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Protein

UDP-glucuronosyltransferase 2B17

Gene

UGT2B17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. The major substrates of this isozyme are eugenol > 4-methylumbelliferone > dihydrotestosterone (DHT) > androstane-3-alpha,17-beta-diol (3-alpha-diol) > testosterone > androsterone (ADT).

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  • glucuronosyltransferase activity Source: UniProtKB

GO - Biological processi

  • cellular glucuronidation Source: UniProtKB
  • steroid metabolic process Source: ProtInc

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.17 2681
ReactomeiR-HSA-156588 Glucuronidation
SABIO-RKiO75795

Protein family/group databases

CAZyiGT1 Glycosyltransferase Family 1

Chemistry databases

SwissLipidsiSLP:000001696

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 2B17 (EC:2.4.1.17)
Short name:
UDPGT 2B17
Alternative name(s):
C19-steroid-specific UDP-glucuronosyltransferase
Short name:
C19-steroid-specific UDPGT
Gene namesi
Name:UGT2B17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000197888.2
HGNCiHGNC:12547 UGT2B17
MIMi601903 gene
neXtProtiNX_O75795

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei495 – 515HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

DisGeNETi7367
MalaCardsiUGT2B17
MIMi612560 phenotype
OpenTargetsiENSG00000197888
PharmGKBiPA37189

Chemistry databases

ChEMBLiCHEMBL4978
DrugBankiDB00678 Losartan

Polymorphism and mutation databases

BioMutaiUGT2B17

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000003604124 – 530UDP-glucuronosyltransferase 2B17Add BLAST507

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi65N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei136N6-succinyllysineBy similarity1
Glycosylationi316N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi483N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO75795
PaxDbiO75795
PeptideAtlasiO75795
PRIDEiO75795
ProteomicsDBi50199

PTM databases

iPTMnetiO75795
PhosphoSitePlusiO75795

Expressioni

Tissue specificityi

Expressed in various tissues including the liver, kidney, testis, uterus, placenta, mammary gland, adrenal gland, skin and prostate.

Gene expression databases

BgeeiENSG00000197888
CleanExiHS_UGT2B17
GenevisibleiO75795 HS

Organism-specific databases

HPAiHPA045108

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000320401

Chemistry databases

BindingDBiO75795

Structurei

3D structure databases

ProteinModelPortaliO75795
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1192 Eukaryota
COG1819 LUCA
GeneTreeiENSGT00760000118949
HOGENOMiHOG000220831
HOVERGENiHBG004033
InParanoidiO75795
KOiK00699
OMAiELCWEYS
OrthoDBiEOG091G06JC
PhylomeDBiO75795
TreeFamiTF315472

Family and domain databases

InterProiView protein in InterPro
IPR002213 UDP_glucos_trans
IPR035595 UDP_glycos_trans_CS
PfamiView protein in Pfam
PF00201 UDPGT, 1 hit
PROSITEiView protein in PROSITE
PS00375 UDPGT, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O75795-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLKWMSVFL LMQLSCYFSS GSCGKVLVWP TEYSHWINMK TILEELVQRG
60 70 80 90 100
HEVIVLTSSA SILVNASKSS AIKLEVYPTS LTKNDLEDFF MKMFDRWTYS
110 120 130 140 150
ISKNTFWSYF SQLQELCWEY SDYNIKLCED AVLNKKLMRK LQESKFDVLL
160 170 180 190 200
ADAVNPCGEL LAELLNIPFL YSLRFSVGYT VEKNGGGFLF PPSYVPVVMS
210 220 230 240 250
ELSDQMIFME RIKNMIYMLY FDFWFQAYDL KKWDQFYSEV LGRPTTLFET
260 270 280 290 300
MGKAEMWLIR TYWDFEFPRP FLPNVDFVGG LHCKPAKPLP KEMEEFVQSS
310 320 330 340 350
GENGIVVFSL GSMISNMSEE SANMIASALA QIPQKVLWRF DGKKPNTLGS
360 370 380 390 400
NTRLYKWLPQ NDLLGHPKTK AFITHGGTNG IYEAIYHGIP MVGIPLFADQ
410 420 430 440 450
HDNIAHMKAK GAALSVDIRT MSSRDLLNAL KSVINDPIYK ENIMKLSRIH
460 470 480 490 500
HDQPVKPLDR AVFWIEFVMR HKGAKHLRVA AHNLTWIQYH SLDVIAFLLA
510 520 530
CVATMIFMIT KCCLFCFRKL AKTGKKKKRD
Length:530
Mass (Da):61,095
Last modified:November 1, 1998 - v1
Checksum:i8E59EBC43CF43760
GO

Polymorphismi

Copy-number variation of UGT2B17 defines the bone mineral density quantitative trait locus 12 (BMND12) [MIMi:612560]. Variance in bone mineral density is a susceptibility factor for osteoporotic fractures.1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59209 mRNA Translation: AAC25491.1
CCDSiCCDS3523.1
RefSeqiNP_001068.1, NM_001077.3
UniGeneiHs.575083

Genome annotation databases

EnsembliENST00000317746; ENSP00000320401; ENSG00000197888
GeneIDi7367
KEGGihsa:7367
UCSCiuc021xov.2 human

Similar proteinsi

Entry informationi

Entry nameiUDB17_HUMAN
AccessioniPrimary (citable) accession number: O75795
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1998
Last modified: June 20, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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