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UniProtKB - O75815 (BCAR3_HUMAN)

Entry version 171 (02 Dec 2020)
Sequence version 1 (01 Nov 1998)
Previous versions | rss
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Protein

Breast cancer anti-estrogen resistance protein 3

Gene

BCAR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers (PubMed:24216110). Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis (PubMed:24216110). Promotes insulin-mediated membrane ruffling (By similarity). In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1 (PubMed:19086031). Inhibits cell migration and invasion via regulation of TGFB-mediated matrix digestion, actin filament rearrangement, and inhibition of invadopodia activity (By similarity). May inhibit TGFB-SMAD signaling, via facilitating BCAR1 and SMAD2 and/or SMAD3 interaction (By similarity). Regulates EGF-induced DNA synthesis (PubMed:18722344). Required for the maintenance of ocular lens morphology and structural integrity, potentially via regulation of focal adhesion complex signaling (By similarity). Acts upstream of PTPRA to regulate the localization of BCAR1 and PTPRA to focal adhesions, via regulation of SRC-mediated phosphorylation of PTPRA (By similarity). Positively regulates integrin-induced tyrosine phosphorylation of BCAR1 (By similarity). Acts as a guanine nucleotide exchange factor (GEF) for small GTPases RALA, RAP1A and RRAS (By similarity). However, in a contrasting study, lacks GEF activity towards RAP1 (PubMed:22081014).By similarity4 Publications

Miscellaneous

Overexpression confers anti-estrogen resistance via RRAS-independent activation of the PI3K pathway, and activation of the cyclin D1 promoter in breast cancer cell lines (PubMed:9582273). Plays a role in insulin-mediated ERK activation and DNA synthesis in breast cancer cells (PubMed:24216110).2 Publications

Caution

The guanine nucleotide exchange factor (GEF) activity is controversial. One study showed GEF activity towards RALA, RAP1A and RRAS (By similarity). However, in another study, a construct containing only the Ras-GEF domain lacks GEF activity towards RAP1 (PubMed:22081014).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O75815

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		O75815

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Breast cancer anti-estrogen resistance protein 3
Alternative name(s):
Novel SH2-containing protein 2
SH2 domain-containing protein 3B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BCAR3
Synonyms:NSP2, SH2D3B
ORF Names:UNQ271/PRO308
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000137936.16

Human Gene Nomenclature Database

More...HGNCi		HGNC:973, BCAR3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604704, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O75815

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell junction, Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi177R → K: Abolishes localization to focal adhesions. Reduces interaction with PTPRA. 1 Publication1
Mutagenesisi744L → E: Weakens interaction with BCAR1. 1 Publication1
Mutagenesisi748R → A: Abolishes interaction with BCAR1 and SRC. 2 Publications1

Organism-specific databases

DisGeNET

More...DisGeNETi		8412

Open Targets

More...OpenTargetsi		ENSG00000137936

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA25283

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O75815, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		BCAR3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002302842 – 825Breast cancer anti-estrogen resistance protein 3Add BLAST824

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei32PhosphoserineCombined sources1
Modified residuei78PhosphoserineCombined sources1
Modified residuei83PhosphoserineCombined sources1
Modified residuei182PhosphoserineCombined sources1
Modified residuei290PhosphoserineCombined sources1
Modified residuei334N6-methyllysineCombined sources1
Modified residuei358PhosphoserineCombined sources1
Modified residuei363PhosphoserineCombined sources1
Modified residuei375PhosphoserineCombined sources1
Modified residuei442Omega-N-methylarginineCombined sources1
Modified residuei471PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on tyrosine residues.By similarity

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O75815

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O75815

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O75815

MaxQB - The MaxQuant DataBase

More...MaxQBi		O75815

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O75815

PeptideAtlas

More...PeptideAtlasi		O75815

PRoteomics IDEntifications database

More...PRIDEi		O75815

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		50205 [O75815-1]
50206 [O75815-2]
65066

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O75815

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O75815

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed. Found in several cancer cell lines, but not in nonmalignant breast tissue.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000137936, Expressed in chorionic villus and 234 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O75815, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O75815, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000137936, Tissue enhanced (placenta)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of a complex comprised of PTPRA, BCAR1, BCAR3 (via SH2 domain) and SRC; the formation of the complex is dependent on integrin mediated-tyrosine phosphorylation of PTPRA (PubMed:22801373). Within the complex, interacts (via SH2 domain) with PTPRA (when phosphorylated on 'Tyr-798') (PubMed:22801373).

