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UniProtKB - O75934 (SPF27_HUMAN)

Entry version 183 (25 May 2022)
Sequence version 1 (01 Nov 1998)
Previous versions | rss
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Protein

Pre-mRNA-splicing factor SPF27

Gene

BCAS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for pre-mRNA splicing as component of the activated spliceosome (PubMed:28502770, PubMed:28076346, PubMed:29360106, PubMed:29301961, PubMed:30705154).

Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR).

7 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O75934

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-72163, mRNA Splicing - Major Pathway

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		O75934

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pre-mRNA-splicing factor SPF27
Alternative name(s):
Breast carcinoma-amplified sequence 2
DNA amplified in mammary carcinoma 1 protein
Spliceosome-associated protein SPF 27
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BCAS2
Synonyms:DAM11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:975, BCAS2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605783, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O75934

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000116752

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus, Spliceosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		10286

Open Targets

More...OpenTargetsi		ENSG00000116752

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA25285

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O75934, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		BCAS2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000648612 – 225Pre-mRNA-splicing factor SPF27Add BLAST224

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei94PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O75934

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O75934

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O75934

MaxQB - The MaxQuant DataBase

More...MaxQBi		O75934

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O75934

PeptideAtlas

More...PeptideAtlasi		O75934

PRoteomics IDEntifications database

More...PRIDEi		O75934

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		50297

Consortium for Top Down Proteomics

More...TopDownProteomicsi		O75934

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...SWISS-2DPAGEi		O75934

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		O75934, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O75934

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O75934

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000116752, Expressed in frontal cortex and 250 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O75934, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O75934, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000116752, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the pre-catalytic and catalytic spliceosome complexes (PubMed:9731529, PubMed:28502770, PubMed:28076346, PubMed:29360106, PubMed:29301961).

Component of the postcatalytic spliceosome P complex (PubMed:30705154).

Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8.

Interacts directly in the complex with PRPF19, CDC5L and PLRG1 (PubMed:20176811).

7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

O75934
With#Exp.IntAct
ACY1 [Q03154]3EBI-1050106,EBI-742064
AIMP2 [Q13155]12EBI-1050106,EBI-745226
C10orf82 - isoform 2 [Q8WW14-2]3EBI-1050106,EBI-12831628
CCDC120 [Q96HB5]3EBI-1050106,EBI-744556
CCDC17 - isoform 2 [Q96LX7-5]3EBI-1050106,EBI-12165781
CDC5L [Q99459]13EBI-1050106,EBI-374880
ECM1 [Q16610]3EBI-1050106,EBI-947964
EMILIN3 [Q9NT22]3EBI-1050106,EBI-3197883
ENKD1 [Q9H0I2]3EBI-1050106,EBI-744099
FAM86C1P - isoform 2 [Q9NVL1-2]3EBI-1050106,EBI-12845222
GFAP [P14136]3EBI-1050106,EBI-744302
GOLGA2 [Q08379]9EBI-1050106,EBI-618309
HGS [O14964]4EBI-1050106,EBI-740220
HSF2BP [O75031]3EBI-1050106,EBI-7116203
IFI35 - isoform 2 [P80217-2]3EBI-1050106,EBI-12823003
IKZF3 [Q9UKT9]5EBI-1050106,EBI-747204
JPH3 [Q8WXH2]3EBI-1050106,EBI-1055254
KLF11 [O14901]3EBI-1050106,EBI-948266
KRT20 [P35900]3EBI-1050106,EBI-742094
KRT27 [Q7Z3Y8]3EBI-1050106,EBI-3044087
KRT31 [Q15323]3EBI-1050106,EBI-948001
KRT34 [O76011]5EBI-1050106,EBI-1047093
KRT35 [Q92764]3EBI-1050106,EBI-1058674
KRT36 - isoform 2 [O76013-2]3EBI-1050106,EBI-11958506
KRT37 [O76014]3EBI-1050106,EBI-1045716
KRT40 [Q6A162]3EBI-1050106,EBI-10171697
KRT75 [O95678]3EBI-1050106,EBI-2949715
KRTAP19-6 [Q3LI70]3EBI-1050106,EBI-12805508
KRTAP8-1 [Q8IUC2]3EBI-1050106,EBI-10261141
LMO1 [P25800]3EBI-1050106,EBI-8639312
LMO2 - isoform 3 [P25791-3]3EBI-1050106,EBI-11959475
LMO3 - isoform 4 [Q8TAP4-4]5EBI-1050106,EBI-11742507
LMO4 [P61968]3EBI-1050106,EBI-2798728
MED29 [Q9NX70]3EBI-1050106,EBI-394656
MIIP [Q5JXC2]3EBI-1050106,EBI-2801965
MYOZ3 [Q8TDC0]3EBI-1050106,EBI-5662487
NUP58 [Q9BVL2]3EBI-1050106,EBI-2811583
OIP5 [O43482]3EBI-1050106,EBI-536879
PAX5 [Q02548]3EBI-1050106,EBI-296331
PCBD2 [Q9H0N5]3EBI-1050106,EBI-634289
PFDN5 [Q99471]3EBI-1050106,EBI-357275
PLAGL2 [Q9UPG8]3EBI-1050106,EBI-2876622
PLEKHF2 [Q9H8W4]3EBI-1050106,EBI-742388
PLRG1 [O43660]2EBI-1050106,EBI-1051504
PPP1R32 - isoform 2 [Q7Z5V6-2]3EBI-1050106,EBI-12000762
PRPF19 [Q9UMS4]7EBI-1050106,EBI-395746
PRPF8 [Q6P2Q9]2EBI-1050106,EBI-538479
SF3B4 [Q15427]2EBI-1050106,EBI-348469
SMARCD1 [Q96GM5]3EBI-1050106,EBI-358489
SMRP1 [Q8NCR6]3EBI-1050106,EBI-10269322
SNRPC [P09234]3EBI-1050106,EBI-766589
TCF4 [P15884]4EBI-1050106,EBI-533224
TCHP [Q9BT92]3EBI-1050106,EBI-740781
TP53BP2 [Q05BL1]3EBI-1050106,EBI-11952721
TXN2 [Q99757]3EBI-1050106,EBI-2932492
USHBP1 [Q8N6Y0]3EBI-1050106,EBI-739895
ZWINT [O95229]3EBI-1050106,EBI-1001132

