UniProtKB - O75794 (CD123_HUMAN)
Protein
Cell division cycle protein 123 homolog
Gene
CDC123
Organism
Homo sapiens (Human)
Status
Functioni
Required for S phase entry of the cell cycle.By similarity
GO - Biological processi
- cell cycle arrest Source: ProtInc
- cell division Source: UniProtKB-KW
- eukaryotic translation initiation factor 2 complex assembly Source: BHF-UCL
- positive regulation of cell population proliferation Source: ProtInc
- positive regulation of translational initiation Source: BHF-UCL
Keywordsi
Biological process | Cell cycle, Cell division |
Enzyme and pathway databases
PathwayCommonsi | O75794 |
Names & Taxonomyi
Protein namesi | Recommended name: Cell division cycle protein 123 homologShort name: Protein D123 Alternative name(s): HT-1080 PZ32 |
Gene namesi | Name:CDC123 Synonyms:C10orf7, D123 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16827, CDC123 |
MIMi | 617708, gene |
neXtProti | NX_O75794 |
VEuPathDBi | HostDB:ENSG00000151465.13 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 8872 |
OpenTargetsi | ENSG00000151465 |
PharmGKBi | PA162382148 |
Miscellaneous databases
Pharosi | O75794, Tbio |
Genetic variation databases
BioMutai | CDC123 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000228662 | 1 – 336 | Cell division cycle protein 123 homologAdd BLAST | 336 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 60 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | O75794 |
jPOSTi | O75794 |
MassIVEi | O75794 |
MaxQBi | O75794 |
PaxDbi | O75794 |
PeptideAtlasi | O75794 |
PRIDEi | O75794 |
ProteomicsDBi | 50198 |
PTM databases
iPTMneti | O75794 |
PhosphoSitePlusi | O75794 |
SwissPalmi | O75794 |
Expressioni
Tissue specificityi
Widely expressed. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocytes with the highest expression in testis.1 Publication
Gene expression databases
Bgeei | ENSG00000151465, Expressed in subventricular zone (inner) (primate) and 245 other tissues |
ExpressionAtlasi | O75794, baseline and differential |
Genevisiblei | O75794, HS |
Organism-specific databases
HPAi | ENSG00000151465, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 114392, 26 interactors |
IntActi | O75794, 15 interactors |
MINTi | O75794 |
STRINGi | 9606.ENSP00000281141 |
Miscellaneous databases
RNActi | O75794, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the CDC123 family.Curated
Phylogenomic databases
eggNOGi | KOG2983, Eukaryota |
GeneTreei | ENSGT00390000003057 |
InParanoidi | O75794 |
OMAi | EDIQWSD |
OrthoDBi | 1539674at2759 |
PhylomeDBi | O75794 |
TreeFami | TF323348 |
Family and domain databases
InterProi | View protein in InterPro IPR009772, CDC123 |
PANTHERi | PTHR15323, PTHR15323, 1 hit |
Pfami | View protein in Pfam PF07065, D123, 1 hit |
PIRSFi | PIRSF007807, Cdc123, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
O75794-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKKEHVLHCQ FSAWYPFFRG VTIKSVILPL PQNVKDYLLD DGTLVVSGRD
60 70 80 90 100
DPPTHSQPDS DDEAEEIQWS DDENTATLTA PEFPEFATKV QEAINSLGGS
110 120 130 140 150
VFPKLNWSAP RDAYWIAMNS SLKCKTLSDI FLLFKSSDFI TRDFTQPFIH
160 170 180 190 200
CTDDSPDPCI EYELVLRKWC ELIPGAEFRC FVKENKLIGI SQRDYTQYYD
210 220 230 240 250
HISKQKEEIR RCIQDFFKKH IQYKFLDEDF VFDIYRDSRG KVWLIDFNPF
260 270 280 290 300
GEVTDSLLFT WEELISENNL NGDFSEVDAQ EQDSPAFRCT NSEVTVQPSP
310 320 330
YLSYRLPKDF VDLSTGEDAH KLIDFLKLKR NQQEDD
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketX6RF82 | X6RF82_HUMAN | Cell division cycle protein 123 hom... | CDC123 | 183 | Annotation score: | ||
H7BZW7 | H7BZW7_HUMAN | Cell division cycle protein 123 hom... | CDC123 | 144 | Annotation score: | ||
X6RA30 | X6RA30_HUMAN | Cell division cycle protein 123 hom... | CDC123 | 295 | Annotation score: | ||
X6RKY7 | X6RKY7_HUMAN | Cell division cycle protein 123 hom... | CDC123 | 157 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 93 | A → P in BAA03593 (PubMed:8601400).Curated | 1 | |
Sequence conflicti | 317 | E → R in BAA03593 (PubMed:8601400).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D14878 mRNA Translation: BAA03593.1 U27112 mRNA Translation: AAC34738.1 CR456966 mRNA Translation: CAG33247.1 AK289362 mRNA Translation: BAF82051.1 AL512770 Genomic DNA No translation available. CH471072 Genomic DNA Translation: EAW86317.1 BC001600 mRNA Translation: AAH01600.1 BC009598 mRNA Translation: AAH09598.1 |
CCDSi | CCDS7090.1 |
RefSeqi | NP_006014.2, NM_006023.2 |
Genome annotation databases
Ensembli | ENST00000281141; ENSP00000281141; ENSG00000151465 |
GeneIDi | 8872 |
KEGGi | hsa:8872 |
UCSCi | uc001ill.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D14878 mRNA Translation: BAA03593.1 U27112 mRNA Translation: AAC34738.1 CR456966 mRNA Translation: CAG33247.1 AK289362 mRNA Translation: BAF82051.1 AL512770 Genomic DNA No translation available. CH471072 Genomic DNA Translation: EAW86317.1 BC001600 mRNA Translation: AAH01600.1 BC009598 mRNA Translation: AAH09598.1 |
CCDSi | CCDS7090.1 |
RefSeqi | NP_006014.2, NM_006023.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 114392, 26 interactors |
IntActi | O75794, 15 interactors |
MINTi | O75794 |
STRINGi | 9606.ENSP00000281141 |
PTM databases
iPTMneti | O75794 |
PhosphoSitePlusi | O75794 |
SwissPalmi | O75794 |
Genetic variation databases
BioMutai | CDC123 |
Proteomic databases
EPDi | O75794 |
jPOSTi | O75794 |
MassIVEi | O75794 |
MaxQBi | O75794 |
PaxDbi | O75794 |
PeptideAtlasi | O75794 |
PRIDEi | O75794 |
ProteomicsDBi | 50198 |
Protocols and materials databases
Antibodypediai | 24692, 395 antibodies |
DNASUi | 8872 |
Genome annotation databases
Ensembli | ENST00000281141; ENSP00000281141; ENSG00000151465 |
GeneIDi | 8872 |
KEGGi | hsa:8872 |
UCSCi | uc001ill.4, human |
Organism-specific databases
CTDi | 8872 |
DisGeNETi | 8872 |
GeneCardsi | CDC123 |
HGNCi | HGNC:16827, CDC123 |
HPAi | ENSG00000151465, Low tissue specificity |
MIMi | 617708, gene |
neXtProti | NX_O75794 |
OpenTargetsi | ENSG00000151465 |
PharmGKBi | PA162382148 |
VEuPathDBi | HostDB:ENSG00000151465.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2983, Eukaryota |
GeneTreei | ENSGT00390000003057 |
InParanoidi | O75794 |
OMAi | EDIQWSD |
OrthoDBi | 1539674at2759 |
PhylomeDBi | O75794 |
TreeFami | TF323348 |
Enzyme and pathway databases
PathwayCommonsi | O75794 |
Miscellaneous databases
BioGRID-ORCSi | 8872, 795 hits in 978 CRISPR screens |
ChiTaRSi | CDC123, human |
GeneWikii | CDC123 |
GenomeRNAii | 8872 |
Pharosi | O75794, Tbio |
PROi | PR:O75794 |
RNActi | O75794, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000151465, Expressed in subventricular zone (inner) (primate) and 245 other tissues |
ExpressionAtlasi | O75794, baseline and differential |
Genevisiblei | O75794, HS |
Family and domain databases
InterProi | View protein in InterPro IPR009772, CDC123 |
PANTHERi | PTHR15323, PTHR15323, 1 hit |
Pfami | View protein in Pfam PF07065, D123, 1 hit |
PIRSFi | PIRSF007807, Cdc123, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CD123_HUMAN | |
Accessioni | O75794Primary (citable) accession number: O75794 Secondary accession number(s): A8JZZ7 Q5T0L9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 21, 2006 |
Last sequence update: | November 1, 1998 | |
Last modified: | April 7, 2021 | |
This is version 156 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families