UniProtKB - O75928 (PIAS2_HUMAN)
E3 SUMO-protein ligase PIAS2
PIAS2
Functioni
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIAS2-beta, but not isoform PIAS2-alpha, promotes MDM2 sumoylation. Isoform PIAS2-alpha promotes PARK7 sumoylation. Isoform PIAS2-beta promotes NCOA2 sumoylation more efficiently than isoform PIAS2-alpha. Isoform PIAS2-alpha sumoylates PML at'Lys-65' and 'Lys-160'.
3 Publications: protein sumoylation Pathwayi
This protein is involved in the pathway protein sumoylation, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein sumoylation and in Protein modification.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 362 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 364 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 385 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 388 | ZincPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 331 – 412 | SP-RING-typePROSITE-ProRule annotationAdd BLAST | 82 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- RNA polymerase II-specific DNA-binding transcription factor binding Source: ParkinsonsUK-UCL
- SUMO ligase activity Source: ParkinsonsUK-UCL
- SUMO transferase activity Source: Reactome
- transcription coregulator activity Source: GO_Central
- ubiquitin protein ligase binding Source: Ensembl
- zinc ion binding Source: ProtInc
GO - Biological processi
- negative regulation of androgen receptor signaling pathway Source: UniProtKB
- negative regulation of DNA-binding transcription factor activity Source: ParkinsonsUK-UCL
- protein sumoylation Source: ParkinsonsUK-UCL
- regulation of transcription by RNA polymerase II Source: GO_Central
- transcription, DNA-templated Source: Ensembl
Keywordsi
Molecular function | DNA-binding, Transferase |
Biological process | Transcription, Transcription regulation, Ubl conjugation pathway |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | O75928 |
Reactomei | R-HSA-3108214, SUMOylation of DNA damage response and repair proteins [O75928-1] R-HSA-3232118, SUMOylation of transcription factors [O75928-1] R-HSA-3232142, SUMOylation of ubiquitinylation proteins [O75928-1] R-HSA-3899300, SUMOylation of transcription cofactors [O75928-1] R-HSA-4090294, SUMOylation of intracellular receptors R-HSA-4551638, SUMOylation of chromatin organization proteins [O75928-2] R-HSA-5617472, Activation of anterior HOX genes in hindbrain development during early embryogenesis |
SignaLinki | O75928 |
SIGNORi | O75928 |
UniPathwayi | UPA00886 |
Names & Taxonomyi
Protein namesi | Recommended name: E3 SUMO-protein ligase PIAS2 (EC:2.3.2.-)Alternative name(s): Androgen receptor-interacting protein 3 Short name: ARIP3 DAB2-interacting protein Short name: DIP E3 SUMO-protein transferase PIAS2Curated Msx-interacting zinc finger protein Short name: Miz1 PIAS-NY protein Protein inhibitor of activated STAT x Protein inhibitor of activated STAT2 |
Gene namesi | Name:PIAS2 Synonyms:PIASX |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17311, PIAS2 |
MIMi | 603567, gene |
neXtProti | NX_O75928 |
VEuPathDBi | HostDB:ENSG00000078043 |
Subcellular locationi
Nucleus
- Nucleus speckle By similarity
- PML body 2 Publications
- Nucleus 2 Publications
Note: Colocalizes at least partially with promyelocytic leukemia nuclear bodies (PML NBs) (PubMed:22406621). Colocalizes with SUMO1 in nuclear granules (By similarity).By similarity1 Publication
Nucleus
- nuclear speck Source: UniProtKB-SubCell
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
