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Protein

Regulator of G-protein signaling 9

Gene

RGS9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to GNAT1. Involved in phototransduction; key element in the recovery phase of visual transduction (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • GTPase activator activity Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionSignal transduction inhibitor
Biological processSensory transduction, Vision

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade
R-HSA-418594 G alpha (i) signalling events
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Regulator of G-protein signaling 9
Short name:
RGS9
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RGS9
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000108370.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10004 RGS9

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604067 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O75916

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Prolonged electroretinal response suppression (PERRS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionCharacterized by difficulty adjusting to sudden changes in luminance levels mediated by cones.
See also OMIM:608415
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_017912299W → R in PERRS. 1 PublicationCorresponds to variant dbSNP:rs121908449EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
8787

MalaCards human disease database

More...
MalaCardsi
RGS9
MIMi608415 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000108370

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
75374 Bradyopsia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34380

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RGS9

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002042031 – 674Regulator of G-protein signaling 9Add BLAST674

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Retinal isoform 3 is light-dependent phosphorylated at 'Ser-478'. Phosphorylation is decreased by light exposition (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O75916

PeptideAtlas

More...
PeptideAtlasi
O75916

PRoteomics IDEntifications database

More...
PRIDEi
O75916

ProteomicsDB human proteome resource

More...
ProteomicsDBi
50271
50272 [O75916-2]
50273 [O75916-3]
50274 [O75916-4]
50275 [O75916-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O75916

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O75916

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in the caudate and putamen, lower levels found in the hypothalamus and nucleus accumbens and very low levels in cerebellum. Not expressed in globus pallidus or cingulate cortex. Isoform 2 is expressed predominantly in pineal gland and retina. Isoform 3 is expressed in retina (abundant in photoreceptors).

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000108370 Expressed in 120 organ(s), highest expression level in caudate nucleus

CleanEx database of gene expression profiles

More...
CleanExi
HS_RGS9

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O75916 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O75916 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA013550
HPA014137

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer with GNB5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with GNB5. Component of the RGS9-1-Gbeta5 complex composed of RGS9 (RGS9-1), Gbeta5 (GNB5) and RGS9BP. Interacts with PDE6G and GNAT1.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
114315, 7 interactors

Protein interaction database and analysis system

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IntActi
O75916, 2 interactors

Molecular INTeraction database

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MINTi
O75916

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000262406

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O75916

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O75916

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 105DEPPROSITE-ProRule annotationAdd BLAST76
Domaini219 – 280G protein gammaAdd BLAST62
Domaini298 – 413RGSPROSITE-ProRule annotationAdd BLAST116

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

In photoreceptor cells the DEP domain is essential for targeting RGS9 to the outer rod segments.1 Publication

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3589 Eukaryota
ENOG410YMJD LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000156505

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG007404

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O75916

KEGG Orthology (KO)

