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Protein

Ribonuclease P protein subunit p20

Gene

POP7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP complex, which cleaves pre-rRNA sequences.

Catalytic activityi

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

GO - Molecular functioni

  • ribonuclease P activity Source: ProtInc
  • RNA binding Source: UniProtKB

GO - Biological processi

  • tRNA 5'-leader removal Source: FlyBase
  • tRNA processing Source: GO_Central

Keywordsi

Molecular functionHydrolase
Biological processtRNA processing

Enzyme and pathway databases

ReactomeiR-HSA-6784531 tRNA processing in the nucleus

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease P protein subunit p20 (EC:3.1.26.5)
Short name:
RNaseP protein p20
Alternative name(s):
Ribonucleases P/MRP protein subunit POP7 homolog
Short name:
hPOP7
Gene namesi
Name:POP7
Synonyms:RPP20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000172336.4
HGNCiHGNC:19949 POP7
MIMi606113 gene
neXtProtiNX_O75817

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10248
OpenTargetsiENSG00000172336
PharmGKBiPA134887425

Polymorphism and mutation databases

BioMutaiPOP7

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000585181 – 140Ribonuclease P protein subunit p20Add BLAST140

Proteomic databases

EPDiO75817
MaxQBiO75817
PaxDbiO75817
PeptideAtlasiO75817
PRIDEiO75817
ProteomicsDBi50207

PTM databases

iPTMnetiO75817
PhosphoSitePlusiO75817

Expressioni

Gene expression databases

BgeeiENSG00000172336 Expressed in 203 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_POP7
ExpressionAtlasiO75817 baseline and differential
GenevisibleiO75817 HS

Organism-specific databases

HPAiHPA021007

Interactioni

Subunit structurei

Component of nuclear RNase P and RNase MRP complexes. RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40. RNase MRP consists of an RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38, RPP40, POP5 and RPP21. Interacts with RPP25 and SMN1. RPP20/POP7 is probably a dimer.3 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi115542, 31 interactors
CORUMiO75817
IntActiO75817, 7 interactors
MINTiO75817
STRINGi9606.ENSP00000304353

Structurei

Secondary structure

1140
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO75817
SMRiO75817
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone-like Alba family.Curated

Phylogenomic databases

eggNOGiENOG410IXMT Eukaryota
ENOG4111R36 LUCA
GeneTreeiENSGT00510000048483
HOGENOMiHOG000253010
HOVERGENiHBG001490
InParanoidiO75817
KOiK14527
OMAiTRGQNAC
OrthoDBiEOG091G0Y8P
PhylomeDBiO75817
TreeFamiTF313948

Family and domain databases

Gene3Di3.30.110.20, 1 hit
InterProiView protein in InterPro
IPR036882 Alba-like_dom_sf
IPR014612 Pop7/Rpp20
PANTHERiPTHR15314 PTHR15314, 1 hit
PfamiView protein in Pfam
PF12328 Rpp20, 1 hit
PIRSFiPIRSF036572 RPP20, 1 hit
SUPFAMiSSF82704 SSF82704, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O75817-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAENREPRGA VEAELDPVEY TLRKRLPSRL PRRPNDIYVN MKTDFKAQLA
60 70 80 90 100
RCQKLLDGGA RGQNACSEIY IHGLGLAINR AINIALQLQA GSFGSLQVAA
110 120 130 140
NTSTVELVDE LEPETDTREP LTRIRNNSAI HIRVFRVTPK
Length:140
Mass (Da):15,651
Last modified:May 30, 2006 - v2
Checksum:iCA380F7D273A64B3
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JYM0C9JYM0_HUMAN
Ribonuclease P protein subunit p20
POP7
137Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti80R → H in AAC24113 (PubMed:9630247).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U94316 mRNA Translation: AAC24113.1
CH236956 Genomic DNA Translation: EAL23821.1
CH471091 Genomic DNA Translation: EAW76495.1
BC001430 mRNA Translation: AAH01430.1
CCDSiCCDS5704.1
RefSeqiNP_005828.2, NM_005837.2
UniGeneiHs.416994

Genome annotation databases

EnsembliENST00000303151; ENSP00000304353; ENSG00000172336
GeneIDi10248
KEGGihsa:10248
UCSCiuc003uwh.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U94316 mRNA Translation: AAC24113.1
CH236956 Genomic DNA Translation: EAL23821.1
CH471091 Genomic DNA Translation: EAW76495.1
BC001430 mRNA Translation: AAH01430.1
CCDSiCCDS5704.1
RefSeqiNP_005828.2, NM_005837.2
UniGeneiHs.416994

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6CWXX-ray2.25A1-140[»]
ProteinModelPortaliO75817
SMRiO75817
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115542, 31 interactors
CORUMiO75817
IntActiO75817, 7 interactors
MINTiO75817
STRINGi9606.ENSP00000304353

PTM databases

iPTMnetiO75817
PhosphoSitePlusiO75817

Polymorphism and mutation databases

BioMutaiPOP7

Proteomic databases

EPDiO75817
MaxQBiO75817
PaxDbiO75817
PeptideAtlasiO75817
PRIDEiO75817
ProteomicsDBi50207

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000303151; ENSP00000304353; ENSG00000172336
GeneIDi10248
KEGGihsa:10248
UCSCiuc003uwh.5 human

Organism-specific databases

CTDi10248
DisGeNETi10248
EuPathDBiHostDB:ENSG00000172336.4
GeneCardsiPOP7
HGNCiHGNC:19949 POP7
HPAiHPA021007
MIMi606113 gene
neXtProtiNX_O75817
OpenTargetsiENSG00000172336
PharmGKBiPA134887425
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXMT Eukaryota
ENOG4111R36 LUCA
GeneTreeiENSGT00510000048483
HOGENOMiHOG000253010
HOVERGENiHBG001490
InParanoidiO75817
KOiK14527
OMAiTRGQNAC
OrthoDBiEOG091G0Y8P
PhylomeDBiO75817
TreeFamiTF313948

Enzyme and pathway databases

ReactomeiR-HSA-6784531 tRNA processing in the nucleus

Miscellaneous databases

GeneWikiiPOP7
GenomeRNAii10248
PROiPR:O75817
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000172336 Expressed in 203 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_POP7
ExpressionAtlasiO75817 baseline and differential
GenevisibleiO75817 HS

Family and domain databases

Gene3Di3.30.110.20, 1 hit
InterProiView protein in InterPro
IPR036882 Alba-like_dom_sf
IPR014612 Pop7/Rpp20
PANTHERiPTHR15314 PTHR15314, 1 hit
PfamiView protein in Pfam
PF12328 Rpp20, 1 hit
PIRSFiPIRSF036572 RPP20, 1 hit
SUPFAMiSSF82704 SSF82704, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPOP7_HUMAN
AccessioniPrimary (citable) accession number: O75817
Secondary accession number(s): A4D2E0, Q9BV74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 30, 2006
Last modified: November 7, 2018
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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