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Protein

Diacylglycerol kinase iota

Gene

DGKI

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri178 – 232Phorbol-ester/DAG-type 1Add BLAST55
Zinc fingeri251 – 309Phorbol-ester/DAG-type 2Add BLAST59

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-114508 Effects of PIP2 hydrolysis

Chemistry databases

SwissLipidsiSLP:000000925

Names & Taxonomyi

Protein namesi
Recommended name:
Diacylglycerol kinase iota (EC:2.7.1.107)
Short name:
DAG kinase iota
Alternative name(s):
Diglyceride kinase iota
Short name:
DGK-iota
Gene namesi
Name:DGKI
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000157680.15
HGNCiHGNC:2855 DGKI
MIMi604072 gene
neXtProtiNX_O75912

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi9162
OpenTargetsiENSG00000157680
PharmGKBiPA27316

Polymorphism and mutation databases

BioMutaiDGKI

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002184661 – 1065Diacylglycerol kinase iotaAdd BLAST1065

Proteomic databases

MaxQBiO75912
PaxDbiO75912
PeptideAtlasiO75912
PRIDEiO75912
ProteomicsDBi50265

PTM databases

iPTMnetiO75912
PhosphoSitePlusiO75912

Expressioni

Gene expression databases

BgeeiENSG00000157680 Expressed in 122 organ(s), highest expression level in putamen
CleanExiHS_DGKI
ExpressionAtlasiO75912 baseline and differential

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
VHLP40337-33EBI-1765520,EBI-301270

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114605, 4 interactors
IntActiO75912, 1 interactor
STRINGi9606.ENSP00000288490

Structurei

3D structure databases

ProteinModelPortaliO75912
SMRiO75912
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini372 – 507DAGKcPROSITE-ProRule annotationAdd BLAST136
Repeati958 – 990ANK 1Add BLAST33
Repeati997 – 1026ANK 2Add BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi20 – 31Poly-AlaAdd BLAST12
Compositional biasi69 – 74Poly-Ser6
Compositional biasi95 – 102Poly-Ala8

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri178 – 232Phorbol-ester/DAG-type 1Add BLAST55
Zinc fingeri251 – 309Phorbol-ester/DAG-type 2Add BLAST59

Keywords - Domaini

ANK repeat, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0782 Eukaryota
ENOG410XSCB LUCA
GeneTreeiENSGT00760000119050
HOGENOMiHOG000231472
HOVERGENiHBG067303
InParanoidiO75912
KOiK00901
PhylomeDBiO75912
TreeFamiTF312817

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
3.40.50.10330, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR017438 ATP-NAD_kinase_N
IPR037607 DGK
IPR000756 Diacylglycerol_kin_accessory
IPR001206 Diacylglycerol_kinase_cat_dom
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002219 PE/DAG-bd
PANTHERiPTHR11255 PTHR11255, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF00130 C1_1, 1 hit
PF00609 DAGK_acc, 1 hit
PF00781 DAGK_cat, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SM00109 C1, 2 hits
SM00045 DAGKa, 1 hit
SM00046 DAGKc, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit
SSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits
PS50146 DAGK, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

O75912-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDAAGRGCHL LPLPAARGPA RAPAAAAAAA ASPPGPCSGA ACAPSAAAGA
60 70 80 90 100
GAMNPSSSAG EEKGATGGSS SSGSGAGSCC LGAEGGADPR GAGSAAAAGA
110 120 130 140 150
AALDEPAAAG QKEKDEALEE KLRNLTFRKQ VSYRKAISRA GLQHLAPAHP
160 170 180 190 200
LSLPVANGPA KEPRATLDWS ENAVNGEHLW LETNVSGDLC YLGEENCQVR
210 220 230 240 250
FAKSALRRKC AVCKIVVHTA CIEQLEKINF RCKPTFREGG SRSPRENFVR
260 270 280 290 300
HHWVHRRRQE GKCKQCGKGF QQKFSFHSKE IVAISCSWCK QAFHNKVTCF
310 320 330 340 350
MLHHIEEPCS LGAHAAVIVP PTWIIKVKKP QNSLKASNRK KKRTSFKRKA
360 370 380 390 400
SKRGMEQENK GRPFVIKPIS SPLMKPLLVF VNPKSGGNQG TKVLQMFMWY
410 420 430 440 450
LNPRQVFDLS QEGPKDALEL YRKVPNLRIL ACGGDGTVGW ILSILDELQL
460 470 480 490 500
SPQPPVGVLP LGTGNDLART LNWGGGYTDE PVSKILCQVE DGTVVQLDRW
510 520 530 540 550
NLHVERNPDL PPEELEDGVC KLPLNVFNNY FSLGFDAHVT LEFHESREAN
560 570 580 590 600
PEKFNSRFRN KMFYAGAAFS DFLQRSSRDL SKHVKVVCDG TDLTPKIQEL
610 620 630 640 650
KFQCIVFLNI PRYCAGTMPW GNPGDHHDFE PQRHDDGYIE VIGFTMASLA
660 670 680 690 700
ALQVGGHGER LHQCREVMLL TYKSIPMQVD GEPCRLAPAM IRISLRNQAN
710 720 730 740 750
MVQKSKRRTS MPLLNDPQSV PDRLRIRVNK ISLQDYEGFH YDKEKLREAS
760 770 780 790 800
ISDWLRTIAG ELVQSFGAIP LGILVVRGDC DLETCRMYID RLQEDLQSVS
810 820 830 840 850
SGSQRVHYQD HETSFPRALS AQRLSPRWCF LDDRSQEHLH FVMEISQDEI
860 870 880 890 900
FILDPDMVVS QPAGTPPGMP DLVVEQASGI SDWWNPALRK RMLSDSGLGM
910 920 930 940 950
IAPYYEDSDL KDLSHSRVLQ SPVSSEDHAI LQAVIAGDLM KLIESYKNGG
960 970 980 990 1000
SLLIQGPDHC SLLHYAAKTG NGEIVKYILD HGPSELLDMA DSETGETALH
1010 1020 1030 1040 1050
KAACQRNRAV CQLLVDAGAS LRKTDSKGKT PQERAQQAGD PDLAAYLESR
1060
QNYKVIGHED LETAV
Length:1,065
Mass (Da):116,997
Last modified:November 1, 1998 - v1
Checksum:iB84971AA7630A799
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EWQ4E7EWQ4_HUMAN
Diacylglycerol kinase
DGKI
1,078Annotation score:
E7EM72E7EM72_HUMAN
Diacylglycerol kinase
DGKI
1,047Annotation score:
A0A087WV00A0A087WV00_HUMAN
Diacylglycerol kinase
DGKI
932Annotation score:
E9PFX6E9PFX6_HUMAN
Diacylglycerol kinase
DGKI
734Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti160A → P in AAF43006 (PubMed:10706894).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_010190153L → F1 PublicationCorresponds to variant dbSNP:rs61757580Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061936 mRNA Translation: AAC62010.1
CH236950 Genomic DNA Translation: EAL24051.1
AH009185 Genomic DNA Translation: AAF43006.1
CCDSiCCDS5845.1
RefSeqiNP_001308637.1, NM_001321708.1
NP_001308638.1, NM_001321709.1
NP_001308639.1, NM_001321710.1
NP_004708.1, NM_004717.3
UniGeneiHs.242947
Hs.636145
Hs.713106

Genome annotation databases

EnsembliENST00000288490; ENSP00000288490; ENSG00000157680
GeneIDi9162
KEGGihsa:9162
UCSCiuc003vtt.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061936 mRNA Translation: AAC62010.1
CH236950 Genomic DNA Translation: EAL24051.1
AH009185 Genomic DNA Translation: AAF43006.1
CCDSiCCDS5845.1
RefSeqiNP_001308637.1, NM_001321708.1
NP_001308638.1, NM_001321709.1
NP_001308639.1, NM_001321710.1
NP_004708.1, NM_004717.3
UniGeneiHs.242947
Hs.636145
Hs.713106

3D structure databases

ProteinModelPortaliO75912
SMRiO75912
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114605, 4 interactors
IntActiO75912, 1 interactor
STRINGi9606.ENSP00000288490

Chemistry databases

SwissLipidsiSLP:000000925

PTM databases

iPTMnetiO75912
PhosphoSitePlusiO75912

Polymorphism and mutation databases

BioMutaiDGKI

Proteomic databases

MaxQBiO75912
PaxDbiO75912
PeptideAtlasiO75912
PRIDEiO75912
ProteomicsDBi50265

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000288490; ENSP00000288490; ENSG00000157680
GeneIDi9162
KEGGihsa:9162
UCSCiuc003vtt.4 human

Organism-specific databases

CTDi9162
DisGeNETi9162
EuPathDBiHostDB:ENSG00000157680.15
GeneCardsiDGKI
HGNCiHGNC:2855 DGKI
MIMi604072 gene
neXtProtiNX_O75912
OpenTargetsiENSG00000157680
PharmGKBiPA27316
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0782 Eukaryota
ENOG410XSCB LUCA
GeneTreeiENSGT00760000119050
HOGENOMiHOG000231472
HOVERGENiHBG067303
InParanoidiO75912
KOiK00901
PhylomeDBiO75912
TreeFamiTF312817

Enzyme and pathway databases

ReactomeiR-HSA-114508 Effects of PIP2 hydrolysis

Miscellaneous databases

ChiTaRSiDGKI human
GenomeRNAii9162
PROiPR:O75912
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000157680 Expressed in 122 organ(s), highest expression level in putamen
CleanExiHS_DGKI
ExpressionAtlasiO75912 baseline and differential

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
3.40.50.10330, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR017438 ATP-NAD_kinase_N
IPR037607 DGK
IPR000756 Diacylglycerol_kin_accessory
IPR001206 Diacylglycerol_kinase_cat_dom
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002219 PE/DAG-bd
PANTHERiPTHR11255 PTHR11255, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF00130 C1_1, 1 hit
PF00609 DAGK_acc, 1 hit
PF00781 DAGK_cat, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SM00109 C1, 2 hits
SM00045 DAGKa, 1 hit
SM00046 DAGKc, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit
SSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits
PS50146 DAGK, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDGKI_HUMAN
AccessioniPrimary (citable) accession number: O75912
Secondary accession number(s): A4D1Q9, Q9NZ49
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 165 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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