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115575, 256 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-5824, PRP19-CDC5L complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		O75934

Protein interaction database and analysis system

More...IntActi		O75934, 108 interactors

Molecular INTeraction database

More...MINTi		O75934

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000358554

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O75934, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1225
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		O75934

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O75934

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili138 – 222Sequence analysisAdd BLAST85

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SPF27 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3096, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000014494

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_082523_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O75934

Identification of Orthologs from Complete Genome Data

More...OMAi		SHLSMRH

Database of Orthologous Groups

More...OrthoDBi		1607056at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O75934

TreeFam database of animal gene trees

More...TreeFami		TF105818

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR008409, SPF27

The PANTHER Classification System

More...PANTHERi		PTHR13296, PTHR13296, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05700, BCAS2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

O75934-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGTGLVAGE VVVDALPYFD QGYEAPGVRE AAAALVEEET RRYRPTKNYL 
        60         70         80         90        100
SYLTAPDYSA FETDIMRNEF ERLAARQPIE LLSMKRYELP APSSGQKNDI 
       110        120        130        140        150
TAWQECVNNS MAQLEHQAVR IENLELMSQH GCNAWKVYNE NLVHMIEHAQ 
       160        170        180        190        200
KELQKLRKHI QDLNWQRKNM QLTAGSKLRE MESNWVSLVS KNYEIERTIV 
       210        220 
QLENEIYQIK QQHGEANKEN IRQDF
Length:225
Mass (Da):26,131
Last modified:November 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9112718EEFD96890
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti24E → D in CAG46834 (Ref. 3) Curated1
Sequence conflicti89L → V in CAG46834 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_035799139N → S in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1197668726Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF081788 mRNA Translation: AAC64059.1
AB020623 mRNA Translation: BAA34863.1
CR542037 mRNA Translation: CAG46834.1
BT019390 mRNA Translation: AAV38197.1
AL390241 Genomic DNA No translation available.
BC005285 mRNA Translation: AAH05285.1
BC012623 mRNA Translation: AAH12623.1
BC022880 mRNA Translation: AAH22880.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS874.1

