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Protein

Sterol O-acyltransferase 2

Gene

SOAT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase. May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei434Sequence analysis1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cholesterol binding Source: BHF-UCL
  • cholesterol O-acyltransferase activity Source: BHF-UCL
  • fatty-acyl-CoA binding Source: BHF-UCL
  • transferase activity, transferring acyl groups Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processCholesterol metabolism, Lipid metabolism, Steroid metabolism, Sterol metabolism

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.3.1.26 2681

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-8964038 LDL clearance

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001262 [O75908-1]

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sterol O-acyltransferase 2 (EC:2.3.1.26)
Alternative name(s):
Acyl-coenzyme A:cholesterol acyltransferase 2
Short name:
ACAT-2
Cholesterol acyltransferase 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SOAT2
Synonyms:ACACT2, ACAT2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000167780.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11178 SOAT2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601311 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O75908

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 122CytoplasmicSequence analysisAdd BLAST122
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei123 – 141HelicalSequence analysisAdd BLAST19
Topological domaini142 – 160LumenalSequence analysisAdd BLAST19
Transmembranei161 – 179HelicalSequence analysisAdd BLAST19
Topological domaini180 – 200CytoplasmicSequence analysisAdd BLAST21
Transmembranei201 – 219HelicalSequence analysisAdd BLAST19
Topological domaini220 – 340LumenalSequence analysisAdd BLAST121
Transmembranei341 – 363HelicalSequence analysisAdd BLAST23
Topological domaini364 – 475CytoplasmicSequence analysisAdd BLAST112
Transmembranei476 – 494HelicalSequence analysisAdd BLAST19
Topological domaini495 – 522LumenalSequence analysisAdd BLAST28

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
8435

Open Targets

More...
OpenTargetsi
ENSG00000167780

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36016

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4465

Drug and drug target database

More...
DrugBanki
DB01094 Hesperetin

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SOAT2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002076451 – 522Sterol O-acyltransferase 2Add BLAST522

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O75908

PeptideAtlas

More...
PeptideAtlasi
O75908

PRoteomics IDEntifications database

More...
PRIDEi
O75908

ProteomicsDB human proteome resource

More...
ProteomicsDBi
50258

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O75908

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O75908

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O75908

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expression seems confined in hepatocytes and enterocytes.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000167780 Expressed in 68 organ(s), highest expression level in liver

CleanEx database of gene expression profiles

More...
CleanExi
HS_ACAT2
HS_SOAT2

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O75908 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O75908 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May form homo- or heterodimers.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114015, 1 interactor

Protein interaction database and analysis system

More...
IntActi
O75908, 3 interactors

Molecular INTeraction database

More...
MINTi
O75908

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000301466

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
O75908

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O75908

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0380 Eukaryota
COG5056 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153815

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000020782

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG058198

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O75908

KEGG Orthology (KO)

More...
KOi
K00637

Identification of Orthologs from Complete Genome Data

More...
OMAi
VAHEYIF

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0991

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O75908

TreeFam database of animal gene trees

More...
TreeFami
TF315226

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004299 MBOAT_fam
IPR014371 Oat_ACAT_DAG_ARE
IPR030687 Sterol_acyltranf_meta

