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Protein

Ras association domain-containing protein 9

Gene

RASSF9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in regulating vesicuar trafficking in cells.By similarity

GO - Molecular functioni

  • transporter activity Source: UniProtKB

GO - Biological processi

  • endosomal transport Source: UniProtKB
  • intracellular transport Source: GO_Central
  • protein targeting Source: UniProtKB
  • signal transduction Source: InterPro

Names & Taxonomyi

Protein namesi
Recommended name:
Ras association domain-containing protein 9
Alternative name(s):
PAM COOH-terminal interactor protein 1
Short name:
P-CIP1
Peptidylglycine alpha-amidating monooxygenase COOH-terminal interactor
Gene namesi
Name:RASSF9
Synonyms:PAMCI, PCIP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000198774.4
HGNCiHGNC:15739 RASSF9
MIMi610383 gene
neXtProtiNX_O75901

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi9182
OpenTargetsiENSG00000198774
PharmGKBiPA162400725

Polymorphism and mutation databases

BioMutaiRASSF9

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002994521 – 435Ras association domain-containing protein 9Add BLAST435

Proteomic databases

EPDiO75901
MaxQBiO75901
PaxDbiO75901
PeptideAtlasiO75901
PRIDEiO75901
ProteomicsDBi50256

PTM databases

iPTMnetiO75901
PhosphoSitePlusiO75901

Expressioni

Gene expression databases

BgeeiENSG00000198774 Expressed in 133 organ(s), highest expression level in mucosa of paranasal sinus
CleanExiHS_RASSF9
GenevisibleiO75901 HS

Organism-specific databases

HPAiHPA039428
HPA039678

Interactioni

Subunit structurei

Interacts with PAM.By similarity

Protein-protein interaction databases

BioGridi114619, 37 interactors
IntActiO75901, 34 interactors
STRINGi9606.ENSP00000354884

Structurei

3D structure databases

ProteinModelPortaliO75901
SMRiO75901
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 119Ras-associatingPROSITE-ProRule annotationAdd BLAST95

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili195 – 290Sequence analysisAdd BLAST96

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1574 Eukaryota
ENOG410XPWB LUCA
GeneTreeiENSGT00510000047164
HOGENOMiHOG000065674
HOVERGENiHBG053178
InParanoidiO75901
KOiK09856
OMAiCDLEKSM
OrthoDBiEOG091G07DQ
PhylomeDBiO75901
TreeFamiTF326923

Family and domain databases

InterProiView protein in InterPro
IPR033593 N-RASSF
IPR000159 RA_dom
IPR033633 RASSF9
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR15286 PTHR15286, 1 hit
PTHR15286:SF10 PTHR15286:SF10, 1 hit
SMARTiView protein in SMART
SM00314 RA, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50200 RA, 1 hit

Sequencei

Sequence statusi: Complete.

O75901-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPFGRNLLK TRHKNRSPTK DMDSEEKEIV VWVCQEEKLV CGLTKRTTSA
60 70 80 90 100
DVIQALLEEH EATFGEKRFL LGKPSDYCII EKWRGSERVL PPLTRILKLW
110 120 130 140 150
KAWGDEQPNM QFVLVKADAF LPVPLWRTAE AKLVQNTEKL WELSPANYMK
160 170 180 190 200
TLPPDKQKRI VRKTFRKLAK IKQDTVSHDR DNMETLVHLI ISQDHTIHQQ
210 220 230 240 250
VKRMKELDLE IEKCEAKFHL DRVENDGENY VQDAYLMPSF SEVEQNLDLQ
260 270 280 290 300
YEENQTLEDL SESDGIEQLE ERLKYYRILI DKLSAEIEKE VKSVCIDINE
310 320 330 340 350
DAEGEAASEL ESSNLESVKC DLEKSMKAGL KIHSHLSGIQ KEIKYSDSLL
360 370 380 390 400
QMKAKEYELL AKEFNSLHIS NKDGCQLKEN RAKESEVPSS NGEIPPFTQR
410 420 430
VFSNYTNDTD SDTGISSNHS QDSETTVGDV VLLST
Length:435
Mass (Da):50,021
Last modified:September 11, 2007 - v2
Checksum:iC9CF3E1C482AAA18
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti39L → F in AAD03250 (PubMed:9837933).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034820285A → T. Corresponds to variant dbSNP:rs7397266Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF056209 mRNA Translation: AAD03250.1
AK022089 mRNA Translation: BAG51066.1
CH471054 Genomic DNA Translation: EAW97399.1
BC031589 mRNA Translation: AAH31589.1
CCDSiCCDS44950.1
RefSeqiNP_005438.2, NM_005447.3
UniGeneiHs.527881

Genome annotation databases

EnsembliENST00000361228; ENSP00000354884; ENSG00000198774
GeneIDi9182
KEGGihsa:9182
UCSCiuc001taf.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF056209 mRNA Translation: AAD03250.1
AK022089 mRNA Translation: BAG51066.1
CH471054 Genomic DNA Translation: EAW97399.1
BC031589 mRNA Translation: AAH31589.1
CCDSiCCDS44950.1
RefSeqiNP_005438.2, NM_005447.3
UniGeneiHs.527881

3D structure databases

ProteinModelPortaliO75901
SMRiO75901
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114619, 37 interactors
IntActiO75901, 34 interactors
STRINGi9606.ENSP00000354884

PTM databases

iPTMnetiO75901
PhosphoSitePlusiO75901

Polymorphism and mutation databases

BioMutaiRASSF9

Proteomic databases

EPDiO75901
MaxQBiO75901
PaxDbiO75901
PeptideAtlasiO75901
PRIDEiO75901
ProteomicsDBi50256

Protocols and materials databases

DNASUi9182
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361228; ENSP00000354884; ENSG00000198774
GeneIDi9182
KEGGihsa:9182
UCSCiuc001taf.2 human

Organism-specific databases

CTDi9182
DisGeNETi9182
EuPathDBiHostDB:ENSG00000198774.4
GeneCardsiRASSF9
HGNCiHGNC:15739 RASSF9
HPAiHPA039428
HPA039678
MIMi610383 gene
neXtProtiNX_O75901
OpenTargetsiENSG00000198774
PharmGKBiPA162400725
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1574 Eukaryota
ENOG410XPWB LUCA
GeneTreeiENSGT00510000047164
HOGENOMiHOG000065674
HOVERGENiHBG053178
InParanoidiO75901
KOiK09856
OMAiCDLEKSM
OrthoDBiEOG091G07DQ
PhylomeDBiO75901
TreeFamiTF326923

Miscellaneous databases

GeneWikiiRASSF9
GenomeRNAii9182
PROiPR:O75901
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198774 Expressed in 133 organ(s), highest expression level in mucosa of paranasal sinus
CleanExiHS_RASSF9
GenevisibleiO75901 HS

Family and domain databases

InterProiView protein in InterPro
IPR033593 N-RASSF
IPR000159 RA_dom
IPR033633 RASSF9
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR15286 PTHR15286, 1 hit
PTHR15286:SF10 PTHR15286:SF10, 1 hit
SMARTiView protein in SMART
SM00314 RA, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50200 RA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRASF9_HUMAN
AccessioniPrimary (citable) accession number: O75901
Secondary accession number(s): B3KMQ4, Q8N5U8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: November 7, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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