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UniProtKB - O75841 (UPK1B_HUMAN)

Entry version 159 (10 Feb 2021)
Sequence version 5 (30 Nov 2010)
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Protein

Uroplakin-1b

Gene

UPK1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • structural molecule activity Source: UniProtKB
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O75841

Protein family/group databases

Transport Classification Database

More...TCDBi		8.A.40.7.2, the tetraspanin (tetraspanin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uroplakin-1b
Short name:
UP1b
Alternative name(s):
Tetraspanin-20
Short name:
Tspan-20
Uroplakin Ib
Short name:
UPIb
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UPK1B
Synonyms:TSPAN20
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:12578, UPK1B

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602380, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O75841

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000114638.7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 15CytoplasmicSequence analysisAdd BLAST15
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei16 – 36HelicalSequence analysisAdd BLAST21
Topological domaini37 – 60ExtracellularSequence analysisAdd BLAST24
Transmembranei61 – 81HelicalSequence analysisAdd BLAST21
Topological domaini82 – 86CytoplasmicSequence analysis5
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Topological domaini108 – 229ExtracellularSequence analysisAdd BLAST122
Transmembranei230 – 250HelicalSequence analysisAdd BLAST21
Topological domaini251 – 260CytoplasmicSequence analysis10

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		7348

Open Targets

More...OpenTargetsi		ENSG00000114638

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37210

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O75841, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		UPK1B

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002192891 – 260Uroplakin-1bAdd BLAST260

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated with high-mannose oligosaccharides.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O75841

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O75841

MaxQB - The MaxQuant DataBase

More...MaxQBi		O75841

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O75841

PeptideAtlas

More...PeptideAtlasi		O75841

PRoteomics IDEntifications database

More...PRIDEi		O75841

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		50224

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O75841

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O75841

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Bladder epithelium.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000114638, Expressed in palpebral conjunctiva and 122 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O75841, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O75841, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000114638, Tissue enhanced (placenta, urinary bladder)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer with uroplakin-3A (UPK3A) or uroplakin-3B (UPK3B).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
O75841
With#Exp.IntAct
BEST2 [Q8NFU1]3EBI-12237619,EBI-19947314
CD53 [P19397]3EBI-12237619,EBI-6657396
CD69 [Q07108]3EBI-12237619,EBI-2836595
CERS4 [Q9HA82]3EBI-12237619,EBI-2622997
CLDN7 [O95471]3EBI-12237619,EBI-740744
DAGLA [Q9Y4D2]6EBI-12237619,EBI-12808806
EDAR - isoform 2 [Q9UNE0-2]3EBI-12237619,EBI-12964110
FAM209A [Q5JX71]3EBI-12237619,EBI-18304435
FFAR2 [O15552]3EBI-12237619,EBI-2833872
FKBP7 [Q9Y680]3EBI-12237619,EBI-3918971
FNDC9 [Q8TBE3]3EBI-12237619,EBI-12142257
GJA8 [P48165]3EBI-12237619,EBI-17458373
GJB1 [P08034]3EBI-12237619,EBI-17565645
GPR161 [Q8N6U8]3EBI-12237619,EBI-6255622
GPR37L1 [O60883]3EBI-12237619,EBI-2927498
GPX8 [Q8TED1]3EBI-12237619,EBI-11721746
ISLR2 [Q6UXK2]3EBI-12237619,EBI-1266923
ITGB2 [P05107]3EBI-12237619,EBI-300173
KASH5 [Q8N6L0]3EBI-12237619,EBI-749265
KCNJ6 [P48051]3EBI-12237619,EBI-12017638
KIR2DL3 [P43628]3EBI-12237619,EBI-8632435
KLRC1 [P26715]3EBI-12237619,EBI-9018187
MFF - isoform 5 [Q9GZY8-5]3EBI-12237619,EBI-11956541
MS4A4A [Q96JQ5]3EBI-12237619,EBI-12820341
NEMP1 - isoform 2 [O14524-2]3EBI-12237619,EBI-10969203
PDZK1IP1 [Q13113]3EBI-12237619,EBI-716063
PIK3IP1 [Q96FE7]3EBI-12237619,EBI-10285708
PLPP4 [Q5VZY2]3EBI-12237619,EBI-10485931
RHCG [Q9UBD6]3EBI-12237619,EBI-15853497
SAR1A [Q9NR31]3EBI-12237619,EBI-3920694
SDHAF4 [Q5VUM1]3EBI-12237619,EBI-16769525
SHISA4 [Q96DD7]3EBI-12237619,EBI-18035902
SIT1 [Q9Y3P8]3EBI-12237619,EBI-6977215
SLC10A2 [Q12908]3EBI-12237619,EBI-18114847
SLC35C2 - isoform 3 [Q9NQQ7-3]3EBI-12237619,EBI-17295964
SLC39A2 [Q9NP94]3EBI-12237619,EBI-12898013
SPINT1 - isoform 2 [O43278-2]3EBI-12237619,EBI-12078338
SSMEM1 [Q8WWF3]3EBI-12237619,EBI-17280858
STX1A [Q16623]3EBI-12237619,EBI-712466
SYT9 [Q86SS6]3EBI-12237619,EBI-19129467
TMEM139 [Q8IV31]3EBI-12237619,EBI-7238458
TMEM237 - isoform 2 [Q96Q45-2]3EBI-12237619,EBI-10982110
TMEM262 [E9PQX1]3EBI-12237619,EBI-17180389
TMEM45B [Q96B21]3EBI-12237619,EBI-3923061
TMEM54 [Q969K7]3EBI-12237619,EBI-3922833
TMEM91 - isoform 2 [Q6ZNR0-2]3EBI-12237619,EBI-13345425
TMUB2 [Q71RG4]3EBI-12237619,EBI-2820477
VSIG1 [Q86XK7]3EBI-12237619,EBI-18323486

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		113195, 56 interactors

Protein interaction database and analysis system

More...IntActi		O75841, 50 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000264234

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O75841, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3882, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160779

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O75841

Identification of Orthologs from Complete Genome Data

More...OMAi		DHCCGVN

Database of Orthologous Groups

More...OrthoDBi		944403at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O75841

TreeFam database of animal gene trees

More...TreeFami		TF335659

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000301, Tetraspanin
IPR018499, Tetraspanin/Peripherin
IPR008952, Tetraspanin_EC2_sf
IPR034766, Uroplakin-1b

The PANTHER Classification System

More...PANTHERi		PTHR19282:SF24, PTHR19282:SF24, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00335, Tetraspanin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00259, TMFOUR

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48652, SSF48652, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

O75841-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKDNSTVRC FQGLLIFGNV IIGCCGIALT AECIFFVSDQ HSLYPLLEAT 
        60         70         80         90        100
DNDDIYGAAW IGIFVGICLF CLSVLGIVGI MKSSRKILLA YFILMFIVYA 
       110        120        130        140        150
FEVASCITAA TQQDFFTPNL FLKQMLERYQ NNSPPNNDDQ WKNNGVTKTW 
       160        170        180        190        200
DRLMLQDNCC GVNGPSDWQK YTSAFRTENN DADYPWPRQC CVMNNLKEPL 
       210        220        230        240        250
NLEACKLGVP GFYHNQGCYE LISGPMNRHA WGVAWFGFAI LCWTFWVLLG 
       260
TMFYWSRIEY
Length:260
Mass (Da):29,643
Last modified:November 30, 2010 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0512AF8D33884C0F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J027C9J027_HUMAN
Tetraspanin
UPK1B
189Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ETN9E7ETN9_HUMAN
Uroplakin Ib
UPK1B
180Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J6N2C9J6N2_HUMAN
Tetraspanin
UPK1B
169Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J9M7C9J9M7_HUMAN
Tetraspanin
UPK1B
252Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti137N → D in BAA33724 (PubMed:9818021).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_028780113Q → R5 PublicationsCorresponds to variant dbSNP:rs9840317Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB015234 mRNA Translation: BAA33724.1
AF042331 mRNA Translation: AAC77794.1
AB002155 mRNA Translation: BAA88878.1
AC083800 Genomic DNA No translation available.
BC063568 mRNA Translation: AAH63568.1
AF082888 mRNA Translation: AAD09401.1
AF067147 Genomic DNA Translation: AAC17446.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2985.1

