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UniProtKB - O75882 (ATRN_HUMAN)

Entry version 200 (10 Feb 2021)
Sequence version 2 (27 Apr 2001)
Previous versions | rss
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Protein

Attractin

Gene

ATRN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti (By similarity). Has a critical role in normal myelination in the central nervous system (By similarity).By similarity1 Publication

Caution

Was originally (PubMed:7539799 and PubMed:9736737) thought to have dipeptidase activity but it was shown later to lack that activity.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processInflammatory response
LigandLectin

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O75882

SIGNOR Signaling Network Open Resource

More...SIGNORi		O75882

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Attractin
Alternative name(s):
DPPT-L
Mahogany homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATRN
Synonyms:KIAA0548, MGCA
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:885, ATRN

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603130, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O75882

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000088812.17

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini84 – 1279ExtracellularSequence analysisAdd BLAST1196
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1280 – 1300HelicalSequence analysisAdd BLAST21
Topological domaini1301 – 1429CytoplasmicSequence analysisAdd BLAST129

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		8455

Open Targets

More...OpenTargetsi		ENSG00000088812

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA25178

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O75882, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ATRN

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 28Sequence analysisAdd BLAST28
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000039477129 – 831 PublicationAdd BLAST55
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000748384 – 1429AttractinAdd BLAST1346

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi101 ↔ 111By similarity
Disulfide bondi105 ↔ 118By similarity
Disulfide bondi120 ↔ 129By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi213N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi237N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi242N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi250 ↔ 260By similarity
Glycosylationi253N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi254 ↔ 271By similarity
Glycosylationi264N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi273 ↔ 282By similarity
Glycosylationi300N-linked (GlcNAc...) (complex) asparagine2 Publications1
Glycosylationi325N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi362N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi383N-linked (GlcNAc...) (complex) asparagine3 Publications1
Glycosylationi416N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi428N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi575N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi623N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi731N-linked (GlcNAc...) (complex) asparagine2 Publications1
Disulfide bondi816 ↔ 918By similarity
Glycosylationi863N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi914N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi923N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi986N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1043N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1054N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1063 ↔ 1071By similarity
Disulfide bondi1065 ↔ 1077By similarity
Glycosylationi1073N-linked (GlcNAc...) (complex) asparagine1 Publication1
Disulfide bondi1080 ↔ 1089By similarity
Glycosylationi1082N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1092 ↔ 1106By similarity
Disulfide bondi1127 ↔ 1137By similarity
Disulfide bondi1140 ↔ 1155By similarity
Glycosylationi1198N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1206N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1250N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1259N-linked (GlcNAc...) asparagine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Heavily glycosylated.6 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-664
non-CPTAC-1089

Encyclopedia of Proteome Dynamics

More...EPDi		O75882

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O75882

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O75882

MaxQB - The MaxQuant DataBase

More...MaxQBi		O75882

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O75882

PeptideAtlas

More...PeptideAtlasi		O75882

PRoteomics IDEntifications database

More...PRIDEi		O75882

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		50238 [O75882-1]
50239 [O75882-2]
50240 [O75882-3]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		679, 47 N-Linked glycans (17 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		O75882, 29 sites, 18 N-linked glycans (10 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O75882

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O75882

SwissPalm database of S-palmitoylation events

More...SwissPalmi		O75882

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 2 is detected in plasma (at protein level). Expressed and secreted by activated T-lymphocytes. Expressed at low to moderate levels in peripheral blood leukocytes, spleen, lymph node, tonsil, bone marrow and fetal liver. At very low levels found in thymus. Isoform 2 is the major isoform in peripheral blood leukocytes.2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Activation of peripheral blood leukocytes with phytohemagglutinin induces strong expression of the membrane isoform followed by the release of the secreted isoform.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000088812, Expressed in occipital lobe and 244 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O75882, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000088812, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer and homotrimer.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114033, 26 interactors

