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Protein

Tumor suppressor candidate 2

Gene

TUSC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as a tumor suppressor, inhibiting colony formation, causing G1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells.

GO - Biological processi

Keywordsi

Biological processCell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor suppressor candidate 2
Alternative name(s):
Fusion 1 protein
Short name:
Fus-1 protein
PDGFA-associated protein 2
Gene namesi
Name:TUSC2
Synonyms:C3orf11, FUS1, LGCC, PDAP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000114383.9
HGNCiHGNC:17034 TUSC2
MIMi607052 gene
neXtProtiNX_O75896

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNETi11334
OpenTargetsiENSG00000114383
PharmGKBiPA134968273

Polymorphism and mutation databases

BioMutaiTUSC2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00001481702 – 110Tumor suppressor candidate 2Add BLAST109

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine1 Publication1
Modified residuei50PhosphoserineCombined sources1

Post-translational modificationi

Myristoylation is required for tumor suppressor activity.1 Publication

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiO75896
MaxQBiO75896
PaxDbiO75896
PeptideAtlasiO75896
PRIDEiO75896
ProteomicsDBi50250

PTM databases

iPTMnetiO75896
PhosphoSitePlusiO75896

Expressioni

Tissue specificityi

Strong expression in heart, lung, skeletal muscle, kidney, and pancreas, followed by brain and liver, lowest levels in placenta.

Gene expression databases

BgeeiENSG00000114383
CleanExiHS_TUSC2
ExpressionAtlasiO75896 baseline and differential
GenevisibleiO75896 HS

Organism-specific databases

HPAiHPA030116

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi116462, 16 interactors
IntActiO75896, 10 interactors
STRINGi9606.ENSP00000232496

Structurei

3D structure databases

ProteinModelPortaliO75896
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TUSC2 family.Curated

Phylogenomic databases

eggNOGiENOG410IYM4 Eukaryota
ENOG4111PVZ LUCA
GeneTreeiENSGT00390000008040
HOGENOMiHOG000007342
HOVERGENiHBG054202
InParanoidiO75896
OMAiSKSKGFW
OrthoDBiEOG091G16LU
PhylomeDBiO75896
TreeFamiTF314634

Family and domain databases

InterProiView protein in InterPro
IPR029393 FUS1
PANTHERiPTHR15453 PTHR15453, 1 hit
PfamiView protein in Pfam
PF15000 TUSC2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O75896-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGASGSKARG LWPFASAAGG GGSEAAGAEQ ALVRPRGRAV PPFVFTRRGS
60 70 80 90 100
MFYDEDGDLA HEFYEETIVT KNGQKRAKLR RVHKNLIPQG IVKLDHPRIH
110
VDFPVILYEV
Length:110
Mass (Da):12,074
Last modified:January 23, 2007 - v3
Checksum:i9503BD10637C1504
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055479 mRNA Translation: AAC35497.1
AK311998 mRNA Translation: BAG34936.1
CH471055 Genomic DNA Translation: EAW65097.1
BC023976 mRNA Translation: AAH23976.1
CCDSiCCDS2819.1
RefSeqiNP_009206.1, NM_007275.2
UniGeneiHs.517981

Genome annotation databases

EnsembliENST00000232496; ENSP00000232496; ENSG00000114383
GeneIDi11334
KEGGihsa:11334
UCSCiuc003czy.2 human

Similar proteinsi

Entry informationi

Entry nameiTUSC2_HUMAN
AccessioniPrimary (citable) accession number: O75896
Secondary accession number(s): B2R4Y9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: July 18, 2018
This is version 138 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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