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Entry version 169 (10 Feb 2021)
Sequence version 1 (01 Nov 1998)
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Protein

Dynactin subunit 3

Gene

DCTN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Together with dynein may be involved in spindle assembly and cytokinesis.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • structural molecule activity Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
O75935

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2132295, MHC class II antigen presentation
R-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition
R-HSA-3371497, HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-HSA-380259, Loss of Nlp from mitotic centrosomes
R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284, Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320, Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912, Anchoring of the basal body to the plasma membrane
R-HSA-6807878, COPI-mediated anterograde transport
R-HSA-6811436, COPI-independent Golgi-to-ER retrograde traffic
R-HSA-8854518, AURKA Activation by TPX2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dynactin subunit 3
Alternative name(s):
Dynactin complex subunit 22 kDa subunit
Short name:
p22
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DCTN3Imported
Synonyms:DCTN22
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:2713, DCTN3

Online Mendelian Inheritance in Man (OMIM)

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MIMi
607387, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O75935

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000137100.15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
11258

Open Targets

More...
OpenTargetsi
ENSG00000137100

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27182

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O75935, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DCTN3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002256032 – 186Dynactin subunit 3Add BLAST185

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O75935

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O75935

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
O75935

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O75935

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O75935

PeptideAtlas

More...
PeptideAtlasi
O75935

PRoteomics IDEntifications database

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PRIDEi
O75935

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
50298 [O75935-1]
50299 [O75935-2]
50300 [O75935-3]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
O75935-1 [O75935-1]
O75935-3 [O75935-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O75935

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O75935

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed. Highly expressed in muscle and pancreas and detected at lower levels in brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000137100, Expressed in anterior cingulate cortex and 241 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O75935, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O75935, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000137100, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Subunit of dynactin, a multiprotein complex associated with dynein.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
116418, 74 interactors

Protein interaction database and analysis system

More...
IntActi
O75935, 48 interactors

Molecular INTeraction database

More...
MINTi
O75935

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000259632

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
O75935, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O75935

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili135 – 157Sequence analysisAdd BLAST23

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the dynactin subunit 3 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG502RYZ0, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00390000016210

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O75935

Identification of Orthologs from Complete Genome Data

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OMAi
KEQDQTE

Database of Orthologous Groups

More...
OrthoDBi
1444664at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O75935

TreeFam database of animal gene trees

More...
TreeFami
TF105248

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009991, DCTN3

The PANTHER Classification System

More...
PANTHERi
PTHR28360, PTHR28360, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07426, Dynactin_p22, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: O75935-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGLTDLQRL QARVEELERW VYGPGGARGS RKVADGLVKV QVALGNISSK
60 70 80 90 100
RERVKILYKK IEDLIKYLDP EYIDRIAIPD ASKLQFILAE EQFILSQVAL
110 120 130 140 150
LEQVNALVPM LDSAHIKAVP EHAARLQRLA QIHIQQQDQC VEITEESKAL
160 170 180
LEEYNKTTML LSKQFVQWDE LLCQLEAATQ VKPAEE
Length:186
Mass (Da):21,119
Last modified:November 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i70A0B26E24603A77
GO
Isoform 21 Publication (identifier: O75935-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     138-186: DQCVEITEES...AATQVKPAEE → APWGVGVRDE...GPTGPVCGNH

Show »
Length:176
Mass (Da):19,469
Checksum:iFE50412C172E1922
GO
Isoform 3Curated (identifier: O75935-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     90-117: Missing.

Show »
Length:158
Mass (Da):18,001
Checksum:i218ABF3564911AB1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X6RLR1X6RLR1_HUMAN
Dynactin subunit 3
DCTN3
176Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X6RA56X6RA56_HUMAN
Dynactin subunit 3
DCTN3
142Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X6RCK5X6RCK5_HUMAN
Dynactin subunit 3
DCTN3
151Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MRV8A0A0A0MRV8_HUMAN
Dynactin subunit 3
DCTN3
160Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAI13144 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI14178 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI14180 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05196190 – 117Missing in isoform 3. CuratedAdd BLAST28
Alternative sequenceiVSP_051964138 – 186DQCVE…KPAEE → APWGVGVRDEAGSLVEDVGF AQFLSVLHFGPTGPVCGNH in isoform 2. 2 PublicationsAdd BLAST49

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF082513 mRNA Translation: AAC61280.1
CR541889 mRNA Translation: CAG46687.1
AK314730 mRNA Translation: BAG37272.1
AL160270, AL450283 Genomic DNA Translation: CAI13143.1
AL160270, AL450283 Genomic DNA Translation: CAI13144.1 Different initiation.
AL160270, AL450283 Genomic DNA Translation: CAI13145.1
AL450283 Genomic DNA Translation: CAI14178.1 Sequence problems.
AL450283, AL160270 Genomic DNA Translation: CAI14180.1 Different initiation.
AL450283, AL160270 Genomic DNA Translation: CAI14181.1
AL450283, AL160270 Genomic DNA Translation: CAI14182.1
CH471071 Genomic DNA Translation: EAW58440.1
CH471071 Genomic DNA Translation: EAW58441.1
BC000319 mRNA Translation: AAH00319.1
BC003004 mRNA Translation: AAH03004.1
BC107697 mRNA Translation: AAI07698.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS65028.1 [O75935-3]
CCDS6560.1 [O75935-1]
CCDS6561.1 [O75935-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001268354.1, NM_001281425.1 [O75935-3]
NP_001268355.1, NM_001281426.1
NP_009165.1, NM_007234.4 [O75935-1]
NP_077324.1, NM_024348.3 [O75935-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000259632; ENSP00000259632; ENSG00000137100 [O75935-1]
ENST00000341694; ENSP00000343986; ENSG00000137100 [O75935-2]
ENST00000378916; ENSP00000368196; ENSG00000137100 [O75935-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
11258