Protein interaction database and analysis system

More...IntActi		O75882, 10 interactors

Molecular INTeraction database

More...MINTi		O75882

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000262919

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O75882, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini101 – 129EGF-likePROSITE-ProRule annotationAdd BLAST29
Domaini132 – 248CUBPROSITE-ProRule annotationAdd BLAST117
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati352 – 402Kelch 1Add BLAST51
Repeati404 – 451Kelch 2Add BLAST48
Repeati461 – 508Kelch 3Add BLAST48
Repeati513 – 564Kelch 4Add BLAST52
Repeati566 – 624Kelch 5Add BLAST59
Repeati625 – 671Kelch 6Add BLAST47
Domaini703 – 748PSI 1Add BLAST46
Domaini755 – 794PSI 2Add BLAST40
Domaini795 – 919C-type lectinPROSITE-ProRule annotationAdd BLAST125
Domaini932 – 983PSI 3Add BLAST52
Domaini986 – 1061PSI 4Add BLAST76
Domaini1063 – 1108Laminin EGF-like 1PROSITE-ProRule annotationAdd BLAST46
Domaini1109 – 1157Laminin EGF-like 2PROSITE-ProRule annotationAdd BLAST49

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi43 – 77Leu-richAdd BLAST35

Keywords - Domaini

EGF-like domain, Kelch repeat, Laminin EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1388, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157346

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_003930_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O75882

Identification of Orthologs from Complete Genome Data

More...OMAi		EACNIAA

Database of Orthologous Groups

More...OrthoDBi		49565at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O75882

TreeFam database of animal gene trees

More...TreeFami		TF321873

Family and domain databases

Conserved Domains Database

More...CDDi		cd03597, CLECT_attractin_like, 1 hit
cd00041, CUB, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.120.10.80, 2 hits
2.60.120.290, 1 hit
3.10.100.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR034011, Attractin-like_CTLD
IPR001304, C-type_lectin-like
IPR016186, C-type_lectin-like/link_sf
IPR016187, CTDL_fold
IPR000859, CUB_dom
IPR000742, EGF-like_dom
IPR011043, Gal_Oxase/kelch_b-propeller
IPR015915, Kelch-typ_b-propeller
IPR006652, Kelch_1
IPR002049, Laminin_EGF
IPR002165, Plexin_repeat
IPR016201, PSI
IPR035914, Sperma_CUB_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00431, CUB, 1 hit
PF01344, Kelch_1, 2 hits
PF00059, Lectin_C, 1 hit
PF01437, PSI, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00034, CLECT, 1 hit
SM00042, CUB, 1 hit
SM00181, EGF, 2 hits
SM00180, EGF_Lam, 2 hits
SM00423, PSI, 5 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49854, SSF49854, 1 hit
SSF50965, SSF50965, 1 hit
SSF56436, SSF56436, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50041, C_TYPE_LECTIN_2, 1 hit
PS01180, CUB, 1 hit
PS00022, EGF_1, 3 hits
PS01186, EGF_2, 1 hit
PS50026, EGF_3, 2 hits
PS01248, EGF_LAM_1, 1 hit
PS50027, EGF_LAM_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O75882-1) [UniParc]FASTAAdd to basket
Also known as: Membrane

