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UniProtKB - O75808 (CAN15_HUMAN)

Entry version 151 (02 Dec 2020)
Sequence version 1 (01 Nov 1998)
Previous versions | rss
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Protein

Calpain-15

Gene

CAPN15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei552By similarity1
Active sitei717By similarity1
Active sitei737By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri3 – 32RanBP2-type 1PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri44 – 73RanBP2-type 2PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri143 – 172RanBP2-type 3PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri338 – 369RanBP2-type 4PROSITE-ProRule annotationAdd BLAST32
Zinc fingeri412 – 441RanBP2-type 5PROSITE-ProRule annotationAdd BLAST30

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O75808

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1474228, Degradation of the extracellular matrix

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calpain-15 (EC:3.4.22.-)
Alternative name(s):
Small optic lobes homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CAPN15
Synonyms:SOLH
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000103326.10

Human Gene Nomenclature Database

More...HGNCi		HGNC:11182, CAPN15

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603267, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O75808

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		6650

Open Targets

More...OpenTargetsi		ENSG00000103326

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36019

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O75808, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CAPN15

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002787701 – 1086Calpain-15Add BLAST1086

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei296PhosphoserineCombined sources1
Modified residuei335PhosphoserineCombined sources1
Modified residuei338PhosphoserineCombined sources1
Modified residuei1070PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O75808

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O75808

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O75808

MaxQB - The MaxQuant DataBase

More...MaxQBi		O75808

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O75808

PeptideAtlas

More...PeptideAtlasi		O75808

PRoteomics IDEntifications database

More...PRIDEi		O75808

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		50203 [O75808-1]
50204 [O75808-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O75808

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O75808

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed with higher expression in brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000103326, Expressed in cerebellum and 201 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O75808, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O75808, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000103326, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112533, 19 interactors

Protein interaction database and analysis system

More...IntActi		O75808, 15 interactors

Molecular INTeraction database

More...MINTi		O75808

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000219611

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O75808, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O75808

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini487 – 793Calpain catalyticPROSITE-ProRule annotationAdd BLAST307

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi124 – 142Glu-richAdd BLAST19

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C2 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri3 – 32RanBP2-type 1PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri44 – 73RanBP2-type 2PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri143 – 172RanBP2-type 3PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri338 – 369RanBP2-type 4PROSITE-ProRule annotationAdd BLAST32
Zinc fingeri412 – 441RanBP2-type 5PROSITE-ProRule annotationAdd BLAST30

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0045, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158312

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_003001_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O75808

