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Protein

Cell division cycle protein 123 homolog

Gene

CDC123

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for S phase entry of the cell cycle.By similarity

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division cycle protein 123 homolog
Short name:
Protein D123
Alternative name(s):
HT-1080
PZ32
Gene namesi
Name:CDC123
Synonyms:C10orf7, D123
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000151465.13
HGNCiHGNC:16827 CDC123
MIMi617708 gene
neXtProtiNX_O75794

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi8872
OpenTargetsiENSG00000151465
PharmGKBiPA162382148

Polymorphism and mutation databases

BioMutaiCDC123

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002286621 – 336Cell division cycle protein 123 homologAdd BLAST336

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei60PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO75794
MaxQBiO75794
PaxDbiO75794
PeptideAtlasiO75794
PRIDEiO75794
ProteomicsDBi50198

PTM databases

iPTMnetiO75794
PhosphoSitePlusiO75794

Expressioni

Tissue specificityi

Widely expressed. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocytes with the highest expression in testis.1 Publication

Gene expression databases

BgeeiENSG00000151465 Expressed in 233 organ(s), highest expression level in caudate nucleus
CleanExiHS_CDC123
ExpressionAtlasiO75794 baseline and differential
GenevisibleiO75794 HS

Organism-specific databases

HPAiHPA037830
HPA057540

Interactioni

Protein-protein interaction databases

BioGridi114392, 20 interactors
IntActiO75794, 12 interactors
MINTiO75794
STRINGi9606.ENSP00000281141

Structurei

3D structure databases

ProteinModelPortaliO75794
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CDC123 family.Curated

Phylogenomic databases

eggNOGiKOG2983 Eukaryota
ENOG410XSVC LUCA
GeneTreeiENSGT00390000003057
HOVERGENiHBG080491
InParanoidiO75794
OMAiCQFSVWY
OrthoDBiEOG091G0A9C
PhylomeDBiO75794
TreeFamiTF323348

Family and domain databases

InterProiView protein in InterPro
IPR009772 CDC123
PANTHERiPTHR15323 PTHR15323, 1 hit
PfamiView protein in Pfam
PF07065 D123, 1 hit
PIRSFiPIRSF007807 Cdc123, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

O75794-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKKEHVLHCQ FSAWYPFFRG VTIKSVILPL PQNVKDYLLD DGTLVVSGRD
60 70 80 90 100
DPPTHSQPDS DDEAEEIQWS DDENTATLTA PEFPEFATKV QEAINSLGGS
110 120 130 140 150
VFPKLNWSAP RDAYWIAMNS SLKCKTLSDI FLLFKSSDFI TRDFTQPFIH
160 170 180 190 200
CTDDSPDPCI EYELVLRKWC ELIPGAEFRC FVKENKLIGI SQRDYTQYYD
210 220 230 240 250
HISKQKEEIR RCIQDFFKKH IQYKFLDEDF VFDIYRDSRG KVWLIDFNPF
260 270 280 290 300
GEVTDSLLFT WEELISENNL NGDFSEVDAQ EQDSPAFRCT NSEVTVQPSP
310 320 330
YLSYRLPKDF VDLSTGEDAH KLIDFLKLKR NQQEDD
Length:336
Mass (Da):39,135
Last modified:November 1, 1998 - v1
Checksum:iB13CF241D06C9D25
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X6RKY7X6RKY7_HUMAN
Cell division cycle protein 123 hom...
CDC123
157Annotation score:
H7BZW7H7BZW7_HUMAN
Cell division cycle protein 123 hom...
CDC123
144Annotation score:
X6RF82X6RF82_HUMAN
Cell division cycle protein 123 hom...
CDC123
183Annotation score:
X6RA30X6RA30_HUMAN
Cell division cycle protein 123 hom...
CDC123
295Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti93A → P in BAA03593 (PubMed:8601400).Curated1
Sequence conflicti317E → R in BAA03593 (PubMed:8601400).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14878 mRNA Translation: BAA03593.1
U27112 mRNA Translation: AAC34738.1
CR456966 mRNA Translation: CAG33247.1
AK289362 mRNA Translation: BAF82051.1
AL512770 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86317.1
BC001600 mRNA Translation: AAH01600.1
BC009598 mRNA Translation: AAH09598.1
CCDSiCCDS7090.1
RefSeqiNP_006014.2, NM_006023.2
UniGeneiHs.412842
Hs.703246

Genome annotation databases

EnsembliENST00000281141; ENSP00000281141; ENSG00000151465
GeneIDi8872
KEGGihsa:8872
UCSCiuc001ill.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14878 mRNA Translation: BAA03593.1
U27112 mRNA Translation: AAC34738.1
CR456966 mRNA Translation: CAG33247.1
AK289362 mRNA Translation: BAF82051.1
AL512770 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86317.1
BC001600 mRNA Translation: AAH01600.1
BC009598 mRNA Translation: AAH09598.1
CCDSiCCDS7090.1
RefSeqiNP_006014.2, NM_006023.2
UniGeneiHs.412842
Hs.703246

3D structure databases

ProteinModelPortaliO75794
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114392, 20 interactors
IntActiO75794, 12 interactors
MINTiO75794
STRINGi9606.ENSP00000281141

PTM databases

iPTMnetiO75794
PhosphoSitePlusiO75794

Polymorphism and mutation databases

BioMutaiCDC123

Proteomic databases

EPDiO75794
MaxQBiO75794
PaxDbiO75794
PeptideAtlasiO75794
PRIDEiO75794
ProteomicsDBi50198

Protocols and materials databases

DNASUi8872
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000281141; ENSP00000281141; ENSG00000151465
GeneIDi8872
KEGGihsa:8872
UCSCiuc001ill.4 human

Organism-specific databases

CTDi8872
DisGeNETi8872
EuPathDBiHostDB:ENSG00000151465.13
GeneCardsiCDC123
HGNCiHGNC:16827 CDC123
HPAiHPA037830
HPA057540
MIMi617708 gene
neXtProtiNX_O75794
OpenTargetsiENSG00000151465
PharmGKBiPA162382148
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2983 Eukaryota
ENOG410XSVC LUCA
GeneTreeiENSGT00390000003057
HOVERGENiHBG080491
InParanoidiO75794
OMAiCQFSVWY
OrthoDBiEOG091G0A9C
PhylomeDBiO75794
TreeFamiTF323348

Miscellaneous databases

ChiTaRSiCDC123 human
GeneWikiiCDC123
GenomeRNAii8872
PROiPR:O75794
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000151465 Expressed in 233 organ(s), highest expression level in caudate nucleus
CleanExiHS_CDC123
ExpressionAtlasiO75794 baseline and differential
GenevisibleiO75794 HS

Family and domain databases

InterProiView protein in InterPro
IPR009772 CDC123
PANTHERiPTHR15323 PTHR15323, 1 hit
PfamiView protein in Pfam
PF07065 D123, 1 hit
PIRSFiPIRSF007807 Cdc123, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCD123_HUMAN
AccessioniPrimary (citable) accession number: O75794
Secondary accession number(s): A8JZZ7
, Q14107, Q5T0L4, Q5T0L5, Q5T0L7, Q5T0L8, Q5T0L9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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