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Protein

Serine/threonine-protein kinase PAK 3

Gene

PAK3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by binding small G proteins. Binding of GTP-bound CDC42 or RAC1 to the autoregulatory region releases monomers from the autoinhibited dimer, enables phosphorylation of Thr-436 and allows the kinase domain to adopt an active structure (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei312ATPPROSITE-ProRule annotation1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei402Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi289 – 297ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • MAP kinase kinase activity Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: Reactome
  • Rac GTPase binding Source: GO_Central
  • SH3 domain binding Source: UniProtKB-KW

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAllosteric enzyme, Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.11.1 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-202433 Generation of second messenger molecules
R-HSA-389359 CD28 dependent Vav1 pathway
R-HSA-3928664 Ephrin signaling
R-HSA-399954 Sema3A PAK dependent Axon repulsion
R-HSA-428540 Activation of RAC1
R-HSA-5218920 VEGFR2 mediated vascular permeability
R-HSA-5621575 CD209 (DC-SIGN) signaling
R-HSA-5627123 RHO GTPases activate PAKs
R-HSA-5687128 MAPK6/MAPK4 signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
O75914

SIGNOR Signaling Network Open Resource

More...
SIGNORi
O75914

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein kinase PAK 3 (EC:2.7.11.1)
Alternative name(s):
Beta-PAK
Oligophrenin-3
p21-activated kinase 3
Short name:
PAK-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PAK3
Synonyms:OPHN3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000077264.14

Human Gene Nomenclature Database

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HGNCi
HGNC:8592 PAK3

Online Mendelian Inheritance in Man (OMIM)

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MIMi
300142 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O75914

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Mental retardation, X-linked 30 (MRX30)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations.
See also OMIM:300558
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02382567R → C in MRX30. 1 PublicationCorresponds to variant dbSNP:rs121434612EnsemblClinVar.1
Natural variantiVAR_023826380A → E in MRX30. 1 PublicationCorresponds to variant dbSNP:rs121434613Ensembl.1

Keywords - Diseasei

Disease mutation, Mental retardation

Organism-specific databases

DisGeNET

More...
DisGeNETi
5063

MalaCards human disease database

More...
MalaCardsi
PAK3
MIMi300558 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000077264

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
777 X-linked non-syndromic intellectual disability

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA32919

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2999

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2135

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PAK3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000864691 – 559Serine/threonine-protein kinase PAK 3Add BLAST559

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2PhosphoserineBy similarity1
Modified residuei50Phosphoserine; by autocatalysisBy similarity1
Modified residuei154Phosphoserine; by autocatalysisBy similarity1
Modified residuei186PhosphoserineBy similarity1
Modified residuei436Phosphothreonine; by autocatalysisBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autophosphorylated when activated by CDC42/p21.
Neddylated.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O75914

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O75914

PeptideAtlas

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PeptideAtlasi
O75914

PRoteomics IDEntifications database

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PRIDEi
O75914

ProteomicsDB human proteome resource

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ProteomicsDBi
50266
50267 [O75914-2]
50268 [O75914-3]
50269 [O75914-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O75914

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O75914

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Restricted to the nervous system. Highly expressed in postmitotic neurons of the developing and postnatal cerebral cortex and hippocampus.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000077264 Expressed in 170 organ(s), highest expression level in middle temporal gyrus

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O75914 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O75914 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA044791
HPA060219

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1. Shows highly specific binding to the SH3 domains of phospholipase C-gamma and of adapter protein NCK. Interacts with the C-terminal of APP (By similarity). Interacts with ARHGEF6 and ARHGEF7.By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
111099, 11 interactors

Protein interaction database and analysis system

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IntActi
O75914, 5 interactors

Molecular INTeraction database

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MINTi
O75914

STRING: functional protein association networks

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STRINGi
9606.ENSP00000353864

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
O75914

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1559
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6FD3X-ray1.52A261-559[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O75914

