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Protein

Dynactin subunit 3

Gene

DCTN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Together with dynein may be involved in spindle assembly and cytokinesis.1 Publication

GO - Molecular functioni

  • structural molecule activity Source: ProtInc

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-HSA-2132295 MHC class II antigen presentation
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-6807878 COPI-mediated anterograde transport
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-HSA-8854518 AURKA Activation by TPX2

Names & Taxonomyi

Protein namesi
Recommended name:
Dynactin subunit 3
Alternative name(s):
Dynactin complex subunit 22 kDa subunit
Short name:
p22
Gene namesi
Name:DCTN3Imported
Synonyms:DCTN22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000137100.15
HGNCiHGNC:2713 DCTN3
MIMi607387 gene
neXtProtiNX_O75935

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore

Pathology & Biotechi

Organism-specific databases

DisGeNETi11258
OpenTargetsiENSG00000137100
PharmGKBiPA27182

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002256032 – 186Dynactin subunit 3Add BLAST185

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiO75935
MaxQBiO75935
PaxDbiO75935
PeptideAtlasiO75935
PRIDEiO75935
ProteomicsDBi50298
50299 [O75935-2]
50300 [O75935-3]
TopDownProteomicsiO75935-1 [O75935-1]
O75935-3 [O75935-3]

PTM databases

iPTMnetiO75935
PhosphoSitePlusiO75935

Expressioni

Tissue specificityi

Ubiquitously expressed. Highly expressed in muscle and pancreas and detected at lower levels in brain.1 Publication

Gene expression databases

BgeeiENSG00000137100 Expressed in 229 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_DCTN3
ExpressionAtlasiO75935 baseline and differential
GenevisibleiO75935 HS

Organism-specific databases

HPAiHPA044905

Interactioni

Subunit structurei

Subunit of dynactin, a multiprotein complex associated with dynein.

Protein-protein interaction databases

BioGridi116418, 61 interactors
CORUMiO75935
IntActiO75935, 29 interactors
MINTiO75935
STRINGi9606.ENSP00000259632

Structurei

3D structure databases

ProteinModelPortaliO75935
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili135 – 157Sequence analysisAdd BLAST23

Sequence similaritiesi

Belongs to the dynactin subunit 3 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IXN7 Eukaryota
ENOG410Y8FP LUCA
GeneTreeiENSGT00390000016210
HOGENOMiHOG000231666
HOVERGENiHBG053181
InParanoidiO75935
KOiK10425
OMAiYNKMMFL
OrthoDBiEOG091G0MGW
PhylomeDBiO75935
TreeFamiTF105248

Family and domain databases

InterProiView protein in InterPro
IPR009991 Dynactin_p22
PfamiView protein in Pfam
PF07426 Dynactin_p22, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: O75935-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGLTDLQRL QARVEELERW VYGPGGARGS RKVADGLVKV QVALGNISSK
60 70 80 90 100
RERVKILYKK IEDLIKYLDP EYIDRIAIPD ASKLQFILAE EQFILSQVAL
110 120 130 140 150
LEQVNALVPM LDSAHIKAVP EHAARLQRLA QIHIQQQDQC VEITEESKAL
160 170 180
LEEYNKTTML LSKQFVQWDE LLCQLEAATQ VKPAEE
Length:186
Mass (Da):21,119
Last modified:November 1, 1998 - v1
Checksum:i70A0B26E24603A77
GO
Isoform 21 Publication (identifier: O75935-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     138-186: DQCVEITEES...AATQVKPAEE → APWGVGVRDE...GPTGPVCGNH

Note: No experimental confirmation available.Curated
Show »
Length:176
Mass (Da):19,469
Checksum:iFE50412C172E1922
GO
Isoform 3Curated (identifier: O75935-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     90-117: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:158
Mass (Da):18,001
Checksum:i218ABF3564911AB1
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X6RLR1X6RLR1_HUMAN
Dynactin subunit 3
DCTN3
176Annotation score:
X6RA56X6RA56_HUMAN
Dynactin subunit 3
DCTN3
142Annotation score:
X6RCK5X6RCK5_HUMAN
Dynactin subunit 3
DCTN3
151Annotation score:
A0A0A0MRV8A0A0A0MRV8_HUMAN
Dynactin subunit 3
DCTN3
160Annotation score:

Sequence cautioni

The sequence CAI13144 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI14178 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI14180 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05196190 – 117Missing in isoform 3. CuratedAdd BLAST28
Alternative sequenceiVSP_051964138 – 186DQCVE…KPAEE → APWGVGVRDEAGSLVEDVGF AQFLSVLHFGPTGPVCGNH in isoform 2. 2 PublicationsAdd BLAST49

