0G2JP78_HUMAN
Cell cycle checkpoint protein RAD17
RAD17
584Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JPT5A0A0G2JPT5_HUMAN
Cell cycle checkpoint protein RAD17
RAD17
681Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JNH5A0A0G2JNH5_HUMAN
Cell cycle checkpoint protein RAD17
RAD17
505Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y9T7H0Y9T7_HUMAN
Cell cycle checkpoint protein RAD17
RAD17
184Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y9J8H0Y9J8_HUMAN
Cell cycle checkpoint protein RAD17
RAD17
165Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RAW6D6RAW6_HUMAN
Cell cycle checkpoint protein RAD17
RAD17
169Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JP31A0A0G2JP31_HUMAN
Cell cycle checkpoint protein RAD17
RAD17
184Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RHU1D6RHU1_HUMAN
Cell cycle checkpoint protein RAD17
RAD17
50Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RA84D6RA84_HUMAN
Cell cycle checkpoint protein RAD17
RAD17
20Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti75I → V in CAD97683 (PubMed:17974005).Curated1
Sequence conflicti187F → L in AAC36334 (PubMed:9933569).Curated1
Sequence conflicti194A → S in AAD01620 (PubMed:10208430).Curated1
Sequence conflicti340L → P in AAC36334 (PubMed:9933569).Curated1
Sequence conflicti445P → S in AAC36334 (PubMed:9933569).Curated1
Sequence conflicti462M → T in AAC36334 (PubMed:9933569).Curated1
Sequence conflicti648N → D in AAC36334 (PubMed:9933569).Curated1
Sequence conflicti672I → M in AAC36334 (PubMed:9933569).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02157432V → I1 PublicationCorresponds to variant dbSNP:rs17229831Ensembl.1
Natural variantiVAR_021575487R → L1 PublicationCorresponds to variant dbSNP:rs17236478Ensembl.1
Natural variantiVAR_021576535K → E1 PublicationCorresponds to variant dbSNP:rs17236485Ensembl.1
Natural variantiVAR_021577557L → R3 PublicationsCorresponds to variant dbSNP:rs1045051Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0133061 – 176Missing in isoform 3. 1 PublicationAdd BLAST176
Alternative sequenceiVSP_0133071 – 97Missing in isoform 4. 1 PublicationAdd BLAST97
Alternative sequenceiVSP_0133081 – 14MSKTF…VSSTK → MNQ in isoform 2. 11 PublicationsAdd BLAST14
Alternative sequenceiVSP_01330998 – 99ET → MN in isoform 4. 1 Publication2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF076838 mRNA Translation: AAC95520.1
AJ004977 mRNA Translation: CAA06251.1
AF112263 mRNA Translation: AAD38878.1
AF085736 mRNA Translation: AAC36334.1
AJ001642 mRNA Translation: CAA04894.1
AJ131296
, AJ131297, AJ131298, AJ131299, AJ131300, AJ131301, AJ131302, AJ131303, AJ131304, AJ131305, AJ131306, AJ131307, AJ131308 Genomic DNA Translation: CAB46364.1
AF017748 mRNA Translation: AAD01620.1
AF126424 mRNA Translation: AAD17334.1
AF098533 mRNA Translation: AAC97950.1
AF098534 mRNA Translation: AAC97951.1
AL122068 mRNA Translation: CAB59244.1
AK292487 mRNA Translation: BAF85176.1
BX537441 mRNA Translation: CAD97683.1
AY612854 Genomic DNA Translation: AAT09763.1
CH471137 Genomic DNA Translation: EAW51283.1
CH471137 Genomic DNA Translation: EAW51284.1
CH471137 Genomic DNA Translation: EAW51285.1
CH471137 Genomic DNA Translation: EAW51286.1
CH471137 Genomic DNA Translation: EAW51288.1
BC032304 mRNA Translation: AAH32304.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4003.1 [O75943-1]
CCDS4004.1 [O75943-2]
CCDS4005.1 [O75943-4]
CCDS47226.1 [O75943-3]