The PANTHER Classification System

More...
PANTHERi
PTHR10408 PTHR10408, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03062 MBOAT, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000439 Oat_ACAT_DAG_ARE, 1 hit
PIRSF500230 Sterol_acyltranf_ACAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O75908-1) [UniParc]FASTAAdd to basket
Also known as: ACAD2a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPGGARLRL QRTEGLGGER ERQPCGDGNT ETHRAPDLVQ WTRHMEAVKA
60 70 80 90 100
QLLEQAQGQL RELLDRAMRE AIQSYPSQDK PLPPPPPGSL SRTQEPSLGK
110 120 130 140 150
QKVFIIRKSL LDELMEVQHF RTIYHMFIAG LCVFIISTLA IDFIDEGRLL
160 170 180 190 200
LEFDLLIFSF GQLPLALVTW VPMFLSTLLA PYQALRLWAR GTWTQATGLG
210 220 230 240 250
CALLAAHAVV LCALPVHVAV EHQLPPASRC VLVFEQVRFL MKSYSFLREA
260 270 280 290 300
VPGTLRARRG EGIQAPSFSS YLYFLFCPTL IYRETYPRTP YVRWNYVAKN
310 320 330 340 350
FAQALGCVLY ACFILGRLCV PVFANMSREP FSTRALVLSI LHATLPGIFM
360 370 380 390 400
LLLIFFAFLH CWLNAFAEML RFGDRMFYRD WWNSTSFSNY YRTWNVVVHD
410 420 430 440 450
WLYSYVYQDG LRLLGARARG VAMLGVFLVS AVAHEYIFCF VLGFFYPVML
460 470 480 490 500
ILFLVIGGML NFMMHDQRTG PAWNVLMWTM LFLGQGIQVS LYCQEWYARR
510 520
HCPLPQATFW GLVTPRSWSC HT
Length:522
Mass (Da):59,896
Last modified:November 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEEAC2DB569FFE729
GO
Isoform 2 (identifier: O75908-2) [UniParc]FASTAAdd to basket
Also known as: ACAD2b

The sequence of this isoform differs from the canonical sequence as follows:
     93-112: Missing.

Note: Lower enzymatic activity.
Show »
Length:502
Mass (Da):57,614
Checksum:i4E8DA0CFFF4E2688
GO
Isoform 3 (identifier: O75908-3) [UniParc]FASTAAdd to basket
Also known as: ACAD2c

The sequence of this isoform differs from the canonical sequence as follows:
     93-148: Missing.
     236-261: Missing.

Note: Lower enzymatic activity.
Show »
Length:440
Mass (Da):50,351
Checksum:iC891C005392C572C
GO
Isoform 4 (identifier: O75908-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     289-310: TPYVRWNYVAKNFAQALGCVLY → PWDVCSMPASSWAASVFLSLPT
     311-522: Missing.

Note: No experimental confirmation available.
Show »
Length:310
Mass (Da):34,882
Checksum:iA5C0D66A8ECCA6EC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VPE9F8VPE9_HUMAN
Sterol O-acyltransferase 2
SOAT2
170Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti22R → P in AAK48829 (PubMed:11401500).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02037314E → G1 PublicationCorresponds to variant dbSNP:rs9658625Ensembl.1
Natural variantiVAR_020374254T → I2 PublicationsCorresponds to variant dbSNP:rs2272296Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05715893 – 148Missing in isoform 3. 1 PublicationAdd BLAST56
Alternative sequenceiVSP_05715993 – 112Missing in isoform 2. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_057160236 – 261Missing in isoform 3. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_057161289 – 310TPYVR…GCVLY → PWDVCSMPASSWAASVFLSL PT in isoform 4. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_057162311 – 522Missing in isoform 4. 1 PublicationAdd BLAST212

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF059203 mRNA Translation: AAC63998.1
AF099031 mRNA Translation: AAC78335.2
AF331516
, AF331502, AF331503, AF331504, AF331505, AF331506, AF331507, AF331508, AF331509, AF331510, AF331511, AF331512, AF331513, AF331514, AF331515 Genomic DNA Translation: AAK18275.1
AF332858, AF332857 Genomic DNA Translation: AAK48829.1
AC073573 Genomic DNA No translation available.
BC096090 mRNA Translation: AAH96090.1
BC096091 mRNA Translation: AAH96091.1
BC096092 mRNA Translation: AAH96092.1
BC099626 mRNA Translation: AAH99626.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS8847.1 [O75908-1]

NCBI Reference Sequences

More...
RefSeqi
NP_003569.1, NM_003578.3 [O75908-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.656544