- PML body Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 362 | C → S or A: Loss of MDM2 and TP53 sumoylation and of autosumoylation; no loss of JUN- and TP53-binding. 2 Publications | 1 | |
Mutagenesisi | 467 | V → A: Reduces affinity for SUMO1. 1 Publication | 1 | |
Mutagenesisi | 469 | V → A: Abolishes binding to SUMO1. 1 Publication | 1 | |
Mutagenesisi | 470 | I → A: Abolishes binding to SUMO1. 1 Publication | 1 | |
Mutagenesisi | 472 | L → A: Abolishes binding to SUMO1. 1 Publication | 1 | |
Mutagenesisi | 473 | T → A: Reduces affinity for SUMO1. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 9063 |
OpenTargetsi | ENSG00000078043 |
PharmGKBi | PA134933292 |
Miscellaneous databases
Pharosi | O75928, Tbio |
Genetic variation databases
BioMutai | PIAS2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000218976 | 1 – 621 | E3 SUMO-protein ligase PIAS2Add BLAST | 621 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Cross-linki | 46 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | |||
Cross-linki | 249 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | |||
Cross-linki | 430 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | |||
Cross-linki | 435 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | |||
Cross-linki | 443 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | |||
Cross-linki | 452 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | |||
Modified residuei | 476 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 477 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 478 | PhosphoserineCombined sources | 1 | ||
Cross-linki | 489 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | |||
Modified residuei | 499 | PhosphoserineBy similarity | 1 | ||
Cross-linki | 502 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | |||
Isoform PIAS2-alpha (identifier: O75928-2) | |||||
Cross-linki | 562 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Post-translational modificationi
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | O75928 |
jPOSTi | O75928 |
MassIVEi | O75928 |
MaxQBi | O75928 |
PaxDbi | O75928 |
PeptideAtlasi | O75928 |
PRIDEi | O75928 |
ProteomicsDBi | 50294 [O75928-1] 50295 [O75928-2] 50296 [O75928-3] |
PTM databases
iPTMneti | O75928 |
PhosphoSitePlusi | O75928 |
Expressioni
Tissue specificityi
Developmental stagei
Inductioni
Gene expression databases
Bgeei | ENSG00000078043, Expressed in testis and 237 other tissues |
ExpressionAtlasi | O75928, baseline and differential |
Genevisiblei | O75928, HS |
Organism-specific databases
HPAi | ENSG00000078043, Tissue enhanced (testis) |
Interactioni
Subunit structurei
Binds SUMO1 and UBE2I.
Interacts with AXIN1, JUN, MDM2, PARK7, TP53 and TP73 isoform alpha, but not TP73 isoform beta.
Interacts with STAT4 following IL12 and IFN-alpha stimulation of T-cells.
Interacts also with GTF2I, GTF2IRD1, IKFZ1, DAB2 and MSX2, as well as with several steroid receptors, including ESR1, ESR2, NR3C1, PGR, AR, and with NCOA2 (By similarity). Sumoylation of a target protein seems to enhance the interaction. Binds to sumoylated ELK1. Binds DNA, such as CDKN1A promoter, in a sequence-specific manner.
Interacts with PLAG1.
Interacts with KLF8; the interaction results in SUMO ligation and repression of KLF8 transcriptional activity and of its cell cycle progression into G1 phase. PIAS2-beta interacts with IFIH1/MDA5. Isoform PIAS2-alpha interacts with PML (isoform PML-12).
Interacts with PRDM1/Blimp-1 (PubMed:28842558).
