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Protein

Short-chain dehydrogenase/reductase 3

Gene

DHRS3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.1 Publication

Miscellaneous

Located in a region of chromosome 1 which is often deleted in aggressive neuroblastoma tumors.

Catalytic activityi

All-trans-retinol + NADP+ = all-trans-retinal + NADPH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei175SubstrateBy similarity1
Active sitei188Proton acceptorBy similarity1

GO - Molecular functioni

  • electron transfer activity Source: UniProtKB
  • NADP-retinol dehydrogenase activity Source: Reactome
  • nucleotide binding Source: ProtInc
  • retinol dehydrogenase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNADP

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000162496-MONOMER
BRENDAi1.1.1.300 2681
ReactomeiR-HSA-2187335 The retinoid cycle in cones (daylight vision)
R-HSA-5365859 RA biosynthesis pathway

Chemistry databases

SwissLipidsiSLP:000001868

Names & Taxonomyi

Protein namesi
Recommended name:
Short-chain dehydrogenase/reductase 3 (EC:1.1.1.300)
Alternative name(s):
DD83.1
Retinal short-chain dehydrogenase/reductase 1
Short name:
retSDR1
Retinol dehydrogenase 17
Short chain dehydrogenase/reductase family 16C member 1
Gene namesi
Name:DHRS3
Synonyms:RDH17, SDR16C1
ORF Names:UNQ2424/PRO4983
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000162496.8
HGNCiHGNC:17693 DHRS3
MIMi612830 gene
neXtProtiNX_O75911

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei9 – 29HelicalSequence analysisAdd BLAST21
Transmembranei170 – 190HelicalSequence analysisAdd BLAST21
Transmembranei195 – 215HelicalSequence analysisAdd BLAST21
Transmembranei253 – 273HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9249
OpenTargetsiENSG00000162496
PharmGKBiPA134952810

Chemistry databases

DrugBankiDB00162 Vitamin A

Polymorphism and mutation databases

BioMutaiDHRS3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000546441 – 302Short-chain dehydrogenase/reductase 3Add BLAST302

Proteomic databases

EPDiO75911
MaxQBiO75911
PaxDbiO75911
PeptideAtlasiO75911
PRIDEiO75911
ProteomicsDBi50263
50264 [O75911-2]

PTM databases

iPTMnetiO75911
PhosphoSitePlusiO75911

Expressioni

Tissue specificityi

Widely expressed with highest levels found in heart, placenta, lung, liver, kidney, pancreas, thyroid, testis, stomach, trachea and spinal cord. Lower levels found in skeletal muscle, intestine and lymph node. No expression detected in brain. In the retina, expressed in cone but not rod outer segments.2 Publications

Inductioni

By retinoic acid.1 Publication

Gene expression databases

BgeeiENSG00000162496 Expressed in 223 organ(s), highest expression level in nasal cavity epithelium
CleanExiHS_DHRS3
ExpressionAtlasiO75911 baseline and differential
GenevisibleiO75911 HS

Organism-specific databases

HPAiHPA010844

Interactioni

Protein-protein interaction databases

BioGridi114675, 11 interactors
IntActiO75911, 1 interactor
STRINGi9606.ENSP00000365397

Structurei

3D structure databases

ProteinModelPortaliO75911
SMRiO75911
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1201 Eukaryota
COG1028 LUCA
GeneTreeiENSGT00930000150823
HOVERGENiHBG051352
InParanoidiO75911
KOiK11146
OMAiWTMHALI
OrthoDBiEOG091G0825
PhylomeDBiO75911
TreeFamiTF312837

Family and domain databases

InterProiView protein in InterPro
IPR032969 DHRS3
IPR036291 NAD(P)-bd_dom_sf
IPR002347 SDR_fam
PANTHERiPTHR24322:SF483 PTHR24322:SF483, 1 hit
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O75911-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVWKRLGALV MFPLQMIYLV VKAAVGLVLP AKLRDLSREN VLITGGGRGI
60 70 80 90 100
GRQLAREFAE RGARKIVLWG RTEKCLKETT EEIRQMGTEC HYFICDVGNR
110 120 130 140 150
EEVYQTAKAV REKVGDITIL VNNAAVVHGK SLMDSDDDAL LKSQHINTLG
160 170 180 190 200
QFWTTKAFLP RMLELQNGHI VCLNSVLALS AIPGAIDYCT SKASAFAFME
210 220 230 240 250
SLTLGLLDCP GVSATTVLPF HTSTEMFQGM RVRFPNLFPP LKPETVARRT
260 270 280 290 300
VEAVQLNQAL LLLPWTMHAL VILKSILPQA ALEEIHKFSG TYTCMNTFKG

RT
Length:302
Mass (Da):33,548
Last modified:March 29, 2005 - v2
Checksum:i8FB4A735278E242E
GO
Isoform 2 (identifier: O75911-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     115-167: GDITILVNNA...FLPRMLELQN → CSLGGSIPST...DSPMKLAPVT
     168-302: Missing.

