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Entry version 148 (07 Apr 2021)
Sequence version 2 (27 Jun 2006)
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Protein

Trafficking protein particle complex subunit 6A

Gene

TRAPPC6A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in vesicular transport during the biogenesis of melanosomes.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processER-Golgi transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
O75865

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-204005, COPII-mediated vesicle transport
R-HSA-8876198, RAB GEFs exchange GTP for GDP on RABs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Trafficking protein particle complex subunit 6A1 Publication
Short name:
TRAPP complex subunit 6A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRAPPC6A1 PublicationImported
ORF Names:HSPC289
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23069, TRAPPC6A

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610396, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O75865

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000007255.10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
79090

Open Targets

More...
OpenTargetsi
ENSG00000007255

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134963625

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O75865, Tbio

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB08342, S-palmitoyl-L-cysteine

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TRAPPC6A

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002445391 – 159Trafficking protein particle complex subunit 6AAdd BLAST159

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei33PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O75865

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O75865

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
O75865

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O75865

PeptideAtlas

More...
PeptideAtlasi
O75865

PRoteomics IDEntifications database

More...
PRIDEi
O75865

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
50231 [O75865-1]
50232 [O75865-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O75865

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O75865

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000007255, Expressed in right uterine tube and 227 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O75865, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O75865, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000007255, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of the multisubunit transport protein particle (TRAPP) complex. Heterodimer with TRAPPC3 (PubMed:16828797, PubMed:16262728). The heterodimer TRAPPC3-TRAPPC6A interacts with TRAPPC2L.

Interacts with TRAPPC2L (PubMed:19416478).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
O75865
With#Exp.IntAct
HEL-S-101 [V9HW27]3EBI-743573,EBI-10178933
IKZF3 [Q9UKT9]3EBI-743573,EBI-747204
RAB3IP [Q96QF0]4EBI-743573,EBI-747844
TRAPPC3 [O43617]9EBI-743573,EBI-743566
ZMIZ2 - isoform 2 [Q8NF64-2]3EBI-743573,EBI-10182121
Hoxa1 [P09022] from Mus musculus.3EBI-743573,EBI-3957603
Isoform 2 [O75865-2]
With#Exp.IntAct
BAG4 [O95429]3EBI-8451480,EBI-2949658
CAVIN2 [O95810]3EBI-8451480,EBI-742141
CD2BP2 [O95400]3EBI-8451480,EBI-768015
CTDSP1 [Q9GZU7]3EBI-8451480,EBI-751587
EFS - isoform Efs2 [O43281-2]3EBI-8451480,EBI-11525448
EYA2 - isoform 2 [O00167-2]3EBI-8451480,EBI-12807776
FOXN1 [O15353]3EBI-8451480,EBI-11319000
GGA3 - isoform Short [Q9NZ52-2]3EBI-8451480,EBI-12075758
GINS3 [Q9BRX5]3EBI-8451480,EBI-2857315
GOLGA6A [Q9NYA3]3EBI-8451480,EBI-11163335
GORASP2 [Q9H8Y8]5EBI-8451480,EBI-739467
HSPB8 [Q9UJY1]3EBI-8451480,EBI-739074
IKZF3 [Q9UKT9]5EBI-8451480,EBI-747204
INCA1 [Q0VD86]3EBI-8451480,EBI-6509505
KANK4 [Q5T7N3]3EBI-8451480,EBI-9355810
KRTAP13-2 [Q52LG2]3EBI-8451480,EBI-11953846
LHX4 [Q969G2]3EBI-8451480,EBI-2865388
MYOZ3 [Q8TDC0]3EBI-8451480,EBI-5662487
PAX6 [P26367]3EBI-8451480,EBI-747278
PFDN5 [Q99471]3EBI-8451480,EBI-357275
RAB3IP - isoform 7 [Q96QF0-7]3EBI-8451480,EBI-11984839
REL - isoform 2 [Q04864-2]3EBI-8451480,EBI-10829018
RUSC1 [Q9BVN2]3EBI-8451480,EBI-6257312
SCOC - isoform 3 [Q9UIL1-3]3EBI-8451480,EBI-10692913
SERTAD3 [Q9UJW9]3EBI-8451480,EBI-748621
SF3B5 [Q9BWJ5]3EBI-8451480,EBI-2555428
SMUG1 - isoform 2 [Q53HV7-2]3EBI-8451480,EBI-12275818
TAX1BP1 [Q86VP1]3EBI-8451480,EBI-529518
TEPSIN [Q96N21]3EBI-8451480,EBI-11139477
TRAPPC2L - isoform 2 [Q9UL33-2]5EBI-8451480,EBI-11119202
TRAPPC3 [O43617]6EBI-8451480,EBI-743566
TRIM35 - isoform 2 [Q9UPQ4-2]3EBI-8451480,EBI-17716262
TTC23 - isoform 3 [Q5W5X9-3]3EBI-8451480,EBI-9090990
UBAP2 [Q5T6F2]3EBI-8451480,EBI-2514383
ZFP90 [Q8TF47]3EBI-8451480,EBI-11419867

