UniProtKB - O75900 (MMP23_HUMAN)
Protein
Matrix metalloproteinase-23
Gene
MMP23B
Organism
Homo sapiens (Human)
Status
Functioni
Protease. May regulate the surface expression of some potassium channels by retaining them in the endoplasmic reticulum (By similarity).By similarity
Cofactori
Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity
Activity regulationi
Inhibited by TIMP2.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 211 | Zinc; catalyticPROSITE-ProRule annotation | 1 | |
Active sitei | 212 | PROSITE-ProRule annotation | 1 | |
Metal bindingi | 215 | Zinc; catalyticPROSITE-ProRule annotation | 1 | |
Metal bindingi | 221 | Zinc; catalyticPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- metalloendopeptidase activity Source: UniProtKB
- metallopeptidase activity Source: UniProtKB
- zinc ion binding Source: UniProtKB
GO - Biological processi
- collagen catabolic process Source: GO_Central
- extracellular matrix organization Source: GO_Central
- proteolysis Source: UniProtKB
- reproduction Source: UniProtKB
Keywordsi
Molecular function | Hydrolase, Metalloprotease, Protease |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | O75900 |
Protein family/group databases
MEROPSi | M10.022 |
TCDBi | 8.B.14.2.2, the sea anemone peptide toxin, class 1 (bgk) family |
Names & Taxonomyi
Protein namesi | Recommended name: Matrix metalloproteinase-23 (EC:3.4.24.-)Short name: MMP-23 Alternative name(s): Femalysin MIFR-1 Matrix metalloproteinase-21 Short name: MMP-21 Matrix metalloproteinase-22 Short name: MMP-22 Cleaved into the following chain: |
Gene namesi | Name:MMP23B Synonyms:MMP21, MMP22 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7171, MMP23B |
MIMi | 603320, gene 603321, gene |
neXtProti | NX_O75900 |
VEuPathDBi | HostDB:ENSG00000189409.12 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Single-pass type II membrane protein By similarity
Other locations
- Membrane 1 Publication; Single-pass type II membrane protein 1 Publication
Note: A secreted form produced by proteolytic cleavage may also exist.Curated
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Extracellular region or secreted
- collagen-containing extracellular matrix Source: BHF-UCL
- extracellular matrix Source: UniProtKB
- extracellular space Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 19 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 20 – 40 | Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 41 – 390 | LumenalSequence analysisAdd BLAST | 350 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 78 | R → G: Abolishes processing of soluble form. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 8510 |
OpenTargetsi | ENSG00000189409 |
PharmGKBi | PA30880 |
Miscellaneous databases
Pharosi | O75900, Tbio |
Chemistry databases
DrugBanki | DB00786, Marimastat |
Genetic variation databases
BioMutai | HGNC:7170 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000259513 | 1 – 390 | Matrix metalloproteinase-23Add BLAST | 390 | |
PropeptideiPRO_0000259514 | 1 – 78 | Sequence analysisAdd BLAST | 78 | |
ChainiPRO_0000259515 | 79 – 390 | Matrix metalloproteinase-23, soluble formAdd BLAST | 312 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 92 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 148 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 232 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 255 ↔ 289 | By similarity | ||
Disulfide bondi | 262 ↔ 282 | By similarity | ||
Disulfide bondi | 271 ↔ 286 | By similarity | ||
Glycosylationi | 316 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 321 ↔ 370 | By similarity |
Post-translational modificationi
N-glycosylated.1 Publication
Proteolytic cleavage might yield an active form.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 78 – 79 | Cleavage; by furin-like proteaseSequence analysis | 2 |
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, ZymogenProteomic databases
CPTACi | CPTAC-2612 |
jPOSTi | O75900 |
MassIVEi | O75900 |
PaxDbi | O75900 |
PeptideAtlasi | O75900 |
PRIDEi | O75900 |
ProteomicsDBi | 50253 [O75900-1] 50254 [O75900-2] 50255 [O75900-3] |
PTM databases