Protein sequence database of the Protein Information Resource

More...
PIRi
T34548

NCBI Reference Sequences

More...
RefSeqi
NP_001265551.1, NM_001278622.1 [O75943-2]
NP_002864.1, NM_002873.1 [O75943-2]
NP_579916.1, NM_133338.2 [O75943-2]
NP_579917.1, NM_133339.2 [O75943-1]
NP_579918.1, NM_133340.2 [O75943-3]
NP_579919.1, NM_133341.2 [O75943-4]
NP_579920.1, NM_133342.2 [O75943-2]
NP_579921.1, NM_133343.1 [O75943-2]
NP_579922.1, NM_133344.2 [O75943-2]
XP_016865168.1, XM_017009679.1
XP_016865169.1, XM_017009680.1
XP_016865170.1, XM_017009681.1 [O75943-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.16184

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000282891; ENSP00000282891; ENSG00000152942 [O75943-4]
ENST00000305138; ENSP00000303134; ENSG00000152942 [O75943-2]
ENST00000345306; ENSP00000311227; ENSG00000152942 [O75943-2]
ENST00000354312; ENSP00000346271; ENSG00000152942 [O75943-2]
ENST00000354868; ENSP00000346938; ENSG00000152942 [O75943-2]
ENST00000358030; ENSP00000350725; ENSG00000152942 [O75943-3]
ENST00000361732; ENSP00000355226; ENSG00000152942 [O75943-2]
ENST00000380774; ENSP00000370151; ENSG00000152942 [O75943-1]
ENST00000509734; ENSP00000426191; ENSG00000152942 [O75943-1]
ENST00000521422; ENSP00000427743; ENSG00000152942 [O75943-3]
ENST00000610770; ENSP00000478167; ENSG00000276618
ENST00000611523; ENSP00000477962; ENSG00000276618
ENST00000612044; ENSP00000477996; ENSG00000276618
ENST00000616488; ENSP00000484854; ENSG00000276618
ENST00000616683; ENSP00000482775; ENSG00000152942 [O75943-2]
ENST00000616759; ENSP00000479160; ENSG00000276618
ENST00000620889; ENSP00000482371; ENSG00000276618

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5884

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5884

UCSC genome browser

More...
UCSCi
uc003jwg.4 human [O75943-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF076838 mRNA Translation: AAC95520.1
AJ004977 mRNA Translation: CAA06251.1
AF112263 mRNA Translation: AAD38878.1
AF085736 mRNA Translation: AAC36334.1
AJ001642 mRNA Translation: CAA04894.1
AJ131296
, AJ131297, AJ131298, AJ131299, AJ131300, AJ131301, AJ131302, AJ131303, AJ131304, AJ131305, AJ131306, AJ131307, AJ131308 Genomic DNA Translation: CAB46364.1
AF017748 mRNA Translation: AAD01620.1
AF126424 mRNA Translation: AAD17334.1
AF098533 mRNA Translation: AAC97950.1
AF098534 mRNA Translation: AAC97951.1
AL122068 mRNA Translation: CAB59244.1
AK292487 mRNA Translation: BAF85176.1
BX537441 mRNA Translation: CAD97683.1
AY612854 Genomic DNA Translation: AAT09763.1
CH471137 Genomic DNA Translation: EAW51283.1
CH471137 Genomic DNA Translation: EAW51284.1
CH471137 Genomic DNA Translation: EAW51285.1
CH471137 Genomic DNA Translation: EAW51286.1
CH471137 Genomic DNA Translation: EAW51288.1
BC032304 mRNA Translation: AAH32304.1
CCDSiCCDS4003.1 [O75943-1]
CCDS4004.1 [O75943-2]
CCDS4005.1 [O75943-4]
CCDS47226.1 [O75943-3]
PIRiT34548
RefSeqiNP_001265551.1, NM_001278622.1 [O75943-2]
NP_002864.1, NM_002873.1 [O75943-2]
NP_579916.1, NM_133338.2 [O75943-2]
NP_579917.1, NM_133339.2 [O75943-1]
NP_579918.1, NM_133340.2 [O75943-3]
NP_579919.1, NM_133341.2 [O75943-4]
NP_579920.1, NM_133342.2 [O75943-2]
NP_579921.1, NM_133343.1 [O75943-2]
NP_579922.1, NM_133344.2 [O75943-2]
XP_016865168.1, XM_017009679.1
XP_016865169.1, XM_017009680.1
XP_016865170.1, XM_017009681.1 [O75943-2]
UniGeneiHs.16184

