Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Gamma-aminobutyric acid type B receptor subunit 2

Gene

GABBR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:9872316, PubMed:9872744, PubMed:15617512, PubMed:18165688, PubMed:22660477, PubMed:24305054). Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (PubMed:18165688). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed:10075644, PubMed:10773016, PubMed:24305054). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (PubMed:10075644, PubMed:9872744, PubMed:10906333, PubMed:10773016). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (PubMed:9872744, PubMed:22660477). Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (PubMed:9872316, PubMed:10075644, PubMed:9872744, PubMed:22660477). Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (Probable).Curated8 Publications

GO - Molecular functioni

  • G protein-coupled GABA receptor activity Source: GO_Central
  • protein heterodimerization activity Source: CAFA

GO - Biological processi

  • chemical synaptic transmission Source: ProtInc
  • gamma-aminobutyric acid signaling pathway Source: UniProtKB
  • G protein-coupled receptor signaling pathway Source: Reactome
  • negative regulation of adenylate cyclase activity Source: ProtInc

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-1296041 Activation of G protein gated Potassium channels
R-HSA-418594 G alpha (i) signalling events
R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)
R-HSA-977444 GABA B receptor activation
R-HSA-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Protein family/group databases

TCDBi9.A.14.15.1 the g-protein-coupled receptor (gpcr) family

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid type B receptor subunit 2
Short name:
GABA-B receptor 2
Short name:
GABA-B-R2
Short name:
GABA-BR2
Short name:
GABABR2
Short name:
Gb2
Alternative name(s):
G-protein coupled receptor 51
HG20
Gene namesi
Name:GABBR2
Synonyms:GPR51, GPRC3B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000136928.5
HGNCiHGNC:4507 GABBR2
MIMi607340 gene
neXtProtiNX_O75899

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini42 – 483ExtracellularSequence analysisAdd BLAST442
Transmembranei484 – 504Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini505 – 522CytoplasmicSequence analysisAdd BLAST18
Transmembranei523 – 543Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini544 – 551ExtracellularSequence analysis8
Transmembranei552 – 572Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini573 – 597CytoplasmicSequence analysisAdd BLAST25
Transmembranei598 – 618Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini619 – 654ExtracellularSequence analysisAdd BLAST36
Transmembranei655 – 675Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini676 – 691CytoplasmicSequence analysisAdd BLAST16
Transmembranei692 – 712Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini713 – 720ExtracellularSequence analysis8
Transmembranei721 – 741Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini742 – 941CytoplasmicSequence analysisAdd BLAST200

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Involvement in diseasei

Neurodevelopmental disorder with poor language and loss of hand skills (NDPLHS)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant disorder characterized by psychomotor developmental stagnation or regression. NDPLHS manifest in the first years of life as loss of purposeful hand movements, loss of language, and intellectual disability.
See also OMIM:617903
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_079029567A → T in NDPLHS; increased basal signaling activity and only weak stimulation by GABA agonist; when injected into Xenopus tadpoles, causes abnormal swimming patterns and increased frequencies of seizure-like behavior compared to wild-type-injected animals; no effect on cell surface expression. 3 PublicationsCorresponds to variant dbSNP:rs922847767EnsemblClinVar.1
Natural variantiVAR_080572707A → T in NDPLHS; increased basal signaling activity and only weak stimulation by GABA agonist; no effect on cell surface expression. 1 Publication1
Epileptic encephalopathy, early infantile, 59 (EIEE59)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of epileptic encephalopathy, a heterogeneous group of severe childhood onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. EIEE59 is an autosomal dominant condition characterized by onset of refractory seizures in early infancy.
See also OMIM:617904
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_080569693G → W in EIEE59; unknown pathological significance. 1 Publication1
Natural variantiVAR_080570695S → I in EIEE59; full signaling activity in the absence of GABA agonist; when injected into Xenopus tadpoles, causes abnormal swimming patterns and increased frequencies of seizure-like behavior compared to wild-type-injected animals; no effect on cell surface expression. 2 Publications1
Natural variantiVAR_080571705I → N in EIEE59; increased basal signaling activity and no stimulation by GABA agonist; when injected into Xenopus tadpoles, causes abnormal swimming patterns and increased frequencies of seizure-like behavior compared to wild-type-injected animals; no effect on cell surface expression. 2 Publications1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi118Y → A: Impairs interaction with GABBR1. Decreases signaling via G-proteins. 1 Publication1

