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Entry version 162 (10 Apr 2019)
Sequence version 2 (29 Mar 2005)
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Protein

Short-chain dehydrogenase/reductase 3

Gene

DHRS3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.1 Publication

Miscellaneous

Located in a region of chromosome 1 which is often deleted in aggressive neuroblastoma tumors.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei175SubstrateBy similarity1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei188Proton acceptorBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
LigandNADP

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:ENSG00000162496-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.1.1.300 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2187335 The retinoid cycle in cones (daylight vision)
R-HSA-5365859 RA biosynthesis pathway

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001868

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Short-chain dehydrogenase/reductase 3 (EC:1.1.1.300)
Alternative name(s):
DD83.1
Retinal short-chain dehydrogenase/reductase 1
Short name:
retSDR1
Retinol dehydrogenase 17
Short chain dehydrogenase/reductase family 16C member 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DHRS3
Synonyms:RDH17, SDR16C1
ORF Names:UNQ2424/PRO4983
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000162496.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17693 DHRS3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612830 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O75911

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei9 – 29HelicalSequence analysisAdd BLAST21
Transmembranei170 – 190HelicalSequence analysisAdd BLAST21
Transmembranei195 – 215HelicalSequence analysisAdd BLAST21
Transmembranei253 – 273HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9249

Open Targets

More...
OpenTargetsi
ENSG00000162496

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134952810

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB00162 Vitamin A

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DHRS3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000546441 – 302Short-chain dehydrogenase/reductase 3Add BLAST302

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O75911

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O75911

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O75911

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O75911

PeptideAtlas

More...
PeptideAtlasi
O75911

PRoteomics IDEntifications database

More...
PRIDEi
O75911

ProteomicsDB human proteome resource

More...
ProteomicsDBi
50263
50264 [O75911-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O75911

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O75911

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed with highest levels found in heart, placenta, lung, liver, kidney, pancreas, thyroid, testis, stomach, trachea and spinal cord. Lower levels found in skeletal muscle, intestine and lymph node. No expression detected in brain. In the retina, expressed in cone but not rod outer segments.2 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By retinoic acid.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000162496 Expressed in 223 organ(s), highest expression level in nasal cavity epithelium

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O75911 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O75911 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA010844

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114675, 11 interactors

Protein interaction database and analysis system

More...
IntActi
O75911, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000480439

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O75911

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O75911

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1201 Eukaryota
COG1028 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158724

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG051352

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O75911

KEGG Orthology (KO)

More...
KOi
K11146

Identification of Orthologs from Complete Genome Data

More...
OMAi
WTMHALI

Database of Orthologous Groups

More...
OrthoDBi
1373099at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O75911

TreeFam database of animal gene trees

More...
TreeFami
TF312837

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032969 DHRS3
IPR036291 NAD(P)-bd_dom_sf
IPR002347 SDR_fam

The PANTHER Classification System

More...
PANTHERi
PTHR24322:SF483 PTHR24322:SF483, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00106 adh_short, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00081 GDHRDH
PR00080 SDRFAMILY

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51735 SSF51735, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O75911-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVWKRLGALV MFPLQMIYLV VKAAVGLVLP AKLRDLSREN VLITGGGRGI
60 70 80 90 100
GRQLAREFAE RGARKIVLWG RTEKCLKETT EEIRQMGTEC HYFICDVGNR
110 120 130 140 150
EEVYQTAKAV REKVGDITIL VNNAAVVHGK SLMDSDDDAL LKSQHINTLG
160 170 180 190 200
QFWTTKAFLP RMLELQNGHI VCLNSVLALS AIPGAIDYCT SKASAFAFME
210 220 230 240 250
SLTLGLLDCP GVSATTVLPF HTSTEMFQGM RVRFPNLFPP LKPETVARRT
260 270 280 290 300
VEAVQLNQAL LLLPWTMHAL VILKSILPQA ALEEIHKFSG TYTCMNTFKG

RT
Length:302
Mass (Da):33,548
Last modified:March 29, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8FB4A735278E242E
GO
Isoform 2 (identifier: O75911-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     115-167: GDITILVNNA...FLPRMLELQN → CSLGGSIPST...DSPMKLAPVT
     168-302: Missing.