Note: No experimental confirmation available.
Show »
Length:167
Mass (Da):18,675
Checksum:i803F9C15FF4F826F
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5SUY4Q5SUY4_HUMAN
Short-chain dehydrogenase/reductase...
DHRS3
147Annotation score:
A0A087WTY3A0A087WTY3_HUMAN
Short-chain dehydrogenase/reductase...
DHRS3
81Annotation score:

Sequence cautioni

The sequence AAQ88460 differs from that shown. Reason: Frameshift at position 15.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0674432V → A3 PublicationsCorresponds to variant dbSNP:rs1128251Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_013256115 – 167GDITI…LELQN → CSLGGSIPSTADHRLIPGKE NILMWPGRELCLWQNGFARG TFGDSPMKLAPVT in isoform 2. 1 PublicationAdd BLAST53
Alternative sequenceiVSP_013257168 – 302Missing in isoform 2. 1 PublicationAdd BLAST135

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061741 mRNA Translation: AAC63263.1
AF179237
, AF179234, AF179235, AF179236 Genomic DNA Translation: AAD55402.1
AY358093 mRNA Translation: AAQ88460.1 Frameshift.
AK312961 mRNA Translation: BAG35800.1
BX648476 mRNA Translation: CAI46033.1
AL513016 Genomic DNA No translation available.
AL645761 Genomic DNA No translation available.
CH471130 Genomic DNA Translation: EAW71743.1
BC002730 mRNA Translation: AAH02730.1
CCDSiCCDS146.1 [O75911-1]
RefSeqiNP_004744.2, NM_004753.6 [O75911-1]
UniGeneiHs.289347
Hs.708470

Genome annotation databases

EnsembliENST00000616661; ENSP00000480439; ENSG00000162496 [O75911-1]
GeneIDi9249
KEGGihsa:9249
UCSCiuc031tpa.2 human [O75911-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061741 mRNA Translation: AAC63263.1
AF179237
, AF179234, AF179235, AF179236 Genomic DNA Translation: AAD55402.1
AY358093 mRNA Translation: AAQ88460.1 Frameshift.
AK312961 mRNA Translation: BAG35800.1
BX648476 mRNA Translation: CAI46033.1
AL513016 Genomic DNA No translation available.
AL645761 Genomic DNA No translation available.
CH471130 Genomic DNA Translation: EAW71743.1
BC002730 mRNA Translation: AAH02730.1
CCDSiCCDS146.1 [O75911-1]
RefSeqiNP_004744.2, NM_004753.6 [O75911-1]
UniGeneiHs.289347
Hs.708470

3D structure databases

ProteinModelPortaliO75911
SMRiO75911
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114675, 11 interactors
IntActiO75911, 1 interactor
STRINGi9606.ENSP00000365397

Chemistry databases

DrugBankiDB00162 Vitamin A
SwissLipidsiSLP:000001868

PTM databases

iPTMnetiO75911
PhosphoSitePlusiO75911

Polymorphism and mutation databases

BioMutaiDHRS3

Proteomic databases

EPDiO75911
MaxQBiO75911
PaxDbiO75911
PeptideAtlasiO75911
PRIDEiO75911
ProteomicsDBi50263
50264 [O75911-2]

Protocols and materials databases

DNASUi9249
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000616661; ENSP00000480439; ENSG00000162496 [O75911-1]
GeneIDi9249
KEGGihsa:9249
UCSCiuc031tpa.2 human [O75911-1]

Organism-specific databases

CTDi9249
DisGeNETi9249
EuPathDBiHostDB:ENSG00000162496.8
GeneCardsiDHRS3
HGNCiHGNC:17693 DHRS3
HPAiHPA010844
MIMi612830 gene
neXtProtiNX_O75911
OpenTargetsiENSG00000162496
PharmGKBiPA134952810
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1201 Eukaryota
COG1028 LUCA
GeneTreeiENSGT00930000150823
HOVERGENiHBG051352
InParanoidiO75911
KOiK11146
OMAiWTMHALI
OrthoDBiEOG091G0825
PhylomeDBiO75911
TreeFamiTF312837

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000162496-MONOMER
BRENDAi1.1.1.300 2681
ReactomeiR-HSA-2187335 The retinoid cycle in cones (daylight vision)
R-HSA-5365859 RA biosynthesis pathway

Miscellaneous databases

ChiTaRSiDHRS3 human
GeneWikiiDHRS3
GenomeRNAii9249
PROiPR:O75911
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000162496 Expressed in 223 organ(s), highest expression level in nasal cavity epithelium
CleanExiHS_DHRS3
ExpressionAtlasiO75911 baseline and differential
GenevisibleiO75911 HS

Family and domain databases

InterProiView protein in InterPro
IPR032969 DHRS3
IPR036291 NAD(P)-bd_dom_sf
IPR002347 SDR_fam
PANTHERiPTHR24322:SF483 PTHR24322:SF483, 1 hit
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDHRS3_HUMAN
AccessioniPrimary (citable) accession number: O75911
Secondary accession number(s): B2R7F3
, Q5VUY3, Q6UY38, Q9BUC8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: March 29, 2005
Last modified: November 7, 2018
This is version 158 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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