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
122538, 56 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-4750, TRAPP III complex

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
O75865

Database of interacting proteins

More...
DIPi
DIP-37869N

Protein interaction database and analysis system

More...
IntActi
O75865, 53 interactors

Molecular INTeraction database

More...
MINTi
O75865

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000006275

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
O75865, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1159
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O75865

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O75865

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3316, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00390000012948

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_076409_3_1_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O75865

Identification of Orthologs from Complete Genome Data

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OMAi
MLAFREE

Database of Orthologous Groups

More...
OrthoDBi
1566836at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O75865

TreeFam database of animal gene trees

More...
TreeFami
TF313010

Family and domain databases

Conserved Domains Database

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CDDi
cd14944, TRAPPC6A_Trs33, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR024096, NO_sig/Golgi_transp_ligand-bd
IPR007194, TRAPP_component
IPR037992, TRAPPC6/Trs33

The PANTHER Classification System

More...
PANTHERi
PTHR12817, PTHR12817, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04051, TRAPP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF111126, SSF111126, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O75865-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADTVLFEFL HTEMVAELWA HDPDPGPGGQ KMSLSVLEGM GFRVGQALGE
60 70 80 90 100
RLPRETLAFR EELDVLKFLC KDLWVAVFQK QMDSLRTNHQ GTYVLQDNSF
110 120 130 140 150
PLLLPMASGL QYLEEAPKFL AFTCGLLRGA LYTLGIESVV TASVAALPVC

KFQVVIPKS
Length:159
Mass (Da):17,605
Last modified:June 27, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE7AF768013E7E031
GO
Isoform 2 (identifier: O75865-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     28-28: G → GVSAGLRGEEAGATK

Show »
Length:173
Mass (Da):18,932
Checksum:i970E1F95E5A4A22A
GO
Isoform 3 (identifier: O75865-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     29-159: GQKMSLSVLE...CKFQVVIPKS → AAPGDAGLQG...PARRPLYPGH

Show »
Length:113
Mass (Da):11,648
Checksum:i76EC39FE7B5821F9
GO
Isoform 4 (identifier: O75865-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     29-159: GQKMSLSVLE...CKFQVVIPKS → VSAGLRGEEA...PARRPLYPGH

Show »
Length:127
Mass (Da):12,976
Checksum:i2169B80FBF05C5D4
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC62259 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAF28967 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti99 – 123SFPLL…FLAFT → KLSPPPPDGLWPAVSGGSTQ VPGLH in AAF28967 (Ref. 1) CuratedAdd BLAST25

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01958528G → GVSAGLRGEEAGATK in isoform 2. 1 Publication1
Alternative sequenceiVSP_04701629 – 159GQKMS…VIPKS → AAPGDAGLQGGAGCPQVLVQ RPVGGGVPEADGQPAHQSPG DLRPARQQLPPPPPDGLWPA VSGGSTQVPGLHLRPPARRP LYPGH in isoform 3. CuratedAdd BLAST131
Alternative sequenceiVSP_04701729 – 159GQKMS…VIPKS → VSAGLRGEEAGATKAAPGDA GLQGGAGCPQVLVQRPVGGG VPEADGQPAHQSPGDLRPAR QQLPPPPPDGLWPAVSGGST QVPGLHLRPPARRPLYPGH in isoform 4. CuratedAdd BLAST131

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF161407 mRNA Translation: AAF28967.1 Different initiation.
AC005757 Genomic DNA Translation: AAC62259.1 Different initiation.
BC001907 mRNA Translation: AAH01907.1
BC004450 mRNA Translation: AAH04450.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12655.1 [O75865-2]
CCDS59395.1 [O75865-4]
CCDS59396.1 [O75865-3]
CCDS59397.1 [O75865-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001257820.1, NM_001270891.1 [O75865-1]
NP_001257821.1, NM_001270892.1 [O75865-4]
NP_001257822.1, NM_001270893.1 [O75865-3]
NP_077013.1, NM_024108.2 [O75865-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000006275; ENSP00000006275; ENSG00000007255 [O75865-2]
ENST00000585934; ENSP00000468612; ENSG00000007255 [O75865-1]
ENST00000588062; ENSP00000468363; ENSG00000007255 [O75865-3]
ENST00000592647; ENSP00000468182; ENSG00000007255 [O75865-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
79090