Keywords - Diseasei

Disease mutation, Epilepsy, Mental retardation

Organism-specific databases

DisGeNETi9568
MalaCardsiGABBR2
MIMi617903 phenotype
617904 phenotype
OpenTargetsiENSG00000136928
Orphaneti3095 Atypical Rett syndrome
PharmGKBiPA28896

Chemistry databases

ChEMBLiCHEMBL5034
DrugBankiDB08891 Arbaclofen
DB08892 Arbaclofen Placarbil
DB00181 Baclofen
DB05010 SGS742
GuidetoPHARMACOLOGYi241

Polymorphism and mutation databases

BioMutaiGABBR2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 41Sequence analysisAdd BLAST41
ChainiPRO_000001295242 – 941Gamma-aminobutyric acid type B receptor subunit 2Add BLAST900

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi90N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi108 ↔ 135
Disulfide bondi237 ↔ 266
Disulfide bondi265 ↔ 302
Glycosylationi298N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi389N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi404N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi453N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei776PhosphoserineBy similarity1
Modified residuei779PhosphoserineBy similarity1
Modified residuei819PhosphothreonineBy similarity1
Modified residuei884PhosphoserineBy similarity1
Modified residuei893PhosphoserineBy similarity1
Modified residuei913PhosphoserineBy similarity1
Modified residuei916PhosphoserineBy similarity1
Modified residuei920PhosphoserineBy similarity1
Modified residuei924PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiO75899
PaxDbiO75899
PeptideAtlasiO75899
PRIDEiO75899
ProteomicsDBi50252

PTM databases

iPTMnetiO75899
PhosphoSitePlusiO75899

Expressioni

Tissue specificityi

Highly expressed in brain, especially in cerebral cortex, thalamus, hippocampus, frontal, occipital and temporal lobe, occipital pole and cerebellum, followed by corpus callosum, caudate nucleus, spinal cord, amygdala and medulla (PubMed:10087195, PubMed:10328880, PubMed:10727622, PubMed:9872744). Weakly expressed in heart, testis and skeletal muscle (PubMed:10087195, PubMed:10727622).4 Publications

Gene expression databases

BgeeiENSG00000136928 Expressed in 149 organ(s), highest expression level in primary visual cortex
CleanExiHS_GABBR2
ExpressionAtlasiO75899 baseline and differential
GenevisibleiO75899 HS

Organism-specific databases

HPAiCAB079065
HPA013820
HPA031684

Interactioni

Subunit structurei

Heterodimer of GABBR1 and GABBR2 (PubMed:9872316, PubMed:9872744, PubMed:10906333, PubMed:10773016, PubMed:15617512, PubMed:18165688, PubMed:22660477, PubMed:24305054). Homodimers may form, but are inactive (PubMed:15617512). Interacts (via C-terminus) with ATF4 (via leucine zipper domain) (By similarity).By similarity7 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114938, 7 interactors
ComplexPortaliCPX-2955 GABA-B receptor complex
CORUMiO75899
DIPiDIP-42851N
IntActiO75899, 6 interactors
MINTiO75899
STRINGi9606.ENSP00000259455

Chemistry databases

BindingDBiO75899

Structurei

Secondary structure

1941
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO75899
SMRiO75899
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili781 – 819Sequence analysisAdd BLAST39

Domaini

Alpha-helical parts of the C-terminal intracellular region mediate heterodimeric interaction with GABBR1.1 Publication

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1055 Eukaryota
ENOG410XNN1 LUCA
GeneTreeiENSGT00530000063129
HOVERGENiHBG080355
InParanoidiO75899
KOiK04615
OMAiVEASKFH
OrthoDBiEOG091G01WG
PhylomeDBiO75899
TreeFamiTF313965