By similarity12 PublicationsBinary interactionsi
O75928
Isoform PIAS2-alpha [O75928-2]
GO - Molecular functioni
- RNA polymerase II-specific DNA-binding transcription factor binding Source: ParkinsonsUK-UCL
- ubiquitin protein ligase binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 114523, 146 interactors |
ELMi | O75928 |
IntActi | O75928, 105 interactors |
MINTi | O75928 |
STRINGi | 9606.ENSP00000465676 |
Miscellaneous databases
RNActi | O75928, protein |
Structurei
Secondary structure
3D structure databases
SMRi | O75928 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O75928 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 11 – 45 | SAPPROSITE-ProRule annotationAdd BLAST | 35 | |
Domaini | 134 – 299 | PINITPROSITE-ProRule annotationAdd BLAST | 166 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 467 – 473 | SUMO1-binding | 7 | |
Regioni | 579 – 621 | DisorderedSequence analysisAdd BLAST | 43 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 19 – 23 | LXXLL motif | 5 | |
Motifi | 484 – 492 | Nuclear localization signalBy similarity | 9 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 331 – 412 | SP-RING-typePROSITE-ProRule annotationAdd BLAST | 82 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG2169, Eukaryota |
GeneTreei | ENSGT01030000234539 |
HOGENOMi | CLU_020768_3_0_1 |
InParanoidi | O75928 |
OMAi | DPQQYCP |
OrthoDBi | 1205949at2759 |
PhylomeDBi | O75928 |
Family and domain databases
DisProti | DP01675 |
Gene3Di | 1.10.720.30, 1 hit 2.60.120.780, 1 hit 3.30.40.10, 1 hit |
IDEALi | IID00136 |
InterProi | View protein in InterPro IPR027228, PIAS2 IPR023321, PINIT IPR038654, PINIT_sf IPR003034, SAP_dom IPR036361, SAP_dom_sf IPR004181, Znf_MIZ IPR013083, Znf_RING/FYVE/PHD |
PANTHERi | PTHR10782:SF12, PTHR10782:SF12, 1 hit |
Pfami | View protein in Pfam PF14324, PINIT, 1 hit PF02891, zf-MIZ, 1 hit |
SMARTi | View protein in SMART SM00513, SAP, 1 hit |
SUPFAMi | SSF68906, SSF68906, 1 hit |
PROSITEi | View protein in PROSITE PS51466, PINIT, 1 hit PS50800, SAP, 1 hit PS51044, ZF_SP_RING, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MADFEELRNM VSSFRVSELQ VLLGFAGRNK SGRKHDLLMR ALHLLKSGCS
60 70 80 90 100
PAVQIKIREL YRRRYPRTLE GLSDLSTIKS SVFSLDGGSS PVEPDLAVAG
110 120 130 140 150
IHSLPSTSVT PHSPSSPVGS VLLQDTKPTF EMQQPSPPIP PVHPDVQLKN
160 170 180 190 200
LPFYDVLDVL IKPTSLVQSS IQRFQEKFFI FALTPQQVRE ICISRDFLPG
210 220 230 240 250
GRRDYTVQVQ LRLCLAETSC PQEDNYPNSL CIKVNGKLFP LPGYAPPPKN
260 270 280 290 300
GIEQKRPGRP LNITSLVRLS SAVPNQISIS WASEIGKNYS MSVYLVRQLT
310 320 330 340 350
SAMLLQRLKM KGIRNPDHSR ALIKEKLTAD PDSEIATTSL RVSLMCPLGK
360 370 380 390 400
MRLTIPCRAV TCTHLQCFDA ALYLQMNEKK PTWICPVCDK KAAYESLILD
410 420 430 440 450
GLFMEILNDC SDVDEIKFQE DGSWCPMRPK KEAMKVSSQP CTKIESSSVL
460 470 480 490 500
SKPCSVTVAS EASKKKVDVI DLTIESSSDE EEDPPAKRKC IFMSETQSSP
510 520 530 540 550
TKGVLMYQPS SVRVPSVTSV DPAAIPPSLT DYSVPFHHTP ISSMSSDLPG
560 570 580 590 600
LDFLSLIPVD PQYCPPMFLD SLTSPLTASS TSVTTTSSHE SSTHVSSSSS
610 620
RSETGVITSS GSNIPDIISL D
The sequence of this isoform differs from the canonical sequence as follows:
551-572: LDFLSLIPVDPQYCPPMFLDSL → EQRRNDINNELKLGTSSDTVQQ
573-621: Missing.