GlyGeni | O75900, 4 sites |
iPTMneti | O75900 |
PhosphoSitePlusi | O75900 |
Expressioni
Tissue specificityi
Predominantly expressed in ovary, testis and prostate.1 Publication
Gene expression databases
Bgeei | ENSG00000189409, Expressed in heart left ventricle and 110 other tissues |
ExpressionAtlasi | O75900, baseline and differential |
Genevisiblei | O75900, HS |
Organism-specific databases
HPAi | ENSG00000189409, Tissue enhanced (ovary) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 114082, 2 interactors |
IntActi | O75900, 1 interactor |
STRINGi | 9606.ENSP00000348308 |
Miscellaneous databases
RNActi | O75900, protein |
Structurei
3D structure databases
BMRBi | O75900 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 255 – 289 | ShKTPROSITE-ProRule annotationAdd BLAST | 35 | |
Domaini | 295 – 380 | Ig-like C2-typeAdd BLAST | 86 |
Domaini
The ShKT domain associates with, and blocks several potassium channels in the nanomolar to low micromolar range. The relative affinity is Kv1.6 > Kv1.3 > Kv1.1 = Kv3.2 > Kv1.4 (By similarity).By similarity
Sequence similaritiesi
Belongs to the peptidase M10A family.Curated
Keywords - Domaini
Immunoglobulin domain, Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1565, Eukaryota |
GeneTreei | ENSGT00940000161187 |
HOGENOMi | CLU_015489_2_1_1 |
InParanoidi | O75900 |
OMAi | AKAFGMW |
OrthoDBi | 1075463at2759 |
PhylomeDBi | O75900 |
TreeFami | TF315428 |
Family and domain databases
CDDi | cd04278, ZnMc_MMP, 1 hit |
Gene3Di | 2.60.40.10, 1 hit 3.40.390.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR033739, M10A_MMP IPR024079, MetalloPept_cat_dom_sf IPR028687, MMP23 IPR001818, Pept_M10_metallopeptidase IPR021190, Pept_M10A IPR006026, Peptidase_Metallo IPR003582, ShKT_dom |
PANTHERi | PTHR10201:SF7, PTHR10201:SF7, 1 hit |
Pfami | View protein in Pfam PF00413, Peptidase_M10, 1 hit PF01549, ShK, 1 hit |
PRINTSi | PR00138, MATRIXIN |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00254, ShKT, 1 hit SM00235, ZnMc, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS51670, SHKT, 1 hit PS00142, ZINC_PROTEASE, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: O75900-1) [UniParc]FASTAAdd to basket
Also known as: MMP21/22A
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGRGARVPSE APGAGVERRW LGAALVALCL LPALVLLARL GAPAVPAWSA
60 70 80 90 100
AQGDVAALGL SAVPPTRVPG PLAPRRRRYT LTPARLRWDH FNLTYRILSF
110 120 130 140 150
PRNLLSPRET RRALAAAFRM WSDVSPFSFR EVAPEQPSDL RIGFYPINHT
160 170 180 190 200
DCLVSALHHC FDGPTGELAH AFFPPHGGIH FDDSEYWVLG PTRYSWKKGV
210 220 230 240 250
WLTDLVHVAA HEIGHALGLM HSQHGRALMH LNATLRGWKA LSQDELWGLH
260 270 280 290 300
RLYGCLDRLF VCASWARRGF CDARRRLMKR LCPSSCDFCY EFPFPTVATT
310 320 330 340 350
PPPPRTKTRL VPEGRNVTFR CGQKILHKKG KVYWYKDQEP LEFSYPGYLA
360 370 380 390
LGEAHLSIIA NAVNEGTYTC VVRRQQRVLT TYSWRVRVRG
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketO75086 | O75086_HUMAN | MIFR-2 | MMP23B mifr-2 | 386 | Annotation score: | ||
B4DMZ6 | B4DMZ6_HUMAN | Matrix metalloproteinase-23 | MMP23B | 238 | Annotation score: | ||
H0Y6I4 | H0Y6I4_HUMAN | Matrix metalloproteinase-23 | MMP23B | 242 | Annotation score: | ||
D6REP6 | D6REP6_HUMAN | Matrix metalloproteinase-23 | MMP23B | 166 | Annotation score: | ||
H0YAE5 | H0YAE5_HUMAN | Matrix metalloproteinase-23 | MMP23B | 258 | Annotation score: | ||
H0YA69 | H0YA69_HUMAN | Matrix metalloproteinase-23 | MMP23B | 265 | Annotation score: | ||
J3KRS4 | J3KRS4_HUMAN | Matrix metalloproteinase-23 | MMP23B | 87 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_028948 | 91 | F → L1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_021411 | 199 | G → GDRPGSSWRPLLCSTVGCRG RALGQTAGGTFRGGGCHWSL AG in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_021412 | 254 | G → GESLCRAGGRGPGGPEPGVL PTLPIG in isoform 3. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF055334 Genomic DNA Translation: AAC63527.1 AF055334 Genomic DNA Translation: AAC63528.1 AF055334 Genomic DNA Translation: AAC63529.1 AF056200 mRNA Translation: AAC62616.1 AF057061 mRNA Translation: AAC62617.1 AF057062 mRNA Translation: AAC62618.1 AJ005256 mRNA Translation: CAB38176.1 AB031068 Genomic DNA Translation: BAA92769.1 AB010961 mRNA Translation: BAA24833.1 AL691432 Genomic DNA No translation available. BC025719 mRNA Translation: AAH25719.1 |
