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Protein

AP-1 complex subunit gamma-like 2

Gene

AP1G2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function in protein sorting in late endosomes or multivesucular bodies (MVBs).1 Publication
(Microbial infection) Involved in MVB-assisted maturation of hepatitis B virus (HBV).2 Publications

Caution

Does not appear to be a subunit of the clathrin-associated adaptor protein complex 1 (AP-1).Curated

GO - Biological processi

  • intracellular protein transport Source: InterPro
  • vesicle-mediated transport Source: UniProtKB
  • viral process Source: UniProtKB-KW

Keywordsi

Biological processHost-virus interaction, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-432720 Lysosome Vesicle Biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
AP-1 complex subunit gamma-like 2
Alternative name(s):
Gamma2-adaptin
Short name:
G2ad
Gene namesi
Name:AP1G2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000213983.11
HGNCiHGNC:556 AP1G2
MIMi603534 gene
neXtProtiNX_O75843

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi369L → G: Greatly diminishes interaction with ubiquitin; when associated with G-372. 1 Publication1
Mutagenesisi372A → G: Greatly diminishes interaction with ubiquitin; when associated with G-369. 1 Publication1
Mutagenesisi372A → G: Greatly diminishes interaction with ubiquitin; when associated with G-376. 1 Publication1
Mutagenesisi376S → G: Greatly diminishes interaction with ubiquitin; when associated with G-372. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000213983
PharmGKBiPA24846

Polymorphism and mutation databases

BioMutaiAP1G2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001937601 – 785AP-1 complex subunit gamma-like 2Add BLAST785

Proteomic databases

EPDiO75843
MaxQBiO75843
PaxDbiO75843
PeptideAtlasiO75843
PRIDEiO75843
ProteomicsDBi50225

PTM databases

iPTMnetiO75843
PhosphoSitePlusiO75843

Expressioni

Tissue specificityi

Expressed in all but one (skeletal muscle) tissues examined.

Gene expression databases

BgeeiENSG00000213983 Expressed in 210 organ(s), highest expression level in cerebellar hemisphere
CleanExiHS_AP1G2
ExpressionAtlasiO75843 baseline and differential
GenevisibleiO75843 HS

Organism-specific databases

HPAiHPA004106

Interactioni

Subunit structurei

Probably interacts with AP1S1/Sigma1A-adaptin AP1S2/Sigma1B-adaptin. Probably does not interact with APB1. Binds ubiquitin.1 Publication
(Microbial infection) Interacts with HBV major surface antigen L. Interacts with HBV core protein C in a ubiquitin-dependent manner.2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi114420, 32 interactors
CORUMiO75843
DIPiDIP-31185N
IntActiO75843, 15 interactors
MINTiO75843
STRINGi9606.ENSP00000312442

Structurei

Secondary structure

1785
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO75843
SMRiO75843
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO75843

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini665 – 780GAEPROSITE-ProRule annotationAdd BLAST116

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni369 – 379Essential for ubiquitin-bindingAdd BLAST11

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1062 Eukaryota
ENOG410XPKK LUCA
GeneTreeiENSGT00390000012618
HOGENOMiHOG000210271
HOVERGENiHBG067473
InParanoidiO75843
KOiK12391
OMAiMCRDLAT
OrthoDBiEOG091G01RV
PhylomeDBiO75843
TreeFamiTF300367

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR017107 AP1_complex_gsu
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR002553 Clathrin/coatomer_adapt-like_N
IPR008152 Clathrin_a/b/g-adaptin_app_Ig
IPR013041 Clathrin_app_Ig-like_sf
IPR008153 GAE_dom
PfamiView protein in Pfam
PF01602 Adaptin_N, 1 hit
PF02883 Alpha_adaptinC2, 1 hit
PIRSFiPIRSF037094 AP1_complex_gamma, 1 hit
SMARTiView protein in SMART
SM00809 Alpha_adaptinC2, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF49348 SSF49348, 1 hit
PROSITEiView protein in PROSITE
PS50180 GAE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