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O75914

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini70 – 83CRIBPROSITE-ProRule annotationAdd BLAST14
Domaini283 – 534Protein kinasePROSITE-ProRule annotationAdd BLAST252

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni65 – 150Autoregulatory regionBy similarityAdd BLAST86
Regioni65 – 123GTPase-bindingBy similarityAdd BLAST59
Regioni84 – 282LinkerAdd BLAST199

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi187 – 201Poly-GluAdd BLAST15

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

SH3-binding

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0578 Eukaryota
ENOG410XP4K LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000153723

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000234202

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG108518

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O75914

KEGG Orthology (KO)

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KOi
K05733

Identification of Orthologs from Complete Genome Data

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OMAi
NENQMAY

Database of Orthologous Groups

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OrthoDBi
750735at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O75914

TreeFam database of animal gene trees

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TreeFami
TF105351

Family and domain databases

Conserved Domains Database

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CDDi
cd01093 CRIB_PAK_like, 1 hit
cd06656 STKc_PAK3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.90.810.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000095 CRIB_dom
IPR036936 CRIB_dom_sf
IPR011009 Kinase-like_dom_sf
IPR035065 PAK2/3
IPR033923 PAK_BD
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR035063 STK_PAK3

The PANTHER Classification System

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PANTHERi
PTHR24361:SF250 PTHR24361:SF250, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00786 PBD, 1 hit
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00285 PBD, 1 hit
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50108 CRIB, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O75914-1) [UniParc]FASTAAdd to basket
Also known as: PAK3b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSDGLDNEEK PPAPPLRMNS NNRDSSALNH SSKPLPMAPE EKNKKARLRS
60 70 80 90 100
IFPGGGDKTN KKKEKERPEI SLPSDFEHTI HVGFDAVTGE FTPDLYGSQM
110 120 130 140 150
CPGKLPEGIP EQWARLLQTS NITKLEQKKN PQAVLDVLKF YDSKETVNNQ
160 170 180 190 200
KYMSFTSGDK SAHGYIAAHP SSTKTASEPP LAPPVSEEED EEEEEEEDEN
210 220 230 240 250
EPPPVIAPRP EHTKSIYTRS VVESIASPAV PNKEVTPPSA ENANSSTLYR
260 270 280 290 300
NTDRQRKKSK MTDEEILEKL RSIVSVGDPK KKYTRFEKIG QGASGTVYTA
310 320 330 340 350
LDIATGQEVA IKQMNLQQQP KKELIINEIL VMRENKNPNI VNYLDSYLVG
360 370 380 390 400
DELWVVMEYL AGGSLTDVVT ETCMDEGQIA AVCRECLQAL DFLHSNQVIH
410 420 430 440 450
RDIKSDNILL GMDGSVKLTD FGFCAQITPE QSKRSTMVGT PYWMAPEVVT
460 470 480 490 500
RKAYGPKVDI WSLGIMAIEM VEGEPPYLNE NPLRALYLIA TNGTPELQNP
510 520 530 540 550
ERLSAVFRDF LNRCLEMDVD RRGSAKELLQ HPFLKLAKPL SSLTPLIIAA

KEAIKNSSR
Length:559
Mass (Da):62,310
Last modified:May 10, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBC39AEC6F0A5478B
GO
Isoform 2 (identifier: O75914-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     93-107: Missing.

Show »
Length:544
Mass (Da):60,693
Checksum:i230AF6952CB049E2
GO
Isoform 3 (identifier: O75914-3) [UniParc]FASTAAdd to basket
Also known as: PAK3cb

The sequence of this isoform differs from the canonical sequence as follows:
     92-92: T → TNSPFQTSRPVTVASSQSEGKM

Show »
Length:580
Mass (Da):64,530
Checksum:i9646E127F2F007A2
GO
Isoform 4 (identifier: O75914-4) [UniParc]FASTAAdd to basket
Also known as: PAK3c

The sequence of this isoform differs from the canonical sequence as follows:
     92-107: TPDLYGSQMCPGKLPE → TNSPFQTSRPVTVASSQSEGKM

