Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 193 (12 Aug 2020)
Sequence version 2 (16 Dec 2008)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Cyclin-K

Gene

CCNK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A).3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division, Mitosis, Transcription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
O75909

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-112382, Formation of RNA Pol II elongation complex
R-HSA-167152, Formation of HIV elongation complex in the absence of HIV Tat
R-HSA-167287, HIV elongation arrest and recovery
R-HSA-167290, Pausing and recovery of HIV elongation
R-HSA-2173796, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
R-HSA-674695, RNA Polymerase II Pre-transcription Events
R-HSA-6796648, TP53 Regulates Transcription of DNA Repair Genes
R-HSA-6807505, RNA polymerase II transcribes snRNA genes
R-HSA-75955, RNA Polymerase II Transcription Elongation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
O75909

SIGNOR Signaling Network Open Resource

More...
SIGNORi
O75909

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cyclin-K
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCNK
Synonyms:CPR4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000090061.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1596, CCNK

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603544, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O75909

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Intellectual developmental disorder with hypertelorism and distinctive facies (IDDHDF)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant neurodevelopmental disorder characterized by developmental delay and intellectual disability, language defects, and distinctive facial dysmorphism including high hairline, hypertelorism, thin eyebrows, dysmorphic ears, broad nasal bridge and tip, and narrow jaw.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_081570111K → E in IDDHDF; contrary to the wild-type protein, does not rescue morpholino knockdown phenotype in zebrafish. 1 Publication1

Keywords - Diseasei

Disease mutation, Mental retardation

Organism-specific databases

DisGeNET

More...
DisGeNETi
8812

MalaCards human disease database

More...
MalaCardsi
CCNK
MIMi618147, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000090061

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26161

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O75909, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3038475
CHEMBL4106169
CHEMBL4296067

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CCNK

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000804781 – 580Cyclin-KAdd BLAST580

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei324PhosphoserineCombined sources1
Modified residuei328PhosphoserineBy similarity1
Modified residuei329PhosphoserineCombined sources1
Modified residuei340PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O75909

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O75909

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
O75909

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O75909

PeptideAtlas

More...
PeptideAtlasi
O75909

PRoteomics IDEntifications database

More...
PRIDEi
O75909

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
50259 [O75909-3]
50260 [O75909-1]
50261 [O75909-2]
50262 [O75909-4]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
O75909, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O75909

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O75909

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Highest levels in testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000090061, Expressed in testis and 218 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O75909, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O75909, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000090061, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Regulatory subunit of cyclin-dependent kinases.

Identified in a complex with a kinase and the RNA polymerase II holoenzyme.

Interacts with POLR2A.

Interacts with CDK12 and CDK13.

Interacts with CDK9 according to PubMed:10574912; does not interact with CDK9 according to PubMed:22012619.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
114339, 67 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-241, Cyclin K-CDK12 complex
CPX-359, Cyclin K-CDK13 complex

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
O75909

Database of interacting proteins

More...
DIPi
DIP-50081N

Protein interaction database and analysis system

More...
IntActi
O75909, 55 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000374529

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
O75909

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
O75909, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1580
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O75909

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O75909

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi312 – 315Poly-Gln4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cyclin family. Cyclin C subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0834, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156384

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_022000_0_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O75909

KEGG Orthology (KO)

More...
KOi
K23326

Identification of Orthologs from Complete Genome Data

More...
OMAi
AQPQQKD

TreeFam database of animal gene trees

More...
TreeFami
TF101010

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00043, CYCLIN, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013763, Cyclin-like
IPR036915, Cyclin-like_sf
IPR043198, Cyclin/Ssn8
IPR004367, Cyclin_C-dom
IPR006671, Cyclin_N