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:79090

UCSC genome browser

More...
UCSCi
uc002pav.5, human [O75865-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161407 mRNA Translation: AAF28967.1 Different initiation.
AC005757 Genomic DNA Translation: AAC62259.1 Different initiation.
BC001907 mRNA Translation: AAH01907.1
BC004450 mRNA Translation: AAH04450.1
CCDSiCCDS12655.1 [O75865-2]
CCDS59395.1 [O75865-4]
CCDS59396.1 [O75865-3]
CCDS59397.1 [O75865-1]
RefSeqiNP_001257820.1, NM_001270891.1 [O75865-1]
NP_001257821.1, NM_001270892.1 [O75865-4]
NP_001257822.1, NM_001270893.1 [O75865-3]
NP_077013.1, NM_024108.2 [O75865-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2C0JX-ray2.20B1-159[»]
2J3TX-ray2.40B1-159[»]
SMRiO75865
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi122538, 56 interactors
ComplexPortaliCPX-4750, TRAPP III complex
CORUMiO75865
DIPiDIP-37869N
IntActiO75865, 53 interactors
MINTiO75865
STRINGi9606.ENSP00000006275

Chemistry databases

DrugBankiDB08342, S-palmitoyl-L-cysteine

PTM databases

iPTMnetiO75865
PhosphoSitePlusiO75865

Genetic variation databases

BioMutaiTRAPPC6A

Proteomic databases

EPDiO75865
jPOSTiO75865
MassIVEiO75865
MaxQBiO75865
PeptideAtlasiO75865
PRIDEiO75865
ProteomicsDBi50231 [O75865-1]
50232 [O75865-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
49152, 130 antibodies

Genome annotation databases

EnsembliENST00000006275; ENSP00000006275; ENSG00000007255 [O75865-2]
ENST00000585934; ENSP00000468612; ENSG00000007255 [O75865-1]
ENST00000588062; ENSP00000468363; ENSG00000007255 [O75865-3]
ENST00000592647; ENSP00000468182; ENSG00000007255 [O75865-4]
GeneIDi79090
KEGGihsa:79090
UCSCiuc002pav.5, human [O75865-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
79090
DisGeNETi79090

GeneCards: human genes, protein and diseases

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GeneCardsi
TRAPPC6A
HGNCiHGNC:23069, TRAPPC6A
HPAiENSG00000007255, Low tissue specificity
MIMi610396, gene
neXtProtiNX_O75865
OpenTargetsiENSG00000007255
PharmGKBiPA134963625
VEuPathDBiHostDB:ENSG00000007255.10

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3316, Eukaryota
GeneTreeiENSGT00390000012948
HOGENOMiCLU_076409_3_1_1
InParanoidiO75865
OMAiMLAFREE
OrthoDBi1566836at2759
PhylomeDBiO75865
TreeFamiTF313010

Enzyme and pathway databases

PathwayCommonsiO75865
ReactomeiR-HSA-204005, COPII-mediated vesicle transport
R-HSA-8876198, RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
79090, 10 hits in 993 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TRAPPC6A, human
EvolutionaryTraceiO75865

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
79090
PharosiO75865, Tbio

Protein Ontology

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PROi
PR:O75865
RNActiO75865, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000007255, Expressed in right uterine tube and 227 other tissues
ExpressionAtlasiO75865, baseline and differential
GenevisibleiO75865, HS

Family and domain databases

CDDicd14944, TRAPPC6A_Trs33, 1 hit
InterProiView protein in InterPro
IPR024096, NO_sig/Golgi_transp_ligand-bd
IPR007194, TRAPP_component
IPR037992, TRAPPC6/Trs33
PANTHERiPTHR12817, PTHR12817, 1 hit
PfamiView protein in Pfam
PF04051, TRAPP, 1 hit
SUPFAMiSSF111126, SSF111126, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTPC6A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75865
Secondary accession number(s): K7ERB1
, K7ERQ4, Q9BQ45, Q9P092
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: April 7, 2021
This is version 148 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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