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Protein

Sterol O-acyltransferase 2

Gene

SOAT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase. May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa.

Catalytic activityi

Acyl-CoA + cholesterol = CoA + cholesterol ester.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei434Sequence analysis1

GO - Molecular functioni

  • cholesterol binding Source: BHF-UCL
  • cholesterol O-acyltransferase activity Source: BHF-UCL
  • fatty-acyl-CoA binding Source: BHF-UCL
  • transferase activity, transferring acyl groups Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processCholesterol metabolism, Lipid metabolism, Steroid metabolism, Sterol metabolism

Enzyme and pathway databases

BRENDAi2.3.1.26 2681
ReactomeiR-HSA-8964038 LDL clearance

Chemistry databases

SwissLipidsiSLP:000001262 [O75908-1]

Names & Taxonomyi

Protein namesi
Recommended name:
Sterol O-acyltransferase 2 (EC:2.3.1.26)
Alternative name(s):
Acyl-coenzyme A:cholesterol acyltransferase 2
Short name:
ACAT-2
Cholesterol acyltransferase 2
Gene namesi
Name:SOAT2
Synonyms:ACACT2, ACAT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000167780.11
HGNCiHGNC:11178 SOAT2
MIMi601311 gene
neXtProtiNX_O75908

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 122CytoplasmicSequence analysisAdd BLAST122
Transmembranei123 – 141HelicalSequence analysisAdd BLAST19
Topological domaini142 – 160LumenalSequence analysisAdd BLAST19
Transmembranei161 – 179HelicalSequence analysisAdd BLAST19
Topological domaini180 – 200CytoplasmicSequence analysisAdd BLAST21
Transmembranei201 – 219HelicalSequence analysisAdd BLAST19
Topological domaini220 – 340LumenalSequence analysisAdd BLAST121
Transmembranei341 – 363HelicalSequence analysisAdd BLAST23
Topological domaini364 – 475CytoplasmicSequence analysisAdd BLAST112
Transmembranei476 – 494HelicalSequence analysisAdd BLAST19
Topological domaini495 – 522LumenalSequence analysisAdd BLAST28

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8435
OpenTargetsiENSG00000167780
PharmGKBiPA36016

Chemistry databases

ChEMBLiCHEMBL4465
DrugBankiDB01094 Hesperetin

Polymorphism and mutation databases

BioMutaiSOAT2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002076451 – 522Sterol O-acyltransferase 2Add BLAST522

Proteomic databases

PaxDbiO75908
PeptideAtlasiO75908
PRIDEiO75908
ProteomicsDBi50258

PTM databases

iPTMnetiO75908
PhosphoSitePlusiO75908
SwissPalmiO75908

Expressioni

Tissue specificityi

Expression seems confined in hepatocytes and enterocytes.1 Publication

Gene expression databases

BgeeiENSG00000167780 Expressed in 68 organ(s), highest expression level in liver
CleanExiHS_ACAT2
HS_SOAT2
ExpressionAtlasiO75908 baseline and differential
GenevisibleiO75908 HS

Interactioni

Subunit structurei

May form homo- or heterodimers.By similarity

Protein-protein interaction databases

BioGridi114015, 1 interactor
IntActiO75908, 3 interactors
MINTiO75908
STRINGi9606.ENSP00000301466

Chemistry databases

BindingDBiO75908

Structurei

3D structure databases

ProteinModelPortaliO75908
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0380 Eukaryota
COG5056 LUCA
GeneTreeiENSGT00530000063122
HOGENOMiHOG000020782
HOVERGENiHBG058198
InParanoidiO75908
KOiK00637
OMAiDRAMWEA
OrthoDBiEOG091G0991
PhylomeDBiO75908
TreeFamiTF315226

