UniProtKB - O75830 (SPI2_HUMAN)
Protein
Serpin I2
Gene
SERPINI2
Organism
Homo sapiens (Human)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 357 – 358 | Reactive bondBy similarity | 2 |
GO - Molecular functioni
- serine-type endopeptidase inhibitor activity Source: GO_Central
GO - Biological processi
- negative regulation of endopeptidase activity Source: GO_Central
- regulation of cell adhesion Source: Ensembl
Keywordsi
Molecular function | Protease inhibitor, Serine protease inhibitor |
Enzyme and pathway databases
PathwayCommonsi | O75830 |
Protein family/group databases
MEROPSi | I04.026 |
Names & Taxonomyi
Protein namesi | Recommended name: Serpin I2Alternative name(s): Myoepithelium-derived serine protease inhibitor Pancpin Pancreas-specific protein TSA2004 Peptidase inhibitor 14 Short name: PI-14 |
Gene namesi | Name:SERPINI2 Synonyms:MEPI, PI14 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:8945, SERPINI2 |
MIMi | 605587, gene |
neXtProti | NX_O75830 |
VEuPathDBi | HostDB:ENSG00000114204.14 |
Subcellular locationi
Extracellular region or secreted
- Secreted Curated
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular space Source: GO_Central
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 5276 |
OpenTargetsi | ENSG00000114204 |
PharmGKBi | PA35513 |
Miscellaneous databases
Pharosi | O75830, Tbio |
Genetic variation databases
BioMutai | SERPINI2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
ChainiPRO_0000032525 | 19 – 405 | Serpin I2Add BLAST | 387 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 202 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 207 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 306 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
EPDi | O75830 |
jPOSTi | O75830 |
MassIVEi | O75830 |
PaxDbi | O75830 |
PeptideAtlasi | O75830 |
PRIDEi | O75830 |
ProteomicsDBi | 50219 |
PTM databases
GlyGeni | O75830, 3 sites |
iPTMneti | O75830 |
PhosphoSitePlusi | O75830 |
Expressioni
Tissue specificityi
Expressed in pancreas and adipose tissues.1 Publication
Gene expression databases
Bgeei | ENSG00000114204, Expressed in pancreas and 126 other tissues |
ExpressionAtlasi | O75830, baseline and differential |
Genevisiblei | O75830, HS |
Organism-specific databases
HPAi | ENSG00000114204, Tissue enriched (pancreas) |
Interactioni
Binary interactionsi
Hide detailsO75830
Protein-protein interaction databases
BioGRIDi | 111294, 12 interactors |
IntActi | O75830, 10 interactors |
MINTi | O75830 |
STRINGi | 9606.ENSP00000481699 |
Miscellaneous databases
RNActi | O75830, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the serpin family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG2392, Eukaryota |
GeneTreei | ENSGT00940000161641 |
HOGENOMi | CLU_023330_0_4_1 |
InParanoidi | O75830 |
OrthoDBi | 1124079at2759 |
PhylomeDBi | O75830 |
TreeFami | TF343094 |
Family and domain databases
Gene3Di | 2.30.39.10, 1 hit 3.30.497.10, 1 hit |
InterProi | View protein in InterPro IPR023795, Serpin_CS IPR023796, Serpin_dom IPR000215, Serpin_fam IPR036186, Serpin_sf IPR042178, Serpin_sf_1 IPR042185, Serpin_sf_2 |
PANTHERi | PTHR11461, PTHR11461, 1 hit |
Pfami | View protein in Pfam PF00079, Serpin, 1 hit |
SMARTi | View protein in SMART SM00093, SERPIN, 1 hit |
SUPFAMi | SSF56574, SSF56574, 1 hit |
PROSITEi | View protein in PROSITE PS00284, SERPIN, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
O75830-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDTIFLWSLL LLFFGSQASR CSAQKNTEFA VDLYQEVSLS HKDNIIFSPL
60 70 80 90 100
GITLVLEMVQ LGAKGKAQQQ IRQTLKQQET SAGEEFFVLK SFFSAISEKK
110 120 130 140 150
QEFTFNLANA LYLQEGFTVK EQYLHGNKEF FQSAIKLVDF QDAKACAEMI
160 170 180 190 200
STWVERKTDG KIKDMFSGEE FGPLTRLVLV NAIYFKGDWK QKFRKEDTQL
210 220 230 240 250
INFTKKNGST VKIPMMKALL RTKYGYFSES SLNYQVLELS YKGDEFSLII
260 270 280 290 300
ILPAEGMDIE EVEKLITAQQ ILKWLSEMQE EEVEISLPRF KVEQKVDFKD
310 320 330 340 350
VLYSLNITEI FSGGCDLSGI TDSSEVYVSQ VTQKVFFEIN EDGSEAATST
360 370 380 390 400
GIHIPVIMSL AQSQFIANHP FLFIMKHNPT ESILFMGRVT NPDTQEIKGR
DLDSL
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0C4DGW9 | A0A0C4DGW9_HUMAN | Serpin I2 | SERPINI2 | 415 | Annotation score: | ||
