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Protein

Sulfotransferase 1C4

Gene

SULT1C4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. May be involved in the activation of carcinogenic hydroxylamines. Shows activity towards p-nitrophenol and N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei115Proton acceptorBy similarity1
Binding sitei137PAPS1 Publication1
Binding sitei145PAPS1 Publication1
Binding sitei200PAPS1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi55 – 60PAPS1 Publication6
Nucleotide bindingi234 – 239PAPS1 Publication6
Nucleotide bindingi262 – 266PAPS1 Publication5

GO - Molecular functioni

  • aryl sulfotransferase activity Source: CAFA
  • sulfotransferase activity Source: BHF-UCL

GO - Biological processi

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

BRENDAi2.8.2.1 2681
ReactomeiR-HSA-156584 Cytosolic sulfonation of small molecules

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfotransferase 1C4 (EC:2.8.2.-)
Short name:
ST1C4
Alternative name(s):
Sulfotransferase 1C2
Short name:
SULT1C#2
Gene namesi
Name:SULT1C4
Synonyms:SULT1C2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000198075.9
HGNCiHGNC:11457 SULT1C4
MIMi608357 gene
neXtProtiNX_O75897

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi27233
OpenTargetsiENSG00000198075
PharmGKBiPA162405070

Chemistry databases

ChEMBLiCHEMBL1743296

Polymorphism and mutation databases

BioMutaiSULT1C4

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000851371 – 302Sulfotransferase 1C4Add BLAST302

Proteomic databases

MaxQBiO75897
PaxDbiO75897
PeptideAtlasiO75897
PRIDEiO75897
ProteomicsDBi50251

PTM databases

iPTMnetiO75897
PhosphoSitePlusiO75897

Expressioni

Tissue specificityi

Expressed at high levels in fetal lung and kidney and at low levels in fetal heart, adult kidney, ovary and spinal chord.

Gene expression databases

BgeeiENSG00000198075 Expressed in 105 organ(s), highest expression level in lung
CleanExiHS_SULT1C2
HS_SULT1C4
GenevisibleiO75897 HS

Organism-specific databases

HPAiHPA034530

Interactioni

Protein-protein interaction databases

BioGridi118082, 4 interactors
STRINGi9606.ENSP00000272452

Structurei

Secondary structure

1302
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO75897
SMRiO75897
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO75897

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni113 – 115Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the sulfotransferase 1 family.Curated

Phylogenomic databases

eggNOGiKOG1584 Eukaryota
ENOG4111H56 LUCA
GeneTreeiENSGT00760000118932
HOGENOMiHOG000037209
HOVERGENiHBG001195
InParanoidiO75897
KOiK01025
OMAiWDQIWNF
OrthoDBiEOG091G0D5F
PhylomeDBiO75897
TreeFamiTF321745

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR000863 Sulfotransferase_dom
PfamiView protein in Pfam
PF00685 Sulfotransfer_1, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O75897-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALHDMEDFT FDGTKRLSVN YVKGILQPTD TCDIWDKIWN FQAKPDDLLI
60 70 80 90 100
STYPKAGTTW TQEIVELIQN EGDVEKSKRA PTHQRFPFLE MKIPSLGSGL
110 120 130 140 150
EQAHAMPSPR ILKTHLPFHL LPPSLLEKNC KIIYVARNPK DNMVSYYHFQ
160 170 180 190 200
RMNKALPAPG TWEEYFETFL AGKVCWGSWH EHVKGWWEAK DKHRILYLFY
210 220 230 240 250
EDMKKNPKHE IQKLAEFIGK KLDDKVLDKI VHYTSFDVMK QNPMANYSSI
260 270 280 290 300
PAEIMDHSIS PFMRKGAVGD WKKHFTVAQN ERFDEDYKKK MTDTRLTFHF

QF
Length:302
Mass (Da):35,520
Last modified:March 7, 2006 - v2
Checksum:i905E1820A6E222F3
GO
Isoform 2 (identifier: O75897-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     99-173: Missing.

Show »
Length:227
Mass (Da):26,841
Checksum:iA66BD789AE8FF92F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0254045D → E2 PublicationsCorresponds to variant dbSNP:rs1402467Ensembl.1
Natural variantiVAR_06188968I → M1 PublicationCorresponds to variant dbSNP:rs41322445Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05625599 – 173Missing in isoform 2. 2 PublicationsAdd BLAST75

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055584 mRNA Translation: AAC95519.1
AF186263 Genomic DNA Translation: AAF72810.1
AK297851 mRNA Translation: BAG60183.1
DQ987914 Genomic DNA Translation: ABI75348.1
AC068941 Genomic DNA Translation: AAY14742.1
CH471182 Genomic DNA Translation: EAW53886.1
BC125043 mRNA Translation: AAI25044.1
CCDSiCCDS2077.1 [O75897-1]
CCDS82492.1 [O75897-2]
RefSeqiNP_001308699.1, NM_001321770.1 [O75897-2]
NP_006579.2, NM_006588.3 [O75897-1]
UniGeneiHs.312644

Genome annotation databases

EnsembliENST00000272452; ENSP00000272452; ENSG00000198075 [O75897-1]
ENST00000409309; ENSP00000387225; ENSG00000198075 [O75897-2]
GeneIDi27233
KEGGihsa:27233
UCSCiuc002tea.2 human [O75897-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055584 mRNA Translation: AAC95519.1
AF186263 Genomic DNA Translation: AAF72810.1
AK297851 mRNA Translation: BAG60183.1
DQ987914 Genomic DNA Translation: ABI75348.1
AC068941 Genomic DNA Translation: AAY14742.1
CH471182 Genomic DNA Translation: EAW53886.1
BC125043 mRNA Translation: AAI25044.1
CCDSiCCDS2077.1 [O75897-1]
CCDS82492.1 [O75897-2]
RefSeqiNP_001308699.1, NM_001321770.1 [O75897-2]
NP_006579.2, NM_006588.3 [O75897-1]
UniGeneiHs.312644

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2AD1X-ray2.00A7-302[»]
2GWHX-ray1.80A/B7-302[»]
ProteinModelPortaliO75897
SMRiO75897
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118082, 4 interactors
STRINGi9606.ENSP00000272452

Chemistry databases

ChEMBLiCHEMBL1743296

PTM databases

iPTMnetiO75897
PhosphoSitePlusiO75897

Polymorphism and mutation databases

BioMutaiSULT1C4

Proteomic databases

MaxQBiO75897
PaxDbiO75897
PeptideAtlasiO75897
PRIDEiO75897
ProteomicsDBi50251

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000272452; ENSP00000272452; ENSG00000198075 [O75897-1]
ENST00000409309; ENSP00000387225; ENSG00000198075 [O75897-2]
GeneIDi27233
KEGGihsa:27233
UCSCiuc002tea.2 human [O75897-1]

Organism-specific databases

CTDi27233
DisGeNETi27233
EuPathDBiHostDB:ENSG00000198075.9
GeneCardsiSULT1C4
H-InvDBiHIX0029964
HGNCiHGNC:11457 SULT1C4
HPAiHPA034530
MIMi608357 gene
neXtProtiNX_O75897
OpenTargetsiENSG00000198075
PharmGKBiPA162405070
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1584 Eukaryota
ENOG4111H56 LUCA
GeneTreeiENSGT00760000118932
HOGENOMiHOG000037209
HOVERGENiHBG001195
InParanoidiO75897
KOiK01025
OMAiWDQIWNF
OrthoDBiEOG091G0D5F
PhylomeDBiO75897
TreeFamiTF321745

Enzyme and pathway databases

BRENDAi2.8.2.1 2681
ReactomeiR-HSA-156584 Cytosolic sulfonation of small molecules

Miscellaneous databases

EvolutionaryTraceiO75897
GeneWikiiSULT1C4
GenomeRNAii27233
PROiPR:O75897
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198075 Expressed in 105 organ(s), highest expression level in lung
CleanExiHS_SULT1C2
HS_SULT1C4
GenevisibleiO75897 HS

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR000863 Sulfotransferase_dom
PfamiView protein in Pfam
PF00685 Sulfotransfer_1, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiST1C4_HUMAN
AccessioniPrimary (citable) accession number: O75897
Secondary accession number(s): Q069I8, Q08AS5, Q53S63
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: March 7, 2006
Last modified: November 7, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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