Family and domain databases

InterProiView protein in InterPro
IPR004299 MBOAT_fam
IPR014371 Oat_ACAT_DAG_ARE
IPR030687 Sterol_acyltranf_meta
PANTHERiPTHR10408 PTHR10408, 1 hit
PfamiView protein in Pfam
PF03062 MBOAT, 1 hit
PIRSFiPIRSF000439 Oat_ACAT_DAG_ARE, 1 hit
PIRSF500230 Sterol_acyltranf_ACAT, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O75908-1) [UniParc]FASTAAdd to basket
Also known as: ACAD2a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPGGARLRL QRTEGLGGER ERQPCGDGNT ETHRAPDLVQ WTRHMEAVKA
60 70 80 90 100
QLLEQAQGQL RELLDRAMRE AIQSYPSQDK PLPPPPPGSL SRTQEPSLGK
110 120 130 140 150
QKVFIIRKSL LDELMEVQHF RTIYHMFIAG LCVFIISTLA IDFIDEGRLL
160 170 180 190 200
LEFDLLIFSF GQLPLALVTW VPMFLSTLLA PYQALRLWAR GTWTQATGLG
210 220 230 240 250
CALLAAHAVV LCALPVHVAV EHQLPPASRC VLVFEQVRFL MKSYSFLREA
260 270 280 290 300
VPGTLRARRG EGIQAPSFSS YLYFLFCPTL IYRETYPRTP YVRWNYVAKN
310 320 330 340 350
FAQALGCVLY ACFILGRLCV PVFANMSREP FSTRALVLSI LHATLPGIFM
360 370 380 390 400
LLLIFFAFLH CWLNAFAEML RFGDRMFYRD WWNSTSFSNY YRTWNVVVHD
410 420 430 440 450
WLYSYVYQDG LRLLGARARG VAMLGVFLVS AVAHEYIFCF VLGFFYPVML
460 470 480 490 500
ILFLVIGGML NFMMHDQRTG PAWNVLMWTM LFLGQGIQVS LYCQEWYARR
510 520
HCPLPQATFW GLVTPRSWSC HT
Length:522
Mass (Da):59,896
Last modified:November 1, 1998 - v1
Checksum:iEEAC2DB569FFE729
GO
Isoform 2 (identifier: O75908-2) [UniParc]FASTAAdd to basket
Also known as: ACAD2b

The sequence of this isoform differs from the canonical sequence as follows:
     93-112: Missing.

Note: Lower enzymatic activity.
Show »
Length:502
Mass (Da):57,614
Checksum:i4E8DA0CFFF4E2688
GO
Isoform 3 (identifier: O75908-3) [UniParc]FASTAAdd to basket
Also known as: ACAD2c

The sequence of this isoform differs from the canonical sequence as follows:
     93-148: Missing.
     236-261: Missing.

Note: Lower enzymatic activity.
Show »
Length:440
Mass (Da):50,351
Checksum:iC891C005392C572C
GO
Isoform 4 (identifier: O75908-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     289-310: TPYVRWNYVAKNFAQALGCVLY → PWDVCSMPASSWAASVFLSLPT
     311-522: Missing.

Note: No experimental confirmation available.
Show »
Length:310
Mass (Da):34,882
Checksum:iA5C0D66A8ECCA6EC
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VPE9F8VPE9_HUMAN
Sterol O-acyltransferase 2
SOAT2
170Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22R → P in AAK48829 (PubMed:11401500).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02037314E → G1 PublicationCorresponds to variant dbSNP:rs9658625Ensembl.1
Natural variantiVAR_020374254T → I2 PublicationsCorresponds to variant dbSNP:rs2272296Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05715893 – 148Missing in isoform 3. 1 PublicationAdd BLAST56
Alternative sequenceiVSP_05715993 – 112Missing in isoform 2. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_057160236 – 261Missing in isoform 3. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_057161289 – 310TPYVR…GCVLY → PWDVCSMPASSWAASVFLSL PT in isoform 4. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_057162311 – 522Missing in isoform 4. 1 PublicationAdd BLAST212

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF059203 mRNA Translation: AAC63998.1
AF099031 mRNA Translation: AAC78335.2
AF331516
, AF331502, AF331503, AF331504, AF331505, AF331506, AF331507, AF331508, AF331509, AF331510, AF331511, AF331512, AF331513, AF331514, AF331515 Genomic DNA Translation: AAK18275.1
AF332858, AF332857 Genomic DNA Translation: AAK48829.1
AC073573 Genomic DNA No translation available.
BC096090 mRNA Translation: AAH96090.1
BC096091 mRNA Translation: AAH96091.1
BC096092 mRNA Translation: AAH96092.1
BC099626 mRNA Translation: AAH99626.1
CCDSiCCDS8847.1 [O75908-1]
RefSeqiNP_003569.1, NM_003578.3 [O75908-1]
UniGeneiHs.656544