The PANTHER Classification System

More...
PANTHERi
PTHR10026, PTHR10026, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02984, Cyclin_C, 1 hit
PF00134, Cyclin_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00385, CYCLIN, 2 hits
SM01332, Cyclin_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47954, SSF47954, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O75909-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKENKENSSP SVTSANLDHT KPCWYWDKKD LAHTPSQLEG LDPATEARYR
60 70 80 90 100
REGARFIFDV GTRLGLHYDT LATGIIYFHR FYMFHSFKQF PRYVTGACCL
110 120 130 140 150
FLAGKVEETP KKCKDIIKTA RSLLNDVQFG QFGDDPKEEV MVLERILLQT
160 170 180 190 200
IKFDLQVEHP YQFLLKYAKQ LKGDKNKIQK LVQMAWTFVN DSLCTTLSLQ
210 220 230 240 250
WEPEIIAVAV MYLAGRLCKF EIQEWTSKPM YRRWWEQFVQ DVPVDVLEDI
260 270 280 290 300
CHQILDLYSQ GKQQMPHHTP HQLQQPPSLQ PTPQVPQVQQ SQPSQSSEPS
310 320 330 340 350
QPQQKDPQQP AQQQQPAQQP KKPSPQPSSP RQVKRAVVVS PKEENKAAEP
360 370 380 390 400
PPPKIPKIET THPPLPPAHP PPDRKPPLAA ALGEAEPPGP VDATDLPKVQ
410 420 430 440 450
IPPPAHPAPV HQPPPLPHRP PPPPPSSYMT GMSTTSSYMS GEGYQSLQSM
460 470 480 490 500
MKTEGPSYGA LPPAYGPPAH LPYHPHVYPP NPPPPPVPPP PASFPPPAIP
510 520 530 540 550
PPTPGYPPPP PTYNPNFPPP PPRLPPTHAV PPHPPPGLGL PPASYPPPAV
560 570 580
PPGGQPPVPP PIPPPGMPPV GGLGRAAWMR
Length:580
Mass (Da):64,240
Last modified:December 16, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8A945E90359AD9F8
GO
Isoform 2 (identifier: O75909-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     308-354: QQPAQQQQPA...NKAAEPPPPK → LILLQGWACR...QLGGWGGQPG
     355-580: Missing.

Show »
Length:354
Mass (Da):40,788
Checksum:i39D8F18FC9429207
GO
Isoform 3 (identifier: O75909-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     351-357: PPPKIPK → APSQHLW
     358-580: Missing.

Show »
Length:357
Mass (Da):41,293
Checksum:iFA7DD89035A66105
GO
Isoform 4 (identifier: O75909-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     338-338: V → VSGLKQALGRAGFPGGGNTQV

Show »
Length:600
Mass (Da):66,137
Checksum:iA79E4E8B190E7199
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V5E1G3V5E1_HUMAN
Cyclin-K
CCNK
378Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V2Q3G3V2Q3_HUMAN
Cyclin-K
CCNK
227Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V235G3V235_HUMAN
Cyclin-K
CCNK
109Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti191D → T in BAD92610 (Ref. 7) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_081570111K → E in IDDHDF; contrary to the wild-type protein, does not rescue morpholino knockdown phenotype in zebrafish. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_010830308 – 354QQPAQ…PPPPK → LILLQGWACRQPATHLLPSP LEDSLLCPRPFPHPACLQLG GWGGQPG in isoform 2. 2 PublicationsAdd BLAST47
Alternative sequenceiVSP_035970338V → VSGLKQALGRAGFPGGGNTQ V in isoform 4. 2 Publications1
Alternative sequenceiVSP_035971351 – 357PPPKIPK → APSQHLW in isoform 3. 1 Publication7
Alternative sequenceiVSP_035972355 – 580Missing in isoform 2. 2 PublicationsAdd BLAST226
Alternative sequenceiVSP_035973358 – 580Missing in isoform 3. 1 PublicationAdd BLAST223

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF060515 mRNA Translation: AAD09978.1
BT006950 mRNA Translation: AAP35596.1
AF542236 Genomic DNA Translation: AAN06829.1
AL110504 Genomic DNA No translation available.
BC015935 mRNA Translation: AAH15935.1
AH009612 Genomic DNA Translation: AAF82290.1
BX247958 mRNA Translation: CAD62298.1
AB209373 Transcribed RNA Translation: BAD92610.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS45160.1 [O75909-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001092872.1, NM_001099402.1 [O75909-3]
XP_005268211.1, XM_005268154.4 [O75909-3]
XP_011535577.1, XM_011537275.2 [O75909-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000389879; ENSP00000374529; ENSG00000090061 [O75909-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8812