C9J7N5 | C9J7N5_HUMAN | Serpin I2 | SERPINI2 | 206 | Annotation score: | ||
C9JWE1 | C9JWE1_HUMAN | Serpin I2 | SERPINI2 | 157 | Annotation score: |
Sequence cautioni
The sequence AAH27859 differs from that shown. Reason: Erroneous initiation.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051957 | 6 | L → V. Corresponds to variant dbSNP:rs17246389Ensembl. | 1 | |
Natural variantiVAR_024357 | 148 | E → G. Corresponds to variant dbSNP:rs9841174Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB006423 mRNA Translation: BAA33766.1 AF130470 mRNA Translation: AAD34723.1 BC027859 mRNA Translation: AAH27859.2 Different initiation. |
CCDSi | CCDS3200.1 CCDS75047.1 |
RefSeqi | NP_001012303.1, NM_001012303.2 NP_006208.1, NM_006217.4 |
Genome annotation databases
Ensembli | ENST00000264677; ENSP00000264677; ENSG00000114204 ENST00000461846; ENSP00000417692; ENSG00000114204 ENST00000471111; ENSP00000419407; ENSG00000114204 ENST00000476257; ENSP00000420621; ENSG00000114204 |
GeneIDi | 5276 |
KEGGi | hsa:5276 |
UCSCi | uc003fer.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB006423 mRNA Translation: BAA33766.1 AF130470 mRNA Translation: AAD34723.1 BC027859 mRNA Translation: AAH27859.2 Different initiation. |
CCDSi | CCDS3200.1 CCDS75047.1 |
RefSeqi | NP_001012303.1, NM_001012303.2 NP_006208.1, NM_006217.4 |
3D structure databases
SMRi | O75830 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 111294, 12 interactors |
IntActi | O75830, 10 interactors |
MINTi | O75830 |
STRINGi | 9606.ENSP00000481699 |
Protein family/group databases
MEROPSi | I04.026 |
PTM databases
GlyGeni | O75830, 3 sites |
iPTMneti | O75830 |
PhosphoSitePlusi | O75830 |
Genetic variation databases
BioMutai | SERPINI2 |
Proteomic databases
EPDi | O75830 |
jPOSTi | O75830 |
MassIVEi | O75830 |
PaxDbi | O75830 |
PeptideAtlasi | O75830 |
PRIDEi | O75830 |
ProteomicsDBi | 50219 |
Protocols and materials databases
Antibodypediai | 33688, 259 antibodies |
DNASUi | 5276 |
Genome annotation databases
Ensembli | ENST00000264677; ENSP00000264677; ENSG00000114204 ENST00000461846; ENSP00000417692; ENSG00000114204 ENST00000471111; ENSP00000419407; ENSG00000114204 ENST00000476257; ENSP00000420621; ENSG00000114204 |
GeneIDi | 5276 |
KEGGi | hsa:5276 |
UCSCi | uc003fer.3, human |
Organism-specific databases
CTDi | 5276 |
DisGeNETi | 5276 |
GeneCardsi | SERPINI2 |
HGNCi | HGNC:8945, SERPINI2 |
HPAi | ENSG00000114204, Tissue enriched (pancreas) |
MIMi | 605587, gene |
neXtProti | NX_O75830 |
OpenTargetsi | ENSG00000114204 |
PharmGKBi | PA35513 |
VEuPathDBi | HostDB:ENSG00000114204.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2392, Eukaryota |
GeneTreei | ENSGT00940000161641 |
HOGENOMi | CLU_023330_0_4_1 |
InParanoidi | O75830 |
OrthoDBi | 1124079at2759 |
PhylomeDBi | O75830 |
TreeFami | TF343094 |
Enzyme and pathway databases
PathwayCommonsi | O75830 |
Miscellaneous databases
BioGRID-ORCSi | 5276, 4 hits in 870 CRISPR screens |
ChiTaRSi | SERPINI2, human |
GeneWikii | SERPINI2 |
GenomeRNAii | 5276 |
Pharosi | O75830, Tbio |
PROi | PR:O75830 |
RNActi | O75830, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000114204, Expressed in pancreas and 126 other tissues |
ExpressionAtlasi | O75830, baseline and differential |
Genevisiblei | O75830, HS |
Family and domain databases
Gene3Di | 2.30.39.10, 1 hit 3.30.497.10, 1 hit |
InterProi | View protein in InterPro IPR023795, Serpin_CS IPR023796, Serpin_dom IPR000215, Serpin_fam IPR036186, Serpin_sf IPR042178, Serpin_sf_1 IPR042185, Serpin_sf_2 |
PANTHERi | PTHR11461, PTHR11461, 1 hit |
Pfami | View protein in Pfam PF00079, Serpin, 1 hit |
SMARTi | View protein in SMART SM00093, SERPIN, 1 hit |
SUPFAMi | SSF56574, SSF56574, 1 hit |
PROSITEi | View protein in PROSITE PS00284, SERPIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SPI2_HUMAN | |
Accessioni | O75830Primary (citable) accession number: O75830 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 23, 2002 |
Last sequence update: | November 1, 1998 | |
Last modified: | February 10, 2021 | |
This is version 175 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants