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UniProtKB - O75891 (AL1L1_HUMAN)

Protein

Cytosolic 10-formyltetrahydrofolate dehydrogenase

Gene

ALDH1L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

The phosphoserine observed at Ser-354 in PubMed:24275569 may result from secondary neutral loss of pantetheine from the phosphodiester linked cofactor.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei106Proton donorBy similarity1
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei142Substrate1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei142Essential for catalytic activityBy similarity1
Active sitei673Proton acceptorPROSITE-ProRule annotation1
Active sitei707Proton donorBy similarity1
Binding sitei757NADPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi571 – 573NADPBy similarity3
Nucleotide bindingi597 – 600NADPBy similarity4
Nucleotide bindingi630 – 635NADPBy similarity6
Nucleotide bindingi650 – 651NADPBy similarity2
Nucleotide bindingi804 – 806NADPBy similarity3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • aldehyde dehydrogenase (NAD) activity Source: Reactome
  • catalytic activity Source: ProtInc
  • formyltetrahydrofolate dehydrogenase activity Source: GO_Central
  • hydroxymethyl-, formyl- and related transferase activity Source: InterPro
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processOne-carbon metabolism
LigandNADP

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:HS07217-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		1.5.1.6 2681

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-196757 Metabolism of folate and pterines

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytosolic 10-formyltetrahydrofolate dehydrogenase (EC:1.5.1.6)
Short name:
10-FTHFDH
Short name:
FDH
Alternative name(s):
Aldehyde dehydrogenase family 1 member L1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ALDH1L1
Synonyms:FTHFD
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000144908.13

Human Gene Nomenclature Database

More...HGNCi		HGNC:3978 ALDH1L1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600249 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O75891

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		10840

Open Targets

More...OpenTargetsi		ENSG00000144908

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA28393

Chemistry databases

Drug and drug target database

More...DrugBanki		DB00116 Tetrahydrofolic acid

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ALDH1L1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001994191 – 902Cytosolic 10-formyltetrahydrofolate dehydrogenaseAdd BLAST902

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei9PhosphoserineCombined sources1
Modified residuei38N6-succinyllysineBy similarity1
Modified residuei354O-(pantetheine 4'-phosphoryl)serine; alternatePROSITE-ProRule annotationCurated1
Modified residuei354Phosphoserine; alternateCombined sources1
Modified residuei629PhosphoserineCombined sources1
Modified residuei631PhosphoserineCombined sources1
Modified residuei660N6-succinyllysineBy similarity1
Modified residuei767N6-succinyllysineBy similarity1
Modified residuei825PhosphoserineCombined sources1
Modified residuei882N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphopantetheine, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O75891

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O75891

MaxQB - The MaxQuant DataBase

More...MaxQBi		O75891

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O75891

PeptideAtlas

More...PeptideAtlasi		O75891

PRoteomics IDEntifications database

More...PRIDEi		O75891

ProteomicsDB human proteome resource

More...ProteomicsDBi		50249

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O75891

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O75891

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in liver, pancreas and kidney.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000144908 Expressed in 200 organ(s), highest expression level in liver

CleanEx database of gene expression profiles

More...CleanExi		HS_ALDH1L1

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O75891 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O75891 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA036900
HPA050139

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		116052, 4 interactors

Protein interaction database and analysis system

More...IntActi		O75891, 4 interactors

Molecular INTeraction database

More...MINTi		O75891

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000377083

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1902
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BW0X-ray1.70A1-307[»]
2CFIX-ray1.85A1-307[»]
2CQ8NMR-A305-401[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		O75891

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O75891

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		O75891

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini318 – 395CarrierPROSITE-ProRule annotationAdd BLAST78

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 203GARTAdd BLAST203
Regioni88 – 90Substrate binding3
Regioni417 – 902Aldehyde dehydrogenaseAdd BLAST486

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the N-terminal section; belongs to the GART family.Curated
In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2450 Eukaryota
COG1012 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160913

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000006902

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG051668

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O75891

KEGG Orthology (KO)

More...KOi		K00289

Identification of Orthologs from Complete Genome Data

More...OMAi		AMKIAVI

Database of Orthologous Groups

More...OrthoDBi		153834at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O75891

TreeFam database of animal gene trees

More...TreeFami		TF354242

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.1200.10, 1 hit
3.10.25.10, 1 hit
3.40.309.10, 1 hit
3.40.605.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011407 10_FTHF_DH
IPR036736 ACP-like_sf
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016160 Ald_DH_CS_CYS
IPR029510 Ald_DH_CS_GLU
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
IPR005793 Formyl_trans_C
IPR037022 Formyl_trans_C_sf
IPR002376 Formyl_transf_N
IPR036477 Formyl_transf_N_sf
IPR011034 Formyl_transferase-like_C_sf
IPR001555 GART_AS
IPR009081 PP-bd_ACP

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00171 Aldedh, 1 hit
PF02911 Formyl_trans_C, 1 hit
PF00551 Formyl_trans_N, 1 hit
PF00550 PP-binding, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF036489 10-FTHFDH, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47336 SSF47336, 1 hit
SSF50486 SSF50486, 1 hit
SSF53328 SSF53328, 1 hit
SSF53720 SSF53720, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00070 ALDEHYDE_DEHYDR_CYS, 1 hit
PS00687 ALDEHYDE_DEHYDR_GLU, 1 hit
PS50075 CARRIER, 1 hit
PS00373 GART, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O75891-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKIAVIGQSL FGQEVYCHLR KEGHEVVGVF TVPDKDGKAD PLGLEAEKDG 
        60         70         80         90        100
VPVFKYSRWR AKGQALPDVV AKYQALGAEL NVLPFCSQFI PMEIISAPRH 
       110        120        130        140        150
GSIIYHPSLL PRHRGASAIN WTLIHGDKKG GFSIFWADDG LDTGDLLLQK 
       160        170        180        190        200
ECEVLPDDTV STLYNRFLFP EGIKGMVQAV RLIAEGKAPR LPQPEEGATY 
       210        220        230        240        250
EGIQKKETAK INWDQPAEAI HNWIRGNDKV PGAWTEACEQ KLTFFNSTLN 
       260        270        280        290        300
TSGLVPEGDA LPIPGAHRPG VVTKAGLILF GNDDKMLLVK NIQLEDGKMI 
       310        320        330        340        350
LASNFFKGAA SSVLELTEAE LVTAEAVRSV WQRILPKVLE VEDSTDFFKS 
       360        370        380        390        400
GAASVDVVRL VEEVKELCDG LELENEDVYM ASTFGDFIQL LVRKLRGDDE 
       410        420        430        440        450
EGECSIDYVE MAVNKRTVRM PHQLFIGGEF VDAEGAKTSE TINPTDGSVI 
       460        470        480        490        500
CQVSLAQVTD VDKAVAAAKD AFENGRWGKI SARDRGRLMY RLADLMEQHQ 
       510        520        530        540        550
EELATIEALD AGAVYTLALK THVGMSIQTF RYFAGWCDKI QGSTIPINQA 
       560        570        580        590        600
RPNRNLTLTR KEPVGVCGII IPWNYPLMML SWKTAACLAA GNTVVIKPAQ 
       610        620        630        640        650
VTPLTALKFA ELTLKAGIPK GVVNVLPGSG SLVGQRLSDH PDVRKIGFTG 
       660        670        680        690        700
STEVGKHIMK SCAISNVKKV SLELGGKSPL IIFADCDLNK AVQMGMSSVF 
       710        720        730        740        750
FNKGENCIAA GRLFVEDSIH DEFVRRVVEE VRKMKVGNPL DRDTDHGPQN 
       760        770        780        790        800
HHAHLVKLME YCQHGVKEGA TLVCGGNQVP RPGFFFEPTV FTDVEDHMFI 
       810        820        830        840        850
AKEESFGPVM IISRFADGDL DAVLSRANAT EFGLASGVFT RDINKALYVS 
       860        870        880        890        900
DKLQAGTVFV NTYNKTDVAA PFGGFKQSGF GKDLGEAALN EYLRVKTVTF 

EY
Length:902
Mass (Da):98,829
Last modified:February 15, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD92CB2930617F7CF
GO
Isoform 2 (identifier: O75891-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     118-218: Missing.

Note: No experimental confirmation available.
Show »
Length:801
Mass (Da):87,602
Checksum:i2749168F3D76D548
GO
Isoform 3 (identifier: O75891-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MAGPSNPPATM

Show »
Length:912
Mass (Da):99,753
Checksum:i4703ADF87C0467D9
GO
Isoform 4 (identifier: O75891-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     492-505: LADLMEQHQEELAT → APPSPSTRPDPTAT
     506-902: Missing.

Note: No experimental confirmation available.
Show »
Length:505
Mass (Da):55,394
Checksum:iF4D59683C0651699
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JYZ6C9JYZ6_HUMAN
Cytosolic 10-formyltetrahydrofolate...
ALDH1L1
168Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JY00C9JY00_HUMAN
Cytosolic 10-formyltetrahydrofolate...
ALDH1L1
157Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9IZ36C9IZ36_HUMAN
Cytosolic 10-formyltetrahydrofolate...
ALDH1L1
177Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RFJ7D6RFJ7_HUMAN
Cytosolic 10-formyltetrahydrofolate...
ALDH1L1
100Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z324F2Z324_HUMAN
Aldehyde dehydrogenase 1 family mem...
ALDH1L1
47Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WC34F8WC34_HUMAN
Cytosolic 10-formyltetrahydrofolate...
ALDH1L1
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti63G → A in AAC35000 (Ref. 1) Curated1
Sequence conflicti85F → S in AAC35000 (Ref. 1) Curated1
Sequence conflicti176M → V in AAC35000 (Ref. 1) Curated1
Sequence conflicti195E → K in AAC35000 (Ref. 1) Curated1
Sequence conflicti470D → G in AAC35000 (Ref. 1) Curated1
Sequence conflicti472F → L in BAG57647 (PubMed:14702039).Curated1
Sequence conflicti677K → E in AAC35000 (Ref. 1) Curated1
Sequence conflicti680L → F in AAC35000 (Ref. 1) Curated1
Sequence conflicti702N → S in AAC35000 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052290254L → P. Corresponds to variant dbSNP:rs3796191Ensembl.1
Natural variantiVAR_052291330V → F. Corresponds to variant dbSNP:rs2886059Ensembl.1
Natural variantiVAR_052292429E → A. Corresponds to variant dbSNP:rs9282691Ensembl.1
Natural variantiVAR_052293436A → T. Corresponds to variant dbSNP:rs9282692Ensembl.1
Natural variantiVAR_052295448S → N. Corresponds to variant dbSNP:rs9282697Ensembl.1
Natural variantiVAR_052296481S → G. Corresponds to variant dbSNP:rs2276724Ensembl.1
Natural variantiVAR_036101511A → V in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs768309358Ensembl.1
Natural variantiVAR_052297793D → G. Corresponds to variant dbSNP:rs1127717Ensembl.1
Natural variantiVAR_052298803E → K. Corresponds to variant dbSNP:rs9282689Ensembl.1
Natural variantiVAR_052299812I → V. Corresponds to variant dbSNP:rs4646750Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0472601M → MAGPSNPPATM in isoform 3. 1 Publication1
Alternative sequenceiVSP_045569118 – 218Missing in isoform 2. 1 PublicationAdd BLAST101
Alternative sequenceiVSP_057429492 – 505LADLM…EELAT → APPSPSTRPDPTAT in isoform 4. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_057430506 – 902Missing in isoform 4. 1 PublicationAdd BLAST397

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF052732 mRNA Translation: AAC35000.1
AK294392 mRNA Translation: BAG57647.1
CR749807 mRNA Translation: CAH18667.1
AC079848 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79370.1
BC027241 mRNA Translation: AAH27241.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3034.1 [O75891-1]
CCDS58850.1 [O75891-2]
CCDS58851.1 [O75891-3]

NCBI Reference Sequences

More...RefSeqi		NP_001257293.1, NM_001270364.1 [O75891-3]
NP_001257294.1, NM_001270365.1 [O75891-2]
NP_036322.2, NM_012190.3 [O75891-1]
XP_006713544.1, XM_006713481.2 [O75891-1]
XP_011510657.1, XM_011512355.1 [O75891-1]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.434435

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000273450; ENSP00000273450; ENSG00000144908 [O75891-3]
ENST00000393431; ENSP00000377081; ENSG00000144908 [O75891-4]
ENST00000393434; ENSP00000377083; ENSG00000144908 [O75891-1]
ENST00000452905; ENSP00000395881; ENSG00000144908 [O75891-2]
ENST00000455064; ENSP00000414126; ENSG00000144908 [O75891-4]
ENST00000472186; ENSP00000420293; ENSG00000144908 [O75891-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10840

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10840

UCSC genome browser

More...UCSCi		uc003eim.3 human [O75891-1]
uc062njt.1 human

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF052732 mRNA Translation: AAC35000.1
AK294392 mRNA Translation: BAG57647.1
CR749807 mRNA Translation: CAH18667.1
AC079848 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79370.1
BC027241 mRNA Translation: AAH27241.1
CCDSiCCDS3034.1 [O75891-1]
CCDS58850.1 [O75891-2]
CCDS58851.1 [O75891-3]
RefSeqiNP_001257293.1, NM_001270364.1 [O75891-3]
NP_001257294.1, NM_001270365.1 [O75891-2]
NP_036322.2, NM_012190.3 [O75891-1]
XP_006713544.1, XM_006713481.2 [O75891-1]
XP_011510657.1, XM_011512355.1 [O75891-1]
UniGeneiHs.434435

