Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

CAAX prenyl protease 1 homolog

Gene

ZMPSTE24

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Proteolytically removes the C-terminal three residues of farnesylated proteins. Acts on lamin A/C.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • The peptide bond hydrolyzed can be designated -C-|-A-A-X in which C is an S-isoprenylated cysteine residue, A is usually aliphatic and X is the C-terminal residue of the substrate protein, and may be any of several amino acids. EC:3.4.24.84

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+1 PublicationNote: Binds 1 zinc ion per subunit.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi335Zinc; catalytic1 Publication1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei3361 Publication1
Metal bindingi339Zinc; catalytic1 Publication1
Metal bindingi415Zinc; catalytic1 Publication1
Active sitei419Proton donorBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • double-stranded DNA binding Source: Ensembl
  • metal ion binding Source: UniProtKB-KW
  • metalloendopeptidase activity Source: GO_Central
  • metalloexopeptidase activity Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.4.24.84 2681

Protein family/group databases

MEROPS protease database

More...
MEROPSi
M48.003

Transport Classification Database

More...
TCDBi
9.B.1.1.1 the integral membrane caax protease (caax protease) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CAAX prenyl protease 1 homolog (EC:3.4.24.84)
Alternative name(s):
Farnesylated proteins-converting enzyme 1
Short name:
FACE-1
Prenyl protein-specific endoprotease 1
Zinc metalloproteinase Ste24 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZMPSTE24
Synonyms:FACE1, STE24
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000084073.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12877 ZMPSTE24

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606480 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O75844

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 18LumenalSequence analysisAdd BLAST18
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei19 – 39HelicalSequence analysisAdd BLAST21
Topological domaini40 – 81NuclearSequence analysisAdd BLAST42
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 123LumenalSequence analysisAdd BLAST21
Transmembranei124 – 144HelicalSequence analysisAdd BLAST21
Topological domaini145 – 170NuclearSequence analysisAdd BLAST26
Transmembranei171 – 191HelicalSequence analysisAdd BLAST21
Topological domaini192 – 195LumenalSequence analysis4
Transmembranei196 – 216HelicalSequence analysisAdd BLAST21
Topological domaini217 – 347NuclearSequence analysisAdd BLAST131
Transmembranei348 – 368HelicalSequence analysisAdd BLAST21
Topological domaini369 – 382LumenalSequence analysisAdd BLAST14
Transmembranei383 – 405HelicalSequence analysisAdd BLAST23
Topological domaini406 – 475NuclearSequence analysisAdd BLAST70

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Mandibuloacral dysplasia with type B lipodystrophy (MADB)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by mandibular and clavicular hypoplasia, acroosteolysis, delayed closure of the cranial suture, joint contractures, and generalized lipodystrophy with loss of subcutaneous fat from the extremities, face, neck and trunk.
See also OMIM:608612
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_064501248P → L in MADB; found in compound heterozygotes carrying a null allele; does not affect enzyme activity. 2 PublicationsCorresponds to variant dbSNP:rs121908095EnsemblClinVar.1
Natural variantiVAR_064502265N → S in MADB. 1 PublicationCorresponds to variant dbSNP:rs281875371EnsemblClinVar.1
Natural variantiVAR_019308340W → R in MADB. 1 PublicationCorresponds to variant dbSNP:rs121908093EnsemblClinVar.1
Lethal tight skin contracture syndrome (LTSCS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionRare disorder mainly characterized by intrauterine growth retardation, tight and rigid skin with erosions, prominent superficial vasculature and epidermal hyperkeratosis, facial features (small mouth, small pinched nose and micrognathia), sparse/absent eyelashes and eyebrows, mineralization defects of the skull, thin dysplastic clavicles, pulmonary hypoplasia, multiple joint contractures and an early neonatal lethal course. Liveborn children usually die within the first week of life. The overall prevalence of consanguineous cases suggested an autosomal recessive inheritance.
See also OMIM:275210

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
10269

MalaCards human disease database

More...
MalaCardsi
ZMPSTE24
MIMi275210 phenotype
608612 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000084073

