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Entry version 149 (02 Dec 2020)
Sequence version 1 (01 Nov 1998)
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Protein

Small EDRK-rich factor 1

Gene

SERF1A

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Positive regulator of amyloid protein aggregation and proteotoxicity (PubMed:20723760, PubMed:22854022, PubMed:31034892). Induces conformational changes in amyloid proteins, such as APP, HTT, and SNCA, driving them into compact formations preceding the formation of aggregates (PubMed:20723760, PubMed:22854022, PubMed:31034892).3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
O75920

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Small EDRK-rich factor 1
Alternative name(s):
Protein 4F5
Short name:
h4F5
SMA modifier 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SERF1A
Synonyms:FAM2A, SERF1, SMAM1
AND
Name:SERF1B
Synonyms:FAM2B, SERF1, SMAM1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

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EuPathDBi
HostDB:ENSG00000172058.15
HostDB:ENSG00000205572.9

Human Gene Nomenclature Database

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HGNCi
HGNC:10755, SERF1A
HGNC:10756, SERF1B

Online Mendelian Inheritance in Man (OMIM)

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MIMi
603011, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_O75920

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi11R → A: No effect on SNCA binding. 1 Publication1
Mutagenesisi11R → E: Decreases SNCA binding. 1 Publication1
Mutagenesisi12Q → A: Slightly decreases SNCA binding. 1 Publication1
Mutagenesisi13K → A: Decreases SNCA binding. 1 Publication1
Mutagenesisi13K → E: Inhibits SNCA binding. 1 Publication1
Mutagenesisi14N → A: Decreases SNCA binding. 1 Publication1
Mutagenesisi16K → A: Drastically decreases SNCA binding. 1 Publication1
Mutagenesisi16K → E: Inhibits SNCA binding. 1 Publication1
Mutagenesisi17K → A: Drastically decreases SNCA binding. 1 Publication1
Mutagenesisi17K → E: Inhibits SNCA binding. 1 Publication1
Mutagenesisi18T → A: No effect on SNCA binding. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
728492
8293

Open Targets

More...
OpenTargetsi
ENSG00000172058
ENSG00000205572

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35675

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O75920, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SERF1A

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000507101 – 110Small EDRK-rich factor 1Add BLAST110

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O75920

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
O75920

MaxQB - The MaxQuant DataBase

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MaxQBi
O75920

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O75920

PeptideAtlas

More...
PeptideAtlasi
O75920

PRoteomics IDEntifications database

More...
PRIDEi
O75920

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
50276 [O75920-1]
50277 [O75920-2]

Consortium for Top Down Proteomics

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TopDownProteomicsi
O75920-2 [O75920-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O75920

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O75920

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform Long is predominantly expressed in heart, brain and skeletal muscle. Isoform Short and Isoform Long are expressed throughout the central nervous system, including spinal cord.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000172058, Expressed in prefrontal cortex and 119 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O75920, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O75920, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000172058, Low tissue specificity
ENSG00000205572, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SNCA; this interaction promotes the aggregation of SNCA.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
113898, 17 interactors
608917, 12 interactors

Protein interaction database and analysis system

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IntActi
O75920, 20 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000370126

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
O75920, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni11 – 17Required for SNCA binding1 Publication7

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SERF family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4488, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000161793

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_165034_1_1_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O75920

Identification of Orthologs from Complete Genome Data

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OMAi
QRDADIM

Database of Orthologous Groups

More...
OrthoDBi
1559007at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O75920

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR040211, SERF1/2
IPR007513, Uncharacterised_SERF_N

The PANTHER Classification System

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PANTHERi
PTHR13596, PTHR13596, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04419, 4F5, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform Long (identifier: O75920-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARGNQRELA RQKNMKKTQE ISKGKRKEDS LTASQRKQSS GGQKSESKMS
60 70 80 90 100
AGPHLPLKAP RENPCFPLPA AGGSRYYLAY GSITPISAFV FVVFFSVFFP
110
SFYEDFCCWI
Length:110
Mass (Da):12,349
Last modified:November 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iED9143455DB925AB
GO
Isoform Short (identifier: O75920-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     39-110: SSGGQKSESK...SFYEDFCCWI → RDSEIMQEKQKAANEKKSMQTREK

