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Entry version 140 (13 Feb 2019)
Sequence version 1 (01 Nov 1998)
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Protein

Calpain-15

Gene

CAPN15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei552By similarity1
Active sitei717By similarity1
Active sitei737By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri3 – 32RanBP2-type 1PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri44 – 73RanBP2-type 2PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri143 – 172RanBP2-type 3PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri338 – 369RanBP2-type 4PROSITE-ProRule annotationAdd BLAST32
Zinc fingeri412 – 441RanBP2-type 5PROSITE-ProRule annotationAdd BLAST30

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium-dependent cysteine-type endopeptidase activity Source: GO_Central
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1474228 Degradation of the extracellular matrix

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calpain-15 (EC:3.4.22.-)
Alternative name(s):
Small optic lobes homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CAPN15
Synonyms:SOLH
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000103326.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11182 CAPN15

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603267 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O75808

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000103326

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36019

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CAPN15

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002787701 – 1086Calpain-15Add BLAST1086

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei296PhosphoserineCombined sources1
Modified residuei335PhosphoserineCombined sources1
Modified residuei338PhosphoserineCombined sources1
Modified residuei1070PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O75808

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O75808

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O75808

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O75808

PeptideAtlas

More...
PeptideAtlasi
O75808

PRoteomics IDEntifications database

More...
PRIDEi
O75808

ProteomicsDB human proteome resource

More...
ProteomicsDBi
50203
50204 [O75808-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O75808

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O75808

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed with higher expression in brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000103326 Expressed in 186 organ(s), highest expression level in cerebellum

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O75808 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O75808 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA011960

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112533, 13 interactors

Protein interaction database and analysis system

More...
IntActi
O75808, 7 interactors

Molecular INTeraction database

More...
MINTi
O75808

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000219611

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O75808

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O75808

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini487 – 793Calpain catalyticPROSITE-ProRule annotationAdd BLAST307

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi124 – 142Glu-richAdd BLAST19

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C2 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri3 – 32RanBP2-type 1PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri44 – 73RanBP2-type 2PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri143 – 172RanBP2-type 3PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri338 – 369RanBP2-type 4PROSITE-ProRule annotationAdd BLAST32
Zinc fingeri412 – 441RanBP2-type 5PROSITE-ProRule annotationAdd BLAST30

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0045 Eukaryota
ENOG410XP0B LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158312

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000007650

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG080984

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O75808

KEGG Orthology (KO)