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000301466; ENSP00000301466; ENSG00000167780 [O75908-1]
ENST00000542365; ENSP00000442234; ENSG00000167780 [O75908-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8435

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8435

UCSC genome browser

More...
UCSCi
uc001sbv.4 human [O75908-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF059203 mRNA Translation: AAC63998.1
AF099031 mRNA Translation: AAC78335.2
AF331516
, AF331502, AF331503, AF331504, AF331505, AF331506, AF331507, AF331508, AF331509, AF331510, AF331511, AF331512, AF331513, AF331514, AF331515 Genomic DNA Translation: AAK18275.1
AF332858, AF332857 Genomic DNA Translation: AAK48829.1
AC073573 Genomic DNA No translation available.
BC096090 mRNA Translation: AAH96090.1
BC096091 mRNA Translation: AAH96091.1
BC096092 mRNA Translation: AAH96092.1
BC099626 mRNA Translation: AAH99626.1
CCDSiCCDS8847.1 [O75908-1]
RefSeqiNP_003569.1, NM_003578.3 [O75908-1]
UniGeneiHs.656544

3D structure databases

ProteinModelPortaliO75908
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114015, 1 interactor
IntActiO75908, 3 interactors
MINTiO75908
STRINGi9606.ENSP00000301466

Chemistry databases

BindingDBiO75908
ChEMBLiCHEMBL4465
DrugBankiDB01094 Hesperetin
SwissLipidsiSLP:000001262 [O75908-1]

PTM databases

iPTMnetiO75908
PhosphoSitePlusiO75908
SwissPalmiO75908

Polymorphism and mutation databases

BioMutaiSOAT2

Proteomic databases

PaxDbiO75908
PeptideAtlasiO75908
PRIDEiO75908
ProteomicsDBi50258

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301466; ENSP00000301466; ENSG00000167780 [O75908-1]
ENST00000542365; ENSP00000442234; ENSG00000167780 [O75908-4]
GeneIDi8435
KEGGihsa:8435
UCSCiuc001sbv.4 human [O75908-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
8435
DisGeNETi8435
EuPathDBiHostDB:ENSG00000167780.11

GeneCards: human genes, protein and diseases

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GeneCardsi
SOAT2
HGNCiHGNC:11178 SOAT2
MIMi601311 gene
neXtProtiNX_O75908
OpenTargetsiENSG00000167780
PharmGKBiPA36016

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0380 Eukaryota
COG5056 LUCA
GeneTreeiENSGT00940000153815
HOGENOMiHOG000020782
HOVERGENiHBG058198
InParanoidiO75908
KOiK00637
OMAiVAHEYIF
OrthoDBiEOG091G0991
PhylomeDBiO75908
TreeFamiTF315226

Enzyme and pathway databases

BRENDAi2.3.1.26 2681
ReactomeiR-HSA-8964038 LDL clearance

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SOAT2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
8435

Protein Ontology

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PROi
PR:O75908

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000167780 Expressed in 68 organ(s), highest expression level in liver
CleanExiHS_ACAT2
HS_SOAT2
ExpressionAtlasiO75908 baseline and differential
GenevisibleiO75908 HS

Family and domain databases

InterProiView protein in InterPro
IPR004299 MBOAT_fam
IPR014371 Oat_ACAT_DAG_ARE
IPR030687 Sterol_acyltranf_meta
PANTHERiPTHR10408 PTHR10408, 1 hit
PfamiView protein in Pfam
PF03062 MBOAT, 1 hit
PIRSFiPIRSF000439 Oat_ACAT_DAG_ARE, 1 hit
PIRSF500230 Sterol_acyltranf_ACAT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSOAT2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75908
Secondary accession number(s): F5H7W4
, I6L9H9, Q4VB99, Q4VBA1, Q96TD4, Q9UNR2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: November 1, 1998
Last modified: December 5, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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