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087WUY7 | A0A087WUY7_HUMAN | E3 SUMO-protein ligase PIAS2 | PIAS2 | 536 | Annotation score: | ||
B4DGW0 | B4DGW0_HUMAN | E3 SUMO-protein ligase PIAS2 | PIAS2 | 282 | Annotation score: | ||
K7EJT4 | K7EJT4_HUMAN | E3 SUMO-protein ligase PIAS2 | PIAS2 | 122 | Annotation score: | ||
K7EQX5 | K7EQX5_HUMAN | E3 SUMO-protein ligase PIAS2 | PIAS2 | 95 | Annotation score: | ||
K7ER97 | K7ER97_HUMAN | E3 SUMO-protein ligase PIAS2 | PIAS2 | 88 | Annotation score: | ||
K7EMP6 | K7EMP6_HUMAN | E3 SUMO-protein ligase PIAS2 | PIAS2 | 89 | Annotation score: | ||
A0A0A0MS92 | A0A0A0MS92_HUMAN | E3 SUMO-protein ligase PIAS2 | PIAS2 | 182 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 144 | P → L in AAK48938 (PubMed:15301740).Curated | 1 | |
Sequence conflicti | 616 | D → E in AAC36705 (PubMed:9724754).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_056693 | 207 | V → A. Corresponds to variant dbSNP:rs16940108Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_012196 | 1 – 8 | MADFEELR → MNAGKQLQRTLH in isoform 3. 1 Publication | 8 | |
Alternative sequenceiVSP_012197 | 402 – 621 | Missing in isoform 3. 1 PublicationAdd BLAST | 220 | |
Alternative sequenceiVSP_050008 | 551 – 572 | LDFLS…FLDSL → EQRRNDINNELKLGTSSDTV QQ in isoform PIAS2-alpha. 2 PublicationsAdd BLAST | 22 | |
Alternative sequenceiVSP_050009 | 573 – 621 | Missing in isoform PIAS2-alpha. 2 PublicationsAdd BLAST | 49 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF077953 mRNA Translation: AAC36704.1 AF077954 mRNA Translation: AAC36705.1 AF361054 mRNA Translation: AAK48938.1 AC090241 Genomic DNA No translation available. AC090373 Genomic DNA No translation available. BC015190 mRNA Translation: AAH15190.1 |
CCDSi | CCDS32824.1 [O75928-1] CCDS32825.1 [O75928-2] |
RefSeqi | NP_001310989.1, NM_001324060.1 [O75928-3] NP_004662.2, NM_004671.4 [O75928-1] NP_775298.1, NM_173206.3 [O75928-2] |
Genome annotation databases
Ensembli | ENST00000324794; ENSP00000317163; ENSG00000078043 [O75928-2] ENST00000585916; ENSP00000465676; ENSG00000078043 |
GeneIDi | 9063 |
KEGGi | hsa:9063 |
MANE-Selecti | ENST00000585916.6; ENSP00000465676.1; NM_004671.5; NP_004662.2 |
UCSCi | uc002lck.4, human [O75928-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF077953 mRNA Translation: AAC36704.1 AF077954 mRNA Translation: AAC36705.1 AF361054 mRNA Translation: AAK48938.1 AC090241 Genomic DNA No translation available. AC090373 Genomic DNA No translation available. BC015190 mRNA Translation: AAH15190.1 |
CCDSi | CCDS32824.1 [O75928-1] CCDS32825.1 [O75928-2] |
RefSeqi | NP_001310989.1, NM_001324060.1 [O75928-3] NP_004662.2, NM_004671.4 [O75928-1] NP_775298.1, NM_173206.3 [O75928-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2ASQ | NMR | - | B | 466-488 | [»] | |
4FO9 | X-ray | 2.39 | A | 147-488 | [»] | |
SMRi | O75928 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 114523, 146 interactors |
ELMi | O75928 |
IntActi | O75928, 105 interactors |
MINTi | O75928 |
STRINGi | 9606.ENSP00000465676 |
PTM databases
iPTMneti | O75928 |
PhosphoSitePlusi | O75928 |
Genetic variation databases
BioMutai | PIAS2 |
Proteomic databases
EPDi | O75928 |
jPOSTi | O75928 |
MassIVEi | O75928 |