Interacts (via Ras-GEF domain) with BCAR1 (PubMed:18722344, PubMed:19086031, PubMed:22081014).

Interacts (via Ras-GEF domain) with NEDD9 (By similarity).

Interacts with PTK2/FAK1 (By similarity).

Interacts with PTPN1.

Interacts (via SH2 domain) with EGFR (when tyrosine-phosphorylated) (PubMed:18722344).

By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114000, 44 interactors

Database of interacting proteins

More...DIPi		DIP-33857N

Protein interaction database and analysis system

More...IntActi		O75815, 41 interactors

Molecular INTeraction database

More...MINTi		O75815

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000359264

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O75815, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1825
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O75815

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini154 – 253SH2PROSITE-ProRule annotationAdd BLAST100
Domaini548 – 818Ras-GEFPROSITE-ProRule annotationAdd BLAST271

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni744 – 748Mediates the interaction with BCAR1/p130CAS1 Publication5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi479 – 482Poly-Asp4

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The SH2 domain mediates interaction with tyrosine-phosphorylated proteins (PubMed:18722344). However, not involved in the binding to phosphorylated BCAR1 (PubMed:18722344). Required for cell cycle progression in response to INS/insulin (PubMed:24216110). Required for regulation of EFR-induced DNA synthesis (PubMed:18722344).2 Publications
The Ras-GEF domain appears to adopt a closed conformation rendering it incapable of carrying out canonical exchange factor function, this closed conformation is probably required for interaction with BCAR1.1 Publication

Keywords - Domaini

SH2 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QPX3, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154130

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_015281_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O75815

Identification of Orthologs from Complete Genome Data

More...OMAi		CSAFHAF

Database of Orthologous Groups

More...OrthoDBi		138275at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O75815

TreeFam database of animal gene trees

More...TreeFami		TF323756

Family and domain databases

Conserved Domains Database

More...CDDi		cd00155, RasGEF, 1 hit
cd10337, SH2_BCAR3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.840.10, 1 hit
3.30.505.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR028849, BCAR3
IPR023578, Ras_GEF_dom_sf
IPR001895, RASGEF_cat_dom
IPR036964, RASGEF_cat_dom_sf
IPR000980, SH2
IPR036860, SH2_dom_sf
IPR044102, SH2_SHEP1/BCAR3/NSP1

The PANTHER Classification System

More...PANTHERi		PTHR14247:SF10, PTHR14247:SF10, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00617, RasGEF, 1 hit
PF00017, SH2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00147, RasGEF, 1 hit
SM00252, SH2, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48366, SSF48366, 1 hit
SSF55550, SSF55550, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50009, RASGEF_CAT, 1 hit
PS50001, SH2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O75815-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAGKFASLP RNMPVNHQFP LASSMDLLSS RSPLAEHRPD AYQDVSIHGT 
        60         70         80         90        100
LPRKKKGPPP IRSCDDFSHM GTLPHSKSPR QNSPVTQDGI QESPWQDRHG 
       110        120        130        140        150
ETFTFRDPHL LDPTVEYVKF SKERHIMDRT PEKLKKELEE ELLLSSEDLR 
       160        170        180        190        200
SHAWYHGRIP RQVSENLVQR DGDFLVRDSL SSPGNFVLTC QWKNLAQHFK 
       210        220        230        240        250
INRTVLRLSE AYSRVQYQFE MESFDSIPGL VRCYVGNRRP ISQQSGAIIF 
       260        270        280        290        300
QPINRTVPLR CLEEHYGTSP GQAREGSLTK GRPDVAKRLS LTMGGVQARE 
       310        320        330        340        350
QNLPRGNLLR NKEKSGSQPA CLDHMQDRRA LSLKAHQSES YLPIGCKLPP 
       360        370        380        390        400
QSSGVDTSPC PNSPVFRTGS EPALSPAVVR RVSSDARAGE ALRGSDSQLC 
       410        420        430        440        450
PKPPPKPCKV PFLKVPSSPS AWLNSEANYC ELNPAFATGC GRGAKLPSCA 
       460        470        480        490        500
QGSHTELLTA KQNEAPGPRN SGVNYLILDD DDRERPWEPA AAQMEKGQWD 
       510        520        530        540        550
KGEFVTPLLE TVSSFRPNEF ESKFLPPENK PLETAMLKRA KELFTNNDPK 
       560        570        580        590        600
VIAQHVLSMD CRVARILGVS EEMRRNMGVS SGLELITLPH GHQLRLDIIE 
       610        620        630        640        650
RHNTMAIGIA VDILGCTGTL EDRAATLSKI IQVAVELKDS MGDLYSFSAL 
       660        670        680        690        700
MKALEMPQIT RLEKTWTALR HQYTQTAILY EKQLKPFSKL LHEGRESTCV 
       710        720        730        740        750
PPNNVSVPLL MPLVTLMERQ AVTFEGTDMW EKNDQSCEIM LNHLATARFM 
       760        770        780        790        800
AEAADSYRMN AERILAGFQP DEEMNEICKT EFQMRLLWGS KGAQVNQTER 
       810        820 
YEKFNQILTA LSRKLEPPPV KQAEL
Length:825
Mass (Da):92,566
Last modified:November 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC55D61BB4AC7D0F2
GO
Isoform 2 (identifier: O75815-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-324: Missing.