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:11258

UCSC genome browser

More...
UCSCi
uc003zuw.3, human [O75935-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF082513 mRNA Translation: AAC61280.1
CR541889 mRNA Translation: CAG46687.1
AK314730 mRNA Translation: BAG37272.1
AL160270, AL450283 Genomic DNA Translation: CAI13143.1
AL160270, AL450283 Genomic DNA Translation: CAI13144.1 Different initiation.
AL160270, AL450283 Genomic DNA Translation: CAI13145.1
AL450283 Genomic DNA Translation: CAI14178.1 Sequence problems.
AL450283, AL160270 Genomic DNA Translation: CAI14180.1 Different initiation.
AL450283, AL160270 Genomic DNA Translation: CAI14181.1
AL450283, AL160270 Genomic DNA Translation: CAI14182.1
CH471071 Genomic DNA Translation: EAW58440.1
CH471071 Genomic DNA Translation: EAW58441.1
BC000319 mRNA Translation: AAH00319.1
BC003004 mRNA Translation: AAH03004.1
BC107697 mRNA Translation: AAI07698.1
CCDSiCCDS65028.1 [O75935-3]
CCDS6560.1 [O75935-1]
CCDS6561.1 [O75935-2]
RefSeqiNP_001268354.1, NM_001281425.1 [O75935-3]
NP_001268355.1, NM_001281426.1
NP_009165.1, NM_007234.4 [O75935-1]
NP_077324.1, NM_024348.3 [O75935-2]

3D structure databases

SMRiO75935
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi116418, 74 interactors
IntActiO75935, 48 interactors
MINTiO75935
STRINGi9606.ENSP00000259632

PTM databases

iPTMnetiO75935
PhosphoSitePlusiO75935

Genetic variation databases

BioMutaiDCTN3

Proteomic databases

EPDiO75935
jPOSTiO75935
MassIVEiO75935
MaxQBiO75935
PaxDbiO75935
PeptideAtlasiO75935
PRIDEiO75935
ProteomicsDBi50298 [O75935-1]
50299 [O75935-2]
50300 [O75935-3]
TopDownProteomicsiO75935-1 [O75935-1]
O75935-3 [O75935-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
25511, 192 antibodies

The DNASU plasmid repository

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DNASUi
11258

Genome annotation databases

EnsembliENST00000259632; ENSP00000259632; ENSG00000137100 [O75935-1]
ENST00000341694; ENSP00000343986; ENSG00000137100 [O75935-2]
ENST00000378916; ENSP00000368196; ENSG00000137100 [O75935-3]
GeneIDi11258
KEGGihsa:11258
UCSCiuc003zuw.3, human [O75935-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
11258
DisGeNETi11258

GeneCards: human genes, protein and diseases

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GeneCardsi
DCTN3
HGNCiHGNC:2713, DCTN3
HPAiENSG00000137100, Low tissue specificity
MIMi607387, gene
neXtProtiNX_O75935
OpenTargetsiENSG00000137100
PharmGKBiPA27182
VEuPathDBiHostDB:ENSG00000137100.15

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG502RYZ0, Eukaryota
GeneTreeiENSGT00390000016210
InParanoidiO75935
OMAiKEQDQTE
OrthoDBi1444664at2759
PhylomeDBiO75935
TreeFamiTF105248

Enzyme and pathway databases

PathwayCommonsiO75935
ReactomeiR-HSA-2132295, MHC class II antigen presentation
R-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition
R-HSA-3371497, HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-HSA-380259, Loss of Nlp from mitotic centrosomes
R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284, Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320, Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912, Anchoring of the basal body to the plasma membrane
R-HSA-6807878, COPI-mediated anterograde transport
R-HSA-6811436, COPI-independent Golgi-to-ER retrograde traffic
R-HSA-8854518, AURKA Activation by TPX2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
11258, 630 hits in 883 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
DCTN3, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
DCTN3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
11258
PharosiO75935, Tdark

Protein Ontology

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PROi
PR:O75935
RNActiO75935, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000137100, Expressed in anterior cingulate cortex and 241 other tissues
ExpressionAtlasiO75935, baseline and differential
GenevisibleiO75935, HS

Family and domain databases

InterProiView protein in InterPro
IPR009991, DCTN3
PANTHERiPTHR28360, PTHR28360, 1 hit
PfamiView protein in Pfam
PF07426, Dynactin_p22, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDCTN3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75935
Secondary accession number(s): A6NII7
, B2RBM5, Q5T1I5, Q5T1I7, Q5T8G3, Q9BPU8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: November 1, 1998
Last modified: February 10, 2021
This is version 169 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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