O75843-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVVPSLKLQD LIEEIRGAKT QAQEREVIQK ECAHIRASFR DGDPVHRHRQ
60 70 80 90 100
LAKLLYVHML GYPAHFGQME CLKLIASSRF TDKRVGYLGA MLLLDERHDA
110 120 130 140 150
HLLITNSIKN DLSQGIQPVQ GLALCTLSTM GSAEMCRDLA PEVEKLLLQP
160 170 180 190 200
SPYVRKKAIL TAVHMIRKVP ELSSVFLPPC AQLLHERHHG ILLGTITLIT
210 220 230 240 250
ELCERSPAAL RHFRKVVPQL VHILRTLVTM GYSTEHSISG VSDPFLQVQI
260 270 280 290 300
LRLLRILGRN HEESSETMND LLAQVATNTD TSRNAGNAVL FETVLTIMDI
310 320 330 340 350
RSAAGLRVLA VNILGRFLLN SDRNIRYVAL TSLLRLVQSD HSAVQRHRPT
360 370 380 390 400
VVECLRETDA SLSRRALELS LALVNSSNVR AMMQELQAFL ESCPPDLRAD
410 420 430 440 450
CASGILLAAE RFAPTKRWHI DTILHVLTTA GTHVRDDAVA NLTQLIGGAQ
460 470 480 490 500
ELHAYSVRRL YNALAEDISQ QPLVQVAAWC IGEYGDLLLA GNCEEIEPLQ
510 520 530 540 550
VDEEEVLALL EKVLQSHMSL PATRGYALTA LMKLSTRLCG DNNRIRQVVS
560 570 580 590 600
IYGSCLDVEL QQRAVEYDTL FRKYDHMRAA ILEKMPLVER DGPQADEEAK
610 620 630 640 650
ESKEAAQLSE AAPVPTEPQA SQLLDLLDLL DGASGDVQHP PHLDPSPGGA
660 670 680 690 700
LVHLLDLPCV PPPPAPIPDL KVFEREGVQL NLSFIRPPEN PALLLITITA
710 720 730 740 750
TNFSEGDVTH FICQAAVPKS LQLQLQAPSG NTVPARGGLP ITQLFRILNP
760 770 780
NKAPLRLKLR LTYDHFHQSV QEIFEVNNLP VESWQ
Length:785
Mass (Da):87,117
Last modified:November 1, 1998 - v1
Checksum:iC189192C9811111C
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YJ47H0YJ47_HUMAN
AP-1 complex subunit gamma-like 2
AP1G2
197Annotation score:
G3V532G3V532_HUMAN
AP-1 complex subunit gamma-like 2
AP1G2
200Annotation score:
H0YJ08H0YJ08_HUMAN
AP-1 complex subunit gamma-like 2
AP1G2
143Annotation score:
G3V3Z2G3V3Z2_HUMAN
AP-1 complex subunit gamma-like 2
AP1G2
136Annotation score:
G3V2V9G3V2V9_HUMAN
AP-1 complex subunit gamma-like 2
AP1G2
68Annotation score:

Sequence cautioni

The sequence AAC67390 differs from that shown. Reason: Frameshift at position 713.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti204 – 206ERS → GRN in AAC67390 (PubMed:9762922).Curated3
Sequence conflicti399A → C in AAC67390 (PubMed:9762922).Curated1
Sequence conflicti402A → D in AAC67390 (PubMed:9762922).Curated1
Sequence conflicti416K → T in AAC67390 (PubMed:9762922).Curated1
Sequence conflicti429T → S in AAC67390 (PubMed:9762922).Curated1
Sequence conflicti439 – 441VAN → AGHT in AAC67390 (PubMed:9762922).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024363377S → F. Corresponds to variant dbSNP:rs12897422Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015318 mRNA Translation: BAA33390.1
AF068706 mRNA Translation: AAC67390.1 Frameshift.
CH471078 Genomic DNA Translation: EAW66132.1
CH471078 Genomic DNA Translation: EAW66134.1
CH471078 Genomic DNA Translation: EAW66138.1
CCDSiCCDS9602.1
RefSeqiNP_003908.1, NM_003917.4
XP_005268229.1, XM_005268172.3
XP_005268230.1, XM_005268173.3
UniGeneiHs.343244
Hs.569375