Family and domain databases

CDDicd15294 7tmC_GABA-B-R2, 1 hit
InterProiView protein in InterPro
IPR001828 ANF_lig-bd_rcpt
IPR002455 GPCR3_GABA-B
IPR000337 GPCR_3
IPR017978 GPCR_3_C
IPR017979 GPCR_3_CS
IPR002457 GPCR_3_GABA_rcpt_B2
IPR028082 Peripla_BP_I
PANTHERiPTHR10519 PTHR10519, 1 hit
PTHR10519:SF62 PTHR10519:SF62, 1 hit
PfamiView protein in Pfam
PF00003 7tm_3, 1 hit
PF01094 ANF_receptor, 1 hit
PRINTSiPR01178 GABAB2RECPTR
PR00248 GPCRMGR
SUPFAMiSSF53822 SSF53822, 1 hit
PROSITEiView protein in PROSITE
PS00981 G_PROTEIN_RECEP_F3_3, 1 hit
PS50259 G_PROTEIN_RECEP_F3_4, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O75899-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASPRSSGQP GPPPPPPPPP ARLLLLLLLP LLLPLAPGAW GWARGAPRPP
60 70 80 90 100
PSSPPLSIMG LMPLTKEVAK GSIGRGVLPA VELAIEQIRN ESLLRPYFLD
110 120 130 140 150
LRLYDTECDN AKGLKAFYDA IKYGPNHLMV FGGVCPSVTS IIAESLQGWN
160 170 180 190 200
LVQLSFAATT PVLADKKKYP YFFRTVPSDN AVNPAILKLL KHYQWKRVGT
210 220 230 240 250
LTQDVQRFSE VRNDLTGVLY GEDIEISDTE SFSNDPCTSV KKLKGNDVRI
260 270 280 290 300
ILGQFDQNMA AKVFCCAYEE NMYGSKYQWI IPGWYEPSWW EQVHTEANSS
310 320 330 340 350
RCLRKNLLAA MEGYIGVDFE PLSSKQIKTI SGKTPQQYER EYNNKRSGVG
360 370 380 390 400
PSKFHGYAYD GIWVIAKTLQ RAMETLHASS RHQRIQDFNY TDHTLGRIIL
410 420 430 440 450
NAMNETNFFG VTGQVVFRNG ERMGTIKFTQ FQDSREVKVG EYNAVADTLE
460 470 480 490 500
IINDTIRFQG SEPPKDKTII LEQLRKISLP LYSILSALTI LGMIMASAFL
510 520 530 540 550
FFNIKNRNQK LIKMSSPYMN NLIILGGMLS YASIFLFGLD GSFVSEKTFE
560 570 580 590 600
TLCTVRTWIL TVGYTTAFGA MFAKTWRVHA IFKNVKMKKK IIKDQKLLVI
610 620 630 640 650
VGGMLLIDLC ILICWQAVDP LRRTVEKYSM EPDPAGRDIS IRPLLEHCEN
660 670 680 690 700
THMTIWLGIV YAYKGLLMLF GCFLAWETRN VSIPALNDSK YIGMSVYNVG
710 720 730 740 750
IMCIIGAAVS FLTRDQPNVQ FCIVALVIIF CSTITLCLVF VPKLITLRTN
760 770 780 790 800
PDAATQNRRF QFTQNQKKED SKTSTSVTSV NQASTSRLEG LQSENHRLRM
810 820 830 840 850
KITELDKDLE EVTMQLQDTP EKTTYIKQNH YQELNDILNL GNFTESTDGG
860 870 880 890 900
KAILKNHLDQ NPQLQWNTTE PSRTCKDPIE DINSPEHIQR RLSLQLPILH
910 920 930 940
HAYLPSIGGV DASCVSPCVS PTASPRHRHV PPSFRVMVSG L
Length:941
Mass (Da):105,821
Last modified:November 1, 1998 - v1
Checksum:i09F1773DB0673C5D
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0U1RR59A0A0U1RR59_HUMAN
Gamma-aminobutyric acid type B rece...
GABBR2
183Annotation score:
A0A1B0GW60A0A1B0GW60_HUMAN
Gamma-aminobutyric acid type B rece...
GABBR2
77Annotation score:

Sequence cautioni

The sequence AAH35071 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6S → R in AAC99345 (PubMed:10087195).Curated1
Sequence conflicti12P → R in AAC99345 (PubMed:10087195).Curated1
Sequence conflicti424G → E in AAD30389 (Ref. 5) Curated1
Sequence conflicti797R → H in AAH35071 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049280163L → P. Corresponds to variant dbSNP:rs35449008Ensembl.1
Natural variantiVAR_079029567A → T in NDPLHS; increased basal signaling activity and only weak stimulation by GABA agonist; when injected into Xenopus tadpoles, causes abnormal swimming patterns and increased frequencies of seizure-like behavior compared to wild-type-injected animals; no effect on cell surface expression. 3 PublicationsCorresponds to variant dbSNP:rs922847767EnsemblClinVar.1
Natural variantiVAR_010148628Y → F1 Publication1
Natural variantiVAR_080569693G → W in EIEE59; unknown pathological significance. 1 Publication1
Natural variantiVAR_080570695S → I in EIEE59; full signaling activity in the absence of GABA agonist; when injected into Xenopus tadpoles, causes abnormal swimming patterns and increased frequencies of seizure-like behavior compared to wild-type-injected animals; no effect on cell surface expression. 2 Publications1
Natural variantiVAR_080571705I → N in EIEE59; increased basal signaling activity and no stimulation by GABA agonist; when injected into Xenopus tadpoles, causes abnormal swimming patterns and increased frequencies of seizure-like behavior compared to wild-type-injected animals; no effect on cell surface expression. 2 Publications1
Natural variantiVAR_080572707A → T in NDPLHS; increased basal signaling activity and only weak stimulation by GABA agonist; no effect on cell surface expression. 1 Publication1
Natural variantiVAR_010149869T → A1 PublicationCorresponds to variant dbSNP:rs10985765Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ012188 mRNA Translation: CAA09942.1
AF069755 mRNA Translation: AAC99345.1
AF099033 mRNA Translation: AAD45867.1
AF056085 mRNA Translation: AAC63228.1
AF095784 mRNA Translation: AAD30389.1
AF074483 mRNA Translation: AAD03336.1
AL445495 Genomic DNA No translation available.
AL353782 Genomic DNA No translation available.
AL356282 Genomic DNA No translation available.
AL591502 Genomic DNA No translation available.
BC035071 mRNA Translation: AAH35071.2 Different initiation.
CCDSiCCDS6736.1
RefSeqiNP_005449.5, NM_005458.7
UniGeneiHs.198612

Genome annotation databases

EnsembliENST00000259455; ENSP00000259455; ENSG00000136928
GeneIDi9568
KEGGihsa:9568
UCSCiuc004ays.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ012188 mRNA Translation: CAA09942.1
AF069755 mRNA Translation: AAC99345.1
AF099033 mRNA Translation: AAD45867.1
AF056085 mRNA Translation: AAC63228.1
AF095784 mRNA Translation: AAD30389.1
AF074483 mRNA Translation: AAD03336.1
AL445495 Genomic DNA No translation available.
AL353782 Genomic DNA No translation available.
AL356282 Genomic DNA No translation available.
AL591502 Genomic DNA No translation available.
BC035071 mRNA Translation: AAH35071.2 Different initiation.
CCDSiCCDS6736.1
RefSeqiNP_005449.5, NM_005458.7
UniGeneiHs.198612

