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Protein

Protein phosphatase 1 regulatory subunit 15A

Gene

PPP1R15A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'.5 Publications

Miscellaneous

The phosphatase activity of the PPP1R15A-PP1 complex toward EIF2S1 is specifically inhibited by Salubrinal, a drug that protects cells from endoplasmic reticulum stress.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • protein kinase binding Source: UniProtKB
  • protein phosphatase 1 binding Source: ParkinsonsUK-UCL
  • protein phosphatase activator activity Source: ParkinsonsUK-UCL
  • protein phosphatase regulator activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis, Stress response, Translation regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2173788 Downregulation of TGF-beta receptor signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
O75807

SIGNOR Signaling Network Open Resource

More...
SIGNORi
O75807

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 15A
Alternative name(s):
Growth arrest and DNA damage-inducible protein GADD34
Myeloid differentiation primary response protein MyD116 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PPP1R15A
Synonyms:GADD34
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000087074.7

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14375 PPP1R15A

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611048 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O75807

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 21Cytoplasmic1 PublicationAdd BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei22 – 39Helical1 PublicationAdd BLAST18
Topological domaini40 – 674Cytoplasmic1 PublicationAdd BLAST635

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Mitochondrion, Mitochondrion outer membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi25V → R: Localizes to cytoplasm, degraded more slowly. 1 Publication1
Mutagenesisi29L → R: Localizes to cytoplasm. 1 Publication1
Mutagenesisi262Y → F: Significantly reduced turnover. 1 Publication1
Mutagenesisi555 – 558KVRF → AAAA: Reduces interaction with SMARCB1. 1 Publication4
Mutagenesisi556 – 558VRF → ARA: Impairs PP1 activation. 1 Publication3
Mutagenesisi612R → K: Reduces PP1-binding; when associated with K-614. 1 Publication1
Mutagenesisi614R → K: Reduces PP1-binding; when associated with K-612. 1 Publication1
Mutagenesisi618R → D: Reduces PP1-binding. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
23645

Open Targets

More...
OpenTargetsi
ENSG00000087074

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33632

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PPP1R15A

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003205181 – 674Protein phosphatase 1 regulatory subunit 15AAdd BLAST674

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei143PhosphoserineCombined sources1
Modified residuei262Phosphotyrosine1 Publication1
Modified residuei391Phosphotyrosine1 Publication1
Modified residuei434Phosphotyrosine1 Publication1
Modified residuei512Phosphotyrosine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated at multiple Ser/Thr residues. Phosphorylated on tyrosine by LYN; which impairs its antiproliferative activity. Phosphorylation at Tyr-262 enhances proteasomal degradation, this position is dephosphorylated by PTPN2.2 Publications
Polyubiquitinated. Exhibits a rapid proteasomal degradation with a half-life under 1 hour, ubiquitination depends on endoplasmic reticulum association.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O75807

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O75807

PeptideAtlas

More...
PeptideAtlasi
O75807

PRoteomics IDEntifications database

More...
PRIDEi
O75807

ProteomicsDB human proteome resource

More...
ProteomicsDBi
50202

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O75807

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O75807

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By methyl methanesulfonate and ionizing irradiation. By IL24/interleukin-24 in melanoma cells; which induces apoptosis.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000087074 Expressed in 225 organ(s), highest expression level in skin of abdomen

CleanEx database of gene expression profiles

More...
CleanExi
HS_PPP1R15A

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O75807 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O75807 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB018395
HPA020240

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PCNA (By similarity). Interacts with LYN and KMT2A/MLL1. Interacts with PP1, PPP1R1A and SMARCB1. Interacts with SMAD7. Interacts with BAG1.By similarity7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
117172, 32 interactors

Protein interaction database and analysis system

More...
IntActi
O75807, 192 interactors

Molecular INTeraction database

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MINTi
O75807

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000200453

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1674
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O75807

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O75807

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati337 – 3691Add BLAST33
Repeati384 – 4172Add BLAST34
Repeati427 – 4603Add BLAST34
Repeati477 – 5104Add BLAST34