3D structure databases

ProteinModelPortaliO75943
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111821, 33 interactors
CORUMiO75943
DIPiDIP-24254N
DIP-34896N
IntActiO75943, 16 interactors
MINTiO75943
STRINGi9606.ENSP00000370151

PTM databases

iPTMnetiO75943
PhosphoSitePlusiO75943

Polymorphism and mutation databases

BioMutaiRAD17

Proteomic databases

jPOSTiO75943
MaxQBiO75943
PaxDbiO75943
PeptideAtlasiO75943
PRIDEiO75943
ProteomicsDBi50304
50305 [O75943-2]
50306 [O75943-3]
50307 [O75943-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
5884
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000282891; ENSP00000282891; ENSG00000152942 [O75943-4]
ENST00000305138; ENSP00000303134; ENSG00000152942 [O75943-2]
ENST00000345306; ENSP00000311227; ENSG00000152942 [O75943-2]
ENST00000354312; ENSP00000346271; ENSG00000152942 [O75943-2]
ENST00000354868; ENSP00000346938; ENSG00000152942 [O75943-2]
ENST00000358030; ENSP00000350725; ENSG00000152942 [O75943-3]
ENST00000361732; ENSP00000355226; ENSG00000152942 [O75943-2]
ENST00000380774; ENSP00000370151; ENSG00000152942 [O75943-1]
ENST00000509734; ENSP00000426191; ENSG00000152942 [O75943-1]
ENST00000521422; ENSP00000427743; ENSG00000152942 [O75943-3]
ENST00000610770; ENSP00000478167; ENSG00000276618
ENST00000611523; ENSP00000477962; ENSG00000276618
ENST00000612044; ENSP00000477996; ENSG00000276618
ENST00000616488; ENSP00000484854; ENSG00000276618
ENST00000616683; ENSP00000482775; ENSG00000152942 [O75943-2]
ENST00000616759; ENSP00000479160; ENSG00000276618
ENST00000620889; ENSP00000482371; ENSG00000276618
GeneIDi5884
KEGGihsa:5884
UCSCiuc003jwg.4 human [O75943-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5884
DisGeNETi5884
EuPathDBiHostDB:ENSG00000152942.18

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RAD17
HGNCiHGNC:9807 RAD17
HPAiCAB004551
HPA005448
MIMi603139 gene
neXtProtiNX_O75943
OpenTargetsiENSG00000152942
PharmGKBiPA34167

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1970 Eukaryota
COG0470 LUCA
GeneTreeiENSGT00440000039046
HOVERGENiHBG059834
InParanoidiO75943
KOiK06662
OMAiAQIAFIQ
OrthoDBi674169at2759
PhylomeDBiO75943

Enzyme and pathway databases

ReactomeiR-HSA-176187 Activation of ATR in response to replication stress
R-HSA-5685938 HDR through Single Strand Annealing (SSA)
R-HSA-5693607 Processing of DNA double-strand break ends
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-69473 G2/M DNA damage checkpoint
SIGNORiO75943

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
RAD17 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
RAD17

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5884

Protein Ontology

More...
PROi
PR:O75943

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000152942 Expressed in 234 organ(s), highest expression level in testis
ExpressionAtlasiO75943 baseline and differential
GenevisibleiO75943 HS

Family and domain databases

InterProiView protein in InterPro
IPR004582 Checkpoint_prot_Rad17_Rad24
IPR027417 P-loop_NTPase
IPR018324 Rad17/Rad24_fun/met
PANTHERiPTHR12172 PTHR12172, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00602 rad24, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRAD17_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75943
Secondary accession number(s): A8K8X2
, D3DWA5, O75714, Q7Z3S4, Q9UNK7, Q9UNR7, Q9UNR8, Q9UPF5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: March 29, 2005
Last modified: February 13, 2019
This is version 168 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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