UniProtKB - O75888 (TNF13_HUMAN)
Tumor necrosis factor ligand superfamily member 13
TNFSF13
Functioni
GO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
- signaling receptor binding Source: GO_Central
- tumor necrosis factor receptor binding Source: InterPro
GO - Biological processi
- immune response Source: InterPro
- positive regulation of cell population proliferation Source: ProtInc
- positive regulation of isotype switching to IgA isotypes Source: MGI
- regulation of mRNA stability Source: Reactome
- signal transduction Source: ProtInc
- tumor necrosis factor-mediated signaling pathway Source: Reactome
Keywordsi
Molecular function | Cytokine |
Biological process | Immunity |
Enzyme and pathway databases
PathwayCommonsi | O75888 |
Reactomei | R-HSA-450520, HuR (ELAVL1) binds and stabilizes mRNA R-HSA-5669034, TNFs bind their physiological receptors |
SIGNORi | O75888 |
Names & Taxonomyi
Protein namesi | Recommended name: Tumor necrosis factor ligand superfamily member 13Alternative name(s): A proliferation-inducing ligand Short name: APRIL TNF- and APOL-related leukocyte expressed ligand 2 Short name: TALL-2 TNF-related death ligand 1 Short name: TRDL-1 CD_antigen: CD256 |
Gene namesi | Name:TNFSF13 Synonyms:APRIL, TALL2, ZTNF2 ORF Names:UNQ383/PRO715 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000161955.16 |
HGNCi | HGNC:11928, TNFSF13 |
MIMi | 604472, gene |
neXtProti | NX_O75888 |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
- extracellular space Source: GO_Central
Nucleus
- nucleoplasm Source: Reactome
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
SecretedPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 101 – 104 | RKRR → AKRA: Abolishes proteolytic processing. 1 Publication | 4 |
Organism-specific databases
DisGeNETi | 8741 |
OpenTargetsi | ENSG00000161955 |
PharmGKBi | PA36621 |
Miscellaneous databases
Pharosi | O75888, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3713436 |
Polymorphism and mutation databases
BioMutai | TNFSF13 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
PropeptideiPRO_0000034524 | 1 – 104 | Add BLAST | 104 | |
ChainiPRO_0000034525 | 105 – 250 | Tumor necrosis factor ligand superfamily member 13Add BLAST | 146 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 124 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 196 ↔ 211 | Sequence analysis |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 104 – 105 | Cleavage; by furin | 2 |
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, GlycoproteinProteomic databases
jPOSTi | O75888 |
MassIVEi | O75888 |
PaxDbi | O75888 |
PeptideAtlasi | O75888 |
PRIDEi | O75888 |
ProteomicsDBi | 2394 50245 [O75888-1] 50246 [O75888-2] 50247 [O75888-3] 50248 [O75888-4] |
PTM databases
GlyGeni | O75888, 1 site |
iPTMneti | O75888 |
PhosphoSitePlusi | O75888 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000161955, Expressed in saliva-secreting gland and 118 other tissues |
ExpressionAtlasi | O75888, baseline and differential |
Genevisiblei | O75888, HS |
Organism-specific databases
HPAi | ENSG00000161955, Tissue enhanced (salivary) |
Interactioni
Subunit structurei
Homotrimer.
CuratedBinary interactionsi
Isoform Gamma [O75888-3]
With | #Exp. | IntAct |
---|---|---|
SGTB [Q96EQ0] | 3 | EBI-12856452,EBI-744081 |
GO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
- signaling receptor binding Source: GO_Central
- tumor necrosis factor receptor binding Source: InterPro
Protein-protein interaction databases
BioGRIDi | 114278, 11 interactors |
DIPi | DIP-6232N |
IntActi | O75888, 5 interactors |
MINTi | O75888 |
STRINGi | 9606.ENSP00000343505 |
Miscellaneous databases
RNActi | O75888, protein |
Structurei
Secondary structure
3D structure databases
SMRi | O75888 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | ENOG502SAX4, Eukaryota |
GeneTreei | ENSGT00940000161488 |
HOGENOMi | CLU_1234667_0_0_1 |