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KOi
K13765

Database of Orthologous Groups

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OrthoDBi
EOG091G05MO

Database for complete collections of gene phylogenies

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PhylomeDBi
O75916

TreeFam database of animal gene trees

More...
TreeFami
TF351956

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00068 GGL, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 1 hit
4.10.260.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000591 DEP_dom
IPR015898 G-protein_gamma-like_dom
IPR036284 GGL_sf
IPR016137 RGS
IPR036305 RGS_sf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00610 DEP, 1 hit
PF00631 G-gamma, 1 hit
PF00615 RGS, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01301 RGSPROTEIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00049 DEP, 1 hit
SM00224 GGL, 1 hit
SM00315 RGS, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785 SSF46785, 1 hit
SSF48097 SSF48097, 1 hit
SSF48670 SSF48670, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50186 DEP, 1 hit
PS50132 RGS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O75916-1) [UniParc]FASTAAdd to basket
Also known as: RGS9L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTIRHQGQQY RPRMAFLQKI EALVKDMQNP ETGVRMQNQR VLVTSVPHAM
60 70 80 90 100
TGSDVLQWIV QRLWISSLEA QNLGNFIVRY GYIYPLQDPK NLILKPDGSL
110 120 130 140 150
YRFQTPYFWP TQQWPAEDTD YAIYLAKRNI KKKGILEEYE KENYNFLNQK
160 170 180 190 200
MNYKWDFVIM QAKEQYRAGK ERNKADRYAL DCQEKAYWLV HRCPPGMDNV
210 220 230 240 250
LDYGLDRVTN PNEVKVNQKQ TVVAVKKEIM YYQQALMRST VKSSVSLGGI
260 270 280 290 300
VKYSEQFSSN DAIMSGCLPS NPWITDDTQF WDLNAKLVEI PTKMRVERWA
310 320 330 340 350
FNFSELIRDP KGRQSFQYFL KKEFSGENLG FWEACEDLKY GDQSKVKEKA
360 370 380 390 400
EEIYKLFLAP GARRWINIDG KTMDITVKGL KHPHRYVLDA AQTHIYMLMK
410 420 430 440 450
KDSYARYLKS PIYKDMLAKA IEPQETTKKS STLPFMRRHL RSSPSPVILR
460 470 480 490 500
QLEEEAKARE AANTVDITQP GQHMAPSPHL TVYTGTCMPP SPSSPFSSSC
510 520 530 540 550
RSPRKPFASP SRFIRRPSTT ICPSPIRVAL ESSSGLEQKG ECSGSMAPRG
560 570 580 590 600
PSVTESSEAS LDTSWPRSRP RAPPKARMAL SFSRFLRRGC LASPVFARLS
610 620 630 640 650
PKCPAVSHGR VQPLGDVGQQ LPRLKSKRVA NFFQIKMDVP TGSGTCLMDS
660 670
EDAGTGESGD RATEKEVICP WESL
Length:674
Mass (Da):76,966
Last modified:November 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8E2B11104B448364
GO
Isoform 2 (identifier: O75916-2) [UniParc]FASTAAdd to basket
Also known as: RGS9S

The sequence of this isoform differs from the canonical sequence as follows:
     470-674: Missing.

Show »
Length:469
Mass (Da):54,982
Checksum:i04A5CF08AE73AEAC
GO
Isoform 3 (identifier: O75916-3) [UniParc]FASTAAdd to basket
Also known as: RGS9-1

The sequence of this isoform differs from the canonical sequence as follows:
     216-218: Missing.
     470-487: PGQHMAPSPHLTVYTGTC → VMSKLDRRSQLKKELPPK
     488-674: Missing.

Show »
Length:484
Mass (Da):56,776
Checksum:i9E7C2371DF3BE3B5
GO
Isoform 4 (identifier: O75916-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-229: Missing.

Show »
Length:445
Mass (Da):49,810
Checksum:iA30CF34166481356
GO
Isoform 5 (identifier: O75916-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     216-218: Missing.