NCBI Reference Sequences

More...RefSeqi		NP_005863.1, NM_005872.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000369541.4; ENSP00000358554.3; ENSG00000116752.6

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10286

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10286

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000369541.4; ENSP00000358554.3; NM_005872.3; NP_005863.1

UCSC genome browser

More...UCSCi		uc001efa.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF081788 mRNA Translation: AAC64059.1
AB020623 mRNA Translation: BAA34863.1
CR542037 mRNA Translation: CAG46834.1
BT019390 mRNA Translation: AAV38197.1
AL390241 Genomic DNA No translation available.
BC005285 mRNA Translation: AAH05285.1
BC012623 mRNA Translation: AAH12623.1
BC022880 mRNA Translation: AAH22880.1
CCDSiCCDS874.1
RefSeqiNP_005863.1, NM_005872.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5MQFelectron microscopy5.90K1-225[»]
5XJCelectron microscopy3.60K1-225[»]
5YZGelectron microscopy4.10K1-225[»]
5Z56electron microscopy5.10K1-225[»]
5Z57electron microscopy6.50K1-225[»]
6FF7electron microscopy4.50K1-225[»]
6ICZelectron microscopy3.00K1-225[»]
6ID0electron microscopy2.90K1-225[»]
6ID1electron microscopy2.86K1-225[»]
6QDVelectron microscopy3.30s1-225[»]
7A5Pelectron microscopy5.00K1-225[»]
AlphaFoldDBiO75934
SMRiO75934
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi115575, 256 interactors
ComplexPortaliCPX-5824, PRP19-CDC5L complex
CORUMiO75934
IntActiO75934, 108 interactors
MINTiO75934
STRINGi9606.ENSP00000358554

PTM databases

GlyGeniO75934, 1 site, 1 O-linked glycan (1 site)
iPTMnetiO75934
PhosphoSitePlusiO75934

Genetic variation databases

BioMutaiBCAS2

2D gel databases

SWISS-2DPAGEiO75934

Proteomic databases

EPDiO75934
jPOSTiO75934
MassIVEiO75934
MaxQBiO75934
PaxDbiO75934
PeptideAtlasiO75934
PRIDEiO75934
ProteomicsDBi50297
TopDownProteomicsiO75934

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		33860, 346 antibodies from 33 providers

The DNASU plasmid repository

More...DNASUi		10286

Genome annotation databases

EnsembliENST00000369541.4; ENSP00000358554.3; ENSG00000116752.6
GeneIDi10286
KEGGihsa:10286
MANE-SelectiENST00000369541.4; ENSP00000358554.3; NM_005872.3; NP_005863.1
UCSCiuc001efa.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10286
DisGeNETi10286

GeneCards: human genes, protein and diseases

More...GeneCardsi		BCAS2
HGNCiHGNC:975, BCAS2
HPAiENSG00000116752, Low tissue specificity
MIMi605783, gene
neXtProtiNX_O75934
OpenTargetsiENSG00000116752
PharmGKBiPA25285
VEuPathDBiHostDB:ENSG00000116752

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3096, Eukaryota
GeneTreeiENSGT00390000014494
HOGENOMiCLU_082523_2_1_1
InParanoidiO75934
OMAiSHLSMRH
OrthoDBi1607056at2759
PhylomeDBiO75934
TreeFamiTF105818

Enzyme and pathway databases

PathwayCommonsiO75934
ReactomeiR-HSA-72163, mRNA Splicing - Major Pathway
SignaLinkiO75934

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		10286, 633 hits in 1084 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		BCAS2, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		BCAS2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10286
PharosiO75934, Tbio

Protein Ontology

More...PROi		PR:O75934
RNActiO75934, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000116752, Expressed in frontal cortex and 250 other tissues
ExpressionAtlasiO75934, baseline and differential
GenevisibleiO75934, HS

Family and domain databases

InterProiView protein in InterPro
IPR008409, SPF27
PANTHERiPTHR13296, PTHR13296, 1 hit
PfamiView protein in Pfam
PF05700, BCAS2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPF27_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75934
Secondary accession number(s): Q6FGS0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: November 1, 1998
Last modified: May 25, 2022
This is version 183 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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