Show »
Length:565
Mass (Da):62,913
Checksum:i6A0C2190BBBBDC1F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X294A0A087X294_HUMAN
Non-specific serine/threonine prote...
PAK3
543Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AKS5B1AKS5_HUMAN
Serine/threonine-protein kinase PAK...
PAK3
181Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti32S → F in AAF67008 (Ref. 2) Curated1
Sequence conflicti36P → S in AAF67008 (Ref. 2) Curated1
Sequence conflicti73P → S in AAF67008 (Ref. 2) Curated1
Sequence conflicti106 – 107PE → SL in AAF67008 (Ref. 2) Curated2
Sequence conflicti123T → P in AAF67008 (Ref. 2) Curated1
Sequence conflicti127 – 130QKKN → PEEE in AAF67008 (Ref. 2) Curated4
Sequence conflicti134 – 137VLDV → CSRC in AAF67008 (Ref. 2) Curated4
Sequence conflicti146 – 148TVN → PVT in AAF67008 (Ref. 2) Curated3
Sequence conflicti175T → P in AAF67008 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02382567R → C in MRX30. 1 PublicationCorresponds to variant dbSNP:rs121434612EnsemblClinVar.1
Natural variantiVAR_023826380A → E in MRX30. 1 PublicationCorresponds to variant dbSNP:rs121434613Ensembl.1
Natural variantiVAR_046764440T → S in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04184092 – 107TPDLY…GKLPE → TNSPFQTSRPVTVASSQSEG KM in isoform 4. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_04183992T → TNSPFQTSRPVTVASSQSEG KM in isoform 3. 1 Publication1
Alternative sequenceiVSP_01024293 – 107Missing in isoform 2. 3 PublicationsAdd BLAST15