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 60Required for localization in the endoplasmic reticulumAdd BLAST60
Regioni337 – 5104 X 34 AA approximate repeatsAdd BLAST174
Regioni337 – 510Interaction with SMAD71 PublicationAdd BLAST174
Regioni483 – 555Interaction with KMT2A/MLL1Add BLAST73
Regioni536 – 583Interaction with SMARCB1Add BLAST48

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi112 – 115Poly-Asp4
Compositional biasi160 – 503Glu-richAdd BLAST344
Compositional biasi518 – 521Poly-Pro4
Compositional biasi661 – 666Poly-Ala6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PPP1R15 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410ITE6 Eukaryota
ENOG410Y1YJ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154404

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000060154

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG052542

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O75807

KEGG Orthology (KO)

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KOi
K14019

Identification of Orthologs from Complete Genome Data

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OMAi
VRAWVYR

Database of Orthologous Groups

More...
OrthoDBi
EOG091G19MD

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O75807

TreeFam database of animal gene trees

More...
TreeFami
TF105547

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019523 Prot_Pase1_reg-su15A/B_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10488 PP1c_bdg, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O75807-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPGQAPHQA TPWRDAHPFF LLSPVMGLLS RAWSRLRGLG PLEPWLVEAV
60 70 80 90 100
KGAALVEAGL EGEARTPLAI PHTPWGRRPE EEAEDSGGPG EDRETLGLKT
110 120 130 140 150
SSSLPEAWGL LDDDDGMYGE REATSVPRGQ GSQFADGQRA PLSPSLLIRT
160 170 180 190 200
LQGSDKNPGE EKAEEEGVAE EEGVNKFSYP PSHRECCPAV EEEDDEEAVK
210 220 230 240 250
KEAHRTSTSA LSPGSKPSTW VSCPGEEENQ ATEDKRTERS KGARKTSVSP
260 270 280 290 300
RSSGSDPRSW EYRSGEASEE KEEKAHKETG KGEAAPGPQS SAPAQRPQLK
310 320 330 340 350
SWWCQPSDEE EGEVKALGAA EKDGEAECPP CIPPPSAFLK AWVYWPGEDT
360 370 380 390 400
EEEEDEEEDE DSDSGSDEEE GEAEASSSTP ATGVFLKSWV YQPGEDTEEE
410 420 430 440 450
EDEDSDTGSA EDEREAETSA STPPASAFLK AWVYRPGEDT EEEEDEDVDS
460 470 480 490 500
EDKEDDSEAA LGEAESDPHP SHPDQRAHFR GWGYRPGKET EEEEAAEDWG
510 520 530 540 550
EAEPCPFRVA IYVPGEKPPP PWAPPRLPLR LQRRLKRPET PTHDPDPETP
560 570 580 590 600
LKARKVRFSE KVTVHFLAVW AGPAQAARQG PWEQLARDRS RFARRITQAQ
610 620 630 640 650
EELSPCLTPA ARARAWARLR NPPLAPIPAL TQTLPSSSVP SSPVQTTPLS
660 670
QAVATPSRSS AAAAAALDLS GRRG
Length:674
Mass (Da):73,478
Last modified:November 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB257AA17456D1403
GO
Isoform 2 (identifier: O75807-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-16: A → D
     17-175: Missing.

Note: No experimental confirmation available.
Show »
Length:515
Mass (Da):56,515
Checksum:i1411EE8095E602B0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QXL1M0QXL1_HUMAN
Protein phosphatase 1 regulatory su...
PPP1R15A
258Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti80E → G in BAA91649 (PubMed:14702039).Curated1
Sequence conflicti297P → L in CAG33540 (Ref. 2) Curated1
Sequence conflicti669L → P in BAG59265 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03918631R → H. Corresponds to variant dbSNP:rs564196Ensembl.1
Natural variantiVAR_03918732A → T1 PublicationCorresponds to variant dbSNP:rs3786734Ensembl.1
Natural variantiVAR_039188199V → A. Corresponds to variant dbSNP:rs611251Ensembl.1
Natural variantiVAR_039189251R → P. Corresponds to variant dbSNP:rs557806Ensembl.1
Natural variantiVAR_039190277K → E1 PublicationCorresponds to variant dbSNP:rs610308Ensembl.1
Natural variantiVAR_062226312G → S1 PublicationCorresponds to variant dbSNP:rs11541192Ensembl.1
Natural variantiVAR_039191316A → P1 PublicationCorresponds to variant dbSNP:rs556052Ensembl.1
Natural variantiVAR_039192381A → V. Corresponds to variant dbSNP:rs1050166Ensembl.1
Natural variantiVAR_039193476R → S1 PublicationCorresponds to variant dbSNP:rs35087747Ensembl.1
Natural variantiVAR_039194594R → C. Corresponds to variant dbSNP:rs2270946Ensembl.1
Natural variantiVAR_039195597T → A1 PublicationCorresponds to variant dbSNP:rs500079Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05708316A → D in isoform 2. 1 Publication1
Alternative sequenceiVSP_05708417 – 175Missing in isoform 2. 1 PublicationAdd BLAST159

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U83981 mRNA Translation: AAC25631.1
CR457259 mRNA Translation: CAG33540.1
AK001361 mRNA Translation: BAA91649.1
AK296668 mRNA Translation: BAG59265.1
CH471177 Genomic DNA Translation: EAW52409.1
BC003067 mRNA Translation: AAH03067.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12738.1 [O75807-1]

NCBI Reference Sequences

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RefSeqi
NP_055145.3, NM_014330.3 [O75807-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.631593

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000200453; ENSP00000200453; ENSG00000087074 [O75807-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23645

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:23645

UCSC genome browser

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UCSCi
uc002pky.5 human [O75807-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U83981 mRNA Translation: AAC25631.1
CR457259 mRNA Translation: CAG33540.1
AK001361 mRNA Translation: BAA91649.1
AK296668 mRNA Translation: BAG59265.1
CH471177 Genomic DNA Translation: EAW52409.1
BC003067 mRNA Translation: AAH03067.1
CCDSiCCDS12738.1 [O75807-1]
RefSeqiNP_055145.3, NM_014330.3 [O75807-1]
UniGeneiHs.631593

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4XPNX-ray2.29B/D552-591[»]
ProteinModelPortaliO75807
SMRiO75807
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117172, 32 interactors
IntActiO75807, 192 interactors
MINTiO75807
STRINGi9606.ENSP00000200453

PTM databases

iPTMnetiO75807
PhosphoSitePlusiO75807

Polymorphism and mutation databases

BioMutaiPPP1R15A

Proteomic databases

MaxQBiO75807
PaxDbiO75807
PeptideAtlasiO75807
PRIDEiO75807
ProteomicsDBi50202

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
23645
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000200453; ENSP00000200453; ENSG00000087074 [O75807-1]
GeneIDi23645
KEGGihsa:23645
UCSCiuc002pky.5 human [O75807-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23645
DisGeNETi23645
EuPathDBiHostDB:ENSG00000087074.7

GeneCards: human genes, protein and diseases

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GeneCardsi
PPP1R15A

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0015305
HIX0174313
HGNCiHGNC:14375 PPP1R15A
HPAiCAB018395
HPA020240
MIMi611048 gene
neXtProtiNX_O75807
OpenTargetsiENSG00000087074
PharmGKBiPA33632

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410ITE6 Eukaryota
ENOG410Y1YJ LUCA
GeneTreeiENSGT00940000154404
HOGENOMiHOG000060154
HOVERGENiHBG052542
InParanoidiO75807
KOiK14019
OMAiVRAWVYR
OrthoDBiEOG091G19MD
PhylomeDBiO75807
TreeFamiTF105547

Enzyme and pathway databases

ReactomeiR-HSA-2173788 Downregulation of TGF-beta receptor signaling
SignaLinkiO75807
SIGNORiO75807

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PPP1R15A human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PPP1R15A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23645

Protein Ontology

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PROi
PR:O75807

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000087074 Expressed in 225 organ(s), highest expression level in skin of abdomen
CleanExiHS_PPP1R15A
ExpressionAtlasiO75807 baseline and differential
GenevisibleiO75807 HS

Family and domain databases

InterProiView protein in InterPro
IPR019523 Prot_Pase1_reg-su15A/B_C
PfamiView protein in Pfam
PF10488 PP1c_bdg, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPR15A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75807
Secondary accession number(s): B4DKQ3, Q6IA96, Q9NVU6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: November 1, 1998
Last modified: December 5, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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