Show »
Length:671
Mass (Da):76,625
Checksum:i3866AC4C0DBB9B6A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PD91E9PD91_HUMAN
Regulator of G-protein-signaling 9
RGS9
628Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QL70J3QL70_HUMAN
Regulator of G-protein-signaling 9
RGS9
494Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GVU3A0A1B0GVU3_HUMAN
Regulator of G-protein-signaling 9
RGS9
674Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC25430 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti112Q → R in AAG09311 (PubMed:10564809).Curated1
Sequence conflicti112Q → R in AAG09312 (PubMed:10564809).Curated1
Sequence conflicti142E → G in AAM12647 (Ref. 3) Curated1
Sequence conflicti306L → S in AAM12646 (Ref. 3) Curated1
Sequence conflicti319F → S in AAM12647 (Ref. 3) Curated1
Sequence conflicti336E → G in AAM12647 (Ref. 3) Curated1
Sequence conflicti392Q → R in AAM12647 (Ref. 3) Curated1
Sequence conflicti417L → Q in AAC25430 (Ref. 7) Curated1
Sequence conflicti422E → D in AAC25430 (Ref. 7) Curated1
Sequence conflicti428K → R in AAM12647 (Ref. 3) Curated1
Sequence conflicti454E → G in AAM12646 (Ref. 3) Curated1
Sequence conflicti460E → K in AAG09311 (PubMed:10564809).Curated1
Sequence conflicti460E → K in AAG09312 (PubMed:10564809).Curated1
Sequence conflicti518 – 519Missing in AAC25430 (Ref. 7) Curated2
Sequence conflicti527 – 531RVALE → LVVLD in AAC25430 (Ref. 7) Curated5
Sequence conflicti544 – 549GSMAPR → WSGANP in AAC25430 (Ref. 7) Curated6
Sequence conflicti555E → D in AAC25430 (Ref. 7) Curated1
Sequence conflicti561L → R in AAC25430 (Ref. 7) Curated1
Sequence conflicti564S → P in AAM12647 (Ref. 3) Curated1
Sequence conflicti566P → T in AAC25430 (Ref. 7) Curated1
Sequence conflicti574P → L in AAC25430 (Ref. 7) Curated1
Sequence conflicti599L → V in AAC25430 (Ref. 7) Curated1
Sequence conflicti668I → T in AAM12646 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051796258S → L. Corresponds to variant dbSNP:rs12452285EnsemblClinVar.1
Natural variantiVAR_017912299W → R in PERRS. 1 PublicationCorresponds to variant dbSNP:rs121908449EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0056741 – 229Missing in isoform 4. 1 PublicationAdd BLAST229
Alternative sequenceiVSP_038381216 – 218Missing in isoform 3 and isoform 5. 2 Publications3
Alternative sequenceiVSP_005675470 – 674Missing in isoform 2. 1 PublicationAdd BLAST205
Alternative sequenceiVSP_038382470 – 487PGQHM…YTGTC → VMSKLDRRSQLKKELPPK in isoform 3. CuratedAdd BLAST18
Alternative sequenceiVSP_038383488 – 674Missing in isoform 3. CuratedAdd BLAST187

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF071476 mRNA Translation: AAC64040.1
AF178070
, AF178056, AF178057, AF178058, AF178059, AF178060, AF178061, AF178062, AF178063, AF178064, AF178065, AF178066, AF178067, AF178068, AF178069 Genomic DNA Translation: AAG09311.1
AF178072
, AF178056, AF178057, AF178058, AF178059, AF178060, AF178061, AF178062, AF178063, AF178064, AF178065, AF178066, AF178067, AF178068, AF178069, AF178070, AF178071 Genomic DNA Translation: AAG09312.1
AF493932 mRNA Translation: AAM12646.1
AF493933 mRNA Translation: AAM12647.1
AY585190 mRNA Translation: AAT79493.1
AY585191 mRNA Translation: AAT79494.1
AK290535 mRNA Translation: BAF83224.1
AC015821 Genomic DNA No translation available.
AC060771 Genomic DNA No translation available.
CH471099 Genomic DNA Translation: EAW88998.1
AF073710 mRNA Translation: AAC25430.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS42373.1 [O75916-1]
CCDS45764.1 [O75916-5]

NCBI Reference Sequences

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RefSeqi
NP_001075424.1, NM_001081955.2 [O75916-5]
NP_003826.2, NM_003835.3 [O75916-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.664380

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000262406; ENSP00000262406; ENSG00000108370 [O75916-1]
ENST00000449996; ENSP00000396329; ENSG00000108370 [O75916-5]