InParanoidi | O75888 |
OMAi | DETFTMG |
OrthoDBi | 1232325at2759 |
PhylomeDBi | O75888 |
TreeFami | TF332331 |
Family and domain databases
CDDi | cd00184, TNF, 1 hit |
Gene3Di | 2.60.120.40, 1 hit |
InterProi | View protein in InterPro IPR021184, TNF_CS IPR006052, TNF_dom IPR008983, Tumour_necrosis_fac-like_dom |
Pfami | View protein in Pfam PF00229, TNF, 1 hit |
SMARTi | View protein in SMART SM00207, TNF, 1 hit |
SUPFAMi | SSF49842, SSF49842, 1 hit |
PROSITEi | View protein in PROSITE PS00251, TNF_1, 1 hit PS50049, TNF_2, 1 hit |
s (6+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 6 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPASSPFLLA PKGPPGNMGG PVREPALSVA LWLSWGAALG AVACAMALLT
60 70 80 90 100
QQTELQSLRR EVSRLQGTGG PSQNGEGYPW QSLPEQSSDA LEAWENGERS
110 120 130 140 150
RKRRAVLTQK QKKQHSVLHL VPINATSKDD SDVTEVMWQP ALRRGRGLQA
160 170 180 190 200
QGYGVRIQDA GVYLLYSQVL FQDVTFTMGQ VVSREGQGRQ ETLFRCIRSM
210 220 230 240 250
PSHPDRAYNS CYSAGVFHLH QGDILSVIIP RARAKLNLSP HGTFLGFVKL
The sequence of this isoform differs from the canonical sequence as follows:
113-129: KQHSVLHLVPINATSKD → N
The sequence of this isoform differs from the canonical sequence as follows:
247-249: Missing.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JF68 | C9JF68_HUMAN | Tumor necrosis factor ligand superf... | TNFSF13 | 158 | Annotation score: | ||
C9JFN2 | C9JFN2_HUMAN | Tumor necrosis factor ligand superf... | TNFSF13 | 150 | Annotation score: | ||
Q2QBA2 | Q2QBA2_HUMAN | Tumor necrosis factor (Ligand) supe... | TNFSF13 | 223 | Annotation score: | ||
K7EJ28 | K7EJ28_HUMAN | Tumor necrosis factor ligand superf... | TNFSF13 | 114 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052586 | 67 | G → R1 PublicationCorresponds to variant dbSNP:rs11552708Ensembl. | 1 | |
Natural variantiVAR_052587 | 96 | N → S1 PublicationCorresponds to variant dbSNP:rs3803800Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_046725 | 1 – 17 | Missing in isoform 5. CuratedAdd BLAST | 17 | |
Alternative sequenceiVSP_043154 | 86 – 113 | Missing in isoform 4. 1 PublicationAdd BLAST | 28 | |
Alternative sequenceiVSP_046726 | 87 – 114 | Missing in isoform 5. CuratedAdd BLAST | 28 | |
Alternative sequenceiVSP_006450 | 113 – 129 | KQHSV…ATSKD → N in isoform Beta. 1 PublicationAdd BLAST | 17 | |
Alternative sequenceiVSP_006451 | 247 – 249 | Missing in isoform Gamma. 2 Publications | 3 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF046888 mRNA Translation: AAC61312.1 AF136294 mRNA Translation: AAD29422.1 AF184972 mRNA Translation: AAF01321.1 AF114011 mRNA Translation: AAF59828.1 AF114012 mRNA Translation: AAF59829.1 AF114013 mRNA Translation: AAF59830.1 AY358880 mRNA Translation: AAQ89239.1 AY081050 mRNA Translation: AAL90442.1 AB222992 Genomic DNA Translation: BAE16556.1 AK301221 mRNA Translation: BAG62794.1 BT019561 mRNA Translation: AAV38368.1 BT019562 mRNA Translation: AAV38369.1 AC016876 Genomic DNA No translation available. BC008042 mRNA Translation: AAH08042.1 |
CCDSi | CCDS11111.1 [O75888-1] CCDS11112.1 [O75888-2] CCDS42256.1 [O75888-3] CCDS56018.1 [O75888-4] CCDS56019.1 [O75888-5] |
RefSeqi | NP_001185552.1, NM_001198623.1 [O75888-4] NP_001185553.1, NM_001198624.1 [O75888-5] NP_003799.1, NM_003808.3 [O75888-1] NP_742084.1, NM_172087.2 [O75888-2] NP_742085.1, NM_172088.2 [O75888-3] |
Genome annotation databases
Ensembli | ENST00000338784; ENSP00000343505; ENSG00000161955 [O75888-1] ENST00000349228; ENSP00000314455; ENSG00000161955 [O75888-2] ENST00000396542; ENSP00000379792; ENSG00000161955 [O75888-5] ENST00000396545; ENSP00000379794; ENSG00000161955 [O75888-3] ENST00000625791; ENSP00000486052; ENSG00000161955 [O75888-4] |
GeneIDi | 8741 |
KEGGi | hsa:8741 |