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8812

UCSC genome browser

More...
UCSCi
uc001ygi.5, human [O75909-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF060515 mRNA Translation: AAD09978.1
BT006950 mRNA Translation: AAP35596.1
AF542236 Genomic DNA Translation: AAN06829.1
AL110504 Genomic DNA No translation available.
BC015935 mRNA Translation: AAH15935.1
AH009612 Genomic DNA Translation: AAF82290.1
BX247958 mRNA Translation: CAD62298.1
AB209373 Transcribed RNA Translation: BAD92610.1
CCDSiCCDS45160.1 [O75909-3]
RefSeqiNP_001092872.1, NM_001099402.1 [O75909-3]
XP_005268211.1, XM_005268154.4 [O75909-3]
XP_011535577.1, XM_011537275.2 [O75909-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2I53X-ray1.50A11-267[»]
4CXAX-ray3.15B/D11-267[»]
4NSTX-ray2.20B/D1-267[»]
4UN0X-ray3.15A/B11-267[»]
5ACBX-ray2.70A/B11-267[»]
5EFQX-ray2.00B/D1-267[»]
6B3EX-ray3.06B/D1-267[»]
6CKXX-ray2.80B/D1-267[»]
SMRiO75909
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114339, 67 interactors
ComplexPortaliCPX-241, Cyclin K-CDK12 complex
CPX-359, Cyclin K-CDK13 complex
CORUMiO75909
DIPiDIP-50081N
IntActiO75909, 55 interactors
STRINGi9606.ENSP00000374529

Chemistry databases

BindingDBiO75909
ChEMBLiCHEMBL3038475
CHEMBL4106169
CHEMBL4296067

PTM databases

GlyGeniO75909, 1 site, 1 O-linked glycan (1 site)
iPTMnetiO75909
PhosphoSitePlusiO75909

Polymorphism and mutation databases

BioMutaiCCNK

Proteomic databases

EPDiO75909
jPOSTiO75909
MassIVEiO75909
PaxDbiO75909
PeptideAtlasiO75909
PRIDEiO75909
ProteomicsDBi50259 [O75909-3]
50260 [O75909-1]
50261 [O75909-2]
50262 [O75909-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
102, 177 antibodies

The DNASU plasmid repository

More...
DNASUi
8812

Genome annotation databases

EnsembliENST00000389879; ENSP00000374529; ENSG00000090061 [O75909-3]
GeneIDi8812
KEGGihsa:8812
UCSCiuc001ygi.5, human [O75909-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8812
DisGeNETi8812
EuPathDBiHostDB:ENSG00000090061.17

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CCNK
HGNCiHGNC:1596, CCNK
HPAiENSG00000090061, Low tissue specificity
MalaCardsiCCNK
MIMi603544, gene
618147, phenotype
neXtProtiNX_O75909
OpenTargetsiENSG00000090061
PharmGKBiPA26161

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0834, Eukaryota
GeneTreeiENSGT00940000156384
HOGENOMiCLU_022000_0_2_1
InParanoidiO75909
KOiK23326
OMAiAQPQQKD
TreeFamiTF101010

Enzyme and pathway databases

PathwayCommonsiO75909
ReactomeiR-HSA-112382, Formation of RNA Pol II elongation complex
R-HSA-167152, Formation of HIV elongation complex in the absence of HIV Tat
R-HSA-167287, HIV elongation arrest and recovery
R-HSA-167290, Pausing and recovery of HIV elongation
R-HSA-2173796, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
R-HSA-674695, RNA Polymerase II Pre-transcription Events
R-HSA-6796648, TP53 Regulates Transcription of DNA Repair Genes
R-HSA-6807505, RNA polymerase II transcribes snRNA genes
R-HSA-75955, RNA Polymerase II Transcription Elongation
SignaLinkiO75909
SIGNORiO75909

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
8812, 704 hits in 883 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CCNK, human
EvolutionaryTraceiO75909

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Cyclin_K

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
8812
PharosiO75909, Tbio

Protein Ontology

More...
PROi
PR:O75909
RNActiO75909, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000090061, Expressed in testis and 218 other tissues
ExpressionAtlasiO75909, baseline and differential
GenevisibleiO75909, HS

Family and domain databases

CDDicd00043, CYCLIN, 2 hits
InterProiView protein in InterPro
IPR013763, Cyclin-like
IPR036915, Cyclin-like_sf
IPR043198, Cyclin/Ssn8
IPR004367, Cyclin_C-dom
IPR006671, Cyclin_N
PANTHERiPTHR10026, PTHR10026, 1 hit
PfamiView protein in Pfam
PF02984, Cyclin_C, 1 hit
PF00134, Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385, CYCLIN, 2 hits
SM01332, Cyclin_C, 1 hit
SUPFAMiSSF47954, SSF47954, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCNK_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75909
Secondary accession number(s): Q59FT6
, Q86U16, Q96B63, Q9NNY9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 16, 2008
Last modified: August 12, 2020
This is version 193 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again