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Protein

DnaJ homolog subfamily C member 8

Gene

DNAJC8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Suppresses polyglutamine (polyQ) aggregation of ATXN3 in neuronal cells (PubMed:27133716).1 Publication

GO - Molecular functioni

  • Hsp70 protein binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily C member 8
Alternative name(s):
Splicing protein spf31
Gene namesi
Name:DNAJC8
Synonyms:SPF31
ORF Names:HSPC315, HSPC331
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000126698.10
HGNCiHGNC:15470 DNAJC8
neXtProtiNX_O75937

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi22826
OpenTargetsiENSG00000126698
PharmGKBiPA27425

Polymorphism and mutation databases

BioMutaiDNAJC8

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000710602 – 253DnaJ homolog subfamily C member 8Add BLAST252

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei35PhosphoserineCombined sources1
Modified residuei146N6-acetyllysineCombined sources1
Modified residuei222PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO75937
MaxQBiO75937
PaxDbiO75937
PeptideAtlasiO75937
PRIDEiO75937
ProteomicsDBi50302
TopDownProteomicsiO75937

PTM databases

iPTMnetiO75937
PhosphoSitePlusiO75937

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000126698
CleanExiHS_DNAJC8
ExpressionAtlasiO75937 baseline and differential
GenevisibleiO75937 HS

Organism-specific databases

HPAiHPA026275
HPA026283

Interactioni

Subunit structurei

Interacts with SRPK1 (PubMed:19240134). Interacts with HSP70 (HSPA1A or HSPA1B) (PubMed:27133716).2 Publications

GO - Molecular functioni

  • Hsp70 protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi116501, 53 interactors
CORUMiO75937
IntActiO75937, 30 interactors
MINTiO75937
STRINGi9606.ENSP00000263697

Structurei

3D structure databases

ProteinModelPortaliO75937
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 124JPROSITE-ProRule annotationAdd BLAST68

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni232 – 253Essential for polyglutamine aggregation suppression1 PublicationAdd BLAST22

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi189 – 192Nuclear localization signal1 Publication4
Motifi203 – 206Nuclear localization signal1 Publication4

Phylogenomic databases

eggNOGiKOG1150 Eukaryota
ENOG4110ZJ4 LUCA
GeneTreeiENSGT00390000012569
HOVERGENiHBG051377
InParanoidiO75937
KOiK09528
OMAiRAQMAFD
OrthoDBiEOG091G0MI7
PhylomeDBiO75937
TreeFamiTF105167

Family and domain databases

CDDicd06257 DnaJ, 1 hit
Gene3Di1.10.287.110, 1 hit
InterProiView protein in InterPro
IPR001623 DnaJ_domain
IPR036869 J_dom_sf
PfamiView protein in Pfam
PF00226 DnaJ, 1 hit
PRINTSiPR00625 JDOMAIN
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
PROSITEiView protein in PROSITE
PS50076 DNAJ_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O75937-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASGESGTS GGGGSTEEAF MTFYSEVKQI EKRDSVLTSK NQIERLTRPG
60 70 80 90 100
SSYFNLNPFE VLQIDPEVTD EEIKKRFRQL SILVHPDKNQ DDADRAQKAF
110 120 130 140 150
EAVDKAYKLL LDQEQKKRAL DVIQAGKEYV EHTVKERKKQ LKKEGKPTIV
160 170 180 190 200
EEDDPELFKQ AVYKQTMKLF AELEIKRKER EAKEMHERKR QREEEIEAQE
210 220 230 240 250
KAKREREWQK NFEESRDGRV DSWRNFQANT KGKKEKKNRT FLRPPKVKME

QRE
Length:253
Mass (Da):29,842
Last modified:April 26, 2005 - v2
Checksum:iC69D6189D69D1588
GO

Sequence cautioni

The sequence AAC35352 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAG33181 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti253E → D in CAG33181 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083190 mRNA Translation: AAC35352.1 Different initiation.
CR456900 mRNA Translation: CAG33181.1 Different initiation.
AK300797 mRNA Translation: BAG62456.1
AL353354 Genomic DNA No translation available.
AL353622 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07707.1
CH471059 Genomic DNA Translation: EAX07710.1
BC033159 mRNA Translation: AAH33159.1
AF161433 mRNA Translation: AAF28993.1
AF161449 mRNA Translation: AAF29009.1
CCDSiCCDS41292.1
RefSeqiNP_055095.2, NM_014280.2
UniGeneiHs.433540

Genome annotation databases

EnsembliENST00000263697; ENSP00000263697; ENSG00000126698
ENST00000645856; ENSP00000494062; ENSG00000285317
GeneIDi22826
KEGGihsa:22826
UCSCiuc001bpn.4 human

Similar proteinsi

Entry informationi

Entry nameiDNJC8_HUMAN
AccessioniPrimary (citable) accession number: O75937
Secondary accession number(s): B4DUU4
, D3DPM0, Q6IBA4, Q8N4Z5, Q9P051, Q9P067
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: April 26, 2005
Last modified: July 18, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM

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