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Entry version 162 (08 May 2019)
Sequence version 2 (25 Jul 2003)
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Protein

Diacylglycerol O-acyltransferase 1

Gene

DGAT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. In liver, plays a role in esterifying exogenous fatty acids to glycerol. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

XP620 is a selective DGAT1 inhibitor.1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=25.9 µM for retinol1 Publication
  2. KM=13.9 µM for palmitoyl coenzyme A1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: glycerolipid metabolism

    This protein is involved in the pathway glycerolipid metabolism, which is part of Lipid metabolism.
    View all proteins of this organism that are known to be involved in the pathway glycerolipid metabolism and in Lipid metabolism.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei415By similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionAcyltransferase, Transferase

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    2.3.1.20 2681

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-1482883 Acyl chain remodeling of DAG and TAG
    R-HSA-6798695 Neutrophil degranulation
    R-HSA-75109 Triglyceride biosynthesis

    SIGNOR Signaling Network Open Resource

    More...
    SIGNORi
    O75907

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00230

    Chemistry databases

    SwissLipids knowledge resource for lipid biology

    More...
    SwissLipidsi
    SLP:000000308

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Diacylglycerol O-acyltransferase 1 (EC:2.3.1.201 Publication)
    Alternative name(s):
    ACAT-related gene product 1
    Acyl-CoA retinol O-fatty-acyltransferase (EC:2.3.1.761 Publication)
    Short name:
    ARAT
    Short name:
    Retinol O-fatty-acyltransferase
    Diglyceride acyltransferase
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:DGAT1
    Synonyms:AGRP1, DGAT
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:2843 DGAT1

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    604900 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_O75907

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 87CytoplasmicSequence analysisAdd BLAST87
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei88 – 109HelicalSequence analysisAdd BLAST22
    Topological domaini110 – 220LumenalSequence analysisAdd BLAST111
    Transmembranei221 – 229HelicalSequence analysis9
    Topological domaini230CytoplasmicSequence analysis1
    Transmembranei231 – 239HelicalSequence analysis9
    Topological domaini240 – 488LumenalSequence analysisAdd BLAST249

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

    Diarrhea 7, protein-losing enteropathy type (DIAR7)1 Publication
    The disease is caused by mutations affecting the gene represented in this entry.
    Disease descriptionA life-threatening disease characterized by severe, intractable, watery diarrhea.
    See also OMIM:615863

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    8694

    MalaCards human disease database

    More...
    MalaCardsi
    DGAT1
    MIMi615863 phenotype

    Open Targets

    More...
    OpenTargetsi
    ENSG00000185000

    Orphanet; a database dedicated to information on rare diseases and orphan drugs

    More...
    Orphaneti
    329242 Congenital chronic diarrhea with protein-losing enteropathy

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA27303

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL6009

    IUPHAR/BPS Guide to PHARMACOLOGY

    More...
    GuidetoPHARMACOLOGYi
    2821

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    DGAT1

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002076541 – 488Diacylglycerol O-acyltransferase 1Add BLAST488

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei17PhosphoserineCombined sources1
    Modified residuei18PhosphoserineCombined sources1

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    O75907

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    O75907

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    O75907

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    O75907

    PeptideAtlas

    More...
    PeptideAtlasi
    O75907

    PRoteomics IDEntifications database

    More...
    PRIDEi
    O75907

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    50257

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    O75907

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    O75907

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000185000 Expressed in 91 organ(s), highest expression level in small intestine Peyer's patch

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    O75907 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    O75907 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    CAB032853

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer or homotetramer.By similarity

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    WithEntry#Exp.IntActNotes
    Q99IB82EBI-3906527,EBI-6927873From Hepatitis C virus genotype 2a (isolate JFH-1).

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    114241, 15 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    O75907, 6 interactors

    Molecular INTeraction database

    More...
    MINTi
    O75907

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000482264

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    O75907

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 91Involved in homomerizationBy similarityAdd BLAST91

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG0380 Eukaryota
    COG5056 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00950000183081

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000213917

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    O75907

    KEGG Orthology (KO)

    More...
    KOi
    K11155

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    YFWLAPT

    Database of Orthologous Groups

    More...
    OrthoDBi
    446616at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    O75907

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF314921

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR027251 Diacylglycerol_acylTrfase1
    IPR004299 MBOAT_fam
    IPR014371 Oat_ACAT_DAG_ARE

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR10408 PTHR10408, 1 hit
    PTHR10408:SF7 PTHR10408:SF7, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF03062 MBOAT, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF000439 Oat_ACAT_DAG_ARE, 1 hit
    PIRSF500231 Oat_dag, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

