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Entry version 124 (08 May 2019)
Sequence version 2 (11 Sep 2007)
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Protein

Ras association domain-containing protein 9

Gene

RASSF9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in regulating vesicuar trafficking in cells.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • transporter activity Source: UniProtKB

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ras association domain-containing protein 9
Alternative name(s):
PAM COOH-terminal interactor protein 1
Short name:
P-CIP1
Peptidylglycine alpha-amidating monooxygenase COOH-terminal interactor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RASSF9
Synonyms:PAMCI, PCIP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:15739 RASSF9

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610383 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O75901

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Endosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000198774

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162400725

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RASSF9

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002994521 – 435Ras association domain-containing protein 9Add BLAST435

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O75901

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O75901

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O75901

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O75901

PeptideAtlas

More...
PeptideAtlasi
O75901

PRoteomics IDEntifications database

More...
PRIDEi
O75901

ProteomicsDB human proteome resource

More...
ProteomicsDBi
50256

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O75901

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O75901

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000198774 Expressed in 133 organ(s), highest expression level in mucosa of paranasal sinus

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O75901 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA039428
HPA039678

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PAM.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114619, 37 interactors

Protein interaction database and analysis system

More...
IntActi
O75901, 34 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000354884

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O75901

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini25 – 119Ras-associatingPROSITE-ProRule annotationAdd BLAST95

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili195 – 290Sequence analysisAdd BLAST96

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1574 Eukaryota
ENOG410XPWB LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182839

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000065674

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O75901

KEGG Orthology (KO)

More...
KOi
K09856

Identification of Orthologs from Complete Genome Data

More...
OMAi
RSPTKDM

Database of Orthologous Groups

More...
OrthoDBi
592471at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O75901

TreeFam database of animal gene trees

More...
TreeFami
TF326923

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033593 N-RASSF
IPR000159 RA_dom
IPR033633 RASSF9
IPR029071 Ubiquitin-like_domsf

The PANTHER Classification System

More...
PANTHERi
PTHR15286 PTHR15286, 1 hit
PTHR15286:SF10 PTHR15286:SF10, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00314 RA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54236 SSF54236, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50200 RA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O75901-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPFGRNLLK TRHKNRSPTK DMDSEEKEIV VWVCQEEKLV CGLTKRTTSA
60 70 80 90 100
DVIQALLEEH EATFGEKRFL LGKPSDYCII EKWRGSERVL PPLTRILKLW
110 120 130 140 150
KAWGDEQPNM QFVLVKADAF LPVPLWRTAE AKLVQNTEKL WELSPANYMK
160 170 180 190 200
TLPPDKQKRI VRKTFRKLAK IKQDTVSHDR DNMETLVHLI ISQDHTIHQQ
210 220 230 240 250
VKRMKELDLE IEKCEAKFHL DRVENDGENY VQDAYLMPSF SEVEQNLDLQ
260 270 280 290 300
YEENQTLEDL SESDGIEQLE ERLKYYRILI DKLSAEIEKE VKSVCIDINE
310 320 330 340 350
DAEGEAASEL ESSNLESVKC DLEKSMKAGL KIHSHLSGIQ KEIKYSDSLL
360 370 380 390 400
QMKAKEYELL AKEFNSLHIS NKDGCQLKEN RAKESEVPSS NGEIPPFTQR
410 420 430
VFSNYTNDTD SDTGISSNHS QDSETTVGDV VLLST
Length:435
Mass (Da):50,021
Last modified:September 11, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC9CF3E1C482AAA18
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti39L → F in AAD03250 (PubMed:9837933).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_034820285A → T. Corresponds to variant dbSNP:rs7397266Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF056209 mRNA Translation: AAD03250.1
AK022089 mRNA Translation: BAG51066.1
CH471054 Genomic DNA Translation: EAW97399.1
BC031589 mRNA Translation: AAH31589.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44950.1

NCBI Reference Sequences

More...
RefSeqi
NP_005438.2, NM_005447.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000361228; ENSP00000354884; ENSG00000198774

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9182

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9182

UCSC genome browser

More...
UCSCi
uc001taf.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF056209 mRNA Translation: AAD03250.1
AK022089 mRNA Translation: BAG51066.1
CH471054 Genomic DNA Translation: EAW97399.1
BC031589 mRNA Translation: AAH31589.1
CCDSiCCDS44950.1
RefSeqiNP_005438.2, NM_005447.3

3D structure databases

SMRiO75901
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114619, 37 interactors
IntActiO75901, 34 interactors
STRINGi9606.ENSP00000354884

PTM databases

iPTMnetiO75901
PhosphoSitePlusiO75901

Polymorphism and mutation databases

BioMutaiRASSF9

Proteomic databases

EPDiO75901
jPOSTiO75901
MaxQBiO75901
PaxDbiO75901
PeptideAtlasiO75901
PRIDEiO75901
ProteomicsDBi50256

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
9182
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361228; ENSP00000354884; ENSG00000198774
GeneIDi9182
KEGGihsa:9182
UCSCiuc001taf.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9182

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RASSF9
HGNCiHGNC:15739 RASSF9
HPAiHPA039428
HPA039678
MIMi610383 gene
neXtProtiNX_O75901
OpenTargetsiENSG00000198774
PharmGKBiPA162400725

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1574 Eukaryota
ENOG410XPWB LUCA
GeneTreeiENSGT00950000182839
HOGENOMiHOG000065674
InParanoidiO75901
KOiK09856
OMAiRSPTKDM
OrthoDBi592471at2759
PhylomeDBiO75901
TreeFamiTF326923

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
RASSF9

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9182

Protein Ontology

More...
PROi
PR:O75901

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000198774 Expressed in 133 organ(s), highest expression level in mucosa of paranasal sinus
GenevisibleiO75901 HS

Family and domain databases

InterProiView protein in InterPro
IPR033593 N-RASSF
IPR000159 RA_dom
IPR033633 RASSF9
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR15286 PTHR15286, 1 hit
PTHR15286:SF10 PTHR15286:SF10, 1 hit
SMARTiView protein in SMART
SM00314 RA, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50200 RA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRASF9_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75901
Secondary accession number(s): B3KMQ4, Q8N5U8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: May 8, 2019
This is version 124 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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