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4F11X-ray2.38A42-466[»]
4F12X-ray3.02A42-466[»]
4MQEX-ray2.35B42-466[»]
4MQFX-ray2.22B42-466[»]
4MR7X-ray2.15B42-466[»]
4MR8X-ray2.15B42-466[»]
4MR9X-ray2.35B42-466[»]
4MRMX-ray2.86B42-466[»]
4MS1X-ray2.25B42-466[»]
4MS3X-ray2.50B42-466[»]
4MS4X-ray1.90B42-466[»]
4PASX-ray1.62B779-819[»]
ProteinModelPortaliO75899
SMRiO75899
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114938, 7 interactors
ComplexPortaliCPX-2955 GABA-B receptor complex
CORUMiO75899
DIPiDIP-42851N
IntActiO75899, 6 interactors
MINTiO75899
STRINGi9606.ENSP00000259455

Chemistry databases

BindingDBiO75899
ChEMBLiCHEMBL5034
DrugBankiDB08891 Arbaclofen
DB08892 Arbaclofen Placarbil
DB00181 Baclofen
DB05010 SGS742
GuidetoPHARMACOLOGYi241

Protein family/group databases

TCDBi9.A.14.15.1 the g-protein-coupled receptor (gpcr) family
GPCRDBiSearch...

PTM databases

iPTMnetiO75899
PhosphoSitePlusiO75899

Polymorphism and mutation databases

BioMutaiGABBR2

Proteomic databases

EPDiO75899
PaxDbiO75899
PeptideAtlasiO75899
PRIDEiO75899
ProteomicsDBi50252

Protocols and materials databases

DNASUi9568
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259455; ENSP00000259455; ENSG00000136928
GeneIDi9568
KEGGihsa:9568
UCSCiuc004ays.4 human

Organism-specific databases

CTDi9568
DisGeNETi9568
EuPathDBiHostDB:ENSG00000136928.5
GeneCardsiGABBR2
HGNCiHGNC:4507 GABBR2
HPAiCAB079065
HPA013820
HPA031684
MalaCardsiGABBR2
MIMi607340 gene
617903 phenotype
617904 phenotype
neXtProtiNX_O75899
OpenTargetsiENSG00000136928
Orphaneti3095 Atypical Rett syndrome
PharmGKBiPA28896
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1055 Eukaryota
ENOG410XNN1 LUCA
GeneTreeiENSGT00530000063129
HOVERGENiHBG080355
InParanoidiO75899
KOiK04615
OMAiVEASKFH
OrthoDBiEOG091G01WG
PhylomeDBiO75899
TreeFamiTF313965

Enzyme and pathway databases

ReactomeiR-HSA-1296041 Activation of G protein gated Potassium channels
R-HSA-418594 G alpha (i) signalling events
R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)
R-HSA-977444 GABA B receptor activation
R-HSA-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Miscellaneous databases

ChiTaRSiGABBR2 human
GeneWikiiGABBR2
GenomeRNAii9568
PROiPR:O75899
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000136928 Expressed in 149 organ(s), highest expression level in primary visual cortex
CleanExiHS_GABBR2
ExpressionAtlasiO75899 baseline and differential
GenevisibleiO75899 HS

Family and domain databases

CDDicd15294 7tmC_GABA-B-R2, 1 hit
InterProiView protein in InterPro
IPR001828 ANF_lig-bd_rcpt
IPR002455 GPCR3_GABA-B
IPR000337 GPCR_3
IPR017978 GPCR_3_C
IPR017979 GPCR_3_CS
IPR002457 GPCR_3_GABA_rcpt_B2
IPR028082 Peripla_BP_I
PANTHERiPTHR10519 PTHR10519, 1 hit
PTHR10519:SF62 PTHR10519:SF62, 1 hit
PfamiView protein in Pfam
PF00003 7tm_3, 1 hit
PF01094 ANF_receptor, 1 hit
PRINTSiPR01178 GABAB2RECPTR
PR00248 GPCRMGR
SUPFAMiSSF53822 SSF53822, 1 hit
PROSITEiView protein in PROSITE
PS00981 G_PROTEIN_RECEP_F3_3, 1 hit
PS50259 G_PROTEIN_RECEP_F3_4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGABR2_HUMAN
AccessioniPrimary (citable) accession number: O75899
Secondary accession number(s): O75974
, O75975, Q5VXZ2, Q8WX04, Q9P1R2, Q9UNR1, Q9UNS9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 179 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  7. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again