Show »
Length:501
Mass (Da):55,745
Checksum:i50F3B53FB4BAF59E
GO
Isoform 3 (identifier: O75815-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-91: Missing.
     92-117: ESPWQDRHGETFTFRDPHLLDPTVEY → MPKECSAFHALSAALCCFYHRKSFIG

Show »
Length:734
Mass (Da):82,357
Checksum:iF48AF61CA484420A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti519E → G in AL833121 (PubMed:17974005).Curated1
Sequence conflicti543L → P in AL833121 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_050689464E → G. Corresponds to variant dbSNP:rs12062278Ensembl.1
Natural variantiVAR_050690593Q → H. Corresponds to variant dbSNP:rs17110107Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0178141 – 324Missing in isoform 2. 1 PublicationAdd BLAST324
Alternative sequenceiVSP_0467161 – 91Missing in isoform 3. 1 PublicationAdd BLAST91
Alternative sequenceiVSP_04671792 – 117ESPWQ…PTVEY → MPKECSAFHALSAALCCFYH RKSFIG in isoform 3. 1 PublicationAdd BLAST26

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U92715 mRNA Translation: AAC39777.1
AF124250 mRNA Translation: AAD28245.1
AY358996 mRNA Translation: AAQ89355.1
AL833121 mRNA No translation available.
AL049796 Genomic DNA No translation available.
AL109613 Genomic DNA No translation available.
AL359820 Genomic DNA No translation available.
AL512488 Genomic DNA No translation available.
CH471097 Genomic DNA Translation: EAW73065.1
CH471097 Genomic DNA Translation: EAW73066.1
CH471097 Genomic DNA Translation: EAW73068.1
BC039895 mRNA Translation: AAH39895.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS58010.1 [O75815-3]
CCDS745.1 [O75815-1]
CCDS76181.1 [O75815-2]

NCBI Reference Sequences

More...RefSeqi		NP_001248337.1, NM_001261408.1 [O75815-1]
NP_001248338.1, NM_001261409.1 [O75815-1]
NP_001248339.1, NM_001261410.1 [O75815-3]
NP_001295180.1, NM_001308251.1 [O75815-2]
NP_003558.1, NM_003567.3 [O75815-1]
XP_016857969.1, XM_017002480.1 [O75815-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000260502; ENSP00000260502; ENSG00000137936 [O75815-1]
ENST00000370243; ENSP00000359263; ENSG00000137936 [O75815-1]
ENST00000370244; ENSP00000359264; ENSG00000137936 [O75815-1]
ENST00000370247; ENSP00000359267; ENSG00000137936 [O75815-3]
ENST00000539242; ENSP00000441343; ENSG00000137936 [O75815-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8412