NCBI Reference Sequences

More...RefSeqi		NP_008883.2, NM_006952.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000264234; ENSP00000264234; ENSG00000114638

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7348

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7348

UCSC genome browser

More...UCSCi		uc003ecc.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015234 mRNA Translation: BAA33724.1
AF042331 mRNA Translation: AAC77794.1
AB002155 mRNA Translation: BAA88878.1
AC083800 Genomic DNA No translation available.
BC063568 mRNA Translation: AAH63568.1
AF082888 mRNA Translation: AAD09401.1
AF067147 Genomic DNA Translation: AAC17446.1
CCDSiCCDS2985.1
RefSeqiNP_008883.2, NM_006952.3

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi113195, 56 interactors
IntActiO75841, 50 interactors
STRINGi9606.ENSP00000264234

Protein family/group databases

TCDBi8.A.40.7.2, the tetraspanin (tetraspanin) family

PTM databases

iPTMnetiO75841
PhosphoSitePlusiO75841

Genetic variation databases

BioMutaiUPK1B

Proteomic databases

jPOSTiO75841
MassIVEiO75841
MaxQBiO75841
PaxDbiO75841
PeptideAtlasiO75841
PRIDEiO75841
ProteomicsDBi50224

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		32685, 232 antibodies

The DNASU plasmid repository

More...DNASUi		7348

Genome annotation databases

EnsembliENST00000264234; ENSP00000264234; ENSG00000114638
GeneIDi7348
KEGGihsa:7348
UCSCiuc003ecc.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7348
DisGeNETi7348

GeneCards: human genes, protein and diseases

More...GeneCardsi		UPK1B
HGNCiHGNC:12578, UPK1B
HPAiENSG00000114638, Tissue enhanced (placenta, urinary bladder)
MIMi602380, gene
neXtProtiNX_O75841
OpenTargetsiENSG00000114638
PharmGKBiPA37210
VEuPathDBiHostDB:ENSG00000114638.7

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3882, Eukaryota
GeneTreeiENSGT00940000160779
InParanoidiO75841
OMAiDHCCGVN
OrthoDBi944403at2759
PhylomeDBiO75841
TreeFamiTF335659

Enzyme and pathway databases

PathwayCommonsiO75841

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7348, 2 hits in 863 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		UPK1B, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		UPK1B

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7348
PharosiO75841, Tbio

Protein Ontology

More...PROi		PR:O75841
RNActiO75841, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000114638, Expressed in palpebral conjunctiva and 122 other tissues
ExpressionAtlasiO75841, baseline and differential
GenevisibleiO75841, HS

Family and domain databases

InterProiView protein in InterPro
IPR000301, Tetraspanin
IPR018499, Tetraspanin/Peripherin
IPR008952, Tetraspanin_EC2_sf
IPR034766, Uroplakin-1b
PANTHERiPTHR19282:SF24, PTHR19282:SF24, 1 hit
PfamiView protein in Pfam
PF00335, Tetraspanin, 1 hit
PRINTSiPR00259, TMFOUR
SUPFAMiSSF48652, SSF48652, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUPK1B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75841
Secondary accession number(s): O60753, Q9UIM2, Q9UNX6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 30, 2010
Last modified: February 10, 2021
This is version 159 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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