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KOi
K08582

Identification of Orthologs from Complete Genome Data

More...
OMAi
CTRCTFL

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O75808

TreeFam database of animal gene trees

More...
TreeFami
TF322245

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00044 CysPc, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR022684 Calpain_cysteine_protease
IPR038765 Papain_like_cys_pep_sf
IPR000169 Pept_cys_AS
IPR001300 Peptidase_C2_calpain_cat
IPR001876 Znf_RanBP2
IPR036443 Znf_RanBP2_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00648 Peptidase_C2, 1 hit
PF00641 zf-RanBP, 3 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00704 CALPAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00230 CysPc, 1 hit
SM00547 ZnF_RBZ, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54001 SSF54001, 1 hit
SSF90209 SSF90209, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50203 CALPAIN_CAT, 1 hit
PS00139 THIOL_PROTEASE_CYS, 1 hit
PS01358 ZF_RANBP2_1, 5 hits
PS50199 ZF_RANBP2_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O75808-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATVGEWSCV RCTFLNPAGQ RQCSICEAPR HKPDLNHILR LSVEEQKWPC
60 70 80 90 100
ARCTFRNFLG KEACEVCGFT PEPAPGAAFL PVLNGVLPKP PAILGEPKGS
110 120 130 140 150
CQEEAGPVRT AGLVATEPAR GQCEDKDEEE KEEQEEEEGA AEPRGGWACP
160 170 180 190 200
RCTLHNTPVA SSCSVCGGPR RLSLPRIPPE ALVVPEVVAP AGFHVVPAAP
210 220 230 240 250
PPGLPGEGAE ANPPATSQGP AAEPEPPRVP PFSPFSSTLQ NNPVPRSRRE
260 270 280 290 300
VPPQLQPPVP EAAQPSPSAG CRGAPQGSGW AGASRLAELL SGKRLSVLEE
310 320 330 340 350
EATEGGTSRV EAGSSTSGSD IIDLAGDTVR YTPASPSSPD FTTWSCAKCT
360 370 380 390 400
LRNPTVAPRC SACGCSKLHG FQEHGEPPTH CPDCGADKPS PCGRSCGRVS
410 420 430 440 450
SAQKAARVLP ERPGQWACPA CTLLNALRAK HCAACHTPQL LVAQRRGAAP
460 470 480 490 500
LRRRESMHVE QRRQTDEGEA KALWENIVAF CRENNVSFVD DSFPPGPESV
510 520 530 540 550
GFPAGDSVQQ RVRQWLRPQE INCSVFRDHR ATWSVFHTLR PSDILQGLLG
560 570 580 590 600
NCWFLSALAV LAERPDLVER VMVTRSLCAE GAYQVRLCKD GTWTTVLVDD
610 620 630 640 650
MLPCDEAGCL LFSQAQRKQL WVALIEKALA KLHGSYFALQ AGRAIEGLAT
660 670 680 690 700
LTGAPCESLA LQLSSTNPRE EPVDTDLIWA KMLSSKEAGF LMGASCGGGN
710 720 730 740 750
MKVDDSAYES LGLRPRHAYS ILDVRDVQGT RLLRLRNPWG RFSWNGSWSD
760 770 780 790 800
EWPHWPGHLR GELMPHGSSE GVFWMEYGDF VRYFDSVDIC KVHSDWQEAR
810 820 830 840 850
VQGCFPSSAS APVGVTALTV LERASLEFAL FQEGSRRSDA VDSHLLDLCI
860 870 880 890 900
LVFRATFGSG GHLSLGRLLA HSKRAVKKFV SCDVMLEPGE YAVVCCAFNH
910 920 930 940 950
WGPPLPGTPA PQASSPSAGV PRASPEPPGH VLAVYSSRLV MVEPVEAQPT
960 970 980 990 1000
TLADAIILLT ESRGERHEGR EGMTCYYLTH GWAGLIVVVE NRHPKAYLHV
1010 1020 1030 1040 1050
QCDCTDSFNV VSTRGSLRTQ DSVPPLHRQV LVILSQLEGN AGFSITHRLA
1060 1070 1080
HRKAAQAFLS DWTASKGTHS PPLTPEVAGL HGPRPL
Length:1,086
Mass (Da):117,314
Last modified:November 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9809A5CF9134A12C
GO
Isoform 2 (identifier: O75808-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     355-415: TVAPRCSACG...ARVLPERPGQ → CPPGLQPLGR...REPRRAARGP
     416-1086: Missing.

Note: No experimental confirmation available.
Show »
Length:415
Mass (Da):43,366
Checksum:i49992E1FBEE9704A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BR03H3BR03_HUMAN
Calpain-15
CAPN15
184Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GVE3A0A1B0GVE3_HUMAN
Calpain-15
CAPN15
465Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BTS4H3BTS4_HUMAN
Calpain-15
CAPN15
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BT55H3BT55_HUMAN
Calpain-15
CAPN15
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_023361355 – 415TVAPR…ERPGQ → CPPGLQPLGRGPESLPRAAG PRAGCVQLEAGHGGARGSPA DHAGRRHHPAHREPRRAARG P in isoform 2. 1 PublicationAdd BLAST61
Alternative sequenceiVSP_023362416 – 1086Missing in isoform 2. 1 PublicationAdd BLAST671

