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Protein

Tumor necrosis factor ligand superfamily member 13

Gene

TNFSF13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes.1 Publication

GO - Molecular functioni

  • cytokine activity Source: UniProtKB-KW
  • signaling receptor binding Source: ProtInc
  • tumor necrosis factor receptor binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processImmunity

Enzyme and pathway databases

ReactomeiR-HSA-450520 HuR (ELAVL1) binds and stabilizes mRNA
R-HSA-5669034 TNFs bind their physiological receptors
SIGNORiO75888

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor ligand superfamily member 13
Alternative name(s):
A proliferation-inducing ligand
Short name:
APRIL
TNF- and APOL-related leukocyte expressed ligand 2
Short name:
TALL-2
TNF-related death ligand 1
Short name:
TRDL-1
CD_antigen: CD256
Gene namesi
Name:TNFSF13
Synonyms:APRIL, TALL2, ZTNF2
ORF Names:UNQ383/PRO715
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000161955.16
HGNCiHGNC:11928 TNFSF13
MIMi604472 gene
neXtProtiNX_O75888

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi101 – 104RKRR → AKRA: Abolishes proteolytic processing. 1 Publication4

Organism-specific databases

DisGeNETi8741
OpenTargetsiENSG00000161955
PharmGKBiPA36621

Chemistry databases

ChEMBLiCHEMBL3713436

Polymorphism and mutation databases

BioMutaiTNFSF13

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000345241 – 104Add BLAST104
ChainiPRO_0000034525105 – 250Tumor necrosis factor ligand superfamily member 13Add BLAST146

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi124N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi196 ↔ 211Sequence analysis

Post-translational modificationi

The precursor is cleaved by furin.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei104 – 105Cleavage; by furin2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO75888
PeptideAtlasiO75888
PRIDEiO75888
ProteomicsDBi50245
50246 [O75888-2]
50247 [O75888-3]
50248 [O75888-4]

PTM databases

iPTMnetiO75888
PhosphoSitePlusiO75888

Expressioni

Tissue specificityi

Expressed at high levels in transformed cell lines, cancers of colon, thyroid, lymphoid tissues and specifically expressed in monocytes and macrophages.

Inductioni

Down-regulated by phorbol myristate acetate/ionomycin treatment.

Gene expression databases

BgeeiENSG00000161955 Expressed in 90 organ(s), highest expression level in leukocyte
CleanExiHS_TNFSF13
ExpressionAtlasiO75888 baseline and differential
GenevisibleiO75888 HS

Organism-specific databases

HPAiHPA004863

Interactioni

Subunit structurei

Homotrimer.Curated

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114278, 10 interactors
DIPiDIP-6232N
IntActiO75888, 5 interactors
MINTiO75888
STRINGi9606.ENSP00000343505

Structurei

Secondary structure

1250
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO75888
SMRiO75888
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tumor necrosis factor family.Curated

Phylogenomic databases

eggNOGiENOG410II60 Eukaryota
ENOG410Y4KC LUCA
GeneTreeiENSGT00530000063837
HOGENOMiHOG000036810
HOVERGENiHBG104367
InParanoidiO75888
KOiK05475
OMAiDVTELMW
OrthoDBiEOG091G0GBQ
PhylomeDBiO75888
TreeFamiTF332331

Family and domain databases

CDDicd00184 TNF, 1 hit
Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR021184 TNF_CS
IPR006052 TNF_dom
IPR008983 Tumour_necrosis_fac-like_dom
PfamiView protein in Pfam
PF00229 TNF, 1 hit
SMARTiView protein in SMART
SM00207 TNF, 1 hit
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS00251 TNF_1, 1 hit
PS50049 TNF_2, 1 hit

Sequences (6+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform Alpha (identifier: O75888-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPASSPFLLA PKGPPGNMGG PVREPALSVA LWLSWGAALG AVACAMALLT
60 70 80 90 100
QQTELQSLRR EVSRLQGTGG PSQNGEGYPW QSLPEQSSDA LEAWENGERS
110 120 130 140 150
RKRRAVLTQK QKKQHSVLHL VPINATSKDD SDVTEVMWQP ALRRGRGLQA
160 170 180 190 200
QGYGVRIQDA GVYLLYSQVL FQDVTFTMGQ VVSREGQGRQ ETLFRCIRSM
210 220 230 240 250
PSHPDRAYNS CYSAGVFHLH QGDILSVIIP RARAKLNLSP HGTFLGFVKL
Length:250
Mass (Da):27,433
Last modified:November 1, 1998 - v1
Checksum:iAE1A6B9457F6E298
GO
Isoform Beta (identifier: O75888-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     113-129: KQHSVLHLVPINATSKD → N

Show »
Length:234
Mass (Da):25,678
Checksum:i9F0012E23EBC0780
GO
Isoform Gamma (identifier: O75888-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     247-249: Missing.