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF068864 mRNA Translation: AAC36097.1
AF155651 mRNA Translation: AAF67008.1
AB102659 mRNA Translation: BAC81128.1
AB102251 Genomic DNA Translation: BAC80750.1
AB102252 Genomic DNA Translation: BAC80751.1
AB102253 Genomic DNA Translation: BAC80752.1
AB102254 Genomic DNA Translation: BAC80753.1
AB102255 Genomic DNA Translation: BAC80754.1
AB102256 Genomic DNA Translation: BAC80755.1
AB102257 Genomic DNA Translation: BAC80756.1
AB102258 Genomic DNA Translation: BAC80757.1
AB102259 Genomic DNA Translation: BAC80758.1
AB102260 Genomic DNA Translation: BAC80759.1
AB102261 Genomic DNA Translation: BAC80760.1
AB102262 Genomic DNA Translation: BAC80761.1
AB102263 Genomic DNA Translation: BAC80762.1
AB102264 Genomic DNA Translation: BAC80763.1
AB102265 Genomic DNA Translation: BAC80764.1
AB102266 Genomic DNA Translation: BAC80765.1
AB102267 Genomic DNA Translation: BAC80766.1
AB102268 Genomic DNA Translation: BAC80767.1
AB102269 Genomic DNA Translation: BAC80768.1
AB102270 Genomic DNA Translation: BAC80769.1
AB102281 Genomic DNA Translation: BAC80780.1
AB102282 Genomic DNA Translation: BAC80781.1
AB102283 Genomic DNA Translation: BAC80782.1
AB102284 Genomic DNA Translation: BAC80783.1
AB102285 Genomic DNA Translation: BAC80784.1
AB102286 Genomic DNA Translation: BAC80785.1
AB102287 Genomic DNA Translation: BAC80786.1
AB102288 Genomic DNA Translation: BAC80787.1
AB102289 Genomic DNA Translation: BAC80788.1
AB102290 Genomic DNA Translation: BAC80789.1
AB102291 Genomic DNA Translation: BAC80790.1
AB102292 Genomic DNA Translation: BAC80791.1
AB102293 Genomic DNA Translation: BAC80792.1
AB102294 Genomic DNA Translation: BAC80793.1
AB102295 Genomic DNA Translation: BAC80794.1
AB102296 Genomic DNA Translation: BAC80795.1
AB102297 Genomic DNA Translation: BAC80796.1
AB102298 Genomic DNA Translation: BAC80797.1
AB102299 Genomic DNA Translation: BAC80798.1
AB102300 Genomic DNA Translation: BAC80799.1
AM943850 mRNA Translation: CAQ16016.1
AM943851 mRNA Translation: CAQ16017.1
AM943852 mRNA Translation: CAQ16018.1
AK290504 mRNA Translation: BAF83193.1
AL356578 Genomic DNA No translation available.
AL357774 Genomic DNA No translation available.
AL031117 Genomic DNA No translation available.
AL117326 Genomic DNA No translation available.
CH471120 Genomic DNA Translation: EAX02654.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14554.1 [O75914-2]
CCDS48151.1 [O75914-3]
CCDS48152.1 [O75914-4]
CCDS48153.1 [O75914-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001121638.1, NM_001128166.2 [O75914-2]
NP_001121639.1, NM_001128167.2 [O75914-2]
NP_001121640.1, NM_001128168.2 [O75914-3]
NP_001121644.1, NM_001128172.2 [O75914-4]
NP_001121645.1, NM_001128173.2 [O75914-1]
NP_001311254.1, NM_001324325.1 [O75914-2]
NP_001311255.1, NM_001324326.1 [O75914-2]
NP_001311256.1, NM_001324327.1 [O75914-1]
NP_001311257.1, NM_001324328.1 [O75914-1]
NP_001311258.1, NM_001324329.1 [O75914-1]
NP_001311259.1, NM_001324330.1 [O75914-2]
NP_001311260.1, NM_001324331.1 [O75914-2]
NP_001311261.1, NM_001324332.1 [O75914-2]
NP_001311262.1, NM_001324333.1 [O75914-1]
NP_001311263.1, NM_001324334.1 [O75914-2]
NP_002569.1, NM_002578.4 [O75914-2]
XP_016885046.1, XM_017029557.1 [O75914-1]
XP_016885050.1, XM_017029561.1 [O75914-2]
XP_016885052.1, XM_017029563.1 [O75914-3]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.593599
Hs.655757
Hs.656789

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000262836; ENSP00000262836; ENSG00000077264 [O75914-1]
ENST00000360648; ENSP00000353864; ENSG00000077264 [O75914-3]
ENST00000372007; ENSP00000361077; ENSG00000077264 [O75914-2]
ENST00000372010; ENSP00000361080; ENSG00000077264 [O75914-1]
ENST00000417227; ENSP00000389172; ENSG00000077264 [O75914-4]
ENST00000425146; ENSP00000401982; ENSG00000077264 [O75914-2]
ENST00000446737; ENSP00000410853; ENSG00000077264 [O75914-2]
ENST00000518291; ENSP00000428921; ENSG00000077264 [O75914-3]
ENST00000519681; ENSP00000429113; ENSG00000077264 [O75914-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5063