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
740 Hutchinson-Gilford progeria syndrome
90154 Mandibuloacral dysplasia with type B lipodystrophy
1662 Restrictive dermopathy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37466

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3739253

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZMPSTE24

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001388441 – 475CAAX prenyl protease 1 homologAdd BLAST475

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O75844

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O75844

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O75844

PeptideAtlas

More...
PeptideAtlasi
O75844

PRoteomics IDEntifications database

More...
PRIDEi
O75844

ProteomicsDB human proteome resource

More...
ProteomicsDBi
50226

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O75844

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O75844

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O75844

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. High levels in kidney, prostate, testis and ovary.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000084073 Expressed in 236 organ(s), highest expression level in testis

CleanEx database of gene expression profiles

More...
CleanExi
HS_ZMPSTE24

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O75844 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA006988

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115560, 45 interactors

Database of interacting proteins

More...
DIPi
DIP-39641N

Protein interaction database and analysis system

More...
IntActi
O75844, 10 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000361845

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1475
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O75844

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O75844

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The metalloprotease domain is constituted by the two C-terminal nuclear regions.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase M48A family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2719 Eukaryota
COG0501 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000002053

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000257874

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG051541

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O75844

KEGG Orthology (KO)

More...
KOi
K06013

Identification of Orthologs from Complete Genome Data

More...
OMAi
RFEYQAD

Database of Orthologous Groups

More...
OrthoDBi
EOG091G074G

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O75844

TreeFam database of animal gene trees

More...
TreeFami
TF105972

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07343 M48A_Zmpste24p_like, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027057 CAXX_Prtase_1
IPR001915 Peptidase_M48
IPR032456 Peptidase_M48_N

The PANTHER Classification System

More...
PANTHERi
PTHR10120 PTHR10120, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01435 Peptidase_M48, 1 hit
PF16491 Peptidase_M48_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O75844-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGMWASLDAL WEMPAEKRIF GAVLLFSWTV YLWETFLAQR QRRIYKTTTH
60 70 80 90 100
VPPELGQIMD SETFEKSRLY QLDKSTFSFW SGLYSETEGT LILLFGGIPY
110 120 130 140 150
LWRLSGRFCG YAGFGPEYEI TQSLVFLLLA TLFSALTGLP WSLYNTFVIE
160 170 180 190 200
EKHGFNQQTL GFFMKDAIKK FVVTQCILLP VSSLLLYIIK IGGDYFFIYA
210 220 230 240 250
WLFTLVVSLV LVTIYADYIA PLFDKFTPLP EGKLKEEIEV MAKSIDFPLT
260 270 280 290 300
KVYVVEGSKR SSHSNAYFYG FFKNKRIVLF DTLLEEYSVL NKDIQEDSGM
310 320 330 340 350
EPRNEEEGNS EEIKAKVKNK KQGCKNEEVL AVLGHELGHW KLGHTVKNII
360 370 380 390 400
ISQMNSFLCF FLFAVLIGRK ELFAAFGFYD SQPTLIGLLI IFQFIFSPYN
410 420 430 440 450
EVLSFCLTVL SRRFEFQADA FAKKLGKAKD LYSALIKLNK DNLGFPVSDW
460 470
LFSMWHYSHP PLLERLQALK TMKQH
Length:475
Mass (Da):54,813
Last modified:April 27, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6C49179DEB0C8F7F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti16E → K in BAA33727 (PubMed:10076063).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034711137T → A1 PublicationCorresponds to variant dbSNP:rs17853725Ensembl.1
Natural variantiVAR_064501248P → L in MADB; found in compound heterozygotes carrying a null allele; does not affect enzyme activity. 2 PublicationsCorresponds to variant dbSNP:rs121908095EnsemblClinVar.1
Natural variantiVAR_064502265N → S in MADB. 1 PublicationCorresponds to variant dbSNP:rs281875371EnsemblClinVar.1
Natural variantiVAR_019308340W → R in MADB. 1 PublicationCorresponds to variant dbSNP:rs121908093EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB016068 mRNA Translation: BAA33727.1
AF064867 mRNA Translation: AAC68866.1
Y13834 mRNA Translation: CAB46277.1
AK075007 mRNA Translation: BAG52049.1
AL050341 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07233.1
CH471059 Genomic DNA Translation: EAX07234.1
BC037283 mRNA Translation: AAH37283.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS449.1