Genome annotation databases

EnsembliENST00000308724; ENSP00000312442; ENSG00000213983
ENST00000397120; ENSP00000380309; ENSG00000213983
GeneIDi8906
KEGGihsa:8906
UCSCiuc001wkl.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015318 mRNA Translation: BAA33390.1
AF068706 mRNA Translation: AAC67390.1 Frameshift.
CH471078 Genomic DNA Translation: EAW66132.1
CH471078 Genomic DNA Translation: EAW66134.1
CH471078 Genomic DNA Translation: EAW66138.1
CCDSiCCDS9602.1
RefSeqiNP_003908.1, NM_003917.4
XP_005268229.1, XM_005268172.3
XP_005268230.1, XM_005268173.3
UniGeneiHs.343244
Hs.569375

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E9GNMR-A662-785[»]
2YMTX-ray1.80A665-785[»]
3ZHFX-ray1.70A665-785[»]
4BCXX-ray2.00A665-785[»]
ProteinModelPortaliO75843
SMRiO75843
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114420, 32 interactors
CORUMiO75843
DIPiDIP-31185N
IntActiO75843, 15 interactors
MINTiO75843
STRINGi9606.ENSP00000312442

PTM databases

iPTMnetiO75843
PhosphoSitePlusiO75843

Polymorphism and mutation databases

BioMutaiAP1G2

Proteomic databases

EPDiO75843
MaxQBiO75843
PaxDbiO75843
PeptideAtlasiO75843
PRIDEiO75843
ProteomicsDBi50225

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308724; ENSP00000312442; ENSG00000213983
ENST00000397120; ENSP00000380309; ENSG00000213983
GeneIDi8906
KEGGihsa:8906
UCSCiuc001wkl.4 human

Organism-specific databases

CTDi8906
EuPathDBiHostDB:ENSG00000213983.11
GeneCardsiAP1G2
HGNCiHGNC:556 AP1G2
HPAiHPA004106
MIMi603534 gene
neXtProtiNX_O75843
OpenTargetsiENSG00000213983
PharmGKBiPA24846
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1062 Eukaryota
ENOG410XPKK LUCA
GeneTreeiENSGT00390000012618
HOGENOMiHOG000210271
HOVERGENiHBG067473
InParanoidiO75843
KOiK12391
OMAiMCRDLAT
OrthoDBiEOG091G01RV
PhylomeDBiO75843
TreeFamiTF300367

Enzyme and pathway databases

ReactomeiR-HSA-432720 Lysosome Vesicle Biogenesis

Miscellaneous databases

ChiTaRSiAP1G2 human
EvolutionaryTraceiO75843
GeneWikiiAP1G2
GenomeRNAii8906
PROiPR:O75843
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000213983 Expressed in 210 organ(s), highest expression level in cerebellar hemisphere
CleanExiHS_AP1G2
ExpressionAtlasiO75843 baseline and differential
GenevisibleiO75843 HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR017107 AP1_complex_gsu
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR002553 Clathrin/coatomer_adapt-like_N
IPR008152 Clathrin_a/b/g-adaptin_app_Ig
IPR013041 Clathrin_app_Ig-like_sf
IPR008153 GAE_dom
PfamiView protein in Pfam
PF01602 Adaptin_N, 1 hit
PF02883 Alpha_adaptinC2, 1 hit
PIRSFiPIRSF037094 AP1_complex_gamma, 1 hit
SMARTiView protein in SMART
SM00809 Alpha_adaptinC2, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF49348 SSF49348, 1 hit
PROSITEiView protein in PROSITE
PS50180 GAE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAP1G2_HUMAN
AccessioniPrimary (citable) accession number: O75843
Secondary accession number(s): D3DS51, O75504
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 160 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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