Show »
Length:247
Mass (Da):27,059
Checksum:iBAB7F6E2989D9DC8
GO
Isoform 4 (identifier: O75888-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     86-113: Missing.

Note: No experimental confirmation available.
Show »
Length:222
Mass (Da):24,151
Checksum:iBF3EA9A2F5AB4106
GO
Isoform TWE-PRIL (identifier: O43508-2) [UniParc]FASTAAdd to basket
Also known as: TNFSF12-TNFSF13
The sequence of this isoform can be found in the external entry O43508.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Based on a readthrough transcript which may produce a TWE-PRIL (TNFSF12-TNFSF13) fusion protein. Expressed at protein level in primary T-lymphocytes and monocytic cell lines.
Length:330
Mass (Da):36,589
GO
Isoform 5 (identifier: O75888-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: Missing.
     87-114: Missing.

Note: Gene prediction based on EST data.
Show »
Length:205
Mass (Da):22,488
Checksum:i98217A3D1F58D3FA
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q2QBA2Q2QBA2_HUMAN
Tumor necrosis factor (Ligand) supe...
TNFSF13
223Annotation score:
C9JF68C9JF68_HUMAN
Tumor necrosis factor ligand superf...
TNFSF13
158Annotation score:
C9JFN2C9JFN2_HUMAN
Tumor necrosis factor ligand superf...
TNFSF13
150Annotation score:
K7EJ28K7EJ28_HUMAN
Tumor necrosis factor ligand superf...
TNFSF13
114Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05258667G → R1 PublicationCorresponds to variant dbSNP:rs11552708Ensembl.1
Natural variantiVAR_05258796N → S1 PublicationCorresponds to variant dbSNP:rs3803800Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0467251 – 17Missing in isoform 5. CuratedAdd BLAST17
Alternative sequenceiVSP_04315486 – 113Missing in isoform 4. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_04672687 – 114Missing in isoform 5. CuratedAdd BLAST28
Alternative sequenceiVSP_006450113 – 129KQHSV…ATSKD → N in isoform Beta. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_006451247 – 249Missing in isoform Gamma. 2 Publications3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF046888 mRNA Translation: AAC61312.1
AF136294 mRNA Translation: AAD29422.1
AF184972 mRNA Translation: AAF01321.1
AF114011 mRNA Translation: AAF59828.1
AF114012 mRNA Translation: AAF59829.1
AF114013 mRNA Translation: AAF59830.1
AY358880 mRNA Translation: AAQ89239.1
AY081050 mRNA Translation: AAL90442.1
AB222992 Genomic DNA Translation: BAE16556.1
AK301221 mRNA Translation: BAG62794.1
BT019561 mRNA Translation: AAV38368.1
BT019562 mRNA Translation: AAV38369.1
AC016876 Genomic DNA No translation available.
BC008042 mRNA Translation: AAH08042.1
CCDSiCCDS11111.1 [O75888-1]
CCDS11112.1 [O75888-2]
CCDS42256.1 [O75888-3]
CCDS56018.1 [O75888-4]
CCDS56019.1 [O75888-5]
RefSeqiNP_001185552.1, NM_001198623.1 [O75888-4]
NP_001185553.1, NM_001198624.1 [O75888-5]
NP_003799.1, NM_003808.3 [O75888-1]
NP_742084.1, NM_172087.2 [O75888-2]
NP_742085.1, NM_172088.2 [O75888-3]
UniGeneiHs.54673