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5063

UCSC genome browser

More...
UCSCi
uc004eoz.3 human [O75914-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF068864 mRNA Translation: AAC36097.1
AF155651 mRNA Translation: AAF67008.1
AB102659 mRNA Translation: BAC81128.1
AB102251 Genomic DNA Translation: BAC80750.1
AB102252 Genomic DNA Translation: BAC80751.1
AB102253 Genomic DNA Translation: BAC80752.1
AB102254 Genomic DNA Translation: BAC80753.1
AB102255 Genomic DNA Translation: BAC80754.1
AB102256 Genomic DNA Translation: BAC80755.1
AB102257 Genomic DNA Translation: BAC80756.1
AB102258 Genomic DNA Translation: BAC80757.1
AB102259 Genomic DNA Translation: BAC80758.1
AB102260 Genomic DNA Translation: BAC80759.1
AB102261 Genomic DNA Translation: BAC80760.1
AB102262 Genomic DNA Translation: BAC80761.1
AB102263 Genomic DNA Translation: BAC80762.1
AB102264 Genomic DNA Translation: BAC80763.1
AB102265 Genomic DNA Translation: BAC80764.1
AB102266 Genomic DNA Translation: BAC80765.1
AB102267 Genomic DNA Translation: BAC80766.1
AB102268 Genomic DNA Translation: BAC80767.1
AB102269 Genomic DNA Translation: BAC80768.1
AB102270 Genomic DNA Translation: BAC80769.1
AB102281 Genomic DNA Translation: BAC80780.1
AB102282 Genomic DNA Translation: BAC80781.1
AB102283 Genomic DNA Translation: BAC80782.1
AB102284 Genomic DNA Translation: BAC80783.1
AB102285 Genomic DNA Translation: BAC80784.1
AB102286 Genomic DNA Translation: BAC80785.1
AB102287 Genomic DNA Translation: BAC80786.1
AB102288 Genomic DNA Translation: BAC80787.1
AB102289 Genomic DNA Translation: BAC80788.1
AB102290 Genomic DNA Translation: BAC80789.1
AB102291 Genomic DNA Translation: BAC80790.1
AB102292 Genomic DNA Translation: BAC80791.1
AB102293 Genomic DNA Translation: BAC80792.1
AB102294 Genomic DNA Translation: BAC80793.1
AB102295 Genomic DNA Translation: BAC80794.1
AB102296 Genomic DNA Translation: BAC80795.1
AB102297 Genomic DNA Translation: BAC80796.1
AB102298 Genomic DNA Translation: BAC80797.1
AB102299 Genomic DNA Translation: BAC80798.1
AB102300 Genomic DNA Translation: BAC80799.1
AM943850 mRNA Translation: CAQ16016.1
AM943851 mRNA Translation: CAQ16017.1
AM943852 mRNA Translation: CAQ16018.1
AK290504 mRNA Translation: BAF83193.1
AL356578 Genomic DNA No translation available.
AL357774 Genomic DNA No translation available.
AL031117 Genomic DNA No translation available.
AL117326 Genomic DNA No translation available.
CH471120 Genomic DNA Translation: EAX02654.1
CCDSiCCDS14554.1 [O75914-2]
CCDS48151.1 [O75914-3]
CCDS48152.1 [O75914-4]
CCDS48153.1 [O75914-1]
RefSeqiNP_001121638.1, NM_001128166.2 [O75914-2]
NP_001121639.1, NM_001128167.2 [O75914-2]
NP_001121640.1, NM_001128168.2 [O75914-3]
NP_001121644.1, NM_001128172.2 [O75914-4]
NP_001121645.1, NM_001128173.2 [O75914-1]
NP_001311254.1, NM_001324325.1 [O75914-2]
NP_001311255.1, NM_001324326.1 [O75914-2]
NP_001311256.1, NM_001324327.1 [O75914-1]
NP_001311257.1, NM_001324328.1 [O75914-1]
NP_001311258.1, NM_001324329.1 [O75914-1]
NP_001311259.1, NM_001324330.1 [O75914-2]
NP_001311260.1, NM_001324331.1 [O75914-2]
NP_001311261.1, NM_001324332.1 [O75914-2]
NP_001311262.1, NM_001324333.1 [O75914-1]
NP_001311263.1, NM_001324334.1 [O75914-2]
NP_002569.1, NM_002578.4 [O75914-2]
XP_016885046.1, XM_017029557.1 [O75914-1]
XP_016885050.1, XM_017029561.1 [O75914-2]
XP_016885052.1, XM_017029563.1 [O75914-3]
UniGeneiHs.593599
Hs.655757
Hs.656789

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6FD3X-ray1.52A261-559[»]
ProteinModelPortaliO75914
SMRiO75914
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111099, 11 interactors
IntActiO75914, 5 interactors
MINTiO75914
STRINGi9606.ENSP00000353864

Chemistry databases

BindingDBiO75914
ChEMBLiCHEMBL2999
GuidetoPHARMACOLOGYi2135

PTM databases

iPTMnetiO75914
PhosphoSitePlusiO75914

Polymorphism and mutation databases

BioMutaiPAK3

Proteomic databases

jPOSTiO75914
PaxDbiO75914
PeptideAtlasiO75914
PRIDEiO75914
ProteomicsDBi50266
50267 [O75914-2]
50268 [O75914-3]
50269 [O75914-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
5063
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262836; ENSP00000262836; ENSG00000077264 [O75914-1]
ENST00000360648; ENSP00000353864; ENSG00000077264 [O75914-3]
ENST00000372007; ENSP00000361077; ENSG00000077264 [O75914-2]
ENST00000372010; ENSP00000361080; ENSG00000077264 [O75914-1]
ENST00000417227; ENSP00000389172; ENSG00000077264 [O75914-4]
ENST00000425146; ENSP00000401982; ENSG00000077264 [O75914-2]
ENST00000446737; ENSP00000410853; ENSG00000077264 [O75914-2]
ENST00000518291; ENSP00000428921; ENSG00000077264 [O75914-3]
ENST00000519681; ENSP00000429113; ENSG00000077264 [O75914-4]
GeneIDi5063
KEGGihsa:5063
UCSCiuc004eoz.3 human [O75914-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5063
DisGeNETi5063
EuPathDBiHostDB:ENSG00000077264.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PAK3
HGNCiHGNC:8592 PAK3
HPAiHPA044791
HPA060219
MalaCardsiPAK3
MIMi300142 gene
300558 phenotype
neXtProtiNX_O75914
OpenTargetsiENSG00000077264
Orphaneti777 X-linked non-syndromic intellectual disability
PharmGKBiPA32919

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0578 Eukaryota
ENOG410XP4K LUCA
GeneTreeiENSGT00940000153723
HOGENOMiHOG000234202
HOVERGENiHBG108518
InParanoidiO75914
KOiK05733
OMAiNENQMAY
OrthoDBi750735at2759
PhylomeDBiO75914
TreeFamiTF105351

Enzyme and pathway databases

BRENDAi2.7.11.1 2681
ReactomeiR-HSA-202433 Generation of second messenger molecules
R-HSA-389359 CD28 dependent Vav1 pathway
R-HSA-3928664 Ephrin signaling
R-HSA-399954 Sema3A PAK dependent Axon repulsion
R-HSA-428540 Activation of RAC1
R-HSA-5218920 VEGFR2 mediated vascular permeability
R-HSA-5621575 CD209 (DC-SIGN) signaling
R-HSA-5627123 RHO GTPases activate PAKs
R-HSA-5687128 MAPK6/MAPK4 signaling
SignaLinkiO75914
SIGNORiO75914

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PAK3 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PAK3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5063

Protein Ontology

More...
PROi
PR:O75914

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000077264 Expressed in 170 organ(s), highest expression level in middle temporal gyrus
ExpressionAtlasiO75914 baseline and differential
GenevisibleiO75914 HS

Family and domain databases

CDDicd01093 CRIB_PAK_like, 1 hit
cd06656 STKc_PAK3, 1 hit
Gene3Di3.90.810.10, 1 hit
InterProiView protein in InterPro
IPR000095 CRIB_dom
IPR036936 CRIB_dom_sf
IPR011009 Kinase-like_dom_sf
IPR035065 PAK2/3
IPR033923 PAK_BD
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR035063 STK_PAK3
PANTHERiPTHR24361:SF250 PTHR24361:SF250, 1 hit
PfamiView protein in Pfam
PF00786 PBD, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00285 PBD, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50108 CRIB, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPAK3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75914
Secondary accession number(s): A8K389
, B1GX77, B1GX78, B1GX79, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 10, 2004
Last modified: January 16, 2019
This is version 193 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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