Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

PRA1 family protein 3

Gene

ARL6IP5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate in a PKC activity-dependent manner. May be involved in membrane traffic.By similarity

GO - Biological processi

  • intrinsic apoptotic signaling pathway in response to oxidative stress Source: UniProtKB
  • L-glutamate transmembrane transport Source: UniProtKB
  • negative regulation of L-glutamate import across plasma membrane Source: UniProtKB
  • negative regulation of mitochondrial membrane potential Source: UniProtKB
  • positive regulation of apoptotic process Source: UniProtKB
  • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
  • positive regulation of stress-activated MAPK cascade Source: UniProtKB

Enzyme and pathway databases

ReactomeiR-HSA-210500 Glutamate Neurotransmitter Release Cycle

Protein family/group databases

TCDBi9.A.49.1.3 the prenylated rab acceptor protein 1 (pra1) family

Names & Taxonomyi

Protein namesi
Recommended name:
PRA1 family protein 3
Alternative name(s):
ADP-ribosylation factor-like protein 6-interacting protein 5
Short name:
ARL-6-interacting protein 5
Short name:
Aip-5
Cytoskeleton-related vitamin A-responsive protein
Dermal papilla-derived protein 11
GTRAP3-18
Glutamate transporter EAAC1-interacting protein
JM5
Prenylated Rab acceptor protein 2
Protein JWa
Putative MAPK-activating protein PM27
Gene namesi
Name:ARL6IP5
Synonyms:DERP11, JWA, PRA2, PRAF3
ORF Names:HSPC127
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000144746.6
HGNCiHGNC:16937 ARL6IP5
MIMi605709 gene
neXtProtiNX_O75915

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 35CytoplasmicBy similarityAdd BLAST35
Transmembranei36 – 56HelicalSequence analysisAdd BLAST21
Transmembranei57 – 77HelicalSequence analysisAdd BLAST21
Topological domaini78 – 93CytoplasmicBy similarityAdd BLAST16
Transmembranei94 – 114HelicalSequence analysisAdd BLAST21
Transmembranei115 – 135HelicalSequence analysisAdd BLAST21
Topological domaini136 – 188CytoplasmicBy similarityAdd BLAST53

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10550
OpenTargetsiENSG00000144746
PharmGKBiPA134898937

Polymorphism and mutation databases

BioMutaiARL6IP5

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002208831 – 188PRA1 family protein 3Add BLAST188

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources2 Publications1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiO75915
MaxQBiO75915
PaxDbiO75915
PeptideAtlasiO75915
PRIDEiO75915
ProteomicsDBi50270
TopDownProteomicsiO75915

PTM databases

iPTMnetiO75915
PhosphoSitePlusiO75915
SwissPalmiO75915

Expressioni

Inductioni

By methyl-beta-cyclodextrin (By similarity). Up-regulated upon induced differentiation and in heat stress.By similarity1 Publication

Gene expression databases

BgeeiENSG00000144746
CleanExiHS_ARL6IP5
ExpressionAtlasiO75915 baseline and differential
GenevisibleiO75915 HS

Organism-specific databases

HPAiCAB019321
HPA015540

Interactioni

Subunit structurei

Homodimer. Heterodimer with ARL6IP1. Forms multimers. Interacts with prenylated RAB1A, RAB3A and SLC1A1/EAAC1. Does not interact with VAMP1, VAMP2 or VAMP3. Interacts with ARL6. Interacts with SLC1A1/EAAC1.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
RNF185Q96GF13EBI-2860752,EBI-2340249

Protein-protein interaction databases

BioGridi115801, 54 interactors
IntActiO75915, 9 interactors
MINTiO75915
STRINGi9606.ENSP00000273258

Structurei

3D structure databases

ProteinModelPortaliO75915
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni103 – 117Required for homodimer formation and heterodimer formation with ARL6IP1By similarityAdd BLAST15
Regioni136 – 188Targeting to endoplasmic reticulum membraneBy similarityAdd BLAST53

Sequence similaritiesi

Belongs to the PRA1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4050 Eukaryota
ENOG4111MUC LUCA
GeneTreeiENSGT00390000008631
HOGENOMiHOG000231363
HOVERGENiHBG053661
InParanoidiO75915
KOiK20393
OMAiAHNKDIL
OrthoDBiEOG091G0QS5
PhylomeDBiO75915
TreeFamiTF105479

Family and domain databases

InterProiView protein in InterPro
IPR004895 Prenylated_rab_accept_PRA1
PfamiView protein in Pfam
PF03208 PRA1, 1 hit

Sequencei

Sequence statusi: Complete.

O75915-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVNIAPLRA WDDFFPGSDR FARPDFRDIS KWNNRVVSNL LYYQTNYLVV
60 70 80 90 100
AAMMISIVGF LSPFNMILGG IVVVLVFTGF VWAAHNKDVL RRMKKRYPTT
110 120 130 140 150
FVMVVMLASY FLISMFGGVM VFVFGITFPL LLMFIHASLR LRNLKNKLEN
160 170 180
KMEGIGLKRT PMGIVLDALE QQEEGINRLT DYISKVKE
Length:188
Mass (Da):21,615
Last modified:November 1, 1998 - v1
Checksum:i3AA708C6D0901B44
GO

Sequence cautioni

The sequence BAD97286 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti28D → G in BAD97286 (Ref. 10) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB052638 mRNA Translation: BAD83603.1
AY102608 mRNA Translation: AAM28950.1
AB014765 mRNA Translation: BAC66462.1
AF070523 mRNA Translation: AAC64360.1
AF115965 mRNA Translation: AAP97237.1
AF125530 mRNA Translation: AAF17224.1
AF161476 mRNA Translation: AAF29091.1
AB097051 mRNA Translation: BAC77404.1
AK223566 mRNA Translation: BAD97286.1 Different initiation.
AK312731 mRNA Translation: BAG35602.1
CH471055 Genomic DNA Translation: EAW65473.1
BC005143 mRNA Translation: AAH05143.1
BC020797 mRNA Translation: AAH20797.1
CCDSiCCDS2912.1
RefSeqiNP_006398.1, NM_006407.3
UniGeneiHs.518060
Hs.745255

Genome annotation databases

EnsembliENST00000273258; ENSP00000273258; ENSG00000144746
GeneIDi10550
KEGGihsa:10550
UCSCiuc003dnr.4 human

Similar proteinsi

Entry informationi

Entry nameiPRAF3_HUMAN
AccessioniPrimary (citable) accession number: O75915
Secondary accession number(s): B2R6V5, Q53ES3, Q5KU08
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: November 1, 1998
Last modified: June 20, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health