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVAAAAATEA RLRRRTAATA ALAGRSGGPH WDWDVTRAGR PGLGAGLRLP 
        60         70         80         90        100
RLLSPPLRPR LLLLLLLLSP PLLLLLLPCE AEAAAAAAAV SGSAAAEAKE 
       110        120        130        140        150
CDRPCVNGGR CNPGTGQCVC PAGWVGEQCQ HCGGRFRLTG SSGFVTDGPG 
       160        170        180        190        200
NYKYKTKCTW LIEGQPNRIM RLRFNHFATE CSWDHLYVYD GDSIYAPLVA 
       210        220        230        240        250
AFSGLIVPER DGNETVPEVV ATSGYALLHF FSDAAYNLTG FNITYSFDMC 
       260        270        280        290        300
PNNCSGRGEC KISNSSDTVE CECSENWKGE ACDIPHCTDN CGFPHRGICN 
       310        320        330        340        350
SSDVRGCSCF SDWQGPGCSV PVPANQSFWT REEYSNLKLP RASHKAVVNG 
       360        370        380        390        400
NIMWVVGGYM FNHSDYNMVL AYDLASREWL PLNRSVNNVV VRYGHSLALY 
       410        420        430        440        450
KDKIYMYGGK IDSTGNVTNE LRVFHIHNES WVLLTPKAKE QYAVVGHSAH 
       460        470        480        490        500
IVTLKNGRVV MLVIFGHCPL YGYISNVQEY DLDKNTWSIL HTQGALVQGG 
       510        520        530        540        550
YGHSSVYDHR TRALYVHGGY KAFSANKYRL ADDLYRYDVD TQMWTILKDS 
       560        570        580        590        600
RFFRYLHTAV IVSGTMLVFG GNTHNDTSMS HGAKCFSSDF MAYDIACDRW 
       610        620        630        640        650
SVLPRPDLHH DVNRFGHSAV LHNSTMYVFG GFNSLLLSDI LVFTSEQCDA 
       660        670        680        690        700
HRSEAACLAA GPGIRCVWNT GSSQCISWAL ATDEQEEKLK SECFSKRTLD 
       710        720        730        740        750
HDRCDQHTDC YSCTANTNDC HWCNDHCVPR NHSCSEGQIS IFRYENCPKD 
       760        770        780        790        800
NPMYYCNKKT SCRSCALDQN CQWEPRNQEC IALPENICGI GWHLVGNSCL 
       810        820        830        840        850
KITTAKENYD NAKLFCRNHN ALLASLTTQK KVEFVLKQLR IMQSSQSMSK 
       860        870        880        890        900
LTLTPWVGLR KINVSYWCWE DMSPFTNSLL QWMPSEPSDA GFCGILSEPS 
       910        920        930        940        950
TRGLKAATCI NPLNGSVCER PANHSAKQCR TPCALRTACG DCTSGSSECM 
       960        970        980        990       1000
WCSNMKQCVD SNAYVASFPF GQCMEWYTMS TCPPENCSGY CTCSHCLEQP 
      1010       1020       1030       1040       1050
GCGWCTDPSN TGKGKCIEGS YKGPVKMPSQ APTGNFYPQP LLNSSMCLED 
      1060       1070       1080       1090       1100
SRYNWSFIHC PACQCNGHSK CINQSICEKC ENLTTGKHCE TCISGFYGDP 
      1110       1120       1130       1140       1150
TNGGKCQPCK CNGHASLCNT NTGKCFCTTK GVKGDECQLC EVENRYQGNP 
      1160       1170       1180       1190       1200
LRGTCYYTLL IDYQFTFSLS QEDDRYYTAI NFVATPDEQN RDLDMFINAS 
      1210       1220       1230       1240       1250
KNFNLNITWA ASFSAGTQAG EEMPVVSKTN IKEYKDSFSN EKFDFRNHPN 
      1260       1270       1280       1290       1300
ITFFVYVSNF TWPIKIQIAF SQHSNFMDLV QFFVTFFSCF LSLLLVAAVV 
      1310       1320       1330       1340       1350
WKIKQSCWAS RRREQLLREM QQMASRPFAS VNVALETDEE PPDLIGGSIK 
      1360       1370       1380       1390       1400
TVPKPIALEP CFGNKAAVLS VFVRLPRGLG GIPPPGQSGL AVASALVDIS 
      1410       1420 
QQMPIVYKEK SGAVRNRKQQ PPAQPGTCI
Length:1,429
Mass (Da):158,537
Last modified:April 27, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9F206A319B7E3DD8
GO
Isoform 2 (identifier: O75882-2) [UniParc]FASTAAdd to basket
Also known as: Secreted

