UniProtKB - O75841 (UPK1B_HUMAN)
Protein
Uroplakin-1b
Gene
UPK1B
Organism
Homo sapiens (Human)
Status
Functioni
Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity).By similarity
GO - Molecular functioni
- structural molecule activity Source: UniProtKB
GO - Biological processi
- epithelial cell differentiation Source: UniProtKB
- response to bacterium Source: Ensembl
Enzyme and pathway databases
PathwayCommonsi | O75841 |
Protein family/group databases
TCDBi | 8.A.40.7.2, the tetraspanin (tetraspanin) family |
Names & Taxonomyi
Protein namesi | Recommended name: Uroplakin-1bShort name: UP1b Alternative name(s): Tetraspanin-20 Short name: Tspan-20 Uroplakin Ib Short name: UPIb |
Gene namesi | Name:UPK1B Synonyms:TSPAN20 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12578, UPK1B |
MIMi | 602380, gene |
neXtProti | NX_O75841 |
VEuPathDBi | HostDB:ENSG00000114638.7 |
Subcellular locationi
Other locations
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Plasma Membrane
- apical plasma membrane urothelial plaque Source: Ensembl
- integral component of plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 15 | CytoplasmicSequence analysisAdd BLAST | 15 | |
Transmembranei | 16 – 36 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 37 – 60 | ExtracellularSequence analysisAdd BLAST | 24 | |
Transmembranei | 61 – 81 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 82 – 86 | CytoplasmicSequence analysis | 5 | |
Transmembranei | 87 – 107 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 108 – 229 | ExtracellularSequence analysisAdd BLAST | 122 | |
Transmembranei | 230 – 250 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 251 – 260 | CytoplasmicSequence analysis | 10 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 7348 |
OpenTargetsi | ENSG00000114638 |
PharmGKBi | PA37210 |
Miscellaneous databases
Pharosi | O75841, Tbio |
Genetic variation databases
BioMutai | UPK1B |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000219289 | 1 – 260 | Uroplakin-1bAdd BLAST | 260 |
Post-translational modificationi
N-glycosylated with high-mannose oligosaccharides.By similarity
Keywords - PTMi
GlycoproteinProteomic databases
jPOSTi | O75841 |
MassIVEi | O75841 |
MaxQBi | O75841 |
PaxDbi | O75841 |
PeptideAtlasi | O75841 |
PRIDEi | O75841 |
ProteomicsDBi | 50224 |
PTM databases
iPTMneti | O75841 |
PhosphoSitePlusi | O75841 |
Expressioni
Tissue specificityi
Bladder epithelium.
Gene expression databases
Bgeei | ENSG00000114638, Expressed in palpebral conjunctiva and 122 other tissues |
ExpressionAtlasi | O75841, baseline and differential |
Genevisiblei | O75841, HS |
Organism-specific databases
HPAi | ENSG00000114638, Tissue enhanced (placenta, urinary bladder) |
Interactioni
Subunit structurei
Heterodimer with uroplakin-3A (UPK3A) or uroplakin-3B (UPK3B).
By similarityBinary interactionsi
Hide detailsO75841
Protein-protein interaction databases
BioGRIDi | 113195, 56 interactors |
IntActi | O75841, 50 interactors |
STRINGi | 9606.ENSP00000264234 |
Miscellaneous databases
RNActi | O75841, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the tetraspanin (TM4SF) family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3882, Eukaryota |
GeneTreei | ENSGT00940000160779 |
InParanoidi | O75841 |
OMAi | DHCCGVN |
OrthoDBi | 944403at2759 |
PhylomeDBi | O75841 |
TreeFami | TF335659 |
Family and domain databases
InterProi | View protein in InterPro IPR000301, Tetraspanin IPR018499, Tetraspanin/Peripherin IPR008952, Tetraspanin_EC2_sf IPR034766, Uroplakin-1b |
PANTHERi | PTHR19282:SF24, PTHR19282:SF24, 1 hit |
Pfami | View protein in Pfam PF00335, Tetraspanin, 1 hit |
PRINTSi | PR00259, TMFOUR |
SUPFAMi | SSF48652, SSF48652, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
O75841-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAKDNSTVRC FQGLLIFGNV IIGCCGIALT AECIFFVSDQ HSLYPLLEAT
60 70 80 90 100
DNDDIYGAAW IGIFVGICLF CLSVLGIVGI MKSSRKILLA YFILMFIVYA
110 120 130 140 150
FEVASCITAA TQQDFFTPNL FLKQMLERYQ NNSPPNNDDQ WKNNGVTKTW
160 170 180 190 200
DRLMLQDNCC GVNGPSDWQK YTSAFRTENN DADYPWPRQC CVMNNLKEPL
210 220 230 240 250
NLEACKLGVP GFYHNQGCYE LISGPMNRHA WGVAWFGFAI LCWTFWVLLG
260
TMFYWSRIEY
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9J027 | C9J027_HUMAN | Tetraspanin | UPK1B | 189 | Annotation score: | ||
E7ETN9 | E7ETN9_HUMAN | Uroplakin Ib | UPK1B | 180 | Annotation score: | ||
C9J6N2 | C9J6N2_HUMAN | Tetraspanin | UPK1B | 169 | Annotation score: | ||
C9J9M7 | C9J9M7_HUMAN | Tetraspanin | UPK1B | 252 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 137 | N → D in BAA33724 (PubMed:9818021).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_028780 | 113 | Q → R5 PublicationsCorresponds to variant dbSNP:rs9840317Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB015234 mRNA Translation: BAA33724.1 AF042331 mRNA Translation: AAC77794.1 AB002155 mRNA Translation: BAA88878.1 AC083800 Genomic DNA No translation available. BC063568 mRNA Translation: AAH63568.1 AF082888 mRNA Translation: AAD09401.1 AF067147 Genomic DNA Translation: AAC17446.1 |
CCDSi | CCDS2985.1 |
RefSeqi | NP_008883.2, NM_006952.3 |
Genome annotation databases
Ensembli | ENST00000264234; ENSP00000264234; ENSG00000114638 |
GeneIDi | 7348 |
KEGGi | hsa:7348 |
UCSCi | uc003ecc.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB015234 mRNA Translation: BAA33724.1 AF042331 mRNA Translation: AAC77794.1 AB002155 mRNA Translation: BAA88878.1 AC083800 Genomic DNA No translation available. BC063568 mRNA Translation: AAH63568.1 AF082888 mRNA Translation: AAD09401.1 AF067147 Genomic DNA Translation: AAC17446.1 |
CCDSi | CCDS2985.1 |
RefSeqi | NP_008883.2, NM_006952.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 113195, 56 interactors |
IntActi | O75841, 50 interactors |
STRINGi | 9606.ENSP00000264234 |
Protein family/group databases
TCDBi | 8.A.40.7.2, the tetraspanin (tetraspanin) family |
PTM databases
iPTMneti | O75841 |
PhosphoSitePlusi | O75841 |
Genetic variation databases
BioMutai | UPK1B |
Proteomic databases
jPOSTi | O75841 |
MassIVEi | O75841 |
MaxQBi | O75841 |
PaxDbi | O75841 |
PeptideAtlasi | O75841 |
PRIDEi | O75841 |
ProteomicsDBi | 50224 |
Protocols and materials databases
Antibodypediai | 32685, 232 antibodies |
DNASUi | 7348 |
Genome annotation databases
Ensembli | ENST00000264234; ENSP00000264234; ENSG00000114638 |
GeneIDi | 7348 |
KEGGi | hsa:7348 |
UCSCi | uc003ecc.4, human |
Organism-specific databases
CTDi | 7348 |
DisGeNETi | 7348 |
GeneCardsi | UPK1B |
HGNCi | HGNC:12578, UPK1B |
HPAi | ENSG00000114638, Tissue enhanced (placenta, urinary bladder) |
MIMi | 602380, gene |
neXtProti | NX_O75841 |
OpenTargetsi | ENSG00000114638 |
PharmGKBi | PA37210 |
VEuPathDBi | HostDB:ENSG00000114638.7 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3882, Eukaryota |
GeneTreei | ENSGT00940000160779 |
InParanoidi | O75841 |
OMAi | DHCCGVN |
OrthoDBi | 944403at2759 |
PhylomeDBi | O75841 |
TreeFami | TF335659 |
Enzyme and pathway databases
PathwayCommonsi | O75841 |
Miscellaneous databases
BioGRID-ORCSi | 7348, 2 hits in 863 CRISPR screens |
ChiTaRSi | UPK1B, human |
GeneWikii | UPK1B |
GenomeRNAii | 7348 |
Pharosi | O75841, Tbio |
PROi | PR:O75841 |
RNActi | O75841, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000114638, Expressed in palpebral conjunctiva and 122 other tissues |
ExpressionAtlasi | O75841, baseline and differential |
Genevisiblei | O75841, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000301, Tetraspanin IPR018499, Tetraspanin/Peripherin IPR008952, Tetraspanin_EC2_sf IPR034766, Uroplakin-1b |
PANTHERi | PTHR19282:SF24, PTHR19282:SF24, 1 hit |
Pfami | View protein in Pfam PF00335, Tetraspanin, 1 hit |
PRINTSi | PR00259, TMFOUR |
SUPFAMi | SSF48652, SSF48652, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | UPK1B_HUMAN | |
Accessioni | O75841Primary (citable) accession number: O75841 Secondary accession number(s): O60753, Q9UIM2, Q9UNX6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | November 30, 2010 | |
Last modified: | February 10, 2021 | |
This is version 159 of the entry and version 5 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families