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Entry version 163 (07 Oct 2020)
Sequence version 1 (01 Nov 1998)
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Protein

Krueppel-like factor 7

Gene

KLF7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional factor (PubMed:9774444, PubMed:16339272). Plays a critical role in neuronal morphogenesis and survival of sensory neurons (By similarity). Represses the corneal epithelium differentiation (PubMed:28916725). Acts also as a metabolic regulator, by modulating insulin sensitivity in pancreatic beta cells and skeletal muscle cells (PubMed:16339272). Inhibits transcriptional inducers of adipogenesis and has a repressive role in the expression of several adipokines, including leptin (PubMed:16339272).By similarity3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri219 – 243C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri249 – 273C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri279 – 301C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
O75840

SIGNOR Signaling Network Open Resource

More...
SIGNORi
O75840

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Krueppel-like factor 7
Alternative name(s):
Ubiquitous krueppel-like factor1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KLF7Imported
Synonyms:UKLF1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000118263.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6350, KLF7

Online Mendelian Inheritance in Man (OMIM)

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MIMi
604865, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O75840

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
8609

Open Targets

More...
OpenTargetsi
ENSG00000118263

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30140

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O75840, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KLF7

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000471741 – 302Krueppel-like factor 7Add BLAST302

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O75840

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
O75840

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O75840

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O75840

PeptideAtlas

More...
PeptideAtlasi
O75840

PRoteomics IDEntifications database

More...
PRIDEi
O75840

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
18843
50223 [O75840-1]
6598
69052
76374

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O75840

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O75840

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000118263, Expressed in forebrain and 239 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O75840, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O75840, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000118263, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with FBXO38.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
114168, 3 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000309570

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
O75840, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O75840

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi93 – 1019aaTAD; inactive1 Publication9
Motifi215 – 220Nuclear localization signalSequence analysis6

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The acidic N-terminal part may favor interaction with the basic domain of transcription factors.1 Publication
The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. In KLF7, the motif is inactive.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri219 – 243C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri249 – 273C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri279 – 301C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1721, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000155235

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002678_33_4_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O75840

KEGG Orthology (KO)

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KOi
K09207

Identification of Orthologs from Complete Genome Data

More...
OMAi
GYTAVNQ

Database of Orthologous Groups

More...
OrthoDBi
982312at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O75840

TreeFam database of animal gene trees

More...
TreeFami
TF350556

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096, zf-C2H2, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355, ZnF_C2H2, 3 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF57667, SSF57667, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 3 hits
PS50157, ZINC_FINGER_C2H2_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O75840-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDVLASYSIF QELQLVHDTG YFSALPSLEE TWQQTCLELE RYLQTEPRRI
60 70 80 90 100
SETFGEDLDC FLHASPPPCI EESFRRLDPL LLPVEAAICE KSSAVDILLS
110 120 130 140 150
RDKLLSETCL SLQPASSSLD SYTAVNQAQL NAVTSLTPPS SPELSRHLVK
160 170 180 190 200
TSQTLSAVDG TVTLKLVAKK AALSSVKVGG VATAAAAVTA AGAVKSGQSD
210 220 230 240 250
SDQGGLGAEA CPENKKRVHR CQFNGCRKVY TKSSHLKAHQ RTHTGEKPYK
260 270 280 290 300
CSWEGCEWRF ARSDELTRHY RKHTGAKPFK CNHCDRCFSR SDHLALHMKR

HI
Length:302
Mass (Da):33,362
Last modified:November 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i95141CE3A42C5774
GO
Isoform 2 (identifier: O75840-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-34: MDVLASYSIFQELQLVHDTGYFSALPSLEETWQQ → M

Show »
Length:269
Mass (Da):29,564
Checksum:iDE6EE837FCE04A5F
GO
Isoform 3 (identifier: O75840-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     179-302: GGVATAAAAV...HLALHMKRHI → RSLISAHGRD...FPGLTILPST

Show »
Length:230
Mass (Da):24,791
Checksum:iDFAB0453E5564923
GO
Isoform 4 (identifier: O75840-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-34: MDVLASYSIFQELQLVHDTGYFSALPSLEETWQQ → MFPSWP

Show »
Length:274
Mass (Da):30,178
Checksum:i8EABCFD4A70D4A2F
GO
Isoform 5 (identifier: O75840-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     55-244: Missing.