NCBI Reference Sequences

More...
RefSeqi
NP_005848.2, NM_005857.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.132642
Hs.721062

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000372759; ENSP00000361845; ENSG00000084073

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10269

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10269

UCSC genome browser

More...
UCSCi
uc001cfg.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016068 mRNA Translation: BAA33727.1
AF064867 mRNA Translation: AAC68866.1
Y13834 mRNA Translation: CAB46277.1
AK075007 mRNA Translation: BAG52049.1
AL050341 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07233.1
CH471059 Genomic DNA Translation: EAX07234.1
BC037283 mRNA Translation: AAH37283.1
CCDSiCCDS449.1
RefSeqiNP_005848.2, NM_005857.4
UniGeneiHs.132642
Hs.721062

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YPTX-ray3.80A/B/D/E1-475[»]
4AW6X-ray3.40A/B/D/E1-475[»]
5SYTX-ray2.00A1-474[»]
6BH8X-ray3.85A/B1-475[»]
ProteinModelPortaliO75844
SMRiO75844
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115560, 45 interactors
DIPiDIP-39641N
IntActiO75844, 10 interactors
STRINGi9606.ENSP00000361845

Chemistry databases

ChEMBLiCHEMBL3739253

Protein family/group databases

MEROPSiM48.003
TCDBi9.B.1.1.1 the integral membrane caax protease (caax protease) family

PTM databases

iPTMnetiO75844
PhosphoSitePlusiO75844
SwissPalmiO75844

Polymorphism and mutation databases

BioMutaiZMPSTE24

Proteomic databases

EPDiO75844
MaxQBiO75844
PaxDbiO75844
PeptideAtlasiO75844
PRIDEiO75844
ProteomicsDBi50226

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10269
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372759; ENSP00000361845; ENSG00000084073
GeneIDi10269
KEGGihsa:10269
UCSCiuc001cfg.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10269
DisGeNETi10269
EuPathDBiHostDB:ENSG00000084073.8

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ZMPSTE24
HGNCiHGNC:12877 ZMPSTE24
HPAiHPA006988
MalaCardsiZMPSTE24
MIMi275210 phenotype
606480 gene
608612 phenotype
neXtProtiNX_O75844
OpenTargetsiENSG00000084073
Orphaneti740 Hutchinson-Gilford progeria syndrome
90154 Mandibuloacral dysplasia with type B lipodystrophy
1662 Restrictive dermopathy
PharmGKBiPA37466

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2719 Eukaryota
COG0501 LUCA
GeneTreeiENSGT00390000002053
HOGENOMiHOG000257874
HOVERGENiHBG051541
InParanoidiO75844
KOiK06013
OMAiRFEYQAD
OrthoDBiEOG091G074G
PhylomeDBiO75844
TreeFamiTF105972

Enzyme and pathway databases

BRENDAi3.4.24.84 2681

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ZMPSTE24 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10269

Protein Ontology

More...
PROi
PR:O75844

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000084073 Expressed in 236 organ(s), highest expression level in testis
CleanExiHS_ZMPSTE24
GenevisibleiO75844 HS

Family and domain databases

CDDicd07343 M48A_Zmpste24p_like, 1 hit
InterProiView protein in InterPro
IPR027057 CAXX_Prtase_1
IPR001915 Peptidase_M48
IPR032456 Peptidase_M48_N
PANTHERiPTHR10120 PTHR10120, 1 hit
PfamiView protein in Pfam
PF01435 Peptidase_M48, 1 hit
PF16491 Peptidase_M48_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFACE1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75844
Secondary accession number(s): B3KQI7
, D3DPU7, Q8NDZ8, Q9UBQ2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: April 27, 2001
Last modified: December 5, 2018
This is version 178 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again