The sequence of this isoform differs from the canonical sequence as follows:
     1268-1429: IAFSQHSNFM...QPPAQPGTCI → VQTEQ

Show »
Length:1,272
Mass (Da):141,429
Checksum:iB2DD527761F6FCEE
GO
Isoform 3 (identifier: O75882-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-104: Missing.
     1268-1429: IAFSQHSNFM...QPPAQPGTCI → VQTEQ

Show »
Length:1,198
Mass (Da):133,702
Checksum:i29173E6048FE995E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti69S → P in AAD03057 (Ref. 2) Curated1
Sequence conflicti267D → E in AAD03057 (Ref. 2) Curated1
Sequence conflicti413S → P in AAD03057 (Ref. 2) Curated1
Sequence conflicti620V → A in BAF85699 (PubMed:14702039).Curated1
Sequence conflicti704C → G AA sequence (PubMed:7539799).Curated1
Sequence conflicti1172E → K in AAF72881 (PubMed:10811918).Curated1
Sequence conflicti1172E → K in AAF72882 (PubMed:10811918).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_048967303D → A. Corresponds to variant dbSNP:rs6107308Ensembl.1
Natural variantiVAR_048968426I → T. Corresponds to variant dbSNP:rs17782078Ensembl.1
Natural variantiVAR_0489691152R → K. Corresponds to variant dbSNP:rs3886999Ensembl.1
Natural variantiVAR_0489701226V → I. Corresponds to variant dbSNP:rs12329487EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00137231 – 104Missing in isoform 3. CuratedAdd BLAST74
Alternative sequenceiVSP_0013751268 – 1429IAFSQ…PGTCI → VQTEQ in isoform 2 and isoform 3. 3 PublicationsAdd BLAST162

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF218915 AF218914 Genomic DNA Translation: AAF72881.1
AF218910 AF218909 Genomic DNA Translation: AAF72882.1
AF106861 mRNA Translation: AAD03057.1
AK293010 mRNA Translation: BAF85699.1
AL109805 Genomic DNA No translation available.
AL132773 Genomic DNA No translation available.
AL353193 Genomic DNA No translation available.
BC101705 mRNA Translation: AAI01706.1
AB011120 mRNA Translation: BAA25474.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13053.1 [O75882-1]
CCDS13054.1 [O75882-2]

NCBI Reference Sequences

More...RefSeqi		NP_001193976.1, NM_001207047.2
NP_001310261.1, NM_001323332.1
NP_647537.1, NM_139321.2 [O75882-1]
NP_647538.1, NM_139322.3 [O75882-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000262919; ENSP00000262919; ENSG00000088812 [O75882-1]
ENST00000446916; ENSP00000416587; ENSG00000088812 [O75882-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8455

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:8455

UCSC genome browser

More...UCSCi		uc002wil.3, human [O75882-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Attractin-2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF218915 AF218914 Genomic DNA Translation: AAF72881.1
AF218910 AF218909 Genomic DNA Translation: AAF72882.1
AF106861 mRNA Translation: AAD03057.1
AK293010 mRNA Translation: BAF85699.1
AL109805 Genomic DNA No translation available.
AL132773 Genomic DNA No translation available.
AL353193 Genomic DNA No translation available.
BC101705 mRNA Translation: AAI01706.1
AB011120 mRNA Translation: BAA25474.1
CCDSiCCDS13053.1 [O75882-1]
CCDS13054.1 [O75882-2]
RefSeqiNP_001193976.1, NM_001207047.2
NP_001310261.1, NM_001323332.1
NP_647537.1, NM_139321.2 [O75882-1]
NP_647538.1, NM_139322.3 [O75882-2]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi114033, 26 interactors
IntActiO75882, 10 interactors
MINTiO75882
STRINGi9606.ENSP00000262919

PTM databases

GlyConnecti679, 47 N-Linked glycans (17 sites)
GlyGeniO75882, 29 sites, 18 N-linked glycans (10 sites)
iPTMnetiO75882
PhosphoSitePlusiO75882
SwissPalmiO75882

