UniProtKB - O75830 (SPI2_HUMAN)

BLAST

>sp|O75830|SPI2_HUMAN Serpin I2 OS=Homo sapiens OX=9606 GN=SERPINI2 PE=1 SV=1
MDTIFLWSLLLLFFGSQASRCSAQKNTEFAVDLYQEVSLSHKDNIIFSPLGITLVLEMVQ
LGAKGKAQQQIRQTLKQQETSAGEEFFVLKSFFSAISEKKQEFTFNLANALYLQEGFTVK
EQYLHGNKEFFQSAIKLVDFQDAKACAEMISTWVERKTDGKIKDMFSGEEFGPLTRLVLV
NAIYFKGDWKQKFRKEDTQLINFTKKNGSTVKIPMMKALLRTKYGYFSESSLNYQVLELS
YKGDEFSLIIILPAEGMDIEEVEKLITAQQILKWLSEMQEEEVEISLPRFKVEQKVDFKD
VLYSLNITEIFSGGCDLSGITDSSEVYVSQVTQKVFFEINEDGSEAATSTGIHIPVIMSL
AQSQFIANHPFLFIMKHNPTESILFMGRVTNPDTQEIKGRDLDSL

Align
Format
Add to basket Added to basket
History
Entry version 158 (07 Nov 2018)
Sequence version 1 (01 Nov 1998)
Previous versions | rss
Other tutorials and videos
Help video
Feedback

Protein

Serpin I2

Gene

SERPINI2

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	357 – 358	Reactive bondBy similarity		2

GO - Molecular functionⁱ

serine-type endopeptidase inhibitor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of endopeptidase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Protease inhibitor, Serine protease inhibitor

Molecular function

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	I04.026

MEROPSⁱ

I04.026

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Serpin I2 Alternative name(s): Myoepithelium-derived serine protease inhibitor Pancpin Pancreas-specific protein TSA2004 Peptidase inhibitor 14 Short name: PI-14
Gene namesⁱ	Name:SERPINI2 Synonyms:MEPI, PI14
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000114204.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:8945 SERPINI2
MIMⁱ	605587 gene
neXtProtⁱ	NX_O75830

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5276
Open Targets More...OpenTargetsⁱ	ENSG00000114204
PharmGKBⁱ	PA35513

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 18	Sequence analysisAdd BLAST		18
ChainⁱPRO_0000032525	19 – 405	Serpin I2Add BLAST		387

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	202	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	207	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	306	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

EPDⁱ	O75830
PaxDbⁱ	O75830
PeptideAtlas More...PeptideAtlasⁱ	O75830
PRIDEⁱ	O75830
ProteomicsDBⁱ	50219

PTM databases

iPTMnetⁱ	O75830
PhosphoSitePlusⁱ	O75830

Expressionⁱ

Tissue specificityⁱ

Expressed in pancreas and adipose tissues.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000114204 Expressed in 109 organ(s), highest expression level in body of pancreas
CleanExⁱ	HS_SERPINI2
ExpressionAtlasⁱ	O75830 baseline and differential
Genevisibleⁱ	O75830 HS

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
SGTB	Q96EQ0	3	EBI-750144,EBI-744081
UBQLN1	Q9UMX0	8	EBI-750144,EBI-741480
UBQLN1	Q9UMX0-2	3	EBI-750144,EBI-10173939

Protein-protein interaction databases

BioGridⁱ	111294, 6 interactors
IntActⁱ	O75830, 6 interactors
Molecular INTeraction database More...MINTⁱ	O75830
STRINGⁱ	9606.ENSP00000264677

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O75830
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the serpin family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	KOG2392 Eukaryota COG4826 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150820
HOVERGENⁱ	HBG005957
InParanoidⁱ	O75830
PhylomeDBⁱ	O75830
TreeFamⁱ	TF343094

Family and domain databases

InterProⁱ	View protein in InterPro IPR023795 Serpin_CS IPR023796 Serpin_dom IPR000215 Serpin_fam IPR036186 Serpin_sf
PANTHERⁱ	PTHR11461 PTHR11461, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00079 Serpin, 1 hit
SMARTⁱ	View protein in SMART SM00093 SERPIN, 1 hit
SUPFAMⁱ	SSF56574 SSF56574, 1 hit
PROSITEⁱ	View protein in PROSITE PS00284 SERPIN, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

O75830-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDTIFLWSLL LLFFGSQASR CSAQKNTEFA VDLYQEVSLS HKDNIIFSPL 
        60         70         80         90        100
GITLVLEMVQ LGAKGKAQQQ IRQTLKQQET SAGEEFFVLK SFFSAISEKK 
       110        120        130        140        150
QEFTFNLANA LYLQEGFTVK EQYLHGNKEF FQSAIKLVDF QDAKACAEMI 
       160        170        180        190        200
STWVERKTDG KIKDMFSGEE FGPLTRLVLV NAIYFKGDWK QKFRKEDTQL 
       210        220        230        240        250
INFTKKNGST VKIPMMKALL RTKYGYFSES SLNYQVLELS YKGDEFSLII 
       260        270        280        290        300
ILPAEGMDIE EVEKLITAQQ ILKWLSEMQE EEVEISLPRF KVEQKVDFKD 
       310        320        330        340        350
VLYSLNITEI FSGGCDLSGI TDSSEVYVSQ VTQKVFFEIN EDGSEAATST 
       360        370        380        390        400
GIHIPVIMSL AQSQFIANHP FLFIMKHNPT ESILFMGRVT NPDTQEIKGR 