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:8412

UCSC genome browser

More...UCSCi		uc001dpx.6, human [O75815-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U92715 mRNA Translation: AAC39777.1
AF124250 mRNA Translation: AAD28245.1
AY358996 mRNA Translation: AAQ89355.1
AL833121 mRNA No translation available.
AL049796 Genomic DNA No translation available.
AL109613 Genomic DNA No translation available.
AL359820 Genomic DNA No translation available.
AL512488 Genomic DNA No translation available.
CH471097 Genomic DNA Translation: EAW73065.1
CH471097 Genomic DNA Translation: EAW73066.1
CH471097 Genomic DNA Translation: EAW73068.1
BC039895 mRNA Translation: AAH39895.1
CCDSiCCDS58010.1 [O75815-3]
CCDS745.1 [O75815-1]
CCDS76181.1 [O75815-2]
RefSeqiNP_001248337.1, NM_001261408.1 [O75815-1]
NP_001248338.1, NM_001261409.1 [O75815-1]
NP_001248339.1, NM_001261410.1 [O75815-3]
NP_001295180.1, NM_001308251.1 [O75815-2]
NP_003558.1, NM_003567.3 [O75815-1]
XP_016857969.1, XM_017002480.1 [O75815-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3T6AX-ray2.40A/B/C/D502-825[»]
SMRiO75815
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114000, 44 interactors
DIPiDIP-33857N
IntActiO75815, 41 interactors
MINTiO75815
STRINGi9606.ENSP00000359264

PTM databases

iPTMnetiO75815
PhosphoSitePlusiO75815

Polymorphism and mutation databases

BioMutaiBCAR3

Proteomic databases

EPDiO75815
jPOSTiO75815
MassIVEiO75815
MaxQBiO75815
PaxDbiO75815
PeptideAtlasiO75815
PRIDEiO75815
ProteomicsDBi50205 [O75815-1]
50206 [O75815-2]
65066

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2973, 153 antibodies

The DNASU plasmid repository

More...DNASUi		8412

Genome annotation databases

EnsembliENST00000260502; ENSP00000260502; ENSG00000137936 [O75815-1]
ENST00000370243; ENSP00000359263; ENSG00000137936 [O75815-1]
ENST00000370244; ENSP00000359264; ENSG00000137936 [O75815-1]
ENST00000370247; ENSP00000359267; ENSG00000137936 [O75815-3]
ENST00000539242; ENSP00000441343; ENSG00000137936 [O75815-2]
GeneIDi8412
KEGGihsa:8412
UCSCiuc001dpx.6, human [O75815-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8412
DisGeNETi8412
EuPathDBiHostDB:ENSG00000137936.16

GeneCards: human genes, protein and diseases

More...GeneCardsi		BCAR3
HGNCiHGNC:973, BCAR3
HPAiENSG00000137936, Tissue enhanced (placenta)
MIMi604704, gene
neXtProtiNX_O75815
OpenTargetsiENSG00000137936
PharmGKBiPA25283

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QPX3, Eukaryota
GeneTreeiENSGT00940000154130
HOGENOMiCLU_015281_0_0_1
InParanoidiO75815
OMAiCSAFHAF
OrthoDBi138275at2759
PhylomeDBiO75815
TreeFamiTF323756

Enzyme and pathway databases

PathwayCommonsiO75815
SignaLinkiO75815

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		8412, 21 hits in 845 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		BCAR3, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		BCAR3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		8412
PharosiO75815, Tbio

Protein Ontology

More...PROi		PR:O75815
RNActiO75815, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000137936, Expressed in chorionic villus and 234 other tissues
ExpressionAtlasiO75815, baseline and differential
GenevisibleiO75815, HS

Family and domain databases

CDDicd00155, RasGEF, 1 hit
cd10337, SH2_BCAR3, 1 hit
Gene3Di1.10.840.10, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR028849, BCAR3
IPR023578, Ras_GEF_dom_sf
IPR001895, RASGEF_cat_dom
IPR036964, RASGEF_cat_dom_sf
IPR000980, SH2
IPR036860, SH2_dom_sf
IPR044102, SH2_SHEP1/BCAR3/NSP1
PANTHERiPTHR14247:SF10, PTHR14247:SF10, 1 hit
PfamiView protein in Pfam
PF00617, RasGEF, 1 hit
PF00017, SH2, 1 hit
SMARTiView protein in SMART
SM00147, RasGEF, 1 hit
SM00252, SH2, 1 hit
SUPFAMiSSF48366, SSF48366, 1 hit
SSF55550, SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50009, RASGEF_CAT, 1 hit
PS50001, SH2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBCAR3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75815
Secondary accession number(s): D3DT43
, Q5TEW3, Q6UW40, Q9BR50
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: November 1, 1998
Last modified: December 2, 2020
This is version 171 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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