Identification of Orthologs from Complete Genome Data

More...OMAi		MSTKGTH

Database for complete collections of gene phylogenies

More...PhylomeDBi		O75808

TreeFam database of animal gene trees

More...TreeFami		TF322245

Family and domain databases

Conserved Domains Database

More...CDDi		cd00044, CysPc, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR022684, Calpain_cysteine_protease
IPR038765, Papain-like_cys_pep_sf
IPR000169, Pept_cys_AS
IPR001300, Peptidase_C2_calpain_cat
IPR001876, Znf_RanBP2
IPR036443, Znf_RanBP2_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00648, Peptidase_C2, 1 hit
PF00641, zf-RanBP, 3 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00704, CALPAIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00230, CysPc, 1 hit
SM00547, ZnF_RBZ, 5 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54001, SSF54001, 1 hit
SSF90209, SSF90209, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50203, CALPAIN_CAT, 1 hit
PS00139, THIOL_PROTEASE_CYS, 1 hit
PS01358, ZF_RANBP2_1, 5 hits
PS50199, ZF_RANBP2_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O75808-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATVGEWSCV RCTFLNPAGQ RQCSICEAPR HKPDLNHILR LSVEEQKWPC 
        60         70         80         90        100
ARCTFRNFLG KEACEVCGFT PEPAPGAAFL PVLNGVLPKP PAILGEPKGS 
       110        120        130        140        150
CQEEAGPVRT AGLVATEPAR GQCEDKDEEE KEEQEEEEGA AEPRGGWACP 
       160        170        180        190        200
RCTLHNTPVA SSCSVCGGPR RLSLPRIPPE ALVVPEVVAP AGFHVVPAAP 
       210        220        230        240        250
PPGLPGEGAE ANPPATSQGP AAEPEPPRVP PFSPFSSTLQ NNPVPRSRRE 
       260        270        280        290        300
VPPQLQPPVP EAAQPSPSAG CRGAPQGSGW AGASRLAELL SGKRLSVLEE 
       310        320        330        340        350
EATEGGTSRV EAGSSTSGSD IIDLAGDTVR YTPASPSSPD FTTWSCAKCT 
       360        370        380        390        400
LRNPTVAPRC SACGCSKLHG FQEHGEPPTH CPDCGADKPS PCGRSCGRVS 
       410        420        430        440        450
SAQKAARVLP ERPGQWACPA CTLLNALRAK HCAACHTPQL LVAQRRGAAP 
       460        470        480        490        500
LRRRESMHVE QRRQTDEGEA KALWENIVAF CRENNVSFVD DSFPPGPESV 
       510        520        530        540        550
GFPAGDSVQQ RVRQWLRPQE INCSVFRDHR ATWSVFHTLR PSDILQGLLG 
       560        570        580        590        600
NCWFLSALAV LAERPDLVER VMVTRSLCAE GAYQVRLCKD GTWTTVLVDD 
       610        620        630        640        650
MLPCDEAGCL LFSQAQRKQL WVALIEKALA KLHGSYFALQ AGRAIEGLAT 
       660        670        680        690        700
LTGAPCESLA LQLSSTNPRE EPVDTDLIWA KMLSSKEAGF LMGASCGGGN 
       710        720        730        740        750
MKVDDSAYES LGLRPRHAYS ILDVRDVQGT RLLRLRNPWG RFSWNGSWSD 
       760        770        780        790        800
EWPHWPGHLR GELMPHGSSE GVFWMEYGDF VRYFDSVDIC KVHSDWQEAR 
       810        820        830        840        850
VQGCFPSSAS APVGVTALTV LERASLEFAL FQEGSRRSDA VDSHLLDLCI 
       860        870        880        890        900
LVFRATFGSG GHLSLGRLLA HSKRAVKKFV SCDVMLEPGE YAVVCCAFNH 
       910        920        930        940        950
WGPPLPGTPA PQASSPSAGV PRASPEPPGH VLAVYSSRLV MVEPVEAQPT 
       960        970        980        990       1000
TLADAIILLT ESRGERHEGR EGMTCYYLTH GWAGLIVVVE NRHPKAYLHV 
      1010       1020       1030       1040       1050
QCDCTDSFNV VSTRGSLRTQ DSVPPLHRQV LVILSQLEGN AGFSITHRLA 
      1060       1070       1080 
HRKAAQAFLS DWTASKGTHS PPLTPEVAGL HGPRPL
Length:1,086
Mass (Da):117,314
Last modified:November 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9809A5CF9134A12C
GO
Isoform 2 (identifier: O75808-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     355-415: TVAPRCSACG...ARVLPERPGQ → CPPGLQPLGR...REPRRAARGP
     416-1086: Missing.

Show »
Length:415
Mass (Da):43,366
Checksum:i49992E1FBEE9704A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GVE3A0A1B0GVE3_HUMAN
Calpain-15
CAPN15
465Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BR03H3BR03_HUMAN
Calpain-15
CAPN15
184Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BT55H3BT55_HUMAN
Calpain-15
CAPN15
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BTS4H3BTS4_HUMAN
Calpain-15
CAPN15
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_023361355 – 415TVAPR…ERPGQ → CPPGLQPLGRGPESLPRAAG PRAGCVQLEAGHGGARGSPA DHAGRRHHPAHREPRRAARG P in isoform 2. 1 PublicationAdd BLAST61
Alternative sequenceiVSP_023362416 – 1086Missing in isoform 2. 1 PublicationAdd BLAST671

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U85647 mRNA Translation: AAC33822.1
AE006464 Genomic DNA Translation: AAK61233.1
Z97986 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85803.1
BC001869 mRNA Translation: AAH01869.1
BC021854 mRNA Translation: AAH21854.1
BC112918 mRNA Translation: AAI12919.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS10410.1 [O75808-1]

