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UniProtKB - O75888 (TNF13_HUMAN)

Entry version 182 (02 Dec 2020)
Sequence version 1 (01 Nov 1998)
Previous versions | rss
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Protein

Tumor necrosis factor ligand superfamily member 13

Gene

TNFSF13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCytokine
Biological processImmunity

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O75888

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-450520, HuR (ELAVL1) binds and stabilizes mRNA
R-HSA-5669034, TNFs bind their physiological receptors

SIGNOR Signaling Network Open Resource

More...SIGNORi		O75888

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tumor necrosis factor ligand superfamily member 13
Alternative name(s):
A proliferation-inducing ligand
Short name:
APRIL
TNF- and APOL-related leukocyte expressed ligand 2
Short name:
TALL-2
TNF-related death ligand 1
Short name:
TRDL-1
CD_antigen: CD256
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TNFSF13
Synonyms:APRIL, TALL2, ZTNF2
ORF Names:UNQ383/PRO715
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000161955.16

Human Gene Nomenclature Database

More...HGNCi		HGNC:11928, TNFSF13

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604472, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O75888

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi101 – 104RKRR → AKRA: Abolishes proteolytic processing. 1 Publication4

Organism-specific databases

DisGeNET

More...DisGeNETi		8741

Open Targets

More...OpenTargetsi		ENSG00000161955

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36621

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O75888, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3713436

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TNFSF13

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_00000345241 – 104Add BLAST104
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000034525105 – 250Tumor necrosis factor ligand superfamily member 13Add BLAST146

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi124N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi196 ↔ 211Sequence analysis

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The precursor is cleaved by furin.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei104 – 105Cleavage; by furin2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O75888

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O75888

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O75888

PeptideAtlas

More...PeptideAtlasi		O75888

PRoteomics IDEntifications database

More...PRIDEi		O75888

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		2394
50245 [O75888-1]
50246 [O75888-2]
50247 [O75888-3]
50248 [O75888-4]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		O75888, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O75888

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O75888

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at high levels in transformed cell lines, cancers of colon, thyroid, lymphoid tissues and specifically expressed in monocytes and macrophages.

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Down-regulated by phorbol myristate acetate/ionomycin treatment.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000161955, Expressed in saliva-secreting gland and 118 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O75888, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O75888, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000161955, Tissue enhanced (salivary)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer.

Curated

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114278, 11 interactors

Database of interacting proteins

More...DIPi		DIP-6232N

Protein interaction database and analysis system

More...IntActi		O75888, 5 interactors

Molecular INTeraction database

More...MINTi		O75888

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000343505

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O75888, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1250
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O75888

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tumor necrosis factor family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502SAX4, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161488

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_1234667_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O75888

Identification of Orthologs from Complete Genome Data

More...OMAi		DETFTMG

Database of Orthologous Groups

More...OrthoDBi		1232325at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O75888

TreeFam database of animal gene trees

More...TreeFami		TF332331

Family and domain databases

Conserved Domains Database

More...CDDi		cd00184, TNF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.120.40, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR021184, TNF_CS
IPR006052, TNF_dom
IPR008983, Tumour_necrosis_fac-like_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00229, TNF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00207, TNF, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49842, SSF49842, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00251, TNF_1, 1 hit
PS50049, TNF_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform Alpha (identifier: O75888-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPASSPFLLA PKGPPGNMGG PVREPALSVA LWLSWGAALG AVACAMALLT 
        60         70         80         90        100
QQTELQSLRR EVSRLQGTGG PSQNGEGYPW QSLPEQSSDA LEAWENGERS 
       110        120        130        140        150
RKRRAVLTQK QKKQHSVLHL VPINATSKDD SDVTEVMWQP ALRRGRGLQA 
       160        170        180        190        200
QGYGVRIQDA GVYLLYSQVL FQDVTFTMGQ VVSREGQGRQ ETLFRCIRSM 
       210        220        230        240        250
PSHPDRAYNS CYSAGVFHLH QGDILSVIIP RARAKLNLSP HGTFLGFVKL
Length:250
Mass (Da):27,433
Last modified:November 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAE1A6B9457F6E298
GO
Isoform Beta (identifier: O75888-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     113-129: KQHSVLHLVPINATSKD → N

Show »
Length:234
Mass (Da):25,678
Checksum:i9F0012E23EBC0780
GO
Isoform Gamma (identifier: O75888-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     247-249: Missing.

Show »
Length:247
Mass (Da):27,059
Checksum:iBAB7F6E2989D9DC8
GO
Isoform 4 (identifier: O75888-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     86-113: Missing.

Show »
Length:222
Mass (Da):24,151
Checksum:iBF3EA9A2F5AB4106
GO
Isoform TWE-PRIL (identifier: O43508-2) [UniParc]FASTAAdd to basket
Also known as: TNFSF12-TNFSF13
The sequence of this isoform can be found in the external entry O43508.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:330
Mass (Da):36,589
GO
Isoform 5 (identifier: O75888-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: Missing.
     87-114: Missing.

Show »
Length:205
Mass (Da):22,488
Checksum:i98217A3D1F58D3FA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JF68C9JF68_HUMAN
Tumor necrosis factor ligand superf...
TNFSF13
158Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JFN2C9JFN2_HUMAN
Tumor necrosis factor ligand superf...
TNFSF13
150Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q2QBA2Q2QBA2_HUMAN
Tumor necrosis factor (Ligand) supe...
TNFSF13
223Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJ28K7EJ28_HUMAN
Tumor necrosis factor ligand superf...
TNFSF13
114Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05258667G → R1 PublicationCorresponds to variant dbSNP:rs11552708Ensembl.1
Natural variantiVAR_05258796N → S1 PublicationCorresponds to variant dbSNP:rs3803800Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0467251 – 17Missing in isoform 5. CuratedAdd BLAST17
Alternative sequenceiVSP_04315486 – 113Missing in isoform 4. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_04672687 – 114Missing in isoform 5. CuratedAdd BLAST28
Alternative sequenceiVSP_006450113 – 129KQHSV…ATSKD → N in isoform Beta. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_006451247 – 249Missing in isoform Gamma. 2 Publications3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF046888 mRNA Translation: AAC61312.1
AF136294 mRNA Translation: AAD29422.1
AF184972 mRNA Translation: AAF01321.1
AF114011 mRNA Translation: AAF59828.1
AF114012 mRNA Translation: AAF59829.1
AF114013 mRNA Translation: AAF59830.1
AY358880 mRNA Translation: AAQ89239.1
AY081050 mRNA Translation: AAL90442.1
AB222992 Genomic DNA Translation: BAE16556.1
AK301221 mRNA Translation: BAG62794.1
BT019561 mRNA Translation: AAV38368.1
BT019562 mRNA Translation: AAV38369.1
AC016876 Genomic DNA No translation available.
BC008042 mRNA Translation: AAH08042.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11111.1 [O75888-1]
CCDS11112.1 [O75888-2]
CCDS42256.1 [O75888-3]
CCDS56018.1 [O75888-4]
CCDS56019.1 [O75888-5]

NCBI Reference Sequences

More...RefSeqi		NP_001185552.1, NM_001198623.1 [O75888-4]
NP_001185553.1, NM_001198624.1 [O75888-5]
NP_003799.1, NM_003808.3 [O75888-1]
NP_742084.1, NM_172087.2 [O75888-2]
NP_742085.1, NM_172088.2 [O75888-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000338784; ENSP00000343505; ENSG00000161955 [O75888-1]
ENST00000349228; ENSP00000314455; ENSG00000161955 [O75888-2]
ENST00000396542; ENSP00000379792; ENSG00000161955 [O75888-5]
ENST00000396545; ENSP00000379794; ENSG00000161955 [O75888-3]
ENST00000625791; ENSP00000486052; ENSG00000161955 [O75888-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8741