Genome annotation databases

EnsembliENST00000301466; ENSP00000301466; ENSG00000167780 [O75908-1]
ENST00000542365; ENSP00000442234; ENSG00000167780 [O75908-4]
GeneIDi8435
KEGGihsa:8435
UCSCiuc001sbv.4 human [O75908-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF059203 mRNA Translation: AAC63998.1
AF099031 mRNA Translation: AAC78335.2
AF331516
, AF331502, AF331503, AF331504, AF331505, AF331506, AF331507, AF331508, AF331509, AF331510, AF331511, AF331512, AF331513, AF331514, AF331515 Genomic DNA Translation: AAK18275.1
AF332858, AF332857 Genomic DNA Translation: AAK48829.1
AC073573 Genomic DNA No translation available.
BC096090 mRNA Translation: AAH96090.1
BC096091 mRNA Translation: AAH96091.1
BC096092 mRNA Translation: AAH96092.1
BC099626 mRNA Translation: AAH99626.1
CCDSiCCDS8847.1 [O75908-1]
RefSeqiNP_003569.1, NM_003578.3 [O75908-1]
UniGeneiHs.656544

3D structure databases

ProteinModelPortaliO75908
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114015, 1 interactor
IntActiO75908, 3 interactors
MINTiO75908
STRINGi9606.ENSP00000301466

Chemistry databases

BindingDBiO75908
ChEMBLiCHEMBL4465
DrugBankiDB01094 Hesperetin
SwissLipidsiSLP:000001262 [O75908-1]

PTM databases

iPTMnetiO75908
PhosphoSitePlusiO75908
SwissPalmiO75908

Polymorphism and mutation databases

BioMutaiSOAT2

Proteomic databases

PaxDbiO75908
PeptideAtlasiO75908
PRIDEiO75908
ProteomicsDBi50258

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301466; ENSP00000301466; ENSG00000167780 [O75908-1]
ENST00000542365; ENSP00000442234; ENSG00000167780 [O75908-4]
GeneIDi8435
KEGGihsa:8435
UCSCiuc001sbv.4 human [O75908-1]

Organism-specific databases

CTDi8435
DisGeNETi8435
EuPathDBiHostDB:ENSG00000167780.11
GeneCardsiSOAT2
HGNCiHGNC:11178 SOAT2
MIMi601311 gene
neXtProtiNX_O75908
OpenTargetsiENSG00000167780
PharmGKBiPA36016
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0380 Eukaryota
COG5056 LUCA
GeneTreeiENSGT00530000063122
HOGENOMiHOG000020782
HOVERGENiHBG058198
InParanoidiO75908
KOiK00637
OMAiDRAMWEA
OrthoDBiEOG091G0991
PhylomeDBiO75908
TreeFamiTF315226

Enzyme and pathway databases

BRENDAi2.3.1.26 2681
ReactomeiR-HSA-8964038 LDL clearance

Miscellaneous databases

GeneWikiiSOAT2
GenomeRNAii8435
PROiPR:O75908
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167780 Expressed in 68 organ(s), highest expression level in liver
CleanExiHS_ACAT2
HS_SOAT2
ExpressionAtlasiO75908 baseline and differential
GenevisibleiO75908 HS

Family and domain databases

InterProiView protein in InterPro
IPR004299 MBOAT_fam
IPR014371 Oat_ACAT_DAG_ARE
IPR030687 Sterol_acyltranf_meta
PANTHERiPTHR10408 PTHR10408, 1 hit
PfamiView protein in Pfam
PF03062 MBOAT, 1 hit
PIRSFiPIRSF000439 Oat_ACAT_DAG_ARE, 1 hit
PIRSF500230 Sterol_acyltranf_ACAT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSOAT2_HUMAN
AccessioniPrimary (citable) accession number: O75908
Secondary accession number(s): F5H7W4
, I6L9H9, Q4VB99, Q4VBA1, Q96TD4, Q9UNR2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: November 1, 1998
Last modified: September 12, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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