UCSCi | uc002ghj.3, human [O75888-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF046888 mRNA Translation: AAC61312.1 AF136294 mRNA Translation: AAD29422.1 AF184972 mRNA Translation: AAF01321.1 AF114011 mRNA Translation: AAF59828.1 AF114012 mRNA Translation: AAF59829.1 AF114013 mRNA Translation: AAF59830.1 AY358880 mRNA Translation: AAQ89239.1 AY081050 mRNA Translation: AAL90442.1 AB222992 Genomic DNA Translation: BAE16556.1 AK301221 mRNA Translation: BAG62794.1 BT019561 mRNA Translation: AAV38368.1 BT019562 mRNA Translation: AAV38369.1 AC016876 Genomic DNA No translation available. BC008042 mRNA Translation: AAH08042.1 |
CCDSi | CCDS11111.1 [O75888-1] CCDS11112.1 [O75888-2] CCDS42256.1 [O75888-3] CCDS56018.1 [O75888-4] CCDS56019.1 [O75888-5] |
RefSeqi | NP_001185552.1, NM_001198623.1 [O75888-4] NP_001185553.1, NM_001198624.1 [O75888-5] NP_003799.1, NM_003808.3 [O75888-1] NP_742084.1, NM_172087.2 [O75888-2] NP_742085.1, NM_172088.2 [O75888-3] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4ZCH | X-ray | 2.43 | A/B | 115-250 | [»] | |
SMRi | O75888 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 114278, 11 interactors |
DIPi | DIP-6232N |
IntActi | O75888, 5 interactors |
MINTi | O75888 |
STRINGi | 9606.ENSP00000343505 |
Chemistry databases
ChEMBLi | CHEMBL3713436 |
PTM databases
GlyGeni | O75888, 1 site |
iPTMneti | O75888 |
PhosphoSitePlusi | O75888 |
Polymorphism and mutation databases
BioMutai | TNFSF13 |
Proteomic databases
jPOSTi | O75888 |
MassIVEi | O75888 |
PaxDbi | O75888 |
PeptideAtlasi | O75888 |
PRIDEi | O75888 |
ProteomicsDBi | 2394 50245 [O75888-1] 50246 [O75888-2] 50247 [O75888-3] 50248 [O75888-4] |
Protocols and materials databases
Antibodypediai | 1191, 752 antibodies |
DNASUi | 8741 |
Genome annotation databases
Ensembli | ENST00000338784; ENSP00000343505; ENSG00000161955 [O75888-1] ENST00000349228; ENSP00000314455; ENSG00000161955 [O75888-2] ENST00000396542; ENSP00000379792; ENSG00000161955 [O75888-5] ENST00000396545; ENSP00000379794; ENSG00000161955 [O75888-3] ENST00000625791; ENSP00000486052; ENSG00000161955 [O75888-4] |
GeneIDi | 8741 |
KEGGi | hsa:8741 |
UCSCi | uc002ghj.3, human [O75888-1] |
Organism-specific databases
CTDi | 8741 |
DisGeNETi | 8741 |
EuPathDBi | HostDB:ENSG00000161955.16 |
GeneCardsi | TNFSF13 |
HGNCi | HGNC:11928, TNFSF13 |
HPAi | ENSG00000161955, Tissue enhanced (salivary) |
MIMi | 604472, gene |
neXtProti | NX_O75888 |
OpenTargetsi | ENSG00000161955 |
PharmGKBi | PA36621 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SAX4, Eukaryota |
GeneTreei | ENSGT00940000161488 |
HOGENOMi | CLU_1234667_0_0_1 |
InParanoidi | O75888 |
OMAi | DETFTMG |
OrthoDBi | 1232325at2759 |
PhylomeDBi | O75888 |
TreeFami | TF332331 |
Enzyme and pathway databases
PathwayCommonsi | O75888 |
Reactomei | R-HSA-450520, HuR (ELAVL1) binds and stabilizes mRNA R-HSA-5669034, TNFs bind their physiological receptors |
SIGNORi | O75888 |
Miscellaneous databases
BioGRID-ORCSi | 8741, 3 hits in 845 CRISPR screens |
GeneWikii | TNFSF13 |
GenomeRNAii | 8741 |
Pharosi | O75888, Tbio |
RNActi | O75888, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000161955, Expressed in saliva-secreting gland and 118 other tissues |
ExpressionAtlasi | O75888, baseline and differential |
Genevisiblei | O75888, HS |
Family and domain databases
CDDi | cd00184, TNF, 1 hit |
Gene3Di | 2.60.120.40, 1 hit |
InterProi | View protein in InterPro IPR021184, TNF_CS IPR006052, TNF_dom IPR008983, Tumour_necrosis_fac-like_dom |
Pfami | View protein in Pfam PF00229, TNF, 1 hit |
SMARTi | View protein in SMART SM00207, TNF, 1 hit |
SUPFAMi | SSF49842, SSF49842, 1 hit |
PROSITEi | View protein in PROSITE PS00251, TNF_1, 1 hit PS50049, TNF_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TNF13_HUMAN | |
Accessioni | O75888Primary (citable) accession number: O75888 Secondary accession number(s): A8MYD5 Q9P1M9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 21, 2001 |
Last sequence update: | November 1, 1998 | |
Last modified: | December 2, 2020 | |
This is version 182 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries