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Protein

Uroplakin-1b

Gene

UPK1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity).By similarity

GO - Molecular functioni

  • structural molecule activity Source: UniProtKB

GO - Biological processi

  • cell surface receptor signaling pathway Source: GO_Central
  • epithelial cell differentiation Source: UniProtKB
  • response to bacterium Source: Ensembl

Protein family/group databases

TCDBi8.A.40.7.2 the tetraspanin (tetraspanin) family

Names & Taxonomyi

Protein namesi
Recommended name:
Uroplakin-1b
Short name:
UP1b
Alternative name(s):
Tetraspanin-20
Short name:
Tspan-20
Uroplakin Ib
Short name:
UPIb
Gene namesi
Name:UPK1B
Synonyms:TSPAN20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000114638.7
HGNCiHGNC:12578 UPK1B
MIMi602380 gene
neXtProtiNX_O75841

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 15CytoplasmicSequence analysisAdd BLAST15
Transmembranei16 – 36HelicalSequence analysisAdd BLAST21
Topological domaini37 – 60ExtracellularSequence analysisAdd BLAST24
Transmembranei61 – 81HelicalSequence analysisAdd BLAST21
Topological domaini82 – 86CytoplasmicSequence analysis5
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Topological domaini108 – 229ExtracellularSequence analysisAdd BLAST122
Transmembranei230 – 250HelicalSequence analysisAdd BLAST21
Topological domaini251 – 260CytoplasmicSequence analysis10

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi7348
OpenTargetsiENSG00000114638
PharmGKBiPA37210

Polymorphism and mutation databases

BioMutaiUPK1B

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192891 – 260Uroplakin-1bAdd BLAST260

Post-translational modificationi

N-glycosylated with high-mannose oligosaccharides.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO75841
PaxDbiO75841
PeptideAtlasiO75841
PRIDEiO75841
ProteomicsDBi50224

PTM databases

iPTMnetiO75841
PhosphoSitePlusiO75841

Expressioni

Tissue specificityi

Bladder epithelium.

Gene expression databases

BgeeiENSG00000114638 Expressed in 109 organ(s), highest expression level in palpebral conjunctiva
CleanExiHS_UPK1B
ExpressionAtlasiO75841 baseline and differential
GenevisibleiO75841 HS

Organism-specific databases

HPAiHPA031799
HPA031800

Interactioni

Subunit structurei

Heterodimer with uroplakin-3A (UPK3A) or uroplakin-3B (UPK3B).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
DAGLAQ9Y4D24EBI-12237619,EBI-12808806

Protein-protein interaction databases

BioGridi113195, 5 interactors
IntActiO75841, 48 interactors
STRINGi9606.ENSP00000264234

Structurei

3D structure databases

ProteinModelPortaliO75841
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00390000000126
HOGENOMiHOG000230653
HOVERGENiHBG054305
InParanoidiO75841
KOiK17347
OMAiIGMCGIA
OrthoDBiEOG091G0G8N
PhylomeDBiO75841
TreeFamiTF335659

Family and domain databases

InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR008952 Tetraspanin_EC2_sf
IPR034766 Uroplakin-1b
PANTHERiPTHR19282:SF24 PTHR19282:SF24, 1 hit
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

O75841-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKDNSTVRC FQGLLIFGNV IIGCCGIALT AECIFFVSDQ HSLYPLLEAT
60 70 80 90 100
DNDDIYGAAW IGIFVGICLF CLSVLGIVGI MKSSRKILLA YFILMFIVYA
110 120 130 140 150
FEVASCITAA TQQDFFTPNL FLKQMLERYQ NNSPPNNDDQ WKNNGVTKTW
160 170 180 190 200
DRLMLQDNCC GVNGPSDWQK YTSAFRTENN DADYPWPRQC CVMNNLKEPL
210 220 230 240 250
NLEACKLGVP GFYHNQGCYE LISGPMNRHA WGVAWFGFAI LCWTFWVLLG
260
TMFYWSRIEY
Length:260
Mass (Da):29,643
Last modified:November 30, 2010 - v5
Checksum:i0512AF8D33884C0F
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J027C9J027_HUMAN
Tetraspanin
UPK1B
189Annotation score:
C9J6N2C9J6N2_HUMAN
Tetraspanin
UPK1B
169Annotation score:
C9J9M7C9J9M7_HUMAN
Tetraspanin
UPK1B
252Annotation score:
E7ETN9E7ETN9_HUMAN
Uroplakin-1b
UPK1B
180Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti137N → D in BAA33724 (PubMed:9818021).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028780113Q → R5 PublicationsCorresponds to variant dbSNP:rs9840317Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015234 mRNA Translation: BAA33724.1
AF042331 mRNA Translation: AAC77794.1
AB002155 mRNA Translation: BAA88878.1
AC083800 Genomic DNA No translation available.
BC063568 mRNA Translation: AAH63568.1
AF082888 mRNA Translation: AAD09401.1
AF067147 Genomic DNA Translation: AAC17446.1
CCDSiCCDS2985.1
RefSeqiNP_008883.2, NM_006952.3
UniGeneiHs.271580

Genome annotation databases

EnsembliENST00000264234; ENSP00000264234; ENSG00000114638
GeneIDi7348
KEGGihsa:7348
UCSCiuc003ecc.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015234 mRNA Translation: BAA33724.1
AF042331 mRNA Translation: AAC77794.1
AB002155 mRNA Translation: BAA88878.1
AC083800 Genomic DNA No translation available.
BC063568 mRNA Translation: AAH63568.1
AF082888 mRNA Translation: AAD09401.1
AF067147 Genomic DNA Translation: AAC17446.1
CCDSiCCDS2985.1
RefSeqiNP_008883.2, NM_006952.3
UniGeneiHs.271580

3D structure databases

ProteinModelPortaliO75841
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113195, 5 interactors
IntActiO75841, 48 interactors
STRINGi9606.ENSP00000264234

Protein family/group databases

TCDBi8.A.40.7.2 the tetraspanin (tetraspanin) family

PTM databases

iPTMnetiO75841
PhosphoSitePlusiO75841

Polymorphism and mutation databases

BioMutaiUPK1B

Proteomic databases

MaxQBiO75841
PaxDbiO75841
PeptideAtlasiO75841
PRIDEiO75841
ProteomicsDBi50224

Protocols and materials databases

DNASUi7348
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264234; ENSP00000264234; ENSG00000114638
GeneIDi7348
KEGGihsa:7348
UCSCiuc003ecc.4 human

Organism-specific databases

CTDi7348
DisGeNETi7348
EuPathDBiHostDB:ENSG00000114638.7
GeneCardsiUPK1B
HGNCiHGNC:12578 UPK1B
HPAiHPA031799
HPA031800
MIMi602380 gene
neXtProtiNX_O75841
OpenTargetsiENSG00000114638
PharmGKBiPA37210
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00390000000126
HOGENOMiHOG000230653
HOVERGENiHBG054305
InParanoidiO75841
KOiK17347
OMAiIGMCGIA
OrthoDBiEOG091G0G8N
PhylomeDBiO75841
TreeFamiTF335659

Miscellaneous databases

ChiTaRSiUPK1B human
GeneWikiiUPK1B
GenomeRNAii7348
PROiPR:O75841
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000114638 Expressed in 109 organ(s), highest expression level in palpebral conjunctiva
CleanExiHS_UPK1B
ExpressionAtlasiO75841 baseline and differential
GenevisibleiO75841 HS

Family and domain databases

InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR008952 Tetraspanin_EC2_sf
IPR034766 Uroplakin-1b
PANTHERiPTHR19282:SF24 PTHR19282:SF24, 1 hit
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUPK1B_HUMAN
AccessioniPrimary (citable) accession number: O75841
Secondary accession number(s): O60753, Q9UIM2, Q9UNX6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 30, 2010
Last modified: November 7, 2018
This is version 144 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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