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:8741

UCSC genome browser

More...UCSCi		uc002ghj.3, human [O75888-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF046888 mRNA Translation: AAC61312.1
AF136294 mRNA Translation: AAD29422.1
AF184972 mRNA Translation: AAF01321.1
AF114011 mRNA Translation: AAF59828.1
AF114012 mRNA Translation: AAF59829.1
AF114013 mRNA Translation: AAF59830.1
AY358880 mRNA Translation: AAQ89239.1
AY081050 mRNA Translation: AAL90442.1
AB222992 Genomic DNA Translation: BAE16556.1
AK301221 mRNA Translation: BAG62794.1
BT019561 mRNA Translation: AAV38368.1
BT019562 mRNA Translation: AAV38369.1
AC016876 Genomic DNA No translation available.
BC008042 mRNA Translation: AAH08042.1
CCDSiCCDS11111.1 [O75888-1]
CCDS11112.1 [O75888-2]
CCDS42256.1 [O75888-3]
CCDS56018.1 [O75888-4]
CCDS56019.1 [O75888-5]
RefSeqiNP_001185552.1, NM_001198623.1 [O75888-4]
NP_001185553.1, NM_001198624.1 [O75888-5]
NP_003799.1, NM_003808.3 [O75888-1]
NP_742084.1, NM_172087.2 [O75888-2]
NP_742085.1, NM_172088.2 [O75888-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4ZCHX-ray2.43A/B115-250[»]
SMRiO75888
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114278, 11 interactors
DIPiDIP-6232N
IntActiO75888, 5 interactors
MINTiO75888
STRINGi9606.ENSP00000343505

Chemistry databases

ChEMBLiCHEMBL3713436

PTM databases

GlyGeniO75888, 1 site
iPTMnetiO75888
PhosphoSitePlusiO75888

Polymorphism and mutation databases

BioMutaiTNFSF13

Proteomic databases

jPOSTiO75888
MassIVEiO75888
PaxDbiO75888
PeptideAtlasiO75888
PRIDEiO75888
ProteomicsDBi2394
50245 [O75888-1]
50246 [O75888-2]
50247 [O75888-3]
50248 [O75888-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1191, 752 antibodies

The DNASU plasmid repository

More...DNASUi		8741

Genome annotation databases

EnsembliENST00000338784; ENSP00000343505; ENSG00000161955 [O75888-1]
ENST00000349228; ENSP00000314455; ENSG00000161955 [O75888-2]
ENST00000396542; ENSP00000379792; ENSG00000161955 [O75888-5]
ENST00000396545; ENSP00000379794; ENSG00000161955 [O75888-3]
ENST00000625791; ENSP00000486052; ENSG00000161955 [O75888-4]
GeneIDi8741
KEGGihsa:8741
UCSCiuc002ghj.3, human [O75888-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8741
DisGeNETi8741
EuPathDBiHostDB:ENSG00000161955.16

GeneCards: human genes, protein and diseases

More...GeneCardsi		TNFSF13
HGNCiHGNC:11928, TNFSF13
HPAiENSG00000161955, Tissue enhanced (salivary)
MIMi604472, gene
neXtProtiNX_O75888
OpenTargetsiENSG00000161955
PharmGKBiPA36621

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502SAX4, Eukaryota
GeneTreeiENSGT00940000161488
HOGENOMiCLU_1234667_0_0_1
InParanoidiO75888
OMAiDETFTMG
OrthoDBi1232325at2759
PhylomeDBiO75888
TreeFamiTF332331

Enzyme and pathway databases

PathwayCommonsiO75888
ReactomeiR-HSA-450520, HuR (ELAVL1) binds and stabilizes mRNA
R-HSA-5669034, TNFs bind their physiological receptors
SIGNORiO75888

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		8741, 3 hits in 845 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		TNFSF13

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		8741
PharosiO75888, Tbio
RNActiO75888, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000161955, Expressed in saliva-secreting gland and 118 other tissues
ExpressionAtlasiO75888, baseline and differential
GenevisibleiO75888, HS

Family and domain databases

CDDicd00184, TNF, 1 hit
Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR021184, TNF_CS
IPR006052, TNF_dom
IPR008983, Tumour_necrosis_fac-like_dom
PfamiView protein in Pfam
PF00229, TNF, 1 hit
SMARTiView protein in SMART
SM00207, TNF, 1 hit
SUPFAMiSSF49842, SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS00251, TNF_1, 1 hit
PS50049, TNF_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTNF13_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75888
Secondary accession number(s): A8MYD5
, B4DVT2, Q541E1, Q5U0G8, Q96HV6, Q9P1M8, Q9P1M9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1998
Last modified: December 2, 2020
This is version 182 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
UniProt is an ELIXIR core data resource
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