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF082513 mRNA Translation: AAC61280.1
CR541889 mRNA Translation: CAG46687.1
AK314730 mRNA Translation: BAG37272.1
AL160270, AL450283 Genomic DNA Translation: CAI13143.1
AL160270, AL450283 Genomic DNA Translation: CAI13144.1 Different initiation.
AL160270, AL450283 Genomic DNA Translation: CAI13145.1
AL450283 Genomic DNA Translation: CAI14178.1 Sequence problems.
AL450283, AL160270 Genomic DNA Translation: CAI14180.1 Different initiation.
AL450283, AL160270 Genomic DNA Translation: CAI14181.1
AL450283, AL160270 Genomic DNA Translation: CAI14182.1
CH471071 Genomic DNA Translation: EAW58440.1
CH471071 Genomic DNA Translation: EAW58441.1
BC000319 mRNA Translation: AAH00319.1
BC003004 mRNA Translation: AAH03004.1
BC107697 mRNA Translation: AAI07698.1
CCDSiCCDS65028.1 [O75935-3]
CCDS6560.1 [O75935-1]
CCDS6561.1 [O75935-2]
RefSeqiNP_001268354.1, NM_001281425.1 [O75935-3]
NP_001268355.1, NM_001281426.1
NP_009165.1, NM_007234.4 [O75935-1]
NP_077324.1, NM_024348.3 [O75935-2]
UniGeneiHs.511768

Genome annotation databases

EnsembliENST00000259632; ENSP00000259632; ENSG00000137100 [O75935-1]
ENST00000341694; ENSP00000343986; ENSG00000137100 [O75935-2]
ENST00000378916; ENSP00000368196; ENSG00000137100 [O75935-3]
GeneIDi11258
KEGGihsa:11258
UCSCiuc003zuw.3 human [O75935-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF082513 mRNA Translation: AAC61280.1
CR541889 mRNA Translation: CAG46687.1
AK314730 mRNA Translation: BAG37272.1
AL160270, AL450283 Genomic DNA Translation: CAI13143.1
AL160270, AL450283 Genomic DNA Translation: CAI13144.1 Different initiation.
AL160270, AL450283 Genomic DNA Translation: CAI13145.1
AL450283 Genomic DNA Translation: CAI14178.1 Sequence problems.
AL450283, AL160270 Genomic DNA Translation: CAI14180.1 Different initiation.
AL450283, AL160270 Genomic DNA Translation: CAI14181.1
AL450283, AL160270 Genomic DNA Translation: CAI14182.1
CH471071 Genomic DNA Translation: EAW58440.1
CH471071 Genomic DNA Translation: EAW58441.1
BC000319 mRNA Translation: AAH00319.1
BC003004 mRNA Translation: AAH03004.1
BC107697 mRNA Translation: AAI07698.1
CCDSiCCDS65028.1 [O75935-3]
CCDS6560.1 [O75935-1]
CCDS6561.1 [O75935-2]
RefSeqiNP_001268354.1, NM_001281425.1 [O75935-3]
NP_001268355.1, NM_001281426.1
NP_009165.1, NM_007234.4 [O75935-1]
NP_077324.1, NM_024348.3 [O75935-2]
UniGeneiHs.511768

3D structure databases

ProteinModelPortaliO75935
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116418, 61 interactors
CORUMiO75935
IntActiO75935, 29 interactors
MINTiO75935
STRINGi9606.ENSP00000259632

PTM databases

iPTMnetiO75935
PhosphoSitePlusiO75935

Proteomic databases

EPDiO75935
MaxQBiO75935
PaxDbiO75935
PeptideAtlasiO75935
PRIDEiO75935
ProteomicsDBi50298
50299 [O75935-2]
50300 [O75935-3]
TopDownProteomicsiO75935-1 [O75935-1]
O75935-3 [O75935-3]

Protocols and materials databases

DNASUi11258
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259632; ENSP00000259632; ENSG00000137100 [O75935-1]
ENST00000341694; ENSP00000343986; ENSG00000137100 [O75935-2]
ENST00000378916; ENSP00000368196; ENSG00000137100 [O75935-3]
GeneIDi11258
KEGGihsa:11258
UCSCiuc003zuw.3 human [O75935-1]

Organism-specific databases

CTDi11258
DisGeNETi11258
EuPathDBiHostDB:ENSG00000137100.15
GeneCardsiDCTN3
HGNCiHGNC:2713 DCTN3
HPAiHPA044905
MIMi607387 gene
neXtProtiNX_O75935
OpenTargetsiENSG00000137100
PharmGKBiPA27182
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXN7 Eukaryota
ENOG410Y8FP LUCA
GeneTreeiENSGT00390000016210
HOGENOMiHOG000231666
HOVERGENiHBG053181
InParanoidiO75935
KOiK10425
OMAiYNKMMFL
OrthoDBiEOG091G0MGW
PhylomeDBiO75935
TreeFamiTF105248

Enzyme and pathway databases

ReactomeiR-HSA-2132295 MHC class II antigen presentation
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-6807878 COPI-mediated anterograde transport
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-HSA-8854518 AURKA Activation by TPX2

Miscellaneous databases

GeneWikiiDCTN3
GenomeRNAii11258
PROiPR:O75935
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000137100 Expressed in 229 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_DCTN3
ExpressionAtlasiO75935 baseline and differential
GenevisibleiO75935 HS

Family and domain databases

InterProiView protein in InterPro
IPR009991 Dynactin_p22
PfamiView protein in Pfam
PF07426 Dynactin_p22, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDCTN3_HUMAN
AccessioniPrimary (citable) accession number: O75935
Secondary accession number(s): A6NII7
, B2RBM5, Q5T1I5, Q5T1I7, Q5T8G3, Q9BPU8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: November 1, 1998
Last modified: September 12, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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