MaxQBi | O75928 |
PaxDbi | O75928 |
PeptideAtlasi | O75928 |
PRIDEi | O75928 |
ProteomicsDBi | 50294 [O75928-1] 50295 [O75928-2] 50296 [O75928-3] |
Protocols and materials databases
Antibodypediai | 9110, 528 antibodies from 41 providers |
DNASUi | 9063 |
Genome annotation databases
Ensembli | ENST00000324794; ENSP00000317163; ENSG00000078043 [O75928-2] ENST00000585916; ENSP00000465676; ENSG00000078043 |
GeneIDi | 9063 |
KEGGi | hsa:9063 |
MANE-Selecti | ENST00000585916.6; ENSP00000465676.1; NM_004671.5; NP_004662.2 |
UCSCi | uc002lck.4, human [O75928-1] |
Organism-specific databases
CTDi | 9063 |
DisGeNETi | 9063 |
GeneCardsi | PIAS2 |
HGNCi | HGNC:17311, PIAS2 |
HPAi | ENSG00000078043, Tissue enhanced (testis) |
MIMi | 603567, gene |
neXtProti | NX_O75928 |
OpenTargetsi | ENSG00000078043 |
PharmGKBi | PA134933292 |
VEuPathDBi | HostDB:ENSG00000078043 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2169, Eukaryota |
GeneTreei | ENSGT01030000234539 |
HOGENOMi | CLU_020768_3_0_1 |
InParanoidi | O75928 |
OMAi | DPQQYCP |
OrthoDBi | 1205949at2759 |
PhylomeDBi | O75928 |
Enzyme and pathway databases
UniPathwayi | UPA00886 |
PathwayCommonsi | O75928 |
Reactomei | R-HSA-3108214, SUMOylation of DNA damage response and repair proteins [O75928-1] R-HSA-3232118, SUMOylation of transcription factors [O75928-1] R-HSA-3232142, SUMOylation of ubiquitinylation proteins [O75928-1] R-HSA-3899300, SUMOylation of transcription cofactors [O75928-1] R-HSA-4090294, SUMOylation of intracellular receptors R-HSA-4551638, SUMOylation of chromatin organization proteins [O75928-2] R-HSA-5617472, Activation of anterior HOX genes in hindbrain development during early embryogenesis |
SignaLinki | O75928 |
SIGNORi | O75928 |
Miscellaneous databases
BioGRID-ORCSi | 9063, 8 hits in 1079 CRISPR screens |
ChiTaRSi | PIAS2, human |
EvolutionaryTracei | O75928 |
GeneWikii | Protein_inhibitor_of_activated_STAT2 |
GenomeRNAii | 9063 |
Pharosi | O75928, Tbio |
PROi | PR:O75928 |
RNActi | O75928, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000078043, Expressed in testis and 237 other tissues |
ExpressionAtlasi | O75928, baseline and differential |
Genevisiblei | O75928, HS |
Family and domain databases
DisProti | DP01675 |
Gene3Di | 1.10.720.30, 1 hit 2.60.120.780, 1 hit 3.30.40.10, 1 hit |
IDEALi | IID00136 |
InterProi | View protein in InterPro IPR027228, PIAS2 IPR023321, PINIT IPR038654, PINIT_sf IPR003034, SAP_dom IPR036361, SAP_dom_sf IPR004181, Znf_MIZ IPR013083, Znf_RING/FYVE/PHD |
PANTHERi | PTHR10782:SF12, PTHR10782:SF12, 1 hit |
Pfami | View protein in Pfam PF14324, PINIT, 1 hit PF02891, zf-MIZ, 1 hit |
SMARTi | View protein in SMART SM00513, SAP, 1 hit |
SUPFAMi | SSF68906, SSF68906, 1 hit |
PROSITEi | View protein in PROSITE PS51466, PINIT, 1 hit PS50800, SAP, 1 hit PS51044, ZF_SP_RING, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PIAS2_HUMAN | |
Accessioni | O75928Primary (citable) accession number: O75928 Secondary accession number(s): O75927, Q96BT5, Q96KE3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 7, 2004 |
Last sequence update: | May 5, 2009 | |
Last modified: | February 23, 2022 | |
This is version 201 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families