Show »
Length:62
Mass (Da):7,336
Checksum:iA8920C1B0C575F10
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RCL9D6RCL9_HUMAN
Small EDRK-rich factor 1
SERF1B SERF1A
96Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RHJ0E5RHJ0_HUMAN
Small EDRK-rich factor 1
SERF1B SERF1A
89Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RC42D6RC42_HUMAN
Small EDRK-rich factor 1
SERF1A SERF1B
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RC90D6RC90_HUMAN
Small EDRK-rich factor 1
SERF1B SERF1A
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RIQ9E5RIQ9_HUMAN
Small EDRK-rich factor 1
SERF1B SERF1A
48Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RIX6E5RIX6_HUMAN
Small EDRK-rich factor 1
SERF1A SERF1B
20Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JNT0A0A0G2JNT0_HUMAN
Small EDRK-rich factor 1
SERF1B
24Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00605739 – 110SSGGQ…FCCWI → RDSEIMQEKQKAANEKKSMQ TREK in isoform Short. 2 PublicationsAdd BLAST72

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF073518 mRNA Translation: AAC63517.1
AF073519 mRNA Translation: AAC63518.1
BC021174 mRNA Translation: AAH21174.1
BC035932 mRNA Translation: AAH35932.1
BC093880 mRNA Translation: AAH93880.1
BC093882 mRNA Translation: AAH93882.1
BC101970 mRNA Translation: AAI01971.1
BC104738 mRNA Translation: AAI04739.1
BC103687 mRNA Translation: AAI03688.1
BC143255 mRNA Translation: AAI43256.1
BC143260 mRNA Translation: AAI43261.1
BC171749 mRNA Translation: AAI71749.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43326.1 [O75920-1]
CCDS47228.1 [O75920-1]
CCDS47229.1 [O75920-2]
CCDS54866.1 [O75920-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001171558.1, NM_001178087.1 [O75920-2]
NP_068802.1, NM_021967.2 [O75920-1]
NP_075257.1, NM_022968.1 [O75920-2]
NP_075267.1, NM_022978.2 [O75920-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000317633; ENSP00000321791; ENSG00000172058 [O75920-2]
ENST00000354833; ENSP00000346892; ENSG00000172058 [O75920-1]
ENST00000380750; ENSP00000370126; ENSG00000205572 [O75920-1]
ENST00000380751; ENSP00000370127; ENSG00000205572 [O75920-2]
ENST00000611616; ENSP00000482392; ENSG00000278839 [O75920-2]
ENST00000613172; ENSP00000484795; ENSG00000277429 [O75920-1]
ENST00000614527; ENSP00000479724; ENSG00000275581 [O75920-1]
ENST00000621283; ENSP00000481118; ENSG00000277429 [O75920-2]
ENST00000622553; ENSP00000480543; ENSG00000278839 [O75920-1]
ENST00000627372; ENSP00000487374; ENSG00000275581 [O75920-2]
ENST00000630567; ENSP00000487531; ENSG00000275581 [O75920-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
728492
8293

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:728492
hsa:8293

UCSC genome browser

More...
UCSCi
uc003jxz.4, human [O75920-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF073518 mRNA Translation: AAC63517.1
AF073519 mRNA Translation: AAC63518.1
BC021174 mRNA Translation: AAH21174.1
BC035932 mRNA Translation: AAH35932.1
BC093880 mRNA Translation: AAH93880.1
BC093882 mRNA Translation: AAH93882.1
BC101970 mRNA Translation: AAI01971.1
BC104738 mRNA Translation: AAI04739.1
BC103687 mRNA Translation: AAI03688.1
BC143255 mRNA Translation: AAI43256.1
BC143260 mRNA Translation: AAI43261.1
BC171749 mRNA Translation: AAI71749.1
CCDSiCCDS43326.1 [O75920-1]
CCDS47228.1 [O75920-1]
CCDS47229.1 [O75920-2]
CCDS54866.1 [O75920-2]
RefSeqiNP_001171558.1, NM_001178087.1 [O75920-2]
NP_068802.1, NM_021967.2 [O75920-1]
NP_075257.1, NM_022968.1 [O75920-2]
NP_075267.1, NM_022978.2 [O75920-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
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Protein-protein interaction databases