Show »
Length:112
Mass (Da):13,444
Checksum:i261E2F7A6F586A33
GO
Isoform 6 (identifier: O75840-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     35-87: TCLELERYLQ...DPLLLPVEAA → VRSLISAHGR...FPGLTILPST
     88-302: Missing.

Show »
Length:87
Mass (Da):9,295
Checksum:i6C032F59FE36958F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EQY2E7EQY2_HUMAN
Krueppel-like factor 7
KLF7
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JX20C9JX20_HUMAN
Krueppel-like factor 7
KLF7
175Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EUU0E7EUU0_HUMAN
Krueppel-like factor 7
KLF7
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PHC9E9PHC9_HUMAN
Krueppel-like factor 7
KLF7
51Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_081574137T → M Found in two patients with developmental delay/intellectual disability, neuromuscular and psychiatric symptoms; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1276619385Ensembl.1
Natural variantiVAR_081575139P → S Found in a patient with developmental delay/intellectual disability, neuromuscular and psychiatric symptoms; unknown pathological significance. 1 Publication1
Natural variantiVAR_081576264D → N Found in a patient with developmental delay/intellectual disability, neuromuscular and psychiatric symptoms; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1057518995EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0470301 – 34MDVLA…ETWQQ → M in isoform 2. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_0470311 – 34MDVLA…ETWQQ → MFPSWP in isoform 4. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_04747735 – 87TCLEL…PVEAA → VRSLISAHGRDVSGVLHEAM SSRGTTGNTQVQSPSNATTA TGVFPGLTILPST in isoform 6. 1 PublicationAdd BLAST53
Alternative sequenceiVSP_04747855 – 244Missing in isoform 5. 1 PublicationAdd BLAST190
Alternative sequenceiVSP_04747988 – 302Missing in isoform 6. 1 PublicationAdd BLAST215
Alternative sequenceiVSP_047032179 – 302GGVAT…MKRHI → RSLISAHGRDVSGVLHEAMS SRGTTGNTQVQSPSNATTAT GVFPGLTILPST in isoform 3. 1 PublicationAdd BLAST124

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB015132 mRNA Translation: BAA33521.1
HF546205 mRNA Translation: CCO02791.1
HF546206 mRNA Translation: CCO02792.1
BX537890 mRNA Translation: CAD97885.1
CR542112 mRNA Translation: CAG46909.1
AK297312 mRNA Translation: BAH12543.1
AK314439 mRNA Translation: BAG37050.1
AC007879 Genomic DNA No translation available.
AC008062 Genomic DNA No translation available.
CH471063 Genomic DNA Translation: EAW70400.1
CH471063 Genomic DNA Translation: EAW70402.1
CH471063 Genomic DNA Translation: EAW70403.1
BC012919 mRNA Translation: AAH12919.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2373.1 [O75840-1]
CCDS59438.1 [O75840-4]
CCDS59439.1 [O75840-3]
CCDS59440.1 [O75840-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001257871.1, NM_001270942.1 [O75840-3]
NP_001257872.1, NM_001270943.1 [O75840-2]
NP_001257873.1, NM_001270944.1 [O75840-4]
NP_003700.1, NM_003709.3 [O75840-1]
XP_016860650.1, XM_017005161.1 [O75840-1]
XP_016860653.1, XM_017005164.1 [O75840-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000309446; ENSP00000309570; ENSG00000118263 [O75840-1]
ENST00000412414; ENSP00000403284; ENSG00000118263 [O75840-4]
ENST00000421199; ENSP00000387510; ENSG00000118263 [O75840-2]
ENST00000423015; ENSP00000398572; ENSG00000118263 [O75840-3]
ENST00000458272; ENSP00000393268; ENSG00000118263 [O75840-5]