Genome annotation databases

EnsembliENST00000338784; ENSP00000343505; ENSG00000161955 [O75888-1]
ENST00000349228; ENSP00000314455; ENSG00000161955 [O75888-2]
ENST00000396542; ENSP00000379792; ENSG00000161955 [O75888-5]
ENST00000396545; ENSP00000379794; ENSG00000161955 [O75888-3]
ENST00000625791; ENSP00000486052; ENSG00000161955 [O75888-4]
GeneIDi8741
KEGGihsa:8741
UCSCiuc002ghj.3 human [O75888-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF046888 mRNA Translation: AAC61312.1
AF136294 mRNA Translation: AAD29422.1
AF184972 mRNA Translation: AAF01321.1
AF114011 mRNA Translation: AAF59828.1
AF114012 mRNA Translation: AAF59829.1
AF114013 mRNA Translation: AAF59830.1
AY358880 mRNA Translation: AAQ89239.1
AY081050 mRNA Translation: AAL90442.1
AB222992 Genomic DNA Translation: BAE16556.1
AK301221 mRNA Translation: BAG62794.1
BT019561 mRNA Translation: AAV38368.1
BT019562 mRNA Translation: AAV38369.1
AC016876 Genomic DNA No translation available.
BC008042 mRNA Translation: AAH08042.1
CCDSiCCDS11111.1 [O75888-1]
CCDS11112.1 [O75888-2]
CCDS42256.1 [O75888-3]
CCDS56018.1 [O75888-4]
CCDS56019.1 [O75888-5]
RefSeqiNP_001185552.1, NM_001198623.1 [O75888-4]
NP_001185553.1, NM_001198624.1 [O75888-5]
NP_003799.1, NM_003808.3 [O75888-1]
NP_742084.1, NM_172087.2 [O75888-2]
NP_742085.1, NM_172088.2 [O75888-3]
UniGeneiHs.54673

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4ZCHX-ray2.43A/B115-250[»]
ProteinModelPortaliO75888
SMRiO75888
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114278, 10 interactors
DIPiDIP-6232N
IntActiO75888, 5 interactors
MINTiO75888
STRINGi9606.ENSP00000343505

Chemistry databases

ChEMBLiCHEMBL3713436

PTM databases

iPTMnetiO75888
PhosphoSitePlusiO75888

Polymorphism and mutation databases

BioMutaiTNFSF13

Proteomic databases

PaxDbiO75888
PeptideAtlasiO75888
PRIDEiO75888
ProteomicsDBi50245
50246 [O75888-2]
50247 [O75888-3]
50248 [O75888-4]

Protocols and materials databases

DNASUi8741
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338784; ENSP00000343505; ENSG00000161955 [O75888-1]
ENST00000349228; ENSP00000314455; ENSG00000161955 [O75888-2]
ENST00000396542; ENSP00000379792; ENSG00000161955 [O75888-5]
ENST00000396545; ENSP00000379794; ENSG00000161955 [O75888-3]
ENST00000625791; ENSP00000486052; ENSG00000161955 [O75888-4]
GeneIDi8741
KEGGihsa:8741
UCSCiuc002ghj.3 human [O75888-1]

Organism-specific databases

CTDi8741
DisGeNETi8741
EuPathDBiHostDB:ENSG00000161955.16
GeneCardsiTNFSF13
HGNCiHGNC:11928 TNFSF13
HPAiHPA004863
MIMi604472 gene
neXtProtiNX_O75888
OpenTargetsiENSG00000161955
PharmGKBiPA36621
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II60 Eukaryota
ENOG410Y4KC LUCA
GeneTreeiENSGT00530000063837
HOGENOMiHOG000036810
HOVERGENiHBG104367
InParanoidiO75888
KOiK05475
OMAiDVTELMW
OrthoDBiEOG091G0GBQ
PhylomeDBiO75888
TreeFamiTF332331

Enzyme and pathway databases

ReactomeiR-HSA-450520 HuR (ELAVL1) binds and stabilizes mRNA
R-HSA-5669034 TNFs bind their physiological receptors
SIGNORiO75888

Miscellaneous databases

GeneWikiiTNFSF13
GenomeRNAii8741
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000161955 Expressed in 90 organ(s), highest expression level in leukocyte
CleanExiHS_TNFSF13
ExpressionAtlasiO75888 baseline and differential
GenevisibleiO75888 HS

Family and domain databases

CDDicd00184 TNF, 1 hit
Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR021184 TNF_CS
IPR006052 TNF_dom
IPR008983 Tumour_necrosis_fac-like_dom
PfamiView protein in Pfam
PF00229 TNF, 1 hit
SMARTiView protein in SMART
SM00207 TNF, 1 hit
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS00251 TNF_1, 1 hit
PS50049 TNF_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTNF13_HUMAN
AccessioniPrimary (citable) accession number: O75888
Secondary accession number(s): A8MYD5
, B4DVT2, Q541E1, Q5U0G8, Q96HV6, Q9P1M8, Q9P1M9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 169 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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Main funding by: National Institutes of Health

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