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U85647 mRNA Translation: AAC33822.1
AE006464 Genomic DNA Translation: AAK61233.1
Z97986 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85803.1
BC001869 mRNA Translation: AAH01869.1
BC021854 mRNA Translation: AAH21854.1
BC112918 mRNA Translation: AAI12919.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS10410.1 [O75808-1]

NCBI Reference Sequences

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RefSeqi
NP_005623.1, NM_005632.2 [O75808-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.632219

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000219611; ENSP00000219611; ENSG00000103326 [O75808-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
6650

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6650

UCSC genome browser

More...
UCSCi
uc002chi.3 human [O75808-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U85647 mRNA Translation: AAC33822.1
AE006464 Genomic DNA Translation: AAK61233.1
Z97986 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85803.1
BC001869 mRNA Translation: AAH01869.1
BC021854 mRNA Translation: AAH21854.1
BC112918 mRNA Translation: AAI12919.1
CCDSiCCDS10410.1 [O75808-1]
RefSeqiNP_005623.1, NM_005632.2 [O75808-1]
UniGeneiHs.632219

3D structure databases

ProteinModelPortaliO75808
SMRiO75808
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112533, 13 interactors
IntActiO75808, 7 interactors
MINTiO75808
STRINGi9606.ENSP00000219611

PTM databases

iPTMnetiO75808
PhosphoSitePlusiO75808

Polymorphism and mutation databases

BioMutaiCAPN15

Proteomic databases

EPDiO75808
jPOSTiO75808
MaxQBiO75808
PaxDbiO75808
PeptideAtlasiO75808
PRIDEiO75808
ProteomicsDBi50203
50204 [O75808-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
6650
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000219611; ENSP00000219611; ENSG00000103326 [O75808-1]
GeneIDi6650
KEGGihsa:6650
UCSCiuc002chi.3 human [O75808-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6650
EuPathDBiHostDB:ENSG00000103326.10

GeneCards: human genes, protein and diseases

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GeneCardsi
CAPN15
HGNCiHGNC:11182 CAPN15
HPAiHPA011960
MIMi603267 gene
neXtProtiNX_O75808
OpenTargetsiENSG00000103326
PharmGKBiPA36019

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0045 Eukaryota
ENOG410XP0B LUCA
GeneTreeiENSGT00940000158312
HOGENOMiHOG000007650
HOVERGENiHBG080984
InParanoidiO75808
KOiK08582
OMAiCTRCTFL
PhylomeDBiO75808
TreeFamiTF322245

Enzyme and pathway databases

ReactomeiR-HSA-1474228 Degradation of the extracellular matrix

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CAPN15 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6650

Protein Ontology

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PROi
PR:O75808

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000103326 Expressed in 186 organ(s), highest expression level in cerebellum
ExpressionAtlasiO75808 baseline and differential
GenevisibleiO75808 HS

Family and domain databases

CDDicd00044 CysPc, 1 hit
InterProiView protein in InterPro
IPR022684 Calpain_cysteine_protease
IPR038765 Papain_like_cys_pep_sf
IPR000169 Pept_cys_AS
IPR001300 Peptidase_C2_calpain_cat
IPR001876 Znf_RanBP2
IPR036443 Znf_RanBP2_sf
PfamiView protein in Pfam
PF00648 Peptidase_C2, 1 hit
PF00641 zf-RanBP, 3 hits
PRINTSiPR00704 CALPAIN
SMARTiView protein in SMART
SM00230 CysPc, 1 hit
SM00547 ZnF_RBZ, 5 hits
SUPFAMiSSF54001 SSF54001, 1 hit
SSF90209 SSF90209, 3 hits
PROSITEiView protein in PROSITE
PS50203 CALPAIN_CAT, 1 hit
PS00139 THIOL_PROTEASE_CYS, 1 hit
PS01358 ZF_RANBP2_1, 5 hits
PS50199 ZF_RANBP2_2, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAN15_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75808
Secondary accession number(s): B1B1M4
, Q2KHS2, Q8WTY9, Q9BUW0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: November 1, 1998
Last modified: February 13, 2019
This is version 140 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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