Database of genes from NCBI RefSeq genomes

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GeneIDi
8609

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8609

UCSC genome browser

More...
UCSCi
uc002vbz.3, human [O75840-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015132 mRNA Translation: BAA33521.1
HF546205 mRNA Translation: CCO02791.1
HF546206 mRNA Translation: CCO02792.1
BX537890 mRNA Translation: CAD97885.1
CR542112 mRNA Translation: CAG46909.1
AK297312 mRNA Translation: BAH12543.1
AK314439 mRNA Translation: BAG37050.1
AC007879 Genomic DNA No translation available.
AC008062 Genomic DNA No translation available.
CH471063 Genomic DNA Translation: EAW70400.1
CH471063 Genomic DNA Translation: EAW70402.1
CH471063 Genomic DNA Translation: EAW70403.1
BC012919 mRNA Translation: AAH12919.1
CCDSiCCDS2373.1 [O75840-1]
CCDS59438.1 [O75840-4]
CCDS59439.1 [O75840-3]
CCDS59440.1 [O75840-2]
RefSeqiNP_001257871.1, NM_001270942.1 [O75840-3]
NP_001257872.1, NM_001270943.1 [O75840-2]
NP_001257873.1, NM_001270944.1 [O75840-4]
NP_003700.1, NM_003709.3 [O75840-1]
XP_016860650.1, XM_017005161.1 [O75840-1]
XP_016860653.1, XM_017005164.1 [O75840-3]

3D structure databases

SMRiO75840
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi114168, 3 interactors
STRINGi9606.ENSP00000309570

PTM databases

iPTMnetiO75840
PhosphoSitePlusiO75840

Polymorphism and mutation databases

BioMutaiKLF7

Proteomic databases

jPOSTiO75840
MassIVEiO75840
MaxQBiO75840
PaxDbiO75840
PeptideAtlasiO75840
PRIDEiO75840
ProteomicsDBi18843
50223 [O75840-1]
6598
69052
76374

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
34186, 233 antibodies

The DNASU plasmid repository

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DNASUi
8609

Genome annotation databases

EnsembliENST00000309446; ENSP00000309570; ENSG00000118263 [O75840-1]
ENST00000412414; ENSP00000403284; ENSG00000118263 [O75840-4]
ENST00000421199; ENSP00000387510; ENSG00000118263 [O75840-2]
ENST00000423015; ENSP00000398572; ENSG00000118263 [O75840-3]
ENST00000458272; ENSP00000393268; ENSG00000118263 [O75840-5]
GeneIDi8609
KEGGihsa:8609
UCSCiuc002vbz.3, human [O75840-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
8609
DisGeNETi8609
EuPathDBiHostDB:ENSG00000118263.14

GeneCards: human genes, protein and diseases

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GeneCardsi
KLF7
HGNCiHGNC:6350, KLF7
HPAiENSG00000118263, Low tissue specificity
MIMi604865, gene
neXtProtiNX_O75840
OpenTargetsiENSG00000118263
PharmGKBiPA30140

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000155235
HOGENOMiCLU_002678_33_4_1
InParanoidiO75840
KOiK09207
OMAiGYTAVNQ
OrthoDBi982312at2759
PhylomeDBiO75840
TreeFamiTF350556

Enzyme and pathway databases

PathwayCommonsiO75840
SIGNORiO75840

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
8609, 77 hits in 890 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
KLF7, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
KLF7

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
8609
PharosiO75840, Tbio

Protein Ontology

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PROi
PR:O75840
RNActiO75840, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000118263, Expressed in forebrain and 239 other tissues
ExpressionAtlasiO75840, baseline and differential
GenevisibleiO75840, HS

Family and domain databases

InterProiView protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF00096, zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 3 hits
SUPFAMiSSF57667, SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 3 hits
PS50157, ZINC_FINGER_C2H2_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKLF7_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75840
Secondary accession number(s): B2RB03
, B7Z4F7, C9JF04, E7EWH1, L0R4P2, Q7Z3H8, Q96E51
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: October 7, 2020
This is version 163 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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