NCBI Reference Sequences

More...RefSeqi		NP_005623.1, NM_005632.2 [O75808-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000219611; ENSP00000219611; ENSG00000103326 [O75808-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6650

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6650

UCSC genome browser

More...UCSCi		uc002chi.3, human [O75808-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U85647 mRNA Translation: AAC33822.1
AE006464 Genomic DNA Translation: AAK61233.1
Z97986 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85803.1
BC001869 mRNA Translation: AAH01869.1
BC021854 mRNA Translation: AAH21854.1
BC112918 mRNA Translation: AAI12919.1
CCDSiCCDS10410.1 [O75808-1]
RefSeqiNP_005623.1, NM_005632.2 [O75808-1]

3D structure databases

SMRiO75808
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi112533, 19 interactors
IntActiO75808, 15 interactors
MINTiO75808
STRINGi9606.ENSP00000219611

PTM databases

iPTMnetiO75808
PhosphoSitePlusiO75808

Polymorphism and mutation databases

BioMutaiCAPN15

Proteomic databases

EPDiO75808
jPOSTiO75808
MassIVEiO75808
MaxQBiO75808
PaxDbiO75808
PeptideAtlasiO75808
PRIDEiO75808
ProteomicsDBi50203 [O75808-1]
50204 [O75808-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		22715, 72 antibodies

The DNASU plasmid repository

More...DNASUi		6650

Genome annotation databases

EnsembliENST00000219611; ENSP00000219611; ENSG00000103326 [O75808-1]
GeneIDi6650
KEGGihsa:6650
UCSCiuc002chi.3, human [O75808-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6650
DisGeNETi6650
EuPathDBiHostDB:ENSG00000103326.10

GeneCards: human genes, protein and diseases

More...GeneCardsi		CAPN15
HGNCiHGNC:11182, CAPN15
HPAiENSG00000103326, Low tissue specificity
MIMi603267, gene
neXtProtiNX_O75808
OpenTargetsiENSG00000103326
PharmGKBiPA36019

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0045, Eukaryota
GeneTreeiENSGT00940000158312
HOGENOMiCLU_003001_0_0_1
InParanoidiO75808
OMAiMSTKGTH
PhylomeDBiO75808
TreeFamiTF322245

Enzyme and pathway databases

PathwayCommonsiO75808
ReactomeiR-HSA-1474228, Degradation of the extracellular matrix

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		6650, 5 hits in 829 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6650
PharosiO75808, Tbio

Protein Ontology

More...PROi		PR:O75808
RNActiO75808, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000103326, Expressed in cerebellum and 201 other tissues
ExpressionAtlasiO75808, baseline and differential
GenevisibleiO75808, HS

Family and domain databases

CDDicd00044, CysPc, 1 hit
InterProiView protein in InterPro
IPR022684, Calpain_cysteine_protease
IPR038765, Papain-like_cys_pep_sf
IPR000169, Pept_cys_AS
IPR001300, Peptidase_C2_calpain_cat
IPR001876, Znf_RanBP2
IPR036443, Znf_RanBP2_sf
PfamiView protein in Pfam
PF00648, Peptidase_C2, 1 hit
PF00641, zf-RanBP, 3 hits
PRINTSiPR00704, CALPAIN
SMARTiView protein in SMART
SM00230, CysPc, 1 hit
SM00547, ZnF_RBZ, 5 hits
SUPFAMiSSF54001, SSF54001, 1 hit
SSF90209, SSF90209, 3 hits
PROSITEiView protein in PROSITE
PS50203, CALPAIN_CAT, 1 hit
PS00139, THIOL_PROTEASE_CYS, 1 hit
PS01358, ZF_RANBP2_1, 5 hits
PS50199, ZF_RANBP2_2, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAN15_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75808
Secondary accession number(s): B1B1M4
, Q2KHS2, Q8WTY9, Q9BUW0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: November 1, 1998
Last modified: December 2, 2020
This is version 151 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  4. Peptidase families
    Classification of peptidase families and list of entries
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