Note: No experimental confirmation available.
Show »
Length:167
Mass (Da):18,675
Checksum:i803F9C15FF4F826F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5SUY4Q5SUY4_HUMAN
Short-chain dehydrogenase/reductase...
DHRS3
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WTY3A0A087WTY3_HUMAN
Short-chain dehydrogenase/reductase...
DHRS3
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAQ88460 differs from that shown. Reason: Frameshift at position 15.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0674432V → A3 PublicationsCorresponds to variant dbSNP:rs1128251Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_013256115 – 167GDITI…LELQN → CSLGGSIPSTADHRLIPGKE NILMWPGRELCLWQNGFARG TFGDSPMKLAPVT in isoform 2. 1 PublicationAdd BLAST53
Alternative sequenceiVSP_013257168 – 302Missing in isoform 2. 1 PublicationAdd BLAST135

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF061741 mRNA Translation: AAC63263.1
AF179237
, AF179234, AF179235, AF179236 Genomic DNA Translation: AAD55402.1
AY358093 mRNA Translation: AAQ88460.1 Frameshift.
AK312961 mRNA Translation: BAG35800.1
BX648476 mRNA Translation: CAI46033.1
AL513016 Genomic DNA No translation available.
AL645761 Genomic DNA No translation available.
CH471130 Genomic DNA Translation: EAW71743.1
BC002730 mRNA Translation: AAH02730.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS146.1 [O75911-1]

NCBI Reference Sequences

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RefSeqi
NP_004744.2, NM_004753.6 [O75911-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.289347
Hs.708470

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000616661; ENSP00000480439; ENSG00000162496 [O75911-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9249

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9249

UCSC genome browser

More...
UCSCi
uc031tpa.2 human [O75911-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061741 mRNA Translation: AAC63263.1
AF179237
, AF179234, AF179235, AF179236 Genomic DNA Translation: AAD55402.1
AY358093 mRNA Translation: AAQ88460.1 Frameshift.
AK312961 mRNA Translation: BAG35800.1
BX648476 mRNA Translation: CAI46033.1
AL513016 Genomic DNA No translation available.
AL645761 Genomic DNA No translation available.
CH471130 Genomic DNA Translation: EAW71743.1
BC002730 mRNA Translation: AAH02730.1
CCDSiCCDS146.1 [O75911-1]
RefSeqiNP_004744.2, NM_004753.6 [O75911-1]
UniGeneiHs.289347
Hs.708470

3D structure databases

ProteinModelPortaliO75911
SMRiO75911
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114675, 11 interactors
IntActiO75911, 1 interactor
STRINGi9606.ENSP00000480439

Chemistry databases

DrugBankiDB00162 Vitamin A
SwissLipidsiSLP:000001868

PTM databases

iPTMnetiO75911
PhosphoSitePlusiO75911

Polymorphism and mutation databases

BioMutaiDHRS3

Proteomic databases

EPDiO75911
jPOSTiO75911
MaxQBiO75911
PaxDbiO75911
PeptideAtlasiO75911
PRIDEiO75911
ProteomicsDBi50263
50264 [O75911-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
9249
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000616661; ENSP00000480439; ENSG00000162496 [O75911-1]
GeneIDi9249
KEGGihsa:9249
UCSCiuc031tpa.2 human [O75911-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9249
DisGeNETi9249
EuPathDBiHostDB:ENSG00000162496.8

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DHRS3
HGNCiHGNC:17693 DHRS3
HPAiHPA010844
MIMi612830 gene
neXtProtiNX_O75911
OpenTargetsiENSG00000162496
PharmGKBiPA134952810

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1201 Eukaryota
COG1028 LUCA
GeneTreeiENSGT00940000158724
HOVERGENiHBG051352
InParanoidiO75911
KOiK11146
OMAiWTMHALI
OrthoDBi1373099at2759
PhylomeDBiO75911
TreeFamiTF312837

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000162496-MONOMER
BRENDAi1.1.1.300 2681
ReactomeiR-HSA-2187335 The retinoid cycle in cones (daylight vision)
R-HSA-5365859 RA biosynthesis pathway

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
DHRS3 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
DHRS3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9249

Protein Ontology

More...
PROi
PR:O75911

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000162496 Expressed in 223 organ(s), highest expression level in nasal cavity epithelium
ExpressionAtlasiO75911 baseline and differential
GenevisibleiO75911 HS

Family and domain databases

InterProiView protein in InterPro
IPR032969 DHRS3
IPR036291 NAD(P)-bd_dom_sf
IPR002347 SDR_fam
PANTHERiPTHR24322:SF483 PTHR24322:SF483, 1 hit
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDHRS3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75911
Secondary accession number(s): B2R7F3
, Q5VUY3, Q6UY38, Q9BUC8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: March 29, 2005
Last modified: April 10, 2019
This is version 162 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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