BioGRIDi113898, 17 interactors
608917, 12 interactors
IntActiO75920, 20 interactors
STRINGi9606.ENSP00000370126

PTM databases

iPTMnetiO75920
PhosphoSitePlusiO75920

Polymorphism and mutation databases

BioMutaiSERF1A

Proteomic databases

jPOSTiO75920
MassIVEiO75920
MaxQBiO75920
PaxDbiO75920
PeptideAtlasiO75920
PRIDEiO75920
ProteomicsDBi50276 [O75920-1]
50277 [O75920-2]
TopDownProteomicsiO75920-2 [O75920-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
24018, 17 antibodies
67412, 123 antibodies

The DNASU plasmid repository

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DNASUi
8293

Genome annotation databases

EnsembliENST00000317633; ENSP00000321791; ENSG00000172058 [O75920-2]
ENST00000354833; ENSP00000346892; ENSG00000172058 [O75920-1]
ENST00000380750; ENSP00000370126; ENSG00000205572 [O75920-1]
ENST00000380751; ENSP00000370127; ENSG00000205572 [O75920-2]
ENST00000611616; ENSP00000482392; ENSG00000278839 [O75920-2]
ENST00000613172; ENSP00000484795; ENSG00000277429 [O75920-1]
ENST00000614527; ENSP00000479724; ENSG00000275581 [O75920-1]
ENST00000621283; ENSP00000481118; ENSG00000277429 [O75920-2]
ENST00000622553; ENSP00000480543; ENSG00000278839 [O75920-1]
ENST00000627372; ENSP00000487374; ENSG00000275581 [O75920-2]
ENST00000630567; ENSP00000487531; ENSG00000275581 [O75920-1]
GeneIDi728492
8293
KEGGihsa:728492
hsa:8293
UCSCiuc003jxz.4, human [O75920-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
728492
8293
DisGeNETi728492
8293
EuPathDBiHostDB:ENSG00000172058.15
HostDB:ENSG00000205572.9

GeneCards: human genes, protein and diseases

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GeneCardsi
SERF1A
SERF1B
HGNCiHGNC:10755, SERF1A
HGNC:10756, SERF1B
HPAiENSG00000172058, Low tissue specificity
ENSG00000205572, Low tissue specificity
MIMi603011, gene
neXtProtiNX_O75920
OpenTargetsiENSG00000172058
ENSG00000205572
PharmGKBiPA35675

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4488, Eukaryota
GeneTreeiENSGT00940000161793
HOGENOMiCLU_165034_1_1_1
InParanoidiO75920
OMAiQRDADIM
OrthoDBi1559007at2759
PhylomeDBiO75920

Enzyme and pathway databases

PathwayCommonsiO75920

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
728492, 7 hits in 59 CRISPR screens
8293, 8 hits in 464 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SERF1B, human
PharosiO75920, Tbio

Protein Ontology

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PROi
PR:O75920
RNActiO75920, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000172058, Expressed in prefrontal cortex and 119 other tissues
ExpressionAtlasiO75920, baseline and differential
GenevisibleiO75920, HS

Family and domain databases

InterProiView protein in InterPro
IPR040211, SERF1/2
IPR007513, Uncharacterised_SERF_N
PANTHERiPTHR13596, PTHR13596, 1 hit
PfamiView protein in Pfam
PF04419, 4F5, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSERF1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75920
Secondary accession number(s): B7ZKM2, O75919, Q52LK5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: November 1, 1998
Last modified: December 2, 2020
This is version 149 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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