    O75907-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MGDRGSSRRR RTGSRPSSHG GGGPAAAEEE VRDAAAGPDV GAAGDAPAPA
    60 70 80 90 100
    PNKDGDAGVG SGHWELRCHR LQDSLFSSDS GFSNYRGILN WCVVMLILSN
    110 120 130 140 150
    ARLFLENLIK YGILVDPIQV VSLFLKDPYS WPAPCLVIAA NVFAVAAFQV
    160 170 180 190 200
    EKRLAVGALT EQAGLLLHVA NLATILCFPA AVVLLVESIT PVGSLLALMA
    210 220 230 240 250
    HTILFLKLFS YRDVNSWCRR ARAKAASAGK KASSAAAPHT VSYPDNLTYR
    260 270 280 290 300
    DLYYFLFAPT LCYELNFPRS PRIRKRFLLR RILEMLFFTQ LQVGLIQQWM
    310 320 330 340 350
    VPTIQNSMKP FKDMDYSRII ERLLKLAVPN HLIWLIFFYW LFHSCLNAVA
    360 370 380 390 400
    ELMQFGDREF YRDWWNSESV TYFWQNWNIP VHKWCIRHFY KPMLRRGSSK
    410 420 430 440 450
    WMARTGVFLA SAFFHEYLVS VPLRMFRLWA FTGMMAQIPL AWFVGRFFQG
    460 470 480
    NYGNAAVWLS LIIGQPIAVL MYVHDYYVLN YEAPAAEA
    Length:488
    Mass (Da):55,278
    Last modified:July 25, 2003 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6574D5DBF15D6171
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    A0A0A0MR74A0A0A0MR74_HUMAN
    Diacylglycerol O-acyltransferase 1
    DGAT1
    315Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti129Y → H in AAC63997 (PubMed:9756920).Curated1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AF059202 mRNA Translation: AAC63997.1
    AB057815 mRNA Translation: BAC66170.1
    CH471162 Genomic DNA Translation: EAW82127.1
    CH471162 Genomic DNA Translation: EAW82129.1
    BC015762 mRNA Translation: AAH15762.1
    BC023565 mRNA Translation: AAH23565.1
    BC150649 mRNA Translation: AAI50650.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS6420.1

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_036211.2, NM_012079.5

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000528718; ENSP00000482264; ENSG00000185000
    ENST00000644790; ENSP00000495489; ENSG00000285482

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    8694

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:8694

    UCSC genome browser

    More...
    UCSCi
    uc003zbv.5 human

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF059202 mRNA Translation: AAC63997.1
    AB057815 mRNA Translation: BAC66170.1
    CH471162 Genomic DNA Translation: EAW82127.1
    CH471162 Genomic DNA Translation: EAW82129.1
    BC015762 mRNA Translation: AAH15762.1
    BC023565 mRNA Translation: AAH23565.1
    BC150649 mRNA Translation: AAI50650.1
    CCDSiCCDS6420.1
    RefSeqiNP_036211.2, NM_012079.5

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Protein-protein interaction databases

    BioGridi114241, 15 interactors
    IntActiO75907, 6 interactors
    MINTiO75907
    STRINGi9606.ENSP00000482264

    Chemistry databases

    BindingDBiO75907
    ChEMBLiCHEMBL6009
    GuidetoPHARMACOLOGYi2821
    SwissLipidsiSLP:000000308

    PTM databases

    iPTMnetiO75907
    PhosphoSitePlusiO75907

    Polymorphism and mutation databases

    BioMutaiDGAT1

    Proteomic databases

    EPDiO75907
    jPOSTiO75907
    MaxQBiO75907
    PaxDbiO75907
    PeptideAtlasiO75907
    PRIDEiO75907
    ProteomicsDBi50257

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    8694
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000528718; ENSP00000482264; ENSG00000185000
    ENST00000644790; ENSP00000495489; ENSG00000285482
    GeneIDi8694
    KEGGihsa:8694
    UCSCiuc003zbv.5 human

    Organism-specific databases

    Comparative Toxicogenomics Database

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    CTDi
    8694
    DisGeNETi8694

    GeneCards: human genes, protein and diseases

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    GeneCardsi
    DGAT1
    HGNCiHGNC:2843 DGAT1
    HPAiCAB032853
    MalaCardsiDGAT1
    MIMi604900 gene
    615863 phenotype
    neXtProtiNX_O75907
    OpenTargetsiENSG00000185000
    Orphaneti329242 Congenital chronic diarrhea with protein-losing enteropathy
    PharmGKBiPA27303

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG0380 Eukaryota
    COG5056 LUCA
    GeneTreeiENSGT00950000183081
    HOGENOMiHOG000213917
    InParanoidiO75907
    KOiK11155
    OMAiYFWLAPT
    OrthoDBi446616at2759
    PhylomeDBiO75907
    TreeFamiTF314921

    Enzyme and pathway databases

    UniPathwayi
    UPA00230

    BRENDAi2.3.1.20 2681
    ReactomeiR-HSA-1482883 Acyl chain remodeling of DAG and TAG
    R-HSA-6798695 Neutrophil degranulation
    R-HSA-75109 Triglyceride biosynthesis
    SIGNORiO75907

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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    ChiTaRSi
    DGAT1 human

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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    GenomeRNAii
    8694

    Protein Ontology

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    PROi
    PR:O75907

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000185000 Expressed in 91 organ(s), highest expression level in small intestine Peyer's patch
    ExpressionAtlasiO75907 baseline and differential
    GenevisibleiO75907 HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR027251 Diacylglycerol_acylTrfase1
    IPR004299 MBOAT_fam
    IPR014371 Oat_ACAT_DAG_ARE
    PANTHERiPTHR10408 PTHR10408, 1 hit
    PTHR10408:SF7 PTHR10408:SF7, 1 hit
    PfamiView protein in Pfam
    PF03062 MBOAT, 1 hit
    PIRSFiPIRSF000439 Oat_ACAT_DAG_ARE, 1 hit
    PIRSF500231 Oat_dag, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

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    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDGAT1_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75907
    Secondary accession number(s): B2RWQ2, D3DWL6, Q96BB8
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
    Last sequence update: July 25, 2003
    Last modified: May 8, 2019
    This is version 162 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. PATHWAY comments
      Index of metabolic and biosynthesis pathways
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