Database of genes from NCBI RefSeq genomes

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GeneIDi
8787

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:8787

UCSC genome browser

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UCSCi
uc002jfd.4 human [O75916-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071476 mRNA Translation: AAC64040.1
AF178070
, AF178056, AF178057, AF178058, AF178059, AF178060, AF178061, AF178062, AF178063, AF178064, AF178065, AF178066, AF178067, AF178068, AF178069 Genomic DNA Translation: AAG09311.1
AF178072
, AF178056, AF178057, AF178058, AF178059, AF178060, AF178061, AF178062, AF178063, AF178064, AF178065, AF178066, AF178067, AF178068, AF178069, AF178070, AF178071 Genomic DNA Translation: AAG09312.1
AF493932 mRNA Translation: AAM12646.1
AF493933 mRNA Translation: AAM12647.1
AY585190 mRNA Translation: AAT79493.1
AY585191 mRNA Translation: AAT79494.1
AK290535 mRNA Translation: BAF83224.1
AC015821 Genomic DNA No translation available.
AC060771 Genomic DNA No translation available.
CH471099 Genomic DNA Translation: EAW88998.1
AF073710 mRNA Translation: AAC25430.1 Different initiation.
CCDSiCCDS42373.1 [O75916-1]
CCDS45764.1 [O75916-5]
RefSeqiNP_001075424.1, NM_001081955.2 [O75916-5]
NP_003826.2, NM_003835.3 [O75916-1]
UniGeneiHs.664380

3D structure databases

ProteinModelPortaliO75916
SMRiO75916
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114315, 7 interactors
IntActiO75916, 2 interactors
MINTiO75916
STRINGi9606.ENSP00000262406

PTM databases

iPTMnetiO75916
PhosphoSitePlusiO75916

Polymorphism and mutation databases

BioMutaiRGS9

Proteomic databases

PaxDbiO75916
PeptideAtlasiO75916
PRIDEiO75916
ProteomicsDBi50271
50272 [O75916-2]
50273 [O75916-3]
50274 [O75916-4]
50275 [O75916-5]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262406; ENSP00000262406; ENSG00000108370 [O75916-1]
ENST00000449996; ENSP00000396329; ENSG00000108370 [O75916-5]
GeneIDi8787
KEGGihsa:8787
UCSCiuc002jfd.4 human [O75916-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
8787
DisGeNETi8787
EuPathDBiHostDB:ENSG00000108370.15

GeneCards: human genes, protein and diseases

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GeneCardsi
RGS9
HGNCiHGNC:10004 RGS9
HPAiHPA013550
HPA014137
MalaCardsiRGS9
MIMi604067 gene
608415 phenotype
neXtProtiNX_O75916
OpenTargetsiENSG00000108370
Orphaneti75374 Bradyopsia
PharmGKBiPA34380

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00940000156505
HOVERGENiHBG007404
InParanoidiO75916
KOiK13765
OrthoDBiEOG091G05MO
PhylomeDBiO75916
TreeFamiTF351956

Enzyme and pathway databases

ReactomeiR-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade
R-HSA-418594 G alpha (i) signalling events
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
RGS9

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
8787

Protein Ontology

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PROi
PR:O75916

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000108370 Expressed in 120 organ(s), highest expression level in caudate nucleus
CleanExiHS_RGS9
ExpressionAtlasiO75916 baseline and differential
GenevisibleiO75916 HS

Family and domain databases

CDDicd00068 GGL, 1 hit
Gene3Di1.10.10.10, 1 hit
4.10.260.10, 1 hit
InterProiView protein in InterPro
IPR000591 DEP_dom
IPR015898 G-protein_gamma-like_dom
IPR036284 GGL_sf
IPR016137 RGS
IPR036305 RGS_sf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00610 DEP, 1 hit
PF00631 G-gamma, 1 hit
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00049 DEP, 1 hit
SM00224 GGL, 1 hit
SM00315 RGS, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF48097 SSF48097, 1 hit
SSF48670 SSF48670, 1 hit
PROSITEiView protein in PROSITE
PS50186 DEP, 1 hit
PS50132 RGS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRGS9_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75916
Secondary accession number(s): A8K3C0
, O75573, Q696R2, Q8TD64, Q8TD65, Q9HC32, Q9HC33
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: December 5, 2018
This is version 180 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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