DLDSL

Length:405

Mass (Da):46,145

Last modified:November 1, 1998 - v1

Checksum:ⁱ5BA18C60E4FDE9A4

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0C4DGW9	A0A0C4DGW9_HUMAN	Serpin I2 Serpin I2	SERPINI2	415	Annotation score:
C9J7N5	C9J7N5_HUMAN	Serpin I2 Serpin I2	SERPINI2	206	Annotation score:
C9JWE1	C9JWE1_HUMAN	Serpin I2 Serpin I2	SERPINI2	157	Annotation score:

Sequence cautionⁱ

The sequence AAH27859 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_051957	6	L → V. Corresponds to variant dbSNP:rs17246389Ensembl.		1
Natural variantⁱVAR_024357	148	E → G. Corresponds to variant dbSNP:rs9841174Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB006423 mRNA Translation: BAA33766.1 AF130470 mRNA Translation: AAD34723.1 BC027859 mRNA Translation: AAH27859.2 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3200.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001012303.1, NM_001012303.2 NP_006208.1, NM_006217.4
UniGeneⁱ	Hs.445555

Genome annotation databases

Ensemblⁱ	ENST00000264677; ENSP00000264677; ENSG00000114204 ENST00000461846; ENSP00000417692; ENSG00000114204 ENST00000471111; ENSP00000419407; ENSG00000114204 ENST00000476257; ENSP00000420621; ENSG00000114204
GeneIDⁱ	5276
KEGGⁱ	hsa:5276
UCSC genome browser More...UCSCⁱ	uc003fer.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O75830	Serpin I2		HUMAN		415	UniRef100_O75830
Serpin I2 (Fragment)		HUMAN		206

Protein	Similar proteins		Species	Score	Length	Source
O75830	Serpin I2		HUMAN		415	UniRef90_O75830
SERPINI2 isoform 3		PANTR		415
Serpin family I member 2		SAIBB		415
Serpin family I member 2		CALJA		415
Uncharacterized protein		MACMU		415
+40

Protein	Similar proteins		Species	Score	Length	Source
O75830	Serpin I2		MOUSE		405	UniRef50_O75830
Serpin I2		HUMAN		415
Uncharacterized protein		COLAP		415
SERPINI2 isoform 3		PONAB		415
Uncharacterized protein		MACFA		415
+138

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB006423 mRNA Translation: BAA33766.1 AF130470 mRNA Translation: AAD34723.1 BC027859 mRNA Translation: AAH27859.2 Different initiation.
CCDSⁱ	CCDS3200.1
RefSeqⁱ	NP_001012303.1, NM_001012303.2 NP_006208.1, NM_006217.4
UniGeneⁱ	Hs.445555

3D structure databases

ProteinModelPortalⁱ	O75830
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111294, 6 interactors
IntActⁱ	O75830, 6 interactors
MINTⁱ	O75830
STRINGⁱ	9606.ENSP00000264677

Protein family/group databases

MEROPSⁱ	I04.026

MEROPSⁱ

I04.026

PTM databases

iPTMnetⁱ	O75830
PhosphoSitePlusⁱ	O75830

Proteomic databases

EPDⁱ	O75830
PaxDbⁱ	O75830
PeptideAtlasⁱ	O75830
PRIDEⁱ	O75830
ProteomicsDBⁱ	50219

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	5276
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000264677; ENSP00000264677; ENSG00000114204 ENST00000461846; ENSP00000417692; ENSG00000114204 ENST00000471111; ENSP00000419407; ENSG00000114204 ENST00000476257; ENSP00000420621; ENSG00000114204
GeneIDⁱ	5276
KEGGⁱ	hsa:5276
UCSCⁱ	uc003fer.3 human

Organism-specific databases

CTDⁱ	5276
DisGeNETⁱ	5276
EuPathDBⁱ	HostDB:ENSG00000114204.14
GeneCardsⁱ	SERPINI2
HGNCⁱ	HGNC:8945 SERPINI2
MIMⁱ	605587 gene
neXtProtⁱ	NX_O75830
OpenTargetsⁱ	ENSG00000114204
PharmGKBⁱ	PA35513
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2392 Eukaryota COG4826 LUCA
GeneTreeⁱ	ENSGT00930000150820
HOVERGENⁱ	HBG005957
InParanoidⁱ	O75830
PhylomeDBⁱ	O75830
TreeFamⁱ	TF343094

Miscellaneous databases

ChiTaRSⁱ	SERPINI2 human
GeneWikiⁱ	SERPINI2
GenomeRNAiⁱ	5276
Protein Ontology More...PROⁱ	PR:O75830
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000114204 Expressed in 109 organ(s), highest expression level in body of pancreas
CleanExⁱ	HS_SERPINI2
ExpressionAtlasⁱ	O75830 baseline and differential
Genevisibleⁱ	O75830 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR023795 Serpin_CS IPR023796 Serpin_dom IPR000215 Serpin_fam IPR036186 Serpin_sf
PANTHERⁱ	PTHR11461 PTHR11461, 1 hit
Pfamⁱ	View protein in Pfam PF00079 Serpin, 1 hit
SMARTⁱ	View protein in SMART SM00093 SERPIN, 1 hit
SUPFAMⁱ	SSF56574 SSF56574, 1 hit
PROSITEⁱ	View protein in PROSITE PS00284 SERPIN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SPI2_HUMAN
Accessionⁱ	O75830Primary (citable) accession number: O75830
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
	Last sequence update:	November 1, 1998
	Last modified:	November 7, 2018
	This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O75830 (SPI2_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Serpin I2

SERPINI2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