UniProtKB - O75794 (CD123_HUMAN)

BLAST

>sp|O75794|CD123_HUMAN Cell division cycle protein 123 homolog OS=Homo sapiens OX=9606 GN=CDC123 PE=1 SV=1
MKKEHVLHCQFSAWYPFFRGVTIKSVILPLPQNVKDYLLDDGTLVVSGRDDPPTHSQPDS
DDEAEEIQWSDDENTATLTAPEFPEFATKVQEAINSLGGSVFPKLNWSAPRDAYWIAMNS
SLKCKTLSDIFLLFKSSDFITRDFTQPFIHCTDDSPDPCIEYELVLRKWCELIPGAEFRC
FVKENKLIGISQRDYTQYYDHISKQKEEIRRCIQDFFKKHIQYKFLDEDFVFDIYRDSRG
KVWLIDFNPFGEVTDSLLFTWEELISENNLNGDFSEVDAQEQDSPAFRCTNSEVTVQPSP
YLSYRLPKDFVDLSTGEDAHKLIDFLKLKRNQQEDD

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History
Entry version 141 (07 Nov 2018)
Sequence version 1 (01 Nov 1998)
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Protein

Cell division cycle protein 123 homolog

Gene

CDC123

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Required for S phase entry of the cell cycle.By similarity

GO - Biological processⁱ

cell cycle arrest
Source: ProtInc
Traceable author statementⁱ
- 8601400
cell division Source: UniProtKB-KW
eukaryotic translation initiation factor 2 complex assembly Source: BHF-UCL
positive regulation of cell proliferation
Source: ProtInc
Traceable author statementⁱ
- 8601400
positive regulation of translational initiation Source: BHF-UCL

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell cycle, Cell division

Biological process

Cell cycle, Cell division

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cell division cycle protein 123 homolog Short name: Protein D123 Alternative name(s): HT-1080 PZ32
Gene namesⁱ	Name:CDC123 Synonyms:C10orf7, D123
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000151465.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16827 CDC123
MIMⁱ	617708 gene
neXtProtⁱ	NX_O75794

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	8872
Open Targets More...OpenTargetsⁱ	ENSG00000151465
PharmGKBⁱ	PA162382148

Polymorphism and mutation databases

BioMutaⁱ	CDC123

BioMutaⁱ

CDC123

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000228662	1 – 336	Cell division cycle protein 123 homologAdd BLAST		336

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	60	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	O75794
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O75794
PaxDbⁱ	O75794
PeptideAtlas More...PeptideAtlasⁱ	O75794
PRIDEⁱ	O75794
ProteomicsDBⁱ	50198

PTM databases

iPTMnetⁱ	O75794
PhosphoSitePlusⁱ	O75794

Expressionⁱ

Tissue specificityⁱ

Widely expressed. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocytes with the highest expression in testis.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000151465 Expressed in 233 organ(s), highest expression level in caudate nucleus
CleanExⁱ	HS_CDC123
ExpressionAtlasⁱ	O75794 baseline and differential
Genevisibleⁱ	O75794 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA037830 HPA057540

HPAⁱ

HPA037830
HPA057540

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	114392, 20 interactors
IntActⁱ	O75794, 12 interactors
Molecular INTeraction database More...MINTⁱ	O75794
STRINGⁱ	9606.ENSP00000281141

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O75794
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the CDC123 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG2983 Eukaryota ENOG410XSVC LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000003057
HOVERGENⁱ	HBG080491
InParanoidⁱ	O75794
OMAⁱ	CQFSVWY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0A9C
PhylomeDBⁱ	O75794
TreeFamⁱ	TF323348

Family and domain databases

InterProⁱ	View protein in InterPro IPR009772 CDC123
PANTHERⁱ	PTHR15323 PTHR15323, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07065 D123, 1 hit
PIRSFⁱ	PIRSF007807 Cdc123, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show all Align All

O75794-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MKKEHVLHCQ FSAWYPFFRG VTIKSVILPL PQNVKDYLLD DGTLVVSGRD 
        60         70         80         90        100
DPPTHSQPDS DDEAEEIQWS DDENTATLTA PEFPEFATKV QEAINSLGGS 
       110        120        130        140        150
VFPKLNWSAP RDAYWIAMNS SLKCKTLSDI FLLFKSSDFI TRDFTQPFIH 
       160        170        180        190        200
CTDDSPDPCI EYELVLRKWC ELIPGAEFRC FVKENKLIGI SQRDYTQYYD 
       210        220        230        240        250
HISKQKEEIR RCIQDFFKKH IQYKFLDEDF VFDIYRDSRG KVWLIDFNPF 
       260        270        280        290        300
GEVTDSLLFT WEELISENNL NGDFSEVDAQ EQDSPAFRCT NSEVTVQPSP 
       310        320        330 
YLSYRLPKDF VDLSTGEDAH KLIDFLKLKR NQQEDD

Length:336

Mass (Da):39,135

Last modified:November 1, 1998 - v1

Checksum:ⁱB13CF241D06C9D25

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

X6RKY7	X6RKY7_HUMAN	Cell division cycle protein 123 hom... Cell division cycle protein 123 homolog	CDC123	157	Annotation score:
H7BZW7	H7BZW7_HUMAN	Cell division cycle protein 123 hom... Cell division cycle protein 123 homolog	CDC123	144	Annotation score:
X6RF82	X6RF82_HUMAN	Cell division cycle protein 123 hom... Cell division cycle protein 123 homolog	CDC123	183	Annotation score:
X6RA30	X6RA30_HUMAN	Cell division cycle protein 123 hom... Cell division cycle protein 123 homolog	CDC123	295	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	93	A → P in BAA03593 (PubMed:8601400).Curated		1
Sequence conflictⁱ	317	E → R in BAA03593 (PubMed:8601400).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D14878 mRNA Translation: BAA03593.1 U27112 mRNA Translation: AAC34738.1 CR456966 mRNA Translation: CAG33247.1 AK289362 mRNA Translation: BAF82051.1 AL512770 Genomic DNA No translation available. CH471072 Genomic DNA Translation: EAW86317.1 BC001600 mRNA Translation: AAH01600.1 BC009598 mRNA Translation: AAH09598.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS7090.1
NCBI Reference Sequences More...RefSeqⁱ	NP_006014.2, NM_006023.2
UniGeneⁱ	Hs.412842 Hs.703246

Genome annotation databases

Ensemblⁱ	ENST00000281141; ENSP00000281141; ENSG00000151465
GeneIDⁱ	8872
KEGGⁱ	hsa:8872
UCSC genome browser More...UCSCⁱ	uc001ill.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O75794	Cell division cycle protein 123 homolog (Fragment)		HUMAN		157	UniRef100_O75794
CDC123 isoform 8 (Fragment)		PANTR		157

Protein	Similar proteins		Species	Score	Length	Source
O75794	Cell division cycle protein 123 homolog		MACFA		336	UniRef90_O75794
Cell division cycle protein 123 homolog		MOUSE		336
Cell division cycle protein 123 homolog		RAT		336
Cell division cycle protein 123 homolog		BOVIN		335
Cell division cycle protein 123 homolog (Fragment)		HUMAN		157
+103

Protein	Similar proteins		Species	Score	Length	Source
O75794	Cell division cycle protein 123 homolog		MOUSE		336	UniRef50_O75794
Cell division cycle protein 123 homolog		RAT		336
Cell division cycle protein 123 homolog		MACFA		336
Cell division cycle protein 123 homolog		BOVIN		335
Cell division cycle protein 123 homolog (Fragment)		HUMAN		157
+151

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D14878 mRNA Translation: BAA03593.1 U27112 mRNA Translation: AAC34738.1 CR456966 mRNA Translation: CAG33247.1 AK289362 mRNA Translation: BAF82051.1 AL512770 Genomic DNA No translation available. CH471072 Genomic DNA Translation: EAW86317.1 BC001600 mRNA Translation: AAH01600.1 BC009598 mRNA Translation: AAH09598.1
CCDSⁱ	CCDS7090.1
RefSeqⁱ	NP_006014.2, NM_006023.2
UniGeneⁱ	Hs.412842 Hs.703246

3D structure databases

ProteinModelPortalⁱ	O75794
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114392, 20 interactors
IntActⁱ	O75794, 12 interactors
MINTⁱ	O75794
STRINGⁱ	9606.ENSP00000281141

PTM databases

iPTMnetⁱ	O75794
PhosphoSitePlusⁱ	O75794

Polymorphism and mutation databases

BioMutaⁱ	CDC123

BioMutaⁱ

CDC123

Proteomic databases

EPDⁱ	O75794
MaxQBⁱ	O75794
PaxDbⁱ	O75794
PeptideAtlasⁱ	O75794
PRIDEⁱ	O75794
ProteomicsDBⁱ	50198

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	8872
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000281141; ENSP00000281141; ENSG00000151465
GeneIDⁱ	8872
KEGGⁱ	hsa:8872
UCSCⁱ	uc001ill.4 human

Organism-specific databases

CTDⁱ	8872
DisGeNETⁱ	8872
EuPathDBⁱ	HostDB:ENSG00000151465.13
GeneCardsⁱ	CDC123
HGNCⁱ	HGNC:16827 CDC123
HPAⁱ	HPA037830 HPA057540
MIMⁱ	617708 gene
neXtProtⁱ	NX_O75794
OpenTargetsⁱ	ENSG00000151465
PharmGKBⁱ	PA162382148
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2983 Eukaryota ENOG410XSVC LUCA
GeneTreeⁱ	ENSGT00390000003057
HOVERGENⁱ	HBG080491
InParanoidⁱ	O75794
OMAⁱ	CQFSVWY
OrthoDBⁱ	EOG091G0A9C
PhylomeDBⁱ	O75794
TreeFamⁱ	TF323348

Miscellaneous databases

ChiTaRSⁱ	CDC123 human
GeneWikiⁱ	CDC123
GenomeRNAiⁱ	8872
Protein Ontology More...PROⁱ	PR:O75794
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000151465 Expressed in 233 organ(s), highest expression level in caudate nucleus
CleanExⁱ	HS_CDC123
ExpressionAtlasⁱ	O75794 baseline and differential
Genevisibleⁱ	O75794 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR009772 CDC123
PANTHERⁱ	PTHR15323 PTHR15323, 1 hit
Pfamⁱ	View protein in Pfam PF07065 D123, 1 hit
PIRSFⁱ	PIRSF007807 Cdc123, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CD123_HUMAN
Accessionⁱ	O75794Primary (citable) accession number: O75794 Secondary accession number(s): A8JZZ7 Q5T0L9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
	Last sequence update:	November 1, 1998
	Last modified:	November 7, 2018
	This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM

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Supporting data

UniProtKB - O75794 (CD123_HUMAN)

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Cell division cycle protein 123 homolog

CDC123

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