CCDSi | CCDS30559.1 [O75900-1] |
RefSeqi | NP_008914.1, NM_006983.1 [O75900-1] |
Genome annotation databases
Ensembli | ENST00000356026; ENSP00000348308; ENSG00000189409 [O75900-1] |
GeneIDi | 8510 |
KEGGi | hsa:8510 |
UCSCi | uc001agp.4, human [O75900-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF055334 Genomic DNA Translation: AAC63527.1 AF055334 Genomic DNA Translation: AAC63528.1 AF055334 Genomic DNA Translation: AAC63529.1 AF056200 mRNA Translation: AAC62616.1 AF057061 mRNA Translation: AAC62617.1 AF057062 mRNA Translation: AAC62618.1 AJ005256 mRNA Translation: CAB38176.1 AB031068 Genomic DNA Translation: BAA92769.1 AB010961 mRNA Translation: BAA24833.1 AL691432 Genomic DNA No translation available. BC025719 mRNA Translation: AAH25719.1 |
CCDSi | CCDS30559.1 [O75900-1] |
RefSeqi | NP_008914.1, NM_006983.1 [O75900-1] |
3D structure databases
BMRBi | O75900 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 114082, 2 interactors |
IntActi | O75900, 1 interactor |
STRINGi | 9606.ENSP00000348308 |
Chemistry databases
DrugBanki | DB00786, Marimastat |
Protein family/group databases
MEROPSi | M10.022 |
TCDBi | 8.B.14.2.2, the sea anemone peptide toxin, class 1 (bgk) family |
PTM databases
GlyGeni | O75900, 4 sites |
iPTMneti | O75900 |
PhosphoSitePlusi | O75900 |
Genetic variation databases
BioMutai | HGNC:7170 |
Proteomic databases
CPTACi | CPTAC-2612 |
jPOSTi | O75900 |
MassIVEi | O75900 |
PaxDbi | O75900 |
PeptideAtlasi | O75900 |
PRIDEi | O75900 |
ProteomicsDBi | 50253 [O75900-1] 50254 [O75900-2] 50255 [O75900-3] |
Protocols and materials databases
Antibodypediai | 3453, 353 antibodies |
DNASUi | 8510 |
Genome annotation databases
Ensembli | ENST00000356026; ENSP00000348308; ENSG00000189409 [O75900-1] |
GeneIDi | 8510 |
KEGGi | hsa:8510 |
UCSCi | uc001agp.4, human [O75900-1] |
Organism-specific databases
CTDi | 8510 |
DisGeNETi | 8510 |
GeneCardsi | MMP23B |
HGNCi | HGNC:7171, MMP23B |
HPAi | ENSG00000189409, Tissue enhanced (ovary) |
MIMi | 603320, gene 603321, gene |
neXtProti | NX_O75900 |
OpenTargetsi | ENSG00000189409 |
PharmGKBi | PA30880 |
VEuPathDBi | HostDB:ENSG00000189409.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1565, Eukaryota |
GeneTreei | ENSGT00940000161187 |
HOGENOMi | CLU_015489_2_1_1 |
InParanoidi | O75900 |
OMAi | AKAFGMW |
OrthoDBi | 1075463at2759 |
PhylomeDBi | O75900 |
TreeFami | TF315428 |
Enzyme and pathway databases
PathwayCommonsi | O75900 |
Miscellaneous databases
BioGRID-ORCSi | 8510, 9 hits in 872 CRISPR screens |
GeneWikii | MMP23B |
GenomeRNAii | 8510 |
Pharosi | O75900, Tbio |
PROi | PR:O75900 |
RNActi | O75900, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000189409, Expressed in heart left ventricle and 110 other tissues |
ExpressionAtlasi | O75900, baseline and differential |
Genevisiblei | O75900, HS |
Family and domain databases
CDDi | cd04278, ZnMc_MMP, 1 hit |
Gene3Di | 2.60.40.10, 1 hit 3.40.390.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR033739, M10A_MMP IPR024079, MetalloPept_cat_dom_sf IPR028687, MMP23 IPR001818, Pept_M10_metallopeptidase IPR021190, Pept_M10A IPR006026, Peptidase_Metallo IPR003582, ShKT_dom |
PANTHERi | PTHR10201:SF7, PTHR10201:SF7, 1 hit |
Pfami | View protein in Pfam PF00413, Peptidase_M10, 1 hit PF01549, ShK, 1 hit |
PRINTSi | PR00138, MATRIXIN |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00254, ShKT, 1 hit SM00235, ZnMc, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS51670, SHKT, 1 hit PS00142, ZINC_PROTEASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MMP23_HUMAN | |
Accessioni | O75900Primary (citable) accession number: O75900 Secondary accession number(s): A2AGN0 Q9UJK8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 31, 2006 |
Last sequence update: | October 31, 2006 | |
Last modified: | February 10, 2021 | |
This is version 166 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Peptidase families
Classification of peptidase families and list of entries