Genetic variation databases

BioMutaiATRN

Proteomic databases

CPTACiCPTAC-664
non-CPTAC-1089
EPDiO75882
jPOSTiO75882
MassIVEiO75882
MaxQBiO75882
PaxDbiO75882
PeptideAtlasiO75882
PRIDEiO75882
ProteomicsDBi50238 [O75882-1]
50239 [O75882-2]
50240 [O75882-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2265, 249 antibodies

Genome annotation databases

EnsembliENST00000262919; ENSP00000262919; ENSG00000088812 [O75882-1]
ENST00000446916; ENSP00000416587; ENSG00000088812 [O75882-2]
GeneIDi8455
KEGGihsa:8455
UCSCiuc002wil.3, human [O75882-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8455
DisGeNETi8455

GeneCards: human genes, protein and diseases

More...GeneCardsi		ATRN
HGNCiHGNC:885, ATRN
HPAiENSG00000088812, Low tissue specificity
MIMi603130, gene
neXtProtiNX_O75882
OpenTargetsiENSG00000088812
PharmGKBiPA25178
VEuPathDBiHostDB:ENSG00000088812.17

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1388, Eukaryota
GeneTreeiENSGT00940000157346
HOGENOMiCLU_003930_0_0_1
InParanoidiO75882
OMAiEACNIAA
OrthoDBi49565at2759
PhylomeDBiO75882
TreeFamiTF321873

Enzyme and pathway databases

PathwayCommonsiO75882
SIGNORiO75882

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		8455, 20 hits in 873 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ATRN, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ATRN

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		8455
PharosiO75882, Tbio

Protein Ontology

More...PROi		PR:O75882
RNActiO75882, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000088812, Expressed in occipital lobe and 244 other tissues
GenevisibleiO75882, HS

Family and domain databases

CDDicd03597, CLECT_attractin_like, 1 hit
cd00041, CUB, 1 hit
Gene3Di2.120.10.80, 2 hits
2.60.120.290, 1 hit
3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR034011, Attractin-like_CTLD
IPR001304, C-type_lectin-like
IPR016186, C-type_lectin-like/link_sf
IPR016187, CTDL_fold
IPR000859, CUB_dom
IPR000742, EGF-like_dom
IPR011043, Gal_Oxase/kelch_b-propeller
IPR015915, Kelch-typ_b-propeller
IPR006652, Kelch_1
IPR002049, Laminin_EGF
IPR002165, Plexin_repeat
IPR016201, PSI
IPR035914, Sperma_CUB_dom_sf
PfamiView protein in Pfam
PF00431, CUB, 1 hit
PF01344, Kelch_1, 2 hits
PF00059, Lectin_C, 1 hit
PF01437, PSI, 2 hits
SMARTiView protein in SMART
SM00034, CLECT, 1 hit
SM00042, CUB, 1 hit
SM00181, EGF, 2 hits
SM00180, EGF_Lam, 2 hits
SM00423, PSI, 5 hits
SUPFAMiSSF49854, SSF49854, 1 hit
SSF50965, SSF50965, 1 hit
SSF56436, SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS50041, C_TYPE_LECTIN_2, 1 hit
PS01180, CUB, 1 hit
PS00022, EGF_1, 3 hits
PS01186, EGF_2, 1 hit
PS50026, EGF_3, 2 hits
PS01248, EGF_LAM_1, 1 hit
PS50027, EGF_LAM_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATRN_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75882
Secondary accession number(s): A8KAE5
, O60295, O95414, Q3MIT3, Q5TDA2, Q5TDA4, Q5VYW3, Q9NTQ3, Q9NTQ4, Q9NU01, Q9NZ57, Q9NZ58, Q9UC75, Q9UDF5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: February 10, 2021
This is version 200 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human variants curated from literature reports
    Index of human variants curated from literature reports
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  4. Human entries with genetic variants
    List of human entries with genetic variants
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