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BW0X-ray1.70A1-307[»]
2CFIX-ray1.85A1-307[»]
2CQ8NMR-A305-401[»]
ProteinModelPortaliO75891
SMRiO75891
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116052, 4 interactors
IntActiO75891, 4 interactors
MINTiO75891
STRINGi9606.ENSP00000377083

Chemistry databases

DrugBankiDB00116 Tetrahydrofolic acid

PTM databases

iPTMnetiO75891
PhosphoSitePlusiO75891

Polymorphism and mutation databases

BioMutaiALDH1L1

Proteomic databases

EPDiO75891
jPOSTiO75891
MaxQBiO75891
PaxDbiO75891
PeptideAtlasiO75891
PRIDEiO75891
ProteomicsDBi50249

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		10840
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000273450; ENSP00000273450; ENSG00000144908 [O75891-3]
ENST00000393431; ENSP00000377081; ENSG00000144908 [O75891-4]
ENST00000393434; ENSP00000377083; ENSG00000144908 [O75891-1]
ENST00000452905; ENSP00000395881; ENSG00000144908 [O75891-2]
ENST00000455064; ENSP00000414126; ENSG00000144908 [O75891-4]
ENST00000472186; ENSP00000420293; ENSG00000144908 [O75891-1]
GeneIDi10840
KEGGihsa:10840
UCSCiuc003eim.3 human [O75891-1]
uc062njt.1 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10840
DisGeNETi10840
EuPathDBiHostDB:ENSG00000144908.13

GeneCards: human genes, protein and diseases

More...GeneCardsi		ALDH1L1
HGNCiHGNC:3978 ALDH1L1
HPAiHPA036900
HPA050139
MIMi600249 gene
neXtProtiNX_O75891
OpenTargetsiENSG00000144908
PharmGKBiPA28393

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2450 Eukaryota
COG1012 LUCA
GeneTreeiENSGT00940000160913
HOGENOMiHOG000006902
HOVERGENiHBG051668
InParanoidiO75891
KOiK00289
OMAiAMKIAVI
OrthoDBi153834at2759
PhylomeDBiO75891
TreeFamiTF354242

Enzyme and pathway databases

BioCyciMetaCyc:HS07217-MONOMER
BRENDAi1.5.1.6 2681
ReactomeiR-HSA-196757 Metabolism of folate and pterines

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ALDH1L1 human
EvolutionaryTraceiO75891

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ALDH1L1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10840

Protein Ontology

More...PROi		PR:O75891

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000144908 Expressed in 200 organ(s), highest expression level in liver
CleanExiHS_ALDH1L1
ExpressionAtlasiO75891 baseline and differential
GenevisibleiO75891 HS

Family and domain databases

Gene3Di1.10.1200.10, 1 hit
3.10.25.10, 1 hit
3.40.309.10, 1 hit
3.40.605.10, 1 hit
InterProiView protein in InterPro
IPR011407 10_FTHF_DH
IPR036736 ACP-like_sf
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016160 Ald_DH_CS_CYS
IPR029510 Ald_DH_CS_GLU
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
IPR005793 Formyl_trans_C
IPR037022 Formyl_trans_C_sf
IPR002376 Formyl_transf_N
IPR036477 Formyl_transf_N_sf
IPR011034 Formyl_transferase-like_C_sf
IPR001555 GART_AS
IPR009081 PP-bd_ACP
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
PF02911 Formyl_trans_C, 1 hit
PF00551 Formyl_trans_N, 1 hit
PF00550 PP-binding, 1 hit
PIRSFiPIRSF036489 10-FTHFDH, 1 hit
SUPFAMiSSF47336 SSF47336, 1 hit
SSF50486 SSF50486, 1 hit
SSF53328 SSF53328, 1 hit
SSF53720 SSF53720, 1 hit
PROSITEiView protein in PROSITE
PS00070 ALDEHYDE_DEHYDR_CYS, 1 hit
PS00687 ALDEHYDE_DEHYDR_GLU, 1 hit
PS50075 CARRIER, 1 hit
PS00373 GART, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAL1L1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75891
Secondary accession number(s): B4DG36
, E9PBX3, Q68CS1, Q8TBP8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 